Incidental Mutation 'R6049:Or7g28'
ID 483453
Institutional Source Beutler Lab
Gene Symbol Or7g28
Ensembl Gene ENSMUSG00000058692
Gene Name olfactory receptor family 7 subfamily G member 28
Synonyms GA_x6K02T2PVTD-13098546-13097608, MOR149-3, Olfr846
MMRRC Submission 044217-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.139) question?
Stock # R6049 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 19271711-19272652 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 19272640 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Stop codon at position 4 (G4*)
Ref Sequence ENSEMBL: ENSMUSP00000150672 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078774] [ENSMUST00000214810]
AlphaFold Q8VET8
Predicted Effect probably null
Transcript: ENSMUST00000078774
AA Change: G4*
SMART Domains Protein: ENSMUSP00000077830
Gene: ENSMUSG00000058692
AA Change: G4*

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.2e-54 PFAM
Pfam:7tm_1 41 290 4.7e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212868
Predicted Effect probably null
Transcript: ENSMUST00000214810
AA Change: G4*
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.3%
Validation Efficiency 98% (60/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921539E11Rik G A 4: 103,088,520 (GRCm39) H229Y probably benign Het
Aadacl2fm2 A C 3: 59,659,570 (GRCm39) D341A probably damaging Het
Abcd2 A G 15: 91,062,439 (GRCm39) F500L probably benign Het
Adgb A G 10: 10,253,770 (GRCm39) L1190P probably damaging Het
Adgrv1 A G 13: 81,545,473 (GRCm39) V5604A probably benign Het
Ank2 T A 3: 126,736,669 (GRCm39) T3072S possibly damaging Het
Arhgap39 A G 15: 76,611,601 (GRCm39) probably null Het
C6 T C 15: 4,764,654 (GRCm39) C117R probably damaging Het
Cacna1a A G 8: 85,365,475 (GRCm39) E2206G probably damaging Het
Cd2bp2 A T 7: 126,793,007 (GRCm39) F338L probably damaging Het
Cemip2 A T 19: 21,803,490 (GRCm39) Q841L probably benign Het
Cngb1 T C 8: 95,997,470 (GRCm39) D575G probably damaging Het
Cplane2 T A 4: 140,945,473 (GRCm39) V108D probably benign Het
Crat A G 2: 30,293,553 (GRCm39) F63S probably damaging Het
Crybg3 T C 16: 59,364,417 (GRCm39) T2402A probably benign Het
Ctsq A G 13: 61,186,572 (GRCm39) probably null Het
Cux1 T C 5: 136,361,564 (GRCm39) R248G probably damaging Het
D7Ertd443e T C 7: 133,899,961 (GRCm39) H420R probably benign Het
Deup1 A G 9: 15,472,552 (GRCm39) F587L possibly damaging Het
Dnah6 T C 6: 73,063,149 (GRCm39) K2651R probably benign Het
Dnah7b A G 1: 46,124,762 (GRCm39) I144V probably benign Het
Dnajc1 T C 2: 18,236,511 (GRCm39) probably null Het
Fscb T C 12: 64,521,094 (GRCm39) N124S possibly damaging Het
Gabbr2 A G 4: 46,787,641 (GRCm39) Y341H probably damaging Het
Greb1 T A 12: 16,731,395 (GRCm39) I1648F probably damaging Het
Hace1 A T 10: 45,562,758 (GRCm39) N758Y probably damaging Het
Irs2 A C 8: 11,056,805 (GRCm39) D542E probably benign Het
Kat6a T A 8: 23,429,053 (GRCm39) H1469Q possibly damaging Het
Kif15 G A 9: 122,840,687 (GRCm39) R36K probably damaging Het
Krt42 C T 11: 100,157,886 (GRCm39) V193M probably damaging Het
Limch1 A T 5: 67,188,203 (GRCm39) E878V probably benign Het
Med18 G T 4: 132,187,024 (GRCm39) D158E probably benign Het
Med6 T C 12: 81,638,097 (GRCm39) N38S probably damaging Het
Mup13 T C 4: 61,183,596 (GRCm39) T76A probably benign Het
Nlrp4b T A 7: 10,448,640 (GRCm39) L281* probably null Het
Or5h23 A T 16: 58,906,509 (GRCm39) C112* probably null Het
Or9r3 A T 10: 129,948,481 (GRCm39) H59Q probably benign Het
Pde4d A T 13: 109,169,119 (GRCm39) R54* probably null Het
Pdpk1 A T 17: 24,317,109 (GRCm39) Y251* probably null Het
Pdzk1 A G 3: 96,758,979 (GRCm39) E128G probably benign Het
Phf12 A G 11: 77,918,996 (GRCm39) probably null Het
Pnliprp2 A G 19: 58,748,884 (GRCm39) E63G possibly damaging Het
Prkcd T C 14: 30,329,254 (GRCm39) E62G possibly damaging Het
Prl7b1 G T 13: 27,790,161 (GRCm39) D77E probably benign Het
Rbck1 G T 2: 152,165,094 (GRCm39) C85* probably null Het
Rfx3 A T 19: 27,779,795 (GRCm39) M481K probably damaging Het
Rmdn3 A G 2: 118,983,906 (GRCm39) F159L probably damaging Het
Rpusd3 A C 6: 113,394,802 (GRCm39) probably null Het
Ska1 T C 18: 74,335,671 (GRCm39) T100A probably benign Het
Slc1a3 T C 15: 8,675,177 (GRCm39) E276G probably damaging Het
Slc27a6 T A 18: 58,731,732 (GRCm39) Y361N probably damaging Het
Smc1b A G 15: 85,005,896 (GRCm39) L336S probably damaging Het
St7 A G 6: 17,694,347 (GRCm39) D46G possibly damaging Het
Supt5 A G 7: 28,014,622 (GRCm39) I1059T probably benign Het
Syne1 A T 10: 5,297,926 (GRCm39) S1124T possibly damaging Het
Szt2 A G 4: 118,260,185 (GRCm39) S54P probably damaging Het
Tanc2 G A 11: 105,758,543 (GRCm39) R768Q probably damaging Het
Tbc1d7 A C 13: 43,312,836 (GRCm39) M19R probably damaging Het
Tbpl2 T C 2: 23,985,004 (GRCm39) N47D possibly damaging Het
Tgfbr3 C T 5: 107,266,351 (GRCm39) A790T probably damaging Het
Tnr T C 1: 159,740,324 (GRCm39) V1166A probably damaging Het
Ttn G A 2: 76,676,654 (GRCm39) probably benign Het
Other mutations in Or7g28
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01560:Or7g28 APN 9 19,271,842 (GRCm39) missense probably benign 0.00
IGL01677:Or7g28 APN 9 19,272,441 (GRCm39) missense probably damaging 1.00
PIT4378001:Or7g28 UTSW 9 19,272,471 (GRCm39) missense probably damaging 1.00
R0471:Or7g28 UTSW 9 19,272,177 (GRCm39) nonsense probably null
R2381:Or7g28 UTSW 9 19,271,753 (GRCm39) missense probably benign 0.01
R4320:Or7g28 UTSW 9 19,272,254 (GRCm39) nonsense probably null
R5093:Or7g28 UTSW 9 19,272,274 (GRCm39) missense probably damaging 1.00
R5109:Or7g28 UTSW 9 19,272,438 (GRCm39) missense probably damaging 1.00
R5130:Or7g28 UTSW 9 19,272,369 (GRCm39) missense possibly damaging 0.81
R6937:Or7g28 UTSW 9 19,271,985 (GRCm39) missense probably damaging 0.99
R7024:Or7g28 UTSW 9 19,272,579 (GRCm39) missense possibly damaging 0.64
R8139:Or7g28 UTSW 9 19,272,504 (GRCm39) missense probably damaging 0.99
R9211:Or7g28 UTSW 9 19,271,824 (GRCm39) missense possibly damaging 0.53
R9476:Or7g28 UTSW 9 19,272,383 (GRCm39) missense probably benign 0.23
Predicted Primers PCR Primer
(F):5'- CTTAGGCAGATGTCAGCAAATG -3'
(R):5'- GGAGTTCTTGCCTCAGGATTC -3'

Sequencing Primer
(F):5'- CAGATGTCAGCAAATGAAAGTTTG -3'
(R):5'- CTTGCCTCAGGATTCAAGTTG -3'
Posted On 2017-07-14