Mutagenetix > Incidental Mutation

Incidental Mutation 'R6052:Zfp882'

484158

Institutional Source

Beutler Lab

Gene Symbol

Zfp882

Ensembl Gene

ENSMUSG00000089857

Gene Name

zinc finger protein 882

Synonyms

ENSMUSG00000052439

MMRRC Submission

044220-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.186) question?

Stock #

R6052 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

71908608-71916354 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 71914505 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Aspartic acid at position 392 (G392D)

Ref Sequence

ENSEMBL: ENSMUSP00000105629 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000110002] [ENSMUST00000125802] [ENSMUST00000126607] [ENSMUST00000131544]

AlphaFold

E9Q4R4

Predicted Effect

probably benign
Transcript: ENSMUST00000110002
AA Change: G392D

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000105629
Gene: ENSMUSG00000089857
AA Change: G392D

Domain	Start	End	E-Value	Type
KRAB	4	61	8.58e-14	SMART
ZnF_C2H2	84	106	1.47e-3	SMART
ZnF_C2H2	168	190	8.47e-4	SMART
ZnF_C2H2	196	218	2.27e-4	SMART
ZnF_C2H2	224	246	6.31e1	SMART
ZnF_C2H2	251	273	1.16e-1	SMART
ZnF_C2H2	279	301	1.25e-1	SMART
ZnF_C2H2	307	329	5.42e-2	SMART
ZnF_C2H2	335	357	1.47e-3	SMART
ZnF_C2H2	363	385	7.26e-3	SMART
ZnF_C2H2	391	413	1.26e-2	SMART
ZnF_C2H2	419	441	3.29e1	SMART
ZnF_C2H2	447	469	2.67e-1	SMART
ZnF_C2H2	475	497	1.04e-3	SMART
ZnF_C2H2	503	525	4.11e-2	SMART
ZnF_C2H2	531	553	4.87e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000118290

Predicted Effect

probably benign
Transcript: ENSMUST00000125802

SMART Domains

Protein: ENSMUSP00000121316
Gene: ENSMUSG00000089857

Domain	Start	End	E-Value	Type
KRAB	12	69	8.58e-14	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000126607

SMART Domains

Protein: ENSMUSP00000119978
Gene: ENSMUSG00000089857

Domain	Start	End	E-Value	Type
KRAB	44	101	8.58e-14	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000131544

SMART Domains

Protein: ENSMUSP00000120213
Gene: ENSMUSG00000066880

Domain	Start	End	E-Value	Type
KRAB	4	56	1.08e-10	SMART
ZnF_C2H2	167	189	8.47e-4	SMART
ZnF_C2H2	195	217	8.34e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000170898

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.2%
20x: 94.7%

Validation Efficiency

96% (80/83)

Allele List at MGI

Other mutations in this stock

Total: 80 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca17	A	G	17: 24,318,191	F473L	probably benign	Het
Ankrd17	T	C	5: 90,253,832	I1449V	probably benign	Het
Aox4	T	A	1: 58,254,318	L943*	probably null	Het
Arap1	G	A	7: 101,404,033	V1257M	probably damaging	Het
B3gnt9	T	C	8: 105,254,598	S53G	probably benign	Het
Baiap3	A	T	17: 25,248,470		probably benign	Het
Canx	T	C	11: 50,297,119	D554G	possibly damaging	Het
Cbfa2t2	T	C	2: 154,510,581	V165A	probably damaging	Het
Ccdc17	C	T	4: 116,599,948		probably null	Het
Cdcp1	A	G	9: 123,185,331	I126T	probably benign	Het
Cdk13	A	T	13: 17,721,215	D1036E	probably damaging	Het
Cfap157	A	G	2: 32,779,851	L240P	probably damaging	Het
Clec18a	C	A	8: 111,078,816	E218*	probably null	Het
Col3a1	T	C	1: 45,345,013		probably benign	Het
Dennd4a	A	G	9: 64,886,945	E682G	probably damaging	Het
Dnah14	T	C	1: 181,666,487	V1736A	possibly damaging	Het
Dpep2	T	A	8: 105,990,638	D162V	possibly damaging	Het
Drd3	C	A	16: 43,821,283	P321T	probably benign	Het
Egfr	A	G	11: 16,911,554	H1111R	probably benign	Het
Entpd1	T	C	19: 40,720,484	S58P	probably damaging	Het
Epha3	C	A	16: 63,603,604	V541L	possibly damaging	Het
Eri3	T	A	4: 117,564,628	D34E	probably damaging	Het
Eya1	T	C	1: 14,283,150	D58G	probably damaging	Het
Fat3	T	A	9: 15,922,679	S26C	probably null	Het
Fgl1	T	C	8: 41,200,511	D115G	probably damaging	Het
Fitm2	T	C	2: 163,470,116	Y59C	probably damaging	Het
Fras1	T	A	5: 96,764,866	I3343N	probably damaging	Het
Gba2	C	A	4: 43,568,330	C679F	probably damaging	Het
Glis2	G	A	16: 4,613,739		probably benign	Het
Gm13088	T	A	4: 143,655,652	D158V	probably damaging	Het
Gm5150	T	A	3: 15,990,753	I103F	probably damaging	Het
H2-Ke6	A	G	17: 34,027,455	L118P	probably damaging	Het
Hhipl2	T	C	1: 183,424,057	S313P	possibly damaging	Het
Hmgcs1	A	G	13: 119,705,459	D474G	probably benign	Het
Homer3	C	T	8: 70,291,426	Q267*	probably null	Het
Igkv8-28	C	T	6: 70,143,689	G90D	probably damaging	Het
Kalrn	T	A	16: 34,360,885	I128F	probably damaging	Het
Krt4	A	G	15: 101,922,759		probably null	Het
Lamb2	T	A	9: 108,487,612	C1188*	probably null	Het
Lsr	A	T	7: 30,958,617	M355K	probably damaging	Het
Map3k11	T	G	19: 5,697,402	D555E	probably benign	Het
Myocd	A	G	11: 65,196,256	Y282H	probably damaging	Het
Nae1	T	C	8: 104,534,544	I7M	probably benign	Het
Nprl3	G	T	11: 32,255,453	H102N	possibly damaging	Het
Nup62	T	A	7: 44,829,040	F160I	possibly damaging	Het
Olfr1490	C	A	19: 13,654,507	P26Q	possibly damaging	Het
Olfr456	T	A	6: 42,486,654	T180S	possibly damaging	Het
Olfr502	A	G	7: 108,523,738	S71P	probably benign	Het
Olfr709-ps1	A	T	7: 106,926,689	F257I	probably benign	Het
Olfr781	C	A	10: 129,333,202	T107K	possibly damaging	Het
Osbpl10	T	C	9: 115,067,315		probably null	Het
Pcdh9	C	T	14: 93,885,846	V963I	probably benign	Het
Phf12	A	G	11: 78,018,218	R375G	probably benign	Het
Piezo1	G	A	8: 122,506,269	T108M	probably damaging	Het
Plxnc1	T	A	10: 94,943,773	Q269L	probably benign	Het
Pomgnt1	T	A	4: 116,151,602	N11K	possibly damaging	Het
Prkd1	A	T	12: 50,366,300		probably null	Het
Prpf40a	T	C	2: 53,159,281	T190A	probably benign	Het
Prrc2b	A	C	2: 32,212,285	H790P	possibly damaging	Het
Rest	T	G	5: 77,281,180	V482G	probably benign	Het
Ros1	T	A	10: 52,163,903	I322L	probably benign	Het
Rpl18	G	A	7: 45,720,130		probably benign	Het
Rsad2	G	A	12: 26,450,578	H237Y	probably benign	Het
Sbf2	A	G	7: 110,441,534	L362S	probably damaging	Het
Sgsm3	A	G	15: 81,009,263	T409A	probably benign	Het
Slc16a14	T	C	1: 84,912,709	T292A	possibly damaging	Het
Spg11	T	G	2: 122,097,356	K649T	probably damaging	Het
Srprb	T	A	9: 103,190,216	I268F	possibly damaging	Het
Tap2	G	A	17: 34,214,709	G566S	probably damaging	Het
Tecpr2	T	C	12: 110,918,891	V168A	possibly damaging	Het
Tln1	G	C	4: 43,555,052	F259L	probably damaging	Het
Tmem181a	T	A	17: 6,280,615	L50H	probably damaging	Het
Tshz1	A	G	18: 84,014,069	I738T	probably damaging	Het
Tspan12	T	C	6: 21,772,638	E304G	probably benign	Het
Urb1	C	T	16: 90,762,383	G1671S	probably damaging	Het
Vmn2r2	T	C	3: 64,117,361	S600G	possibly damaging	Het
Wnt3	C	A	11: 103,808,174	Y35*	probably null	Het
Xpo7	T	C	14: 70,683,719	Y603C	possibly damaging	Het
Zfp457	G	A	13: 67,293,951	H91Y	probably damaging	Het
Zfp664	T	A	5: 124,886,186	C215S	unknown	Het

Other mutations in Zfp882

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00676:Zfp882	APN	8	71913827	missense	probably benign
R0244:Zfp882	UTSW	8	71913523	missense	possibly damaging	0.79
R0270:Zfp882	UTSW	8	71914615	missense	probably benign	0.05
R0636:Zfp882	UTSW	8	71914337	missense	probably benign	0.01
R0840:Zfp882	UTSW	8	71914686	nonsense	probably null
R1299:Zfp882	UTSW	8	71913473	missense	probably damaging	1.00
R4439:Zfp882	UTSW	8	71913609	missense	probably damaging	0.97
R4829:Zfp882	UTSW	8	71914389	missense	probably damaging	1.00
R5028:Zfp882	UTSW	8	71914654	missense	possibly damaging	0.70
R5296:Zfp882	UTSW	8	71914360	missense	probably damaging	1.00
R5882:Zfp882	UTSW	8	71913459	critical splice acceptor site	probably null
R5974:Zfp882	UTSW	8	71913155	missense	probably damaging	1.00
R6383:Zfp882	UTSW	8	71914640	missense	probably damaging	1.00
R6888:Zfp882	UTSW	8	71914286	missense	probably benign	0.01
R6987:Zfp882	UTSW	8	71914673	missense	probably benign	0.01
R7045:Zfp882	UTSW	8	71913249	critical splice donor site	probably null
R7780:Zfp882	UTSW	8	71914229	missense	possibly damaging	0.89
R7793:Zfp882	UTSW	8	71913141	missense	probably damaging	1.00
R8386:Zfp882	UTSW	8	71914118	missense	probably benign	0.00
R9452:Zfp882	UTSW	8	71914987	missense	probably damaging	1.00
R9694:Zfp882	UTSW	8	71914071	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- CTTTGAGGAAGGTTGAAAGTCATG -3'
(R):5'- TGGCTTACACACAGTGCACT -3'

Sequencing Primer
(F):5'- GTTCCCTTCAGTGCCATGAAAAG -3'
(R):5'- GGAACCATGAGTACTGTAGGATTTCC -3'

Posted On

2017-07-14