Mutagenetix > Incidental Mutation

Incidental Mutation 'R6050:Vmn2r24'

483499

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r24

Ensembl Gene

ENSMUSG00000072780

Gene Name

vomeronasal 2, receptor 24

Synonyms

EG243628

MMRRC Submission

044218-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

R6050 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

123755930-123793239 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 123792691 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 673 (S673P)

Ref Sequence

ENSEMBL: ENSMUSP00000074602 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075095]

AlphaFold

D3YUI0

Predicted Effect

probably damaging
Transcript: ENSMUST00000075095
AA Change: S673P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000074602
Gene: ENSMUSG00000072780
AA Change: S673P

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	1.6e-32	PFAM
Pfam:NCD3G	518	571	1.1e-22	PFAM
Pfam:7tm_3	602	839	1.1e-54	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.3%
20x: 95.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca8b	C	A	11: 109,868,639 (GRCm39)	G175V	probably damaging	Het
Ahdc1	A	G	4: 132,793,202 (GRCm39)	D1481G	possibly damaging	Het
Ak9	A	G	10: 41,265,108 (GRCm39)	E955G	possibly damaging	Het
Aox3	T	C	1: 58,219,814 (GRCm39)	F1138S	possibly damaging	Het
Bbs2	T	A	8: 94,819,160 (GRCm39)	N70Y	probably damaging	Het
BC048679	T	C	7: 81,145,339 (GRCm39)	I70V	possibly damaging	Het
Catspere2	G	A	1: 177,931,490 (GRCm39)	A470T	unknown	Het
Ccdc141	G	T	2: 76,842,075 (GRCm39)	A1452E	probably benign	Het
Celsr1	T	C	15: 85,814,812 (GRCm39)	D1883G	probably benign	Het
Clhc1	A	G	11: 29,511,397 (GRCm39)	I280M	possibly damaging	Het
Cmtr1	G	T	17: 29,901,108 (GRCm39)	K678N	probably damaging	Het
Daam2	T	C	17: 49,793,530 (GRCm39)	D329G	possibly damaging	Het
Dnah2	C	T	11: 69,349,746 (GRCm39)	R2399Q	probably benign	Het
Duox1	C	T	2: 122,149,956 (GRCm39)	P116S	probably benign	Het
Fcf1	G	A	12: 85,029,017 (GRCm39)	C154Y	probably damaging	Het
Frem2	T	C	3: 53,560,433 (GRCm39)	N1358S	probably damaging	Het
Gtf2h3	C	T	5: 124,722,360 (GRCm39)	T121I	probably benign	Het
Gtf3c3	T	C	1: 54,445,229 (GRCm39)	I608M	probably benign	Het
Gzf1	G	A	2: 148,526,158 (GRCm39)	D210N	possibly damaging	Het
Ift140	C	T	17: 25,309,979 (GRCm39)	R1129C	probably damaging	Het
Lias	A	G	5: 65,551,315 (GRCm39)	I83V	possibly damaging	Het
Mlh3	T	C	12: 85,287,620 (GRCm39)	T1342A	possibly damaging	Het
Mn1	A	G	5: 111,567,263 (GRCm39)	Y411C	probably damaging	Het
Mrps21	C	T	3: 95,770,200 (GRCm39)	R43H	probably benign	Het
Ncam2	C	T	16: 81,240,054 (GRCm39)	Q172*	probably null	Het
Notch3	T	C	17: 32,362,501 (GRCm39)	T1375A	probably benign	Het
Oga	A	C	19: 45,753,919 (GRCm39)	S652A	possibly damaging	Het
Ovol3	T	A	7: 29,933,819 (GRCm39)	Y101F	probably benign	Het
Pcbp4	T	C	9: 106,339,422 (GRCm39)	V45A	probably benign	Het
Plec	T	C	15: 76,072,458 (GRCm39)	E709G	probably damaging	Het
Prcc	G	A	3: 87,777,191 (GRCm39)	T261I	probably damaging	Het
Psg25	A	G	7: 18,260,403 (GRCm39)	V165A	probably benign	Het
Rfk	C	T	19: 17,376,896 (GRCm39)	P133S	probably benign	Het
Scaf8	C	T	17: 3,218,383 (GRCm39)	T251M	unknown	Het
Sec14l2	T	C	11: 4,061,477 (GRCm39)	D67G	probably benign	Het
Smtnl1	A	G	2: 84,641,797 (GRCm39)	I441T	probably damaging	Het
Tbce	C	T	13: 14,173,019 (GRCm39)	V471I	possibly damaging	Het
Tnip1	G	A	11: 54,808,703 (GRCm39)	R495C	probably damaging	Het
Trbv19	A	G	6: 41,155,944 (GRCm39)	K105R	probably benign	Het
Ttc5	T	A	14: 51,010,744 (GRCm39)	N229I	probably damaging	Het
Ush2a	T	C	1: 188,689,521 (GRCm39)	F5028L	probably benign	Het
Zfp780b	A	T	7: 27,663,727 (GRCm39)	I276N	probably damaging	Het

Other mutations in Vmn2r24

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00954:Vmn2r24	APN	6	123,792,596 (GRCm39)	missense	probably damaging	1.00
IGL01382:Vmn2r24	APN	6	123,763,938 (GRCm39)	missense	possibly damaging	0.62
IGL01592:Vmn2r24	APN	6	123,764,445 (GRCm39)	missense	probably benign	0.30
IGL01754:Vmn2r24	APN	6	123,781,120 (GRCm39)	missense	probably damaging	1.00
IGL01939:Vmn2r24	APN	6	123,764,404 (GRCm39)	missense	probably benign
IGL02140:Vmn2r24	APN	6	123,757,631 (GRCm39)	missense	probably damaging	0.98
IGL02272:Vmn2r24	APN	6	123,763,843 (GRCm39)	missense	possibly damaging	0.94
IGL02568:Vmn2r24	APN	6	123,792,812 (GRCm39)	missense	probably benign	0.36
IGL02748:Vmn2r24	APN	6	123,793,057 (GRCm39)	missense	possibly damaging	0.90
IGL03022:Vmn2r24	APN	6	123,755,967 (GRCm39)	missense	probably damaging	0.99
IGL03343:Vmn2r24	APN	6	123,793,070 (GRCm39)	missense	probably damaging	1.00
R0357:Vmn2r24	UTSW	6	123,792,369 (GRCm39)	frame shift	probably null
R0453:Vmn2r24	UTSW	6	123,757,350 (GRCm39)	critical splice acceptor site	probably null
R0538:Vmn2r24	UTSW	6	123,793,012 (GRCm39)	missense	probably benign	0.32
R0607:Vmn2r24	UTSW	6	123,763,893 (GRCm39)	missense	probably benign
R1381:Vmn2r24	UTSW	6	123,763,692 (GRCm39)	missense	probably damaging	1.00
R1589:Vmn2r24	UTSW	6	123,783,479 (GRCm39)	splice site	probably benign
R1848:Vmn2r24	UTSW	6	123,793,183 (GRCm39)	missense	probably damaging	1.00
R2035:Vmn2r24	UTSW	6	123,793,019 (GRCm39)	missense	probably damaging	1.00
R2077:Vmn2r24	UTSW	6	123,792,358 (GRCm39)	missense	probably damaging	1.00
R2122:Vmn2r24	UTSW	6	123,792,353 (GRCm39)	missense	possibly damaging	0.81
R2145:Vmn2r24	UTSW	6	123,755,972 (GRCm39)	missense	probably benign
R2483:Vmn2r24	UTSW	6	123,792,997 (GRCm39)	missense	probably damaging	1.00
R2512:Vmn2r24	UTSW	6	123,763,985 (GRCm39)	missense	probably benign	0.01
R3001:Vmn2r24	UTSW	6	123,781,231 (GRCm39)	missense	probably benign	0.00
R3002:Vmn2r24	UTSW	6	123,781,231 (GRCm39)	missense	probably benign	0.00
R3236:Vmn2r24	UTSW	6	123,755,984 (GRCm39)	nonsense	probably null
R3623:Vmn2r24	UTSW	6	123,792,997 (GRCm39)	missense	probably damaging	1.00
R3624:Vmn2r24	UTSW	6	123,792,997 (GRCm39)	missense	probably damaging	1.00
R3835:Vmn2r24	UTSW	6	123,764,412 (GRCm39)	missense	probably benign	0.33
R4074:Vmn2r24	UTSW	6	123,764,374 (GRCm39)	missense	possibly damaging	0.92
R4075:Vmn2r24	UTSW	6	123,764,374 (GRCm39)	missense	possibly damaging	0.92
R4812:Vmn2r24	UTSW	6	123,756,144 (GRCm39)	missense	probably benign	0.00
R4825:Vmn2r24	UTSW	6	123,792,739 (GRCm39)	missense	probably benign	0.02
R5351:Vmn2r24	UTSW	6	123,793,223 (GRCm39)	missense	possibly damaging	0.80
R5665:Vmn2r24	UTSW	6	123,763,938 (GRCm39)	missense	possibly damaging	0.62
R5790:Vmn2r24	UTSW	6	123,792,499 (GRCm39)	missense	probably benign
R5808:Vmn2r24	UTSW	6	123,792,597 (GRCm39)	nonsense	probably null
R5879:Vmn2r24	UTSW	6	123,764,226 (GRCm39)	missense	possibly damaging	0.89
R5923:Vmn2r24	UTSW	6	123,792,751 (GRCm39)	missense	probably damaging	0.96
R5969:Vmn2r24	UTSW	6	123,755,981 (GRCm39)	missense	probably benign	0.00
R6171:Vmn2r24	UTSW	6	123,764,205 (GRCm39)	missense	probably damaging	0.98
R6174:Vmn2r24	UTSW	6	123,793,236 (GRCm39)	missense	probably benign	0.00
R6356:Vmn2r24	UTSW	6	123,783,368 (GRCm39)	missense	possibly damaging	0.93
R6562:Vmn2r24	UTSW	6	123,757,386 (GRCm39)	missense	probably benign	0.01
R6563:Vmn2r24	UTSW	6	123,781,137 (GRCm39)	missense	possibly damaging	0.86
R6584:Vmn2r24	UTSW	6	123,792,764 (GRCm39)	missense	possibly damaging	0.53
R6630:Vmn2r24	UTSW	6	123,763,981 (GRCm39)	missense	probably benign	0.00
R6803:Vmn2r24	UTSW	6	123,755,960 (GRCm39)	missense	possibly damaging	0.64
R6864:Vmn2r24	UTSW	6	123,756,117 (GRCm39)	missense	possibly damaging	0.89
R7252:Vmn2r24	UTSW	6	123,764,191 (GRCm39)	missense	possibly damaging	0.90
R7369:Vmn2r24	UTSW	6	123,792,638 (GRCm39)	missense	probably damaging	0.99
R7646:Vmn2r24	UTSW	6	123,793,169 (GRCm39)	missense	probably benign	0.20
R7799:Vmn2r24	UTSW	6	123,757,422 (GRCm39)	missense	probably benign	0.00
R7803:Vmn2r24	UTSW	6	123,757,438 (GRCm39)	missense	probably benign	0.00
R7959:Vmn2r24	UTSW	6	123,755,949 (GRCm39)	missense	possibly damaging	0.86
R8215:Vmn2r24	UTSW	6	123,756,077 (GRCm39)	missense	probably benign	0.10
R8796:Vmn2r24	UTSW	6	123,757,500 (GRCm39)	missense	probably benign
R9172:Vmn2r24	UTSW	6	123,783,432 (GRCm39)	missense	probably damaging	1.00
R9300:Vmn2r24	UTSW	6	123,793,030 (GRCm39)	missense	possibly damaging	0.46
R9369:Vmn2r24	UTSW	6	123,792,357 (GRCm39)	missense	probably damaging	1.00
R9375:Vmn2r24	UTSW	6	123,792,542 (GRCm39)	missense	probably damaging	1.00
R9523:Vmn2r24	UTSW	6	123,763,950 (GRCm39)	missense	possibly damaging	0.89
R9546:Vmn2r24	UTSW	6	123,764,266 (GRCm39)	missense	probably damaging	0.98
RF006:Vmn2r24	UTSW	6	123,783,378 (GRCm39)	missense	probably damaging	1.00
RF016:Vmn2r24	UTSW	6	123,781,174 (GRCm39)	missense	probably benign	0.04
X0023:Vmn2r24	UTSW	6	123,764,359 (GRCm39)	missense	probably damaging	0.99
Z1088:Vmn2r24	UTSW	6	123,781,155 (GRCm39)	missense	probably benign	0.00
Z1177:Vmn2r24	UTSW	6	123,763,719 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TCTGCTATCGGGACACATCC -3'
(R):5'- CCCCTCATTACAACAGAGGATG -3'

Sequencing Primer
(F):5'- GGACACATCCATTGTCAGAGC -3'
(R):5'- TCTGAGTGCATGTCAACATCAGG -3'

Posted On

2017-07-14