|Institutional Source||Beutler Lab|
|Gene Name||syndecan binding protein (syntenin) 2|
|Is this an essential gene?||Probably non essential (E-score: 0.181)|
|Stock #||R6042 (G1)|
|Chromosomal Location||151572622-151590005 bp(+) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||T to A at 151582726 bp|
|Amino Acid Change||Tyrosine to Stop codon at position 5 (Y5*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000028950 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000028950]|
|Predicted Effect||probably null
AA Change: Y5*
AA Change: Y5*
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Sdcbp2||
(F):5'- GCTCGAGAAACAGACTGGTG -3'
(R):5'- ATGCCTACTCAGACTCCAAGG -3'
(F):5'- GAAACAGACTGGTGTAAATCCTC -3'
(R):5'- TACTCAGACTCCAAGGGCCTTG -3'