Incidental Mutation 'R6078:Vmn1r29'
| ID |
482831 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r29
|
| Ensembl Gene |
ENSMUSG00000091734 |
| Gene Name |
vomeronasal 1 receptor 29 |
| Synonyms |
V1rc2 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.067)
|
| Stock # |
R6078 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
58284282-58285193 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 58285080 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 267
(F267L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154278
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168416]
[ENSMUST00000226971]
[ENSMUST00000227761]
[ENSMUST00000228038]
[ENSMUST00000228909]
|
| AlphaFold |
Q9EQ41 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168416
AA Change: F267L
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000129069
Gene: ENSMUSG00000091734
AA Change: F267L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
1.7e-53 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226971
AA Change: F267L
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227761
AA Change: F267L
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228038
AA Change: F267L
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228909
AA Change: F267L
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.3%
- 20x: 95.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 21 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700012B07Rik |
G |
T |
11: 109,684,980 (GRCm39) |
C172* |
probably null |
Het |
| Abcc8 |
T |
C |
7: 45,755,268 (GRCm39) |
M1511V |
probably benign |
Het |
| Abcc9 |
A |
G |
6: 142,585,301 (GRCm39) |
F801S |
probably damaging |
Het |
| Adam39 |
C |
T |
8: 41,277,630 (GRCm39) |
A7V |
probably benign |
Het |
| Adgra2 |
G |
A |
8: 27,604,457 (GRCm39) |
A511T |
probably damaging |
Het |
| Akap9 |
T |
C |
5: 4,117,924 (GRCm39) |
|
probably null |
Het |
| Atp2b4 |
TTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTT |
TTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTT |
1: 133,629,440 (GRCm39) |
|
probably benign |
Het |
| Cbfa2t3 |
T |
C |
8: 123,370,236 (GRCm39) |
H53R |
probably benign |
Het |
| Edc4 |
C |
T |
8: 106,614,180 (GRCm39) |
R19C |
probably benign |
Het |
| Fam90a1b |
T |
C |
X: 93,400,191 (GRCm39) |
N213S |
probably benign |
Het |
| Gkn3 |
C |
T |
6: 87,360,507 (GRCm39) |
A163T |
probably damaging |
Het |
| Insm2 |
T |
C |
12: 55,646,799 (GRCm39) |
I181T |
probably damaging |
Het |
| Lgr6 |
C |
T |
1: 134,921,748 (GRCm39) |
A199T |
probably damaging |
Het |
| Muc4 |
T |
A |
16: 32,575,621 (GRCm39) |
|
probably benign |
Het |
| Nop14 |
T |
C |
5: 34,815,295 (GRCm39) |
D85G |
probably damaging |
Het |
| Pramel27 |
T |
G |
4: 143,578,155 (GRCm39) |
H87Q |
possibly damaging |
Het |
| Rad23b |
C |
T |
4: 55,370,400 (GRCm39) |
A142V |
probably damaging |
Het |
| Shroom3 |
G |
T |
5: 93,090,945 (GRCm39) |
V1151F |
probably damaging |
Het |
| Tfe3 |
T |
C |
X: 7,637,288 (GRCm39) |
L231P |
probably damaging |
Het |
| Vmn2r79 |
T |
A |
7: 86,653,319 (GRCm39) |
V528D |
possibly damaging |
Het |
| Zfp1 |
T |
C |
8: 112,396,975 (GRCm39) |
F299S |
probably damaging |
Het |
|
| Other mutations in Vmn1r29 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02504:Vmn1r29
|
APN |
6 |
58,284,655 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03351:Vmn1r29
|
APN |
6 |
58,284,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0457:Vmn1r29
|
UTSW |
6 |
58,285,072 (GRCm39) |
missense |
probably benign |
0.35 |
|
R0594:Vmn1r29
|
UTSW |
6 |
58,284,757 (GRCm39) |
missense |
probably benign |
0.35 |
|
R0735:Vmn1r29
|
UTSW |
6 |
58,284,717 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1422:Vmn1r29
|
UTSW |
6 |
58,284,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1476:Vmn1r29
|
UTSW |
6 |
58,284,663 (GRCm39) |
missense |
probably benign |
0.23 |
|
R1679:Vmn1r29
|
UTSW |
6 |
58,285,003 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1831:Vmn1r29
|
UTSW |
6 |
58,284,692 (GRCm39) |
nonsense |
probably null |
|
|
R1925:Vmn1r29
|
UTSW |
6 |
58,285,087 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1933:Vmn1r29
|
UTSW |
6 |
58,284,405 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4582:Vmn1r29
|
UTSW |
6 |
58,285,017 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4677:Vmn1r29
|
UTSW |
6 |
58,284,285 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4706:Vmn1r29
|
UTSW |
6 |
58,285,136 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5023:Vmn1r29
|
UTSW |
6 |
58,285,052 (GRCm39) |
nonsense |
probably null |
|
|
R5542:Vmn1r29
|
UTSW |
6 |
58,285,108 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5649:Vmn1r29
|
UTSW |
6 |
58,284,676 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5656:Vmn1r29
|
UTSW |
6 |
58,285,152 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5906:Vmn1r29
|
UTSW |
6 |
58,284,736 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6349:Vmn1r29
|
UTSW |
6 |
58,284,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7946:Vmn1r29
|
UTSW |
6 |
58,284,834 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8554:Vmn1r29
|
UTSW |
6 |
58,285,191 (GRCm39) |
makesense |
probably null |
|
|
R8944:Vmn1r29
|
UTSW |
6 |
58,284,274 (GRCm39) |
start gained |
probably benign |
|
|
R8955:Vmn1r29
|
UTSW |
6 |
58,284,284 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R9268:Vmn1r29
|
UTSW |
6 |
58,284,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9688:Vmn1r29
|
UTSW |
6 |
58,284,739 (GRCm39) |
missense |
probably benign |
0.02 |
|
RF020:Vmn1r29
|
UTSW |
6 |
58,284,528 (GRCm39) |
missense |
probably benign |
0.01 |
|
U15987:Vmn1r29
|
UTSW |
6 |
58,285,080 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCAAGCATCTTCATAGCATCAG -3'
(R):5'- TCTTACCTCTGTGGGCACTAGG -3'
Sequencing Primer
(F):5'- AGCTATCTGAGAGCATCCCCTG -3'
(R):5'- CCTCTGTGGGCACTAGGAATATAC -3'
|
| Posted On |
2017-07-14 |
Incidental Mutation