Incidental Mutation 'R6060:Lpxn'
| ID |
483211 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lpxn
|
| Ensembl Gene |
ENSMUSG00000024696 |
| Gene Name |
leupaxin |
| Synonyms |
4933402K05Rik, A530083L21Rik |
| MMRRC Submission |
044426-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R6060 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
19 |
| Chromosomal Location |
12773557-12811171 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 12810489 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 311
(L311P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000025601
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000025601]
|
| AlphaFold |
Q99N69 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000025601
AA Change: L311P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000025601
Gene: ENSMUSG00000024696
AA Change: L311P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
12 |
N/A |
INTRINSIC |
|
LIM
|
151 |
202 |
3.17e-17 |
SMART |
|
LIM
|
210 |
261 |
1.98e-18 |
SMART |
|
LIM
|
269 |
320 |
3.26e-19 |
SMART |
|
LIM
|
328 |
379 |
3.34e-16 |
SMART |
|
| Meta Mutation Damage Score |
0.7158 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 97.9%
- 20x: 93.6%
|
| Validation Efficiency |
100% (56/56) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 41 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110057P08Rik |
A |
G |
16: 88,966,630 (GRCm39) |
|
probably null |
Het |
| Adh1 |
T |
C |
3: 137,992,544 (GRCm39) |
I220T |
probably damaging |
Het |
| Ajap1 |
G |
A |
4: 153,516,699 (GRCm39) |
T214I |
probably damaging |
Het |
| Ank2 |
A |
G |
3: 126,749,601 (GRCm39) |
F476S |
probably damaging |
Het |
| Atp6v1g3 |
A |
G |
1: 138,201,582 (GRCm39) |
K27E |
possibly damaging |
Het |
| BC034090 |
A |
G |
1: 155,117,245 (GRCm39) |
I291T |
probably benign |
Het |
| Cnot9 |
T |
A |
1: 74,556,285 (GRCm39) |
N27K |
probably benign |
Het |
| Cyp2c70 |
A |
T |
19: 40,153,857 (GRCm39) |
L244* |
probably null |
Het |
| Cyp2d22 |
T |
C |
15: 82,260,086 (GRCm39) |
T6A |
probably benign |
Het |
| D630045J12Rik |
T |
C |
6: 38,107,799 (GRCm39) |
E1829G |
probably damaging |
Het |
| Dnajc4 |
G |
T |
19: 6,968,093 (GRCm39) |
S61* |
probably null |
Het |
| Dpysl4 |
A |
G |
7: 138,669,324 (GRCm39) |
M1V |
probably null |
Het |
| Fam149a |
T |
A |
8: 45,811,799 (GRCm39) |
|
probably benign |
Het |
| Fam184b |
T |
C |
5: 45,710,489 (GRCm39) |
E547G |
probably damaging |
Het |
| Fam47e |
T |
A |
5: 92,727,472 (GRCm39) |
F127I |
possibly damaging |
Het |
| Ifi207 |
G |
A |
1: 173,558,093 (GRCm39) |
T215I |
unknown |
Het |
| Iftap |
T |
C |
2: 101,440,950 (GRCm39) |
K18E |
probably benign |
Het |
| Lrp1b |
A |
T |
2: 40,640,946 (GRCm39) |
N3499K |
|
Het |
| Mknk2 |
A |
T |
10: 80,507,468 (GRCm39) |
D76E |
probably benign |
Het |
| Nectin2 |
A |
T |
7: 19,451,700 (GRCm39) |
Y445N |
probably damaging |
Het |
| Ngb |
A |
C |
12: 87,146,963 (GRCm39) |
S85A |
probably benign |
Het |
| Nrp1 |
C |
A |
8: 129,224,419 (GRCm39) |
H727Q |
probably damaging |
Het |
| Or5b112 |
C |
T |
19: 13,319,497 (GRCm39) |
A125V |
probably benign |
Het |
| Or6k2 |
C |
A |
1: 173,986,907 (GRCm39) |
C189* |
probably null |
Het |
| Pold3 |
A |
C |
7: 99,749,819 (GRCm39) |
Y115* |
probably null |
Het |
| Ppp1r12b |
C |
G |
1: 134,883,262 (GRCm39) |
V87L |
probably benign |
Het |
| Ppp1r26 |
A |
G |
2: 28,341,042 (GRCm39) |
N224S |
probably benign |
Het |
| Prl7a1 |
G |
A |
13: 27,821,571 (GRCm39) |
P122S |
probably damaging |
Het |
| Rc3h2 |
T |
C |
2: 37,289,612 (GRCm39) |
H400R |
possibly damaging |
Het |
| Rnf32 |
A |
T |
5: 29,411,752 (GRCm39) |
I214L |
probably benign |
Het |
| Safb2 |
A |
T |
17: 56,870,246 (GRCm39) |
|
probably null |
Het |
| Serpinb6e |
A |
G |
13: 34,025,256 (GRCm39) |
C12R |
possibly damaging |
Het |
| Sh2b2 |
A |
T |
5: 136,261,209 (GRCm39) |
N2K |
possibly damaging |
Het |
| Slc12a4 |
G |
A |
8: 106,672,338 (GRCm39) |
A821V |
probably damaging |
Het |
| Slc41a1 |
A |
G |
1: 131,767,972 (GRCm39) |
M179V |
probably benign |
Het |
| Slc9a3 |
A |
G |
13: 74,299,004 (GRCm39) |
Y141C |
probably damaging |
Het |
| Tenm4 |
G |
A |
7: 96,522,918 (GRCm39) |
V1450I |
probably damaging |
Het |
| Trmt1l |
A |
G |
1: 151,333,331 (GRCm39) |
N642S |
possibly damaging |
Het |
| Ttll13 |
G |
A |
7: 79,908,491 (GRCm39) |
R576H |
probably damaging |
Het |
| Zar1 |
T |
A |
5: 72,738,272 (GRCm39) |
R43S |
probably benign |
Het |
| Zfp455 |
A |
G |
13: 67,355,257 (GRCm39) |
Y175C |
probably damaging |
Het |
|
| Other mutations in Lpxn |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01895:Lpxn
|
APN |
19 |
12,810,450 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03088:Lpxn
|
APN |
19 |
12,810,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03203:Lpxn
|
APN |
19 |
12,796,770 (GRCm39) |
missense |
probably benign |
0.01 |
|
mascherano
|
UTSW |
19 |
12,810,536 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0848:Lpxn
|
UTSW |
19 |
12,781,401 (GRCm39) |
missense |
probably benign |
|
|
R1514:Lpxn
|
UTSW |
19 |
12,801,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1532:Lpxn
|
UTSW |
19 |
12,781,456 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1880:Lpxn
|
UTSW |
19 |
12,781,452 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1937:Lpxn
|
UTSW |
19 |
12,802,274 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2182:Lpxn
|
UTSW |
19 |
12,810,122 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2897:Lpxn
|
UTSW |
19 |
12,796,722 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4194:Lpxn
|
UTSW |
19 |
12,810,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Lpxn
|
UTSW |
19 |
12,810,654 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4844:Lpxn
|
UTSW |
19 |
12,810,536 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5567:Lpxn
|
UTSW |
19 |
12,810,023 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5570:Lpxn
|
UTSW |
19 |
12,810,023 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6366:Lpxn
|
UTSW |
19 |
12,802,163 (GRCm39) |
missense |
probably benign |
0.12 |
|
R6615:Lpxn
|
UTSW |
19 |
12,802,163 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7116:Lpxn
|
UTSW |
19 |
12,788,622 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7135:Lpxn
|
UTSW |
19 |
12,810,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7808:Lpxn
|
UTSW |
19 |
12,802,185 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R8290:Lpxn
|
UTSW |
19 |
12,810,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8897:Lpxn
|
UTSW |
19 |
12,802,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8983:Lpxn
|
UTSW |
19 |
12,810,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9415:Lpxn
|
UTSW |
19 |
12,802,336 (GRCm39) |
missense |
probably benign |
0.40 |
|
Z1176:Lpxn
|
UTSW |
19 |
12,802,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTAGCACACAGAACCAATTGTG -3'
(R):5'- GCTCCTTGAAGATGCCTTTCGG -3'
Sequencing Primer
(F):5'- CCAATTGTGGGCCTTTGCAG -3'
(R):5'- CCTTTCGGCAGCTGTGTCAG -3'
|
| Posted On |
2017-07-14 |
Incidental Mutation