Incidental Mutation 'R6042:Or8b39'
ID 483617
Institutional Source Beutler Lab
Gene Symbol Or8b39
Ensembl Gene ENSMUSG00000096167
Gene Name olfactory receptor family 8 subfamily B member 39
Synonyms GA_x6K02T2PVTD-31764095-31765024, MOR162-5, Olfr887
MMRRC Submission 044210-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R6042 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 37996134-37997063 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 37996390 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 86 (V86E)
Ref Sequence ENSEMBL: ENSMUSP00000148361 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074681] [ENSMUST00000212502] [ENSMUST00000213091]
AlphaFold Q9EQA6
Predicted Effect probably damaging
Transcript: ENSMUST00000074681
AA Change: V86E

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000074248
Gene: ENSMUSG00000096167
AA Change: V86E

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 3.7e-49 PFAM
Pfam:7TM_GPCR_Srsx 35 253 3.1e-5 PFAM
Pfam:7tm_1 41 288 8.2e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000212502
AA Change: V86E

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
Predicted Effect possibly damaging
Transcript: ENSMUST00000213091
AA Change: V86E

PolyPhen 2 Score 0.868 (Sensitivity: 0.83; Specificity: 0.93)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn1 T A 12: 80,224,023 (GRCm39) K478M probably benign Het
Ankar G T 1: 72,713,213 (GRCm39) S474* probably null Het
Barx2 C A 9: 31,758,199 (GRCm39) E246D probably benign Het
Cdh20 A T 1: 110,065,997 (GRCm39) Q757L probably damaging Het
Cnr1 T C 4: 33,944,751 (GRCm39) F380L probably damaging Het
Cntnap5b G A 1: 100,318,317 (GRCm39) A655T probably benign Het
Col2a1 T A 15: 97,898,451 (GRCm39) probably benign Het
Crybg3 C T 16: 59,370,838 (GRCm39) R2340Q possibly damaging Het
Ctsb G T 14: 63,379,305 (GRCm39) D306Y probably damaging Het
Cyp2a22 A C 7: 26,633,664 (GRCm39) Y349D probably damaging Het
Dcpp2 T C 17: 24,117,886 (GRCm39) L22S probably damaging Het
Dnah8 G T 17: 30,966,239 (GRCm39) M2476I probably damaging Het
Dst A G 1: 34,228,053 (GRCm39) E1882G probably damaging Het
Esrp1 T C 4: 11,357,580 (GRCm39) K511E possibly damaging Het
Fat3 T A 9: 16,289,113 (GRCm39) T137S probably benign Het
Fbxw24 T A 9: 109,436,079 (GRCm39) M318L probably benign Het
Fpr-rs7 T A 17: 20,333,477 (GRCm39) T338S probably benign Het
Gcgr T C 11: 120,425,584 (GRCm39) M1T probably null Het
Grifin C A 5: 140,549,311 (GRCm39) R135L possibly damaging Het
Helz T C 11: 107,504,946 (GRCm39) probably null Het
Hivep3 C G 4: 119,955,061 (GRCm39) Q1126E possibly damaging Het
Htr3a T A 9: 48,815,999 (GRCm39) H146L probably damaging Het
Lama3 T A 18: 12,707,311 (GRCm39) V3081E probably damaging Het
Mgat5 T A 1: 127,387,636 (GRCm39) C531S probably damaging Het
Mical2 A G 7: 111,979,619 (GRCm39) D106G probably benign Het
Nectin2 C T 7: 19,472,063 (GRCm39) A109T probably benign Het
Olig3 T C 10: 19,232,503 (GRCm39) S43P probably damaging Het
Or5an9 A T 19: 12,187,286 (GRCm39) M119L probably damaging Het
Pcdh12 T C 18: 38,414,558 (GRCm39) R856G probably damaging Het
Phpt1 T A 2: 25,464,851 (GRCm39) M1L probably benign Het
Polr2m T C 9: 71,391,080 (GRCm39) I41V probably damaging Het
Pramel28 G T 4: 143,692,631 (GRCm39) D123E probably benign Het
Pzp A G 6: 128,500,977 (GRCm39) V127A possibly damaging Het
Rgs7 G T 1: 174,977,226 (GRCm39) T126K probably damaging Het
RP23-399J5.1 T C 8: 71,542,571 (GRCm39) noncoding transcript Het
Rras A T 7: 44,669,820 (GRCm39) D112V probably damaging Het
Sdcbp2 T A 2: 151,424,646 (GRCm39) Y5* probably null Het
Slc43a2 T C 11: 75,461,433 (GRCm39) F462L probably damaging Het
Smchd1 T A 17: 71,684,052 (GRCm39) K1436* probably null Het
Snrnp27 A C 6: 86,659,902 (GRCm39) S31A unknown Het
Sqstm1 A C 11: 50,098,251 (GRCm39) F172V probably benign Het
Stk32b T A 5: 37,806,458 (GRCm39) I29F probably damaging Het
Syt10 G A 15: 89,725,824 (GRCm39) T50I probably benign Het
Syt16 T C 12: 74,313,504 (GRCm39) Y477H probably damaging Het
Tacr3 A T 3: 134,638,153 (GRCm39) T437S probably benign Het
Tg G A 15: 66,555,842 (GRCm39) D845N probably benign Het
Uqcc1 G T 2: 155,763,564 (GRCm39) S36R possibly damaging Het
Vmn1r20 T C 6: 57,409,391 (GRCm39) V239A possibly damaging Het
Xpo7 T A 14: 70,933,103 (GRCm39) Q263L possibly damaging Het
Zfp442 T C 2: 150,250,016 (GRCm39) K572E probably damaging Het
Zswim5 A C 4: 116,819,818 (GRCm39) S408R probably benign Het
Other mutations in Or8b39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02506:Or8b39 APN 9 37,996,741 (GRCm39) missense probably damaging 1.00
R0639:Or8b39 UTSW 9 37,996,666 (GRCm39) missense probably damaging 1.00
R0671:Or8b39 UTSW 9 37,996,423 (GRCm39) missense possibly damaging 0.91
R1957:Or8b39 UTSW 9 37,996,419 (GRCm39) missense probably damaging 1.00
R1958:Or8b39 UTSW 9 37,996,419 (GRCm39) missense probably damaging 1.00
R2126:Or8b39 UTSW 9 37,996,572 (GRCm39) missense probably benign 0.02
R5329:Or8b39 UTSW 9 37,996,422 (GRCm39) missense probably benign 0.00
R5541:Or8b39 UTSW 9 37,996,419 (GRCm39) missense probably damaging 1.00
R5681:Or8b39 UTSW 9 37,996,927 (GRCm39) missense possibly damaging 0.90
R6417:Or8b39 UTSW 9 37,996,890 (GRCm39) missense probably benign 0.18
R6420:Or8b39 UTSW 9 37,996,890 (GRCm39) missense probably benign 0.18
R9299:Or8b39 UTSW 9 37,996,785 (GRCm39) missense probably benign 0.38
R9399:Or8b39 UTSW 9 37,997,020 (GRCm39) missense probably benign 0.00
R9409:Or8b39 UTSW 9 37,996,584 (GRCm39) missense probably damaging 1.00
R9748:Or8b39 UTSW 9 37,996,353 (GRCm39) missense probably benign 0.23
Predicted Primers PCR Primer
(F):5'- TCTGTTGGGCTTGACACAG -3'
(R):5'- ACCCATCATCATGAAGTGGCAG -3'

Sequencing Primer
(F):5'- TTGGGCTTGACACAGCAACC -3'
(R):5'- CATCATCATGAAGTGGCAGACCTG -3'
Posted On 2017-07-14