Incidental Mutation 'R0519:Clasrp'
ID 48387
Institutional Source Beutler Lab
Gene Symbol Clasrp
Ensembl Gene ENSMUSG00000061028
Gene Name CLK4-associating serine/arginine rich protein
Synonyms SWAP2, Sfrs16, Srsf16
MMRRC Submission 038712-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0519 (G1)
Quality Score 178
Status Validated
Chromosome 7
Chromosomal Location 19314960-19338411 bp(-) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) A to G at 19318089 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000147103 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086041] [ENSMUST00000108453] [ENSMUST00000207524] [ENSMUST00000207907] [ENSMUST00000208068] [ENSMUST00000207663]
AlphaFold Q8CFC7
Predicted Effect unknown
Transcript: ENSMUST00000086041
AA Change: I616T
SMART Domains Protein: ENSMUSP00000083205
Gene: ENSMUSG00000061028
AA Change: I616T

DomainStartEndE-ValueType
low complexity region 19 35 N/A INTRINSIC
DRY_EERY 39 171 1.28e-64 SMART
low complexity region 172 212 N/A INTRINSIC
low complexity region 241 260 N/A INTRINSIC
low complexity region 263 283 N/A INTRINSIC
low complexity region 302 324 N/A INTRINSIC
low complexity region 339 368 N/A INTRINSIC
low complexity region 372 446 N/A INTRINSIC
low complexity region 453 476 N/A INTRINSIC
low complexity region 480 532 N/A INTRINSIC
coiled coil region 574 630 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108453
SMART Domains Protein: ENSMUSP00000104093
Gene: ENSMUSG00000011267

DomainStartEndE-ValueType
ZnF_C2H2 138 161 5.07e0 SMART
ZnF_C2H2 212 234 2.05e-2 SMART
ZnF_C2H2 240 262 1.1e-2 SMART
low complexity region 281 295 N/A INTRINSIC
low complexity region 317 329 N/A INTRINSIC
ZnF_C2H2 360 382 1.95e-3 SMART
ZnF_C2H2 388 410 3.39e-3 SMART
ZnF_C2H2 418 441 1.14e0 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207253
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207264
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207447
Predicted Effect probably benign
Transcript: ENSMUST00000207524
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208427
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208716
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208464
Predicted Effect probably benign
Transcript: ENSMUST00000207907
Predicted Effect probably benign
Transcript: ENSMUST00000208068
Predicted Effect probably benign
Transcript: ENSMUST00000207663
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209059
Meta Mutation Damage Score 0.0854 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 98.8%
  • 10x: 96.6%
  • 20x: 93.2%
Validation Efficiency 99% (74/75)
MGI Phenotype FUNCTION: The protein encoded by this gene contains serine/arginine (SR) dipeptide repeat domains, and is thought to be involved in the regulation of alternative splicing. This protein is thought to interact with, and be phosphorylated by, Clk4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700028K03Rik A G 5: 107,696,067 (GRCm39) R168G probably benign Het
2810004N23Rik C T 8: 125,566,668 (GRCm39) G251R possibly damaging Het
3425401B19Rik A G 14: 32,384,919 (GRCm39) S349P possibly damaging Het
Ackr4 A G 9: 103,976,650 (GRCm39) V99A probably benign Het
Acsbg3 T A 17: 57,192,169 (GRCm39) Y577* probably null Het
Asxl3 A G 18: 22,656,577 (GRCm39) Q1529R possibly damaging Het
Atg12 T C 18: 46,874,477 (GRCm39) E46G probably benign Het
Cdcp2 A G 4: 106,964,389 (GRCm39) probably benign Het
Clip2 A G 5: 134,545,005 (GRCm39) V383A probably benign Het
Cntln C T 4: 84,923,290 (GRCm39) probably benign Het
Colgalt2 G T 1: 152,384,312 (GRCm39) A551S possibly damaging Het
Csmd2 A C 4: 128,380,798 (GRCm39) Y2118S possibly damaging Het
Dip2c T A 13: 9,613,244 (GRCm39) V415E probably damaging Het
Dpy19l2 C T 9: 24,469,391 (GRCm39) R755Q probably benign Het
Dsn1 A T 2: 156,840,633 (GRCm39) probably benign Het
Dtd2 T C 12: 52,051,742 (GRCm39) probably benign Het
Dync1i1 A G 6: 6,027,399 (GRCm39) T602A probably benign Het
Ercc6 A C 14: 32,248,799 (GRCm39) D450A probably damaging Het
Fgf12 A T 16: 28,008,380 (GRCm39) V104D probably benign Het
Frem1 A T 4: 82,888,870 (GRCm39) probably null Het
Gcgr G T 11: 120,426,982 (GRCm39) W88L probably damaging Het
Glb1 ACCC ACC 9: 114,250,812 (GRCm39) probably null Het
Hapln1 A G 13: 89,732,835 (GRCm39) probably benign Het
Hmgn3 T C 9: 82,994,301 (GRCm39) E40G probably damaging Het
Hsdl1 G A 8: 120,292,450 (GRCm39) A255V probably damaging Het
Hyls1 T C 9: 35,472,499 (GRCm39) K306E probably damaging Het
Jcad C T 18: 4,649,122 (GRCm39) probably benign Het
Kif14 C A 1: 136,396,885 (GRCm39) A397E probably damaging Het
Lcmt2 A T 2: 120,969,825 (GRCm39) probably null Het
Lifr T C 15: 7,207,061 (GRCm39) L524P probably damaging Het
Ly6g6f T C 17: 35,301,828 (GRCm39) K209E possibly damaging Het
Macf1 G A 4: 123,365,113 (GRCm39) T1651I probably benign Het
Mapk4 T C 18: 74,103,392 (GRCm39) D39G probably damaging Het
Mbl1 A G 14: 40,880,522 (GRCm39) M137V probably damaging Het
Mcm10 G A 2: 5,013,356 (GRCm39) S92L probably benign Het
Mug1 A G 6: 121,828,383 (GRCm39) K265R possibly damaging Het
Mxra7 A G 11: 116,701,612 (GRCm39) probably null Het
Neu3 G A 7: 99,472,524 (GRCm39) probably benign Het
Nsd1 A G 13: 55,460,648 (GRCm39) T2395A probably benign Het
Or1j1 T A 2: 36,702,627 (GRCm39) H159L probably damaging Het
Or5m9 A T 2: 85,877,411 (GRCm39) Y195F probably benign Het
Or6s1 T A 14: 51,308,614 (GRCm39) I79F probably damaging Het
Or7g34 A T 9: 19,478,245 (GRCm39) I145N probably benign Het
Osgepl1 T C 1: 53,360,255 (GRCm39) V327A probably damaging Het
Pcdhb21 T C 18: 37,649,085 (GRCm39) V738A possibly damaging Het
Plekha8 A T 6: 54,599,092 (GRCm39) probably benign Het
Ptprq A C 10: 107,374,781 (GRCm39) probably benign Het
Pus10 T A 11: 23,661,201 (GRCm39) F263Y probably benign Het
Rad54b A T 4: 11,599,809 (GRCm39) I338F probably damaging Het
Rad54l2 A G 9: 106,585,498 (GRCm39) F756L probably damaging Het
Scn11a A G 9: 119,619,185 (GRCm39) L719P probably damaging Het
Slc2a2 G A 3: 28,772,965 (GRCm39) V253I possibly damaging Het
Slc39a4 A T 15: 76,499,338 (GRCm39) N192K probably benign Het
Soat1 T A 1: 156,268,816 (GRCm39) I245F probably damaging Het
Sorcs2 G A 5: 36,188,534 (GRCm39) A858V probably benign Het
Tcim T C 8: 24,928,651 (GRCm39) T88A possibly damaging Het
Tecta G A 9: 42,259,188 (GRCm39) probably benign Het
Tgm5 C A 2: 120,879,376 (GRCm39) L553F probably damaging Het
Tjp1 A G 7: 64,952,669 (GRCm39) V1555A probably benign Het
Tmem214 A C 5: 31,027,012 (GRCm39) M1L probably null Het
Togaram1 T C 12: 65,012,776 (GRCm39) probably benign Het
Topaz1 C A 9: 122,578,544 (GRCm39) L485I possibly damaging Het
Ttn T C 2: 76,548,626 (GRCm39) probably benign Het
Ube2o A G 11: 116,437,285 (GRCm39) probably null Het
Ubr7 T A 12: 102,734,465 (GRCm39) D246E probably benign Het
Vcpkmt T C 12: 69,629,102 (GRCm39) D132G probably benign Het
Vmn2r111 T A 17: 22,792,102 (GRCm39) Q51H probably benign Het
Vmn2r95 C T 17: 18,659,765 (GRCm39) P170S probably damaging Het
Zbtb38 A G 9: 96,567,826 (GRCm39) I1086T probably damaging Het
Zfp444 G A 7: 6,191,172 (GRCm39) A118T probably benign Het
Zp2 A G 7: 119,737,372 (GRCm39) I272T probably damaging Het
Other mutations in Clasrp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02394:Clasrp APN 7 19,337,179 (GRCm39) missense probably damaging 1.00
clarissa UTSW 7 19,324,173 (GRCm39) missense possibly damaging 0.82
suet UTSW 7 19,320,393 (GRCm39) utr 3 prime probably benign
R0518:Clasrp UTSW 7 19,322,528 (GRCm39) missense probably benign 0.32
R0521:Clasrp UTSW 7 19,322,528 (GRCm39) missense probably benign 0.32
R0626:Clasrp UTSW 7 19,318,418 (GRCm39) utr 3 prime probably benign
R0826:Clasrp UTSW 7 19,318,226 (GRCm39) utr 3 prime probably benign
R1918:Clasrp UTSW 7 19,319,188 (GRCm39) nonsense probably null
R2044:Clasrp UTSW 7 19,320,640 (GRCm39) utr 3 prime probably benign
R2256:Clasrp UTSW 7 19,320,510 (GRCm39) utr 3 prime probably benign
R2257:Clasrp UTSW 7 19,320,510 (GRCm39) utr 3 prime probably benign
R2870:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R2870:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R2871:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R2871:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R2940:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R3408:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R3691:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R4168:Clasrp UTSW 7 19,315,079 (GRCm39) unclassified probably benign
R4496:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R4505:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R4507:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R4572:Clasrp UTSW 7 19,318,389 (GRCm39) splice site probably null
R4753:Clasrp UTSW 7 19,328,865 (GRCm39) missense probably damaging 1.00
R4871:Clasrp UTSW 7 19,324,173 (GRCm39) missense possibly damaging 0.82
R4938:Clasrp UTSW 7 19,318,703 (GRCm39) splice site probably null
R5538:Clasrp UTSW 7 19,318,707 (GRCm39) utr 3 prime probably benign
R5582:Clasrp UTSW 7 19,320,781 (GRCm39) missense probably damaging 0.97
R5615:Clasrp UTSW 7 19,320,372 (GRCm39) utr 3 prime probably benign
R5794:Clasrp UTSW 7 19,325,034 (GRCm39) missense probably damaging 0.99
R5944:Clasrp UTSW 7 19,328,431 (GRCm39) missense probably damaging 1.00
R6102:Clasrp UTSW 7 19,320,393 (GRCm39) utr 3 prime probably benign
R6171:Clasrp UTSW 7 19,318,747 (GRCm39) splice site probably benign
R6485:Clasrp UTSW 7 19,320,294 (GRCm39) utr 3 prime probably benign
R6600:Clasrp UTSW 7 19,324,207 (GRCm39) nonsense probably null
R7383:Clasrp UTSW 7 19,319,198 (GRCm39) missense unknown
R7719:Clasrp UTSW 7 19,321,769 (GRCm39) missense probably damaging 0.99
R7750:Clasrp UTSW 7 19,318,516 (GRCm39) makesense probably null
R7808:Clasrp UTSW 7 19,322,671 (GRCm39) splice site probably null
R8192:Clasrp UTSW 7 19,329,387 (GRCm39) missense possibly damaging 0.83
R8820:Clasrp UTSW 7 19,320,362 (GRCm39) missense unknown
R8821:Clasrp UTSW 7 19,320,362 (GRCm39) missense unknown
R8924:Clasrp UTSW 7 19,318,232 (GRCm39) missense unknown
R9471:Clasrp UTSW 7 19,319,172 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GCTGCTCAGACATGAGGTCAGAAG -3'
(R):5'- AAGGCTCTGAACCGCCAGTGTAAG -3'

Sequencing Primer
(F):5'- GGTGAACAGGCCACCAG -3'
(R):5'- AACCGCCAGTGTAAGTCCTG -3'
Posted On 2013-06-12