Incidental Mutation 'R6079:Adgra2'
ID 482857
Institutional Source Beutler Lab
Gene Symbol Adgra2
Ensembl Gene ENSMUSG00000031486
Gene Name adhesion G protein-coupled receptor A2
Synonyms Tem5, 8430414O08Rik, Gpr124, 9530074E10Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6079 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 27575611-27613464 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 27604457 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 511 (A511T)
Ref Sequence ENSEMBL: ENSMUSP00000136277 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033876] [ENSMUST00000178514] [ENSMUST00000179351]
AlphaFold Q91ZV8
Predicted Effect probably damaging
Transcript: ENSMUST00000033876
AA Change: A511T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000033876
Gene: ENSMUSG00000031486
AA Change: A511T

DomainStartEndE-ValueType
signal peptide 1 33 N/A INTRINSIC
LRR 82 106 1.06e2 SMART
LRR_TYP 107 130 2.71e-2 SMART
LRR_TYP 131 154 1.28e-3 SMART
LRR 155 178 7.38e1 SMART
LRRCT 190 240 4.63e-6 SMART
IG 253 346 3.49e-3 SMART
low complexity region 629 639 N/A INTRINSIC
low complexity region 663 674 N/A INTRINSIC
Pfam:GPS 709 750 1.1e-7 PFAM
Pfam:7tm_2 770 990 5.3e-13 PFAM
transmembrane domain 1016 1038 N/A INTRINSIC
transmembrane domain 1045 1064 N/A INTRINSIC
low complexity region 1075 1095 N/A INTRINSIC
low complexity region 1110 1129 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000178514
AA Change: A511T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000136277
Gene: ENSMUSG00000031486
AA Change: A511T

DomainStartEndE-ValueType
signal peptide 1 33 N/A INTRINSIC
LRR 82 106 4.4e-1 SMART
LRR_TYP 107 130 1.1e-4 SMART
LRR_TYP 131 154 5.3e-6 SMART
LRR 155 178 3.1e-1 SMART
LRRCT 190 240 2.2e-8 SMART
IG 253 346 1.4e-5 SMART
HormR 349 426 1.8e-4 SMART
Pfam:7tm_2 554 775 3.2e-11 PFAM
transmembrane domain 801 823 N/A INTRINSIC
transmembrane domain 830 849 N/A INTRINSIC
low complexity region 860 880 N/A INTRINSIC
low complexity region 895 914 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000179207
AA Change: A61T
Predicted Effect probably benign
Transcript: ENSMUST00000179351
SMART Domains Protein: ENSMUSP00000137457
Gene: ENSMUSG00000031486

DomainStartEndE-ValueType
Pfam:GPS 5 49 4.5e-11 PFAM
transmembrane domain 67 89 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for null mutations display fetal or perinatal lethality with CNS hemorrhage and angiogenic arrest in the CNS. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B07Rik G T 11: 109,684,980 (GRCm39) C172* probably null Het
Abcc8 T C 7: 45,755,268 (GRCm39) M1511V probably benign Het
Adamts2 T A 11: 50,647,533 (GRCm39) I302N probably damaging Het
Anxa10 C A 8: 62,530,960 (GRCm39) M83I probably benign Het
Atp2b4 TTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTT TTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTT 1: 133,629,440 (GRCm39) probably benign Het
Cdc20b T C 13: 113,220,576 (GRCm39) F485S probably damaging Het
Edc4 C T 8: 106,614,180 (GRCm39) R19C probably benign Het
Fam90a1b T C X: 93,400,191 (GRCm39) N213S probably benign Het
Gkn3 C T 6: 87,360,507 (GRCm39) A163T probably damaging Het
Itgae A G 11: 73,006,400 (GRCm39) E356G possibly damaging Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Lrrc19 A T 4: 94,531,580 (GRCm39) F11I probably benign Het
Msl1 G T 11: 98,689,519 (GRCm39) G9C probably benign Het
Muc4 T A 16: 32,575,621 (GRCm39) probably benign Het
Myo7a C T 7: 97,714,997 (GRCm39) W1558* probably null Het
Or5p81 T A 7: 108,267,412 (GRCm39) V263E probably damaging Het
Pgk1 C A X: 105,238,098 (GRCm39) L85I possibly damaging Het
Ppp4r1 G A 17: 66,121,343 (GRCm39) V268I possibly damaging Het
Rad23b C T 4: 55,370,400 (GRCm39) A142V probably damaging Het
Satl1 T C X: 111,315,613 (GRCm39) T281A probably benign Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Synrg A G 11: 83,915,126 (GRCm39) E1044G probably damaging Het
Syt12 T C 19: 4,506,896 (GRCm39) D83G probably benign Het
Taf4b T C 18: 14,955,255 (GRCm39) C603R possibly damaging Het
Tbx5 T C 5: 120,021,211 (GRCm39) S406P probably benign Het
Tfe3 T C X: 7,637,288 (GRCm39) L231P probably damaging Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Vmn2r79 T A 7: 86,653,319 (GRCm39) V528D possibly damaging Het
Other mutations in Adgra2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00910:Adgra2 APN 8 27,576,011 (GRCm39) missense possibly damaging 0.81
IGL01599:Adgra2 APN 8 27,608,761 (GRCm39) missense possibly damaging 0.67
IGL01627:Adgra2 APN 8 27,608,761 (GRCm39) missense possibly damaging 0.67
IGL01629:Adgra2 APN 8 27,608,761 (GRCm39) missense possibly damaging 0.67
IGL01632:Adgra2 APN 8 27,608,761 (GRCm39) missense possibly damaging 0.67
IGL01968:Adgra2 APN 8 27,611,263 (GRCm39) nonsense probably null
IGL02551:Adgra2 APN 8 27,609,250 (GRCm39) missense probably benign
IGL02820:Adgra2 APN 8 27,607,535 (GRCm39) missense probably damaging 1.00
PIT1430001:Adgra2 UTSW 8 27,604,216 (GRCm39) missense possibly damaging 0.73
R0735:Adgra2 UTSW 8 27,607,346 (GRCm39) missense probably damaging 1.00
R0799:Adgra2 UTSW 8 27,602,523 (GRCm39) missense probably damaging 1.00
R1183:Adgra2 UTSW 8 27,604,416 (GRCm39) missense probably damaging 1.00
R1276:Adgra2 UTSW 8 27,609,852 (GRCm39) missense probably damaging 0.99
R1389:Adgra2 UTSW 8 27,601,116 (GRCm39) missense probably damaging 1.00
R1514:Adgra2 UTSW 8 27,611,306 (GRCm39) nonsense probably null
R1601:Adgra2 UTSW 8 27,600,046 (GRCm39) splice site probably null
R1760:Adgra2 UTSW 8 27,609,795 (GRCm39) missense probably damaging 1.00
R1957:Adgra2 UTSW 8 27,601,196 (GRCm39) missense possibly damaging 0.64
R1977:Adgra2 UTSW 8 27,605,789 (GRCm39) missense possibly damaging 0.80
R2164:Adgra2 UTSW 8 27,604,232 (GRCm39) nonsense probably null
R2181:Adgra2 UTSW 8 27,611,701 (GRCm39) missense probably damaging 0.99
R4282:Adgra2 UTSW 8 27,609,272 (GRCm39) missense possibly damaging 0.54
R4724:Adgra2 UTSW 8 27,588,850 (GRCm39) missense possibly damaging 0.91
R4749:Adgra2 UTSW 8 27,604,225 (GRCm39) missense probably damaging 1.00
R4809:Adgra2 UTSW 8 27,600,507 (GRCm39) nonsense probably null
R5718:Adgra2 UTSW 8 27,603,514 (GRCm39) critical splice donor site probably null
R6025:Adgra2 UTSW 8 27,604,491 (GRCm39) missense probably damaging 0.99
R6078:Adgra2 UTSW 8 27,604,457 (GRCm39) missense probably damaging 1.00
R6138:Adgra2 UTSW 8 27,604,457 (GRCm39) missense probably damaging 1.00
R6140:Adgra2 UTSW 8 27,605,433 (GRCm39) missense probably damaging 1.00
R6232:Adgra2 UTSW 8 27,609,193 (GRCm39) missense probably benign 0.19
R6321:Adgra2 UTSW 8 27,604,190 (GRCm39) missense probably benign 0.02
R6385:Adgra2 UTSW 8 27,608,878 (GRCm39) missense probably damaging 1.00
R6676:Adgra2 UTSW 8 27,601,268 (GRCm39) missense possibly damaging 0.50
R6724:Adgra2 UTSW 8 27,604,210 (GRCm39) missense possibly damaging 0.93
R6862:Adgra2 UTSW 8 27,603,465 (GRCm39) missense probably damaging 0.98
R6862:Adgra2 UTSW 8 27,603,464 (GRCm39) missense probably benign 0.01
R7140:Adgra2 UTSW 8 27,610,929 (GRCm39) critical splice donor site probably null
R7242:Adgra2 UTSW 8 27,612,055 (GRCm39) missense probably damaging 1.00
R7861:Adgra2 UTSW 8 27,604,485 (GRCm39) missense probably damaging 0.98
R7882:Adgra2 UTSW 8 27,607,440 (GRCm39) missense probably benign 0.15
R8069:Adgra2 UTSW 8 27,609,251 (GRCm39) missense probably benign 0.01
R8146:Adgra2 UTSW 8 27,604,202 (GRCm39) missense probably damaging 0.99
R9080:Adgra2 UTSW 8 27,604,529 (GRCm39) missense probably benign 0.02
R9103:Adgra2 UTSW 8 27,603,436 (GRCm39) missense probably damaging 1.00
R9135:Adgra2 UTSW 8 27,610,979 (GRCm39) missense probably damaging 1.00
R9425:Adgra2 UTSW 8 27,576,094 (GRCm39) missense probably benign 0.04
R9473:Adgra2 UTSW 8 27,610,943 (GRCm39) missense probably damaging 0.99
R9643:Adgra2 UTSW 8 27,612,031 (GRCm39) missense possibly damaging 0.48
R9648:Adgra2 UTSW 8 27,609,172 (GRCm39) missense probably damaging 1.00
X0050:Adgra2 UTSW 8 27,603,446 (GRCm39) missense probably benign 0.32
X0062:Adgra2 UTSW 8 27,610,834 (GRCm39) missense possibly damaging 0.47
Predicted Primers PCR Primer
(F):5'- TTTGGGTTACGTTGACCAGATC -3'
(R):5'- AGGCATGTCCCTTCTATGAACC -3'

Sequencing Primer
(F):5'- TTGACCAGATCAAGGAGGTGAGATTC -3'
(R):5'- CAACTGCTACGCTCTCAGG -3'
Posted On 2017-07-14