Incidental Mutation 'IGL00336:Minar1'
ID 4835
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Minar1
Ensembl Gene ENSMUSG00000039313
Gene Name membrane integral NOTCH2 associated receptor 1
Synonyms DD1, AF529169
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00336
Quality Score
Status
Chromosome 9
Chromosomal Location 89469269-89505178 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 89485196 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 67 (D67G)
Ref Sequence ENSEMBL: ENSMUSP00000140942 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044491] [ENSMUST00000191465]
AlphaFold Q8K3V7
Predicted Effect probably damaging
Transcript: ENSMUST00000044491
AA Change: D67G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000046111
Gene: ENSMUSG00000039313
AA Change: D67G

DomainStartEndE-ValueType
low complexity region 508 522 N/A INTRINSIC
Pfam:UPF0258 760 915 8.7e-73 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000191465
AA Change: D67G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000140942
Gene: ENSMUSG00000039313
AA Change: D67G

DomainStartEndE-ValueType
low complexity region 508 522 N/A INTRINSIC
Pfam:UPF0258 759 854 6.1e-38 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A430033K04Rik A G 5: 138,645,366 (GRCm39) Y417C probably damaging Het
Adam28 T A 14: 68,859,569 (GRCm39) H548L possibly damaging Het
Agbl3 A T 6: 34,823,771 (GRCm39) D812V probably damaging Het
Aopep A T 13: 63,163,237 (GRCm39) D86V possibly damaging Het
Aox1 T A 1: 58,098,203 (GRCm39) L305Q probably damaging Het
Arhgef38 A G 3: 132,837,812 (GRCm39) V706A probably benign Het
Arl15 A G 13: 114,291,288 (GRCm39) I171V probably benign Het
Cacna1s C A 1: 136,012,011 (GRCm39) Y237* probably null Het
Ccnt1 T C 15: 98,462,990 (GRCm39) T61A possibly damaging Het
Col25a1 T A 3: 129,975,433 (GRCm39) probably benign Het
Col4a1 T A 8: 11,290,077 (GRCm39) probably benign Het
Dcun1d1 T C 3: 35,970,455 (GRCm39) E130G possibly damaging Het
Dnah7b G A 1: 46,181,309 (GRCm39) M1065I probably benign Het
Ephb2 T G 4: 136,384,795 (GRCm39) K872T probably damaging Het
Fga G A 3: 82,938,981 (GRCm39) G452D probably damaging Het
Flrt1 T A 19: 7,074,277 (GRCm39) N90I probably damaging Het
Fut10 T A 8: 31,685,319 (GRCm39) probably null Het
Gm4553 T C 7: 141,718,964 (GRCm39) S155G unknown Het
Gpr137b T C 13: 13,549,000 (GRCm39) probably benign Het
Gprc5d G A 6: 135,093,488 (GRCm39) Q140* probably null Het
Ifi27l2b T C 12: 103,417,476 (GRCm39) K237R unknown Het
Ipo8 A T 6: 148,684,284 (GRCm39) M836K possibly damaging Het
Kcnq4 G A 4: 120,555,213 (GRCm39) Q657* probably null Het
Lama1 A T 17: 68,120,943 (GRCm39) H2693L probably benign Het
Lrrc23 A G 6: 124,755,889 (GRCm39) W40R probably damaging Het
Morn2 C A 17: 80,602,933 (GRCm39) probably benign Het
Ms4a6b T A 19: 11,506,854 (GRCm39) N214K possibly damaging Het
Nags A T 11: 102,039,892 (GRCm39) S527C probably damaging Het
Ndst1 C T 18: 60,841,028 (GRCm39) G218D probably damaging Het
Or10j5 G A 1: 172,785,045 (GRCm39) V228M probably benign Het
Or5b94 T A 19: 12,651,924 (GRCm39) Y118* probably null Het
Or8h7 C T 2: 86,720,589 (GRCm39) C310Y probably benign Het
Oxa1l G T 14: 54,600,802 (GRCm39) G92* probably null Het
Parp16 A T 9: 65,137,245 (GRCm39) E157V probably damaging Het
Pcdh17 A T 14: 84,684,984 (GRCm39) I484F probably damaging Het
Pex16 A G 2: 92,209,580 (GRCm39) R263G probably benign Het
Pkd1l3 G A 8: 110,356,869 (GRCm39) E765K possibly damaging Het
Plce1 T C 19: 38,640,350 (GRCm39) V532A probably damaging Het
Polq A G 16: 36,885,609 (GRCm39) probably benign Het
Pramel5 T C 4: 143,998,191 (GRCm39) T351A probably damaging Het
Prokr1 A T 6: 87,565,593 (GRCm39) I84N probably damaging Het
Prss30 A T 17: 24,192,695 (GRCm39) S162T probably benign Het
Ranbp2 A G 10: 58,287,806 (GRCm39) K25E probably damaging Het
Rapsn A G 2: 90,866,205 (GRCm39) T22A probably damaging Het
Rhoj G T 12: 75,355,680 (GRCm39) G9V probably damaging Het
Rnf213 A G 11: 119,340,169 (GRCm39) R3467G probably benign Het
Rreb1 C A 13: 38,113,622 (GRCm39) S327* probably null Het
Scn5a G A 9: 119,315,290 (GRCm39) P1806L probably damaging Het
Sema6a C A 18: 47,423,042 (GRCm39) probably null Het
Stag3 G A 5: 138,295,921 (GRCm39) E416K probably benign Het
Stpg1 T A 4: 135,256,856 (GRCm39) S216T possibly damaging Het
Tfeb C A 17: 48,102,589 (GRCm39) N426K probably benign Het
Trp53bp1 G T 2: 121,087,060 (GRCm39) Q199K possibly damaging Het
Ubr4 A G 4: 139,155,877 (GRCm39) D2234G probably damaging Het
Ush1c T G 7: 45,846,194 (GRCm39) Q866P probably benign Het
Vdr T A 15: 97,782,735 (GRCm39) D29V probably damaging Het
Vps13c T C 9: 67,853,224 (GRCm39) V2439A probably benign Het
Xirp2 T C 2: 67,342,942 (GRCm39) S1728P possibly damaging Het
Zfp9 A G 6: 118,441,436 (GRCm39) S409P probably damaging Het
Other mutations in Minar1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Minar1 APN 9 89,483,853 (GRCm39) missense probably benign 0.02
IGL00163:Minar1 APN 9 89,473,150 (GRCm39) unclassified probably benign
IGL01608:Minar1 APN 9 89,478,551 (GRCm39) missense probably benign 0.15
IGL01818:Minar1 APN 9 89,483,366 (GRCm39) missense probably damaging 0.99
IGL02012:Minar1 APN 9 89,483,491 (GRCm39) missense probably benign 0.01
IGL02259:Minar1 APN 9 89,484,412 (GRCm39) missense possibly damaging 0.93
IGL02894:Minar1 APN 9 89,485,155 (GRCm39) missense probably damaging 0.99
IGL03008:Minar1 APN 9 89,478,731 (GRCm39) missense probably damaging 1.00
IGL02988:Minar1 UTSW 9 89,484,792 (GRCm39) missense probably benign 0.02
R0410:Minar1 UTSW 9 89,484,256 (GRCm39) missense probably damaging 0.97
R0825:Minar1 UTSW 9 89,485,332 (GRCm39) nonsense probably null
R0883:Minar1 UTSW 9 89,484,470 (GRCm39) missense probably benign 0.05
R0989:Minar1 UTSW 9 89,484,088 (GRCm39) missense probably damaging 0.99
R1376:Minar1 UTSW 9 89,473,299 (GRCm39) missense probably damaging 1.00
R1376:Minar1 UTSW 9 89,473,299 (GRCm39) missense probably damaging 1.00
R1632:Minar1 UTSW 9 89,484,413 (GRCm39) missense probably damaging 0.96
R1804:Minar1 UTSW 9 89,485,152 (GRCm39) missense possibly damaging 0.91
R1974:Minar1 UTSW 9 89,483,256 (GRCm39) missense probably damaging 1.00
R2151:Minar1 UTSW 9 89,484,221 (GRCm39) missense possibly damaging 0.53
R2882:Minar1 UTSW 9 89,484,855 (GRCm39) missense possibly damaging 0.86
R2909:Minar1 UTSW 9 89,473,331 (GRCm39) missense probably damaging 1.00
R3961:Minar1 UTSW 9 89,483,963 (GRCm39) missense probably damaging 1.00
R3962:Minar1 UTSW 9 89,483,963 (GRCm39) missense probably damaging 1.00
R3963:Minar1 UTSW 9 89,483,963 (GRCm39) missense probably damaging 1.00
R4676:Minar1 UTSW 9 89,483,606 (GRCm39) missense probably damaging 1.00
R4778:Minar1 UTSW 9 89,485,155 (GRCm39) missense probably damaging 1.00
R4931:Minar1 UTSW 9 89,483,705 (GRCm39) missense probably benign 0.05
R5300:Minar1 UTSW 9 89,485,252 (GRCm39) missense probably damaging 1.00
R5702:Minar1 UTSW 9 89,473,208 (GRCm39) missense probably benign 0.22
R5759:Minar1 UTSW 9 89,483,125 (GRCm39) missense probably benign 0.01
R6187:Minar1 UTSW 9 89,473,220 (GRCm39) missense probably damaging 1.00
R7320:Minar1 UTSW 9 89,483,679 (GRCm39) missense probably benign
R7542:Minar1 UTSW 9 89,483,964 (GRCm39) missense probably damaging 1.00
R7552:Minar1 UTSW 9 89,483,888 (GRCm39) missense probably benign 0.00
R8826:Minar1 UTSW 9 89,483,234 (GRCm39) missense probably damaging 1.00
R9181:Minar1 UTSW 9 89,485,394 (GRCm39) start codon destroyed probably null 1.00
R9220:Minar1 UTSW 9 89,484,398 (GRCm39) missense probably damaging 1.00
R9560:Minar1 UTSW 9 89,484,531 (GRCm39) missense probably benign 0.00
R9666:Minar1 UTSW 9 89,484,072 (GRCm39) missense probably benign 0.06
U24488:Minar1 UTSW 9 89,485,100 (GRCm39) missense probably damaging 1.00
Z1177:Minar1 UTSW 9 89,485,215 (GRCm39) missense probably damaging 1.00
Posted On 2012-04-20