Mutagenetix > Incidental Mutation

Incidental Mutation 'R6061:Cyp2j11'

483225

Institutional Source

Beutler Lab

Gene Symbol

Cyp2j11

Ensembl Gene

ENSMUSG00000066097

Gene Name

cytochrome P450, family 2, subfamily j, polypeptide 11

Synonyms

Cyp2j11-ps

MMRRC Submission

044226-MU

Accession Numbers

Genbank: NM_001004141; MGI: 2140224

Is this an essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

R6061 (G1)

Quality Score

220.009

Status

Not validated

Chromosome

Chromosomal Location

96294508-96348662 bp(-) (GRCm38)

Type of Mutation

start gained

DNA Base Change (assembly)

T to A at 96348616 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000132180 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000015368]

AlphaFold

Q3UNV2

Predicted Effect

probably benign
Transcript: ENSMUST00000015368

SMART Domains

Protein: ENSMUSP00000132180
Gene: ENSMUSG00000066097

Domain	Start	End	E-Value	Type
transmembrane domain	7	29	N/A	INTRINSIC
Pfam:p450	44	500	4.3e-133	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.7%
20x: 92.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2ml1	A	C	6: 128,568,712	F484C	probably damaging	Het
Cdsn	A	G	17: 35,554,906	S111G	unknown	Het
Ctnnal1	T	C	4: 56,812,349	T726A	probably benign	Het
Ddx60	T	A	8: 62,023,241	M1541K	probably null	Het
Dnah14	C	T	1: 181,709,051	P2420S	probably damaging	Het
Doxl2	A	C	6: 48,976,601	I487L	probably benign	Het
Fhit	T	C	14: 9,573,435	E205G	probably benign	Het
Glipr1l1	C	T	10: 112,076,170	T203M	probably benign	Het
Gm4353	T	A	7: 116,084,269	D97V	probably benign	Het
Gprc6a	A	T	10: 51,615,811	I543K	probably damaging	Het
Ifi205	T	C	1: 174,027,264	T110A	possibly damaging	Het
Med27	T	A	2: 29,509,441	S95T	probably damaging	Het
Mocs1	T	C	17: 49,450,313	S308P	probably damaging	Het
Mrpl11	C	T	19: 4,963,369	S88F	possibly damaging	Het
Nav3	A	T	10: 109,866,984	Y229*	probably null	Het
Olfr138	A	G	17: 38,274,881	M37V	probably benign	Het
Olfr38	A	T	6: 42,762,965	L304F	probably damaging	Het
Olfr569	C	A	7: 102,887,951	L67F	probably benign	Het
Olfr668	C	T	7: 104,925,392	R124H	probably benign	Het
Olfr996	T	A	2: 85,579,542	M101K	possibly damaging	Het
Pear1	A	G	3: 87,755,931	I460T	probably benign	Het
Phc3	T	A	3: 30,914,529	K816N	probably damaging	Het
Phf19	T	A	2: 34,897,117	D445V	probably damaging	Het
Pkd2l2	T	C	18: 34,430,689	F486L	probably damaging	Het
Plagl1	G	T	10: 13,127,895		probably benign	Het
Prkca	A	G	11: 108,057,845	I106T	probably benign	Het
Ptpn3	C	T	4: 57,248,681	G218R	probably damaging	Het
Ptx3	A	G	3: 66,224,709	D217G	possibly damaging	Het
Rab3d	T	C	9: 21,910,519	T209A	probably benign	Het
Rfx2	A	G	17: 56,777,473	F642S	possibly damaging	Het
Rhpn2	T	A	7: 35,376,211	M271K	possibly damaging	Het
Serpinb6b	A	G	13: 32,977,994	T259A	probably damaging	Het
Speer3	G	A	5: 13,794,691	V123M	possibly damaging	Het
Svil	T	G	18: 5,106,724	V1855G	probably damaging	Het
Thbs4	A	G	13: 92,751,795	F950L	probably benign	Het
Tiparp	T	C	3: 65,553,243	V551A	probably damaging	Het
Vmn2r71	T	A	7: 85,619,274	D228E	probably benign	Het
Vmn2r85	T	C	10: 130,425,662	I269V	probably benign	Het
Vps9d1	A	T	8: 123,245,671	M497K	probably damaging	Het
Wnt5b	A	G	6: 119,433,642	V241A	probably damaging	Het
Xdh	T	C	17: 73,921,347	N353S	probably damaging	Het
Zfp526	C	T	7: 25,226,332	T672M	probably damaging	Het

Other mutations in Cyp2j11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01101:Cyp2j11	APN	4	96339095	missense	probably benign
IGL01816:Cyp2j11	APN	4	96294924	missense	probably damaging	1.00
IGL02406:Cyp2j11	APN	4	96348539	missense	possibly damaging	0.56
E7848:Cyp2j11	UTSW	4	96319365	missense	probably benign	0.09
R0020:Cyp2j11	UTSW	4	96307404	missense	probably benign	0.19
R0020:Cyp2j11	UTSW	4	96307404	missense	probably benign	0.19
R1298:Cyp2j11	UTSW	4	96307260	critical splice donor site	probably null
R1411:Cyp2j11	UTSW	4	96345216	missense	probably benign	0.03
R1428:Cyp2j11	UTSW	4	96294880	missense	probably benign	0.01
R1740:Cyp2j11	UTSW	4	96319376	missense	probably benign	0.00
R1818:Cyp2j11	UTSW	4	96297739	missense	probably damaging	0.97
R1819:Cyp2j11	UTSW	4	96297739	missense	probably damaging	0.97
R1917:Cyp2j11	UTSW	4	96339974	missense	probably damaging	1.00
R2084:Cyp2j11	UTSW	4	96339201	missense	probably damaging	1.00
R2146:Cyp2j11	UTSW	4	96316358	missense	probably damaging	1.00
R2148:Cyp2j11	UTSW	4	96316358	missense	probably damaging	1.00
R2150:Cyp2j11	UTSW	4	96316358	missense	probably damaging	1.00
R4963:Cyp2j11	UTSW	4	96316382	missense	probably damaging	1.00
R5335:Cyp2j11	UTSW	4	96307352	missense	probably damaging	1.00
R5450:Cyp2j11	UTSW	4	96339876	missense	probably benign	0.44
R5688:Cyp2j11	UTSW	4	96345121	missense	probably damaging	1.00
R5978:Cyp2j11	UTSW	4	96319352	missense	probably damaging	1.00
R6075:Cyp2j11	UTSW	4	96345085	missense	probably benign	0.04
R6912:Cyp2j11	UTSW	4	96294871	missense	probably benign	0.00
R7338:Cyp2j11	UTSW	4	96307287	missense	possibly damaging	0.64
R7394:Cyp2j11	UTSW	4	96316440	missense	probably benign	0.00
R7464:Cyp2j11	UTSW	4	96345120	missense	probably damaging	1.00
R7972:Cyp2j11	UTSW	4	96297634	missense	probably damaging	1.00
R8152:Cyp2j11	UTSW	4	96307292	missense	probably damaging	1.00
R8328:Cyp2j11	UTSW	4	96348368	missense	probably benign	0.03
R8383:Cyp2j11	UTSW	4	96348458	missense	probably benign	0.00
R8519:Cyp2j11	UTSW	4	96319302	missense	probably benign	0.44
R8789:Cyp2j11	UTSW	4	96339168	missense	probably damaging	0.99
R9268:Cyp2j11	UTSW	4	96319544	intron	probably benign
R9323:Cyp2j11	UTSW	4	96307382	missense	probably benign	0.01
R9457:Cyp2j11	UTSW	4	96307359	missense	probably damaging	0.98
R9590:Cyp2j11	UTSW	4	96307377	missense	probably benign	0.11
Z1176:Cyp2j11	UTSW	4	96307303	missense	probably damaging	0.99
Z1176:Cyp2j11	UTSW	4	96307436	missense	probably damaging	0.99

Predicted Primers

Posted On

2017-07-14