Incidental Mutation 'R6051:Arhgef37'
ID484121
Institutional Source Beutler Lab
Gene Symbol Arhgef37
Ensembl Gene ENSMUSG00000045094
Gene NameRho guanine nucleotide exchange factor (GEF) 37
Synonyms4933429F08Rik
MMRRC Submission 044219-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.157) question?
Stock #R6051 (G1)
Quality Score225.009
Status Not validated
Chromosome18
Chromosomal Location61493794-61536536 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 61507274 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 238 (I238T)
Ref Sequence ENSEMBL: ENSMUSP00000130560 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171629]
Predicted Effect probably damaging
Transcript: ENSMUST00000171629
AA Change: I238T

PolyPhen 2 Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000130560
Gene: ENSMUSG00000045094
AA Change: I238T

DomainStartEndE-ValueType
RhoGEF 34 212 2.62e-35 SMART
Pfam:BAR 311 444 5.6e-10 PFAM
SH3 509 568 8.06e-1 SMART
SH3 606 665 2.56e-14 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010300C02Rik G T 1: 37,624,225 P864Q probably damaging Het
2310035C23Rik G T 1: 105,721,272 G712V probably damaging Het
2700049A03Rik G T 12: 71,184,530 A1021S possibly damaging Het
Abl2 A G 1: 156,642,085 D869G probably damaging Het
Adamts9 A G 6: 92,890,118 Y96H probably damaging Het
Adamts9 G A 6: 92,859,926 A615V possibly damaging Het
Atr T A 9: 95,908,369 H1587Q possibly damaging Het
BB014433 T C 8: 15,042,179 T225A possibly damaging Het
Bcas2 T C 3: 103,174,341 Y87H possibly damaging Het
Brca1 C T 11: 101,524,246 E160K probably damaging Het
Cd2ap T C 17: 42,796,328 *638W probably null Het
Chd2 A T 7: 73,435,842 D1681E probably benign Het
Cit C T 5: 115,846,405 P12L probably benign Het
Crisp1 T C 17: 40,305,126 Y120C possibly damaging Het
Cyp2c65 A G 19: 39,061,166 D46G probably benign Het
Cyp2d34 A T 15: 82,616,770 V387D probably damaging Het
E130311K13Rik T C 3: 63,915,641 H194R probably benign Het
Egfr C A 11: 16,883,607 T625N possibly damaging Het
Fat3 A G 9: 16,375,455 V924A possibly damaging Het
Fgd6 T C 10: 94,137,565 probably null Het
Galnt6 A T 15: 100,694,668 C553S probably damaging Het
Gm5617 T C 9: 48,495,887 L107P possibly damaging Het
Hectd1 G T 12: 51,754,104 T2035N probably benign Het
Hp1bp3 A G 4: 138,234,304 T154A possibly damaging Het
Il10rb A G 16: 91,421,864 T262A probably benign Het
Kansl1l A T 1: 66,726,726 N704K probably null Het
Kbtbd12 T C 6: 88,617,948 D300G possibly damaging Het
Lama4 G A 10: 39,067,902 A734T probably benign Het
Mllt6 G T 11: 97,680,743 G1069* probably null Het
Mns1 T C 9: 72,449,453 L302P probably damaging Het
Muc5ac T A 7: 141,811,857 C2039S possibly damaging Het
Myof A G 19: 38,024,361 L42P probably damaging Het
Ncoa3 T C 2: 166,058,765 L868S probably damaging Het
Ndc80 C T 17: 71,517,578 G212E probably benign Het
Ntn4 A G 10: 93,745,795 H610R probably benign Het
Nufip2 T A 11: 77,691,916 Y219N probably damaging Het
Olfr631 T C 7: 103,928,877 F18S probably damaging Het
Pbxip1 T C 3: 89,443,170 S41P probably benign Het
Phactr2 A T 10: 13,261,811 C196S probably null Het
Ppp3ca T A 3: 136,876,122 Y140N probably damaging Het
Ptprb C A 10: 116,341,090 Y1260* probably null Het
Rap1a C T 3: 105,750,297 R2H possibly damaging Het
Rbbp8 G A 18: 11,738,607 V794I probably benign Het
Rbks T C 5: 31,651,819 N200S probably damaging Het
Rnf186 G T 4: 138,967,966 K272N probably damaging Het
Rtl1 G A 12: 109,593,024 P794S probably damaging Het
Tbc1d30 T A 10: 121,296,845 I205F probably damaging Het
Tkt C T 14: 30,568,196 P261S probably benign Het
Trp53 G A 11: 69,589,608 R267H possibly damaging Het
Ttc14 T C 3: 33,808,924 probably benign Het
Ttn A G 2: 76,907,461 S4245P probably benign Het
Vmn1r75 A T 7: 11,881,051 I237F probably damaging Het
Vmn2r57 T A 7: 41,448,472 H57L probably benign Het
Wdr62 T C 7: 30,261,384 N40S possibly damaging Het
Xcr1 A T 9: 123,856,116 F194I probably benign Het
Zmiz1 T A 14: 25,572,070 M1K probably null Het
Other mutations in Arhgef37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00485:Arhgef37 APN 18 61523871 missense probably damaging 1.00
IGL00801:Arhgef37 APN 18 61499834 missense probably damaging 1.00
IGL01146:Arhgef37 APN 18 61518010 missense possibly damaging 0.93
IGL02052:Arhgef37 APN 18 61499768 missense probably damaging 1.00
IGL02489:Arhgef37 APN 18 61506469 missense possibly damaging 0.91
IGL03236:Arhgef37 APN 18 61523826 missense probably damaging 1.00
R0715:Arhgef37 UTSW 18 61508789 missense probably damaging 0.98
R0746:Arhgef37 UTSW 18 61517993 critical splice donor site probably null
R1843:Arhgef37 UTSW 18 61518050 missense probably damaging 0.99
R1934:Arhgef37 UTSW 18 61523943 missense probably benign 0.00
R1980:Arhgef37 UTSW 18 61508696 missense probably damaging 0.98
R2012:Arhgef37 UTSW 18 61504356 missense possibly damaging 0.56
R2237:Arhgef37 UTSW 18 61504406 missense probably damaging 1.00
R3024:Arhgef37 UTSW 18 61501888 missense probably damaging 0.96
R4864:Arhgef37 UTSW 18 61494925 missense probably benign
R4876:Arhgef37 UTSW 18 61498239 nonsense probably null
R5024:Arhgef37 UTSW 18 61506440 missense probably damaging 0.99
R5050:Arhgef37 UTSW 18 61504331 missense probably benign 0.43
R5512:Arhgef37 UTSW 18 61499774 nonsense probably null
R5611:Arhgef37 UTSW 18 61507263 missense probably benign 0.03
R6488:Arhgef37 UTSW 18 61518052 missense probably benign 0.43
R6612:Arhgef37 UTSW 18 61494881 missense probably benign
R7117:Arhgef37 UTSW 18 61504410 missense probably benign 0.00
R7351:Arhgef37 UTSW 18 61498215 missense possibly damaging 0.93
R7426:Arhgef37 UTSW 18 61504385 missense probably damaging 1.00
R7571:Arhgef37 UTSW 18 61504332 missense probably damaging 0.97
R7992:Arhgef37 UTSW 18 61505756 missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- CAAGCTCAGAGCCTGATTCCTC -3'
(R):5'- CCATCCTGTGGGGTGTAACTTG -3'

Sequencing Primer
(F):5'- GAGCCTGATTCCTCTATAAGCAG -3'
(R):5'- CTTGATGGAGCAGAGTGCC -3'
Posted On2017-07-14