Incidental Mutation 'R6052:Map3k11'
ID 484200
Institutional Source Beutler Lab
Gene Symbol Map3k11
Ensembl Gene ENSMUSG00000004054
Gene Name mitogen-activated protein kinase kinase kinase 11
Synonyms Mlk3, 2610017K16Rik
MMRRC Submission 044220-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.340) question?
Stock # R6052 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 5738770-5752893 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 5747430 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 555 (D555E)
Ref Sequence ENSEMBL: ENSMUSP00000004156 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004156]
AlphaFold Q80XI6
Predicted Effect probably benign
Transcript: ENSMUST00000004156
AA Change: D555E

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000004156
Gene: ENSMUSG00000004054
AA Change: D555E

DomainStartEndE-ValueType
low complexity region 11 36 N/A INTRINSIC
SH3 45 105 6.79e-19 SMART
TyrKc 118 377 6.83e-81 SMART
coiled coil region 398 444 N/A INTRINSIC
low complexity region 467 476 N/A INTRINSIC
low complexity region 593 610 N/A INTRINSIC
low complexity region 614 632 N/A INTRINSIC
low complexity region 676 697 N/A INTRINSIC
low complexity region 759 778 N/A INTRINSIC
low complexity region 786 805 N/A INTRINSIC
low complexity region 809 820 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.7%
Validation Efficiency 96% (80/83)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted or spontaneous mutation display a pattern of dark red stripes of thin dorsal epithelium during pre-wean development, and necrotic dental pulp has been reported for the spontaneous mutant. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 A G 17: 24,537,165 (GRCm39) F473L probably benign Het
Ankrd17 T C 5: 90,401,691 (GRCm39) I1449V probably benign Het
Aox4 T A 1: 58,293,477 (GRCm39) L943* probably null Het
Arap1 G A 7: 101,053,240 (GRCm39) V1257M probably damaging Het
B3gnt9 T C 8: 105,981,230 (GRCm39) S53G probably benign Het
Baiap3 A T 17: 25,467,444 (GRCm39) probably benign Het
Canx T C 11: 50,187,946 (GRCm39) D554G possibly damaging Het
Cbfa2t2 T C 2: 154,352,501 (GRCm39) V165A probably damaging Het
Ccdc17 C T 4: 116,457,145 (GRCm39) probably null Het
Cdcp1 A G 9: 123,014,396 (GRCm39) I126T probably benign Het
Cdk13 A T 13: 17,895,800 (GRCm39) D1036E probably damaging Het
Cfap157 A G 2: 32,669,863 (GRCm39) L240P probably damaging Het
Clec18a C A 8: 111,805,448 (GRCm39) E218* probably null Het
Col3a1 T C 1: 45,384,173 (GRCm39) probably benign Het
Dennd4a A G 9: 64,794,227 (GRCm39) E682G probably damaging Het
Dnah14 T C 1: 181,494,052 (GRCm39) V1736A possibly damaging Het
Dpep2 T A 8: 106,717,270 (GRCm39) D162V possibly damaging Het
Drd3 C A 16: 43,641,646 (GRCm39) P321T probably benign Het
Egfr A G 11: 16,861,554 (GRCm39) H1111R probably benign Het
Entpd1 T C 19: 40,708,928 (GRCm39) S58P probably damaging Het
Epha3 C A 16: 63,423,967 (GRCm39) V541L possibly damaging Het
Eri3 T A 4: 117,421,825 (GRCm39) D34E probably damaging Het
Eya1 T C 1: 14,353,374 (GRCm39) D58G probably damaging Het
Fat3 T A 9: 15,833,975 (GRCm39) S26C probably null Het
Fgl1 T C 8: 41,653,548 (GRCm39) D115G probably damaging Het
Fitm2 T C 2: 163,312,036 (GRCm39) Y59C probably damaging Het
Fras1 T A 5: 96,912,725 (GRCm39) I3343N probably damaging Het
Gba2 C A 4: 43,568,330 (GRCm39) C679F probably damaging Het
Glis2 G A 16: 4,431,603 (GRCm39) probably benign Het
Gm5150 T A 3: 16,044,917 (GRCm39) I103F probably damaging Het
Hhipl2 T C 1: 183,204,965 (GRCm39) S313P possibly damaging Het
Hmgcs1 A G 13: 120,166,995 (GRCm39) D474G probably benign Het
Homer3 C T 8: 70,744,076 (GRCm39) Q267* probably null Het
Hsd17b8 A G 17: 34,246,429 (GRCm39) L118P probably damaging Het
Igkv8-28 C T 6: 70,120,673 (GRCm39) G90D probably damaging Het
Kalrn T A 16: 34,181,255 (GRCm39) I128F probably damaging Het
Krt4 A G 15: 101,831,194 (GRCm39) probably null Het
Lamb2 T A 9: 108,364,811 (GRCm39) C1188* probably null Het
Lsr A T 7: 30,658,042 (GRCm39) M355K probably damaging Het
Myocd A G 11: 65,087,082 (GRCm39) Y282H probably damaging Het
Nae1 T C 8: 105,261,176 (GRCm39) I7M probably benign Het
Nprl3 G T 11: 32,205,453 (GRCm39) H102N possibly damaging Het
Nup62 T A 7: 44,478,464 (GRCm39) F160I possibly damaging Het
Or10w1 C A 19: 13,631,871 (GRCm39) P26Q possibly damaging Het
Or2d3c A T 7: 106,525,896 (GRCm39) F257I probably benign Het
Or2r2 T A 6: 42,463,588 (GRCm39) T180S possibly damaging Het
Or5p76 A G 7: 108,122,945 (GRCm39) S71P probably benign Het
Or6c35 C A 10: 129,169,071 (GRCm39) T107K possibly damaging Het
Osbpl10 T C 9: 114,896,383 (GRCm39) probably null Het
Pcdh9 C T 14: 94,123,282 (GRCm39) V963I probably benign Het
Phf12 A G 11: 77,909,044 (GRCm39) R375G probably benign Het
Piezo1 G A 8: 123,233,008 (GRCm39) T108M probably damaging Het
Plxnc1 T A 10: 94,779,635 (GRCm39) Q269L probably benign Het
Pomgnt1 T A 4: 116,008,799 (GRCm39) N11K possibly damaging Het
Pramel22 T A 4: 143,382,222 (GRCm39) D158V probably damaging Het
Prkd1 A T 12: 50,413,083 (GRCm39) probably null Het
Prpf40a T C 2: 53,049,293 (GRCm39) T190A probably benign Het
Prrc2b A C 2: 32,102,297 (GRCm39) H790P possibly damaging Het
Rest T G 5: 77,429,027 (GRCm39) V482G probably benign Het
Ros1 T A 10: 52,039,999 (GRCm39) I322L probably benign Het
Rpl18 G A 7: 45,369,554 (GRCm39) probably benign Het
Rsad2 G A 12: 26,500,577 (GRCm39) H237Y probably benign Het
Sbf2 A G 7: 110,040,741 (GRCm39) L362S probably damaging Het
Sgsm3 A G 15: 80,893,464 (GRCm39) T409A probably benign Het
Slc16a14 T C 1: 84,890,430 (GRCm39) T292A possibly damaging Het
Spg11 T G 2: 121,927,837 (GRCm39) K649T probably damaging Het
Srprb T A 9: 103,067,415 (GRCm39) I268F possibly damaging Het
Tap2 G A 17: 34,433,683 (GRCm39) G566S probably damaging Het
Tecpr2 T C 12: 110,885,325 (GRCm39) V168A possibly damaging Het
Tln1 G C 4: 43,555,052 (GRCm39) F259L probably damaging Het
Tmem181a T A 17: 6,330,890 (GRCm39) L50H probably damaging Het
Tshz1 A G 18: 84,032,194 (GRCm39) I738T probably damaging Het
Tspan12 T C 6: 21,772,637 (GRCm39) E304G probably benign Het
Urb1 C T 16: 90,559,271 (GRCm39) G1671S probably damaging Het
Vmn2r2 T C 3: 64,024,782 (GRCm39) S600G possibly damaging Het
Wnt3 C A 11: 103,699,000 (GRCm39) Y35* probably null Het
Xpo7 T C 14: 70,921,159 (GRCm39) Y603C possibly damaging Het
Zfp457 G A 13: 67,442,015 (GRCm39) H91Y probably damaging Het
Zfp664 T A 5: 124,963,250 (GRCm39) C215S unknown Het
Zfp882 G A 8: 72,668,349 (GRCm39) G392D probably benign Het
Other mutations in Map3k11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02017:Map3k11 APN 19 5,747,651 (GRCm39) missense possibly damaging 0.91
IGL02581:Map3k11 APN 19 5,750,834 (GRCm39) missense probably benign
pow UTSW 19 5,750,622 (GRCm39) missense probably benign 0.03
yow UTSW 19 5,747,429 (GRCm39) missense probably benign 0.34
R0130:Map3k11 UTSW 19 5,740,843 (GRCm39) missense probably damaging 1.00
R0193:Map3k11 UTSW 19 5,745,874 (GRCm39) missense probably damaging 0.99
R1621:Map3k11 UTSW 19 5,740,834 (GRCm39) missense probably damaging 1.00
R1736:Map3k11 UTSW 19 5,747,429 (GRCm39) missense probably benign 0.34
R1791:Map3k11 UTSW 19 5,745,600 (GRCm39) nonsense probably null
R3500:Map3k11 UTSW 19 5,740,275 (GRCm39) start codon destroyed probably benign 0.08
R3836:Map3k11 UTSW 19 5,740,831 (GRCm39) missense possibly damaging 0.71
R3892:Map3k11 UTSW 19 5,752,311 (GRCm39) missense probably benign 0.13
R4303:Map3k11 UTSW 19 5,740,852 (GRCm39) missense probably damaging 1.00
R4513:Map3k11 UTSW 19 5,752,238 (GRCm39) missense probably damaging 0.97
R4613:Map3k11 UTSW 19 5,747,499 (GRCm39) missense probably damaging 0.98
R4613:Map3k11 UTSW 19 5,747,498 (GRCm39) missense probably benign 0.18
R4631:Map3k11 UTSW 19 5,740,941 (GRCm39) missense probably benign 0.30
R4780:Map3k11 UTSW 19 5,740,966 (GRCm39) missense probably damaging 0.99
R5213:Map3k11 UTSW 19 5,740,669 (GRCm39) missense probably damaging 0.99
R5266:Map3k11 UTSW 19 5,750,622 (GRCm39) missense probably benign 0.03
R5372:Map3k11 UTSW 19 5,740,990 (GRCm39) missense probably damaging 1.00
R5736:Map3k11 UTSW 19 5,746,739 (GRCm39) missense probably damaging 1.00
R5899:Map3k11 UTSW 19 5,745,937 (GRCm39) critical splice donor site probably null
R6388:Map3k11 UTSW 19 5,740,279 (GRCm39) missense probably damaging 0.96
R6623:Map3k11 UTSW 19 5,745,631 (GRCm39) missense probably damaging 0.97
R6975:Map3k11 UTSW 19 5,740,755 (GRCm39) missense possibly damaging 0.91
R7309:Map3k11 UTSW 19 5,740,486 (GRCm39) missense probably damaging 0.99
R7771:Map3k11 UTSW 19 5,740,636 (GRCm39) missense probably damaging 0.99
R7815:Map3k11 UTSW 19 5,745,667 (GRCm39) missense possibly damaging 0.89
R8988:Map3k11 UTSW 19 5,752,166 (GRCm39) missense probably damaging 1.00
R9130:Map3k11 UTSW 19 5,746,038 (GRCm39) missense possibly damaging 0.69
R9502:Map3k11 UTSW 19 5,740,624 (GRCm39) missense probably damaging 1.00
X0025:Map3k11 UTSW 19 5,746,223 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- TGGCCAATAAGTGACAGAGC -3'
(R):5'- GAATCTAGGTACCACGTGGC -3'

Sequencing Primer
(F):5'- GCACAAATTCAGACATTCTCATTGC -3'
(R):5'- AGGTACCACGTGGCTTCATC -3'
Posted On 2017-07-14