Incidental Mutation 'R0519:Ly6g6f'
ID 48424
Institutional Source Beutler Lab
Gene Symbol Ly6g6f
Ensembl Gene ENSMUSG00000034923
Gene Name lymphocyte antigen 6 family member G6F
Synonyms
MMRRC Submission 038712-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R0519 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 35299514-35304571 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 35301828 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 209 (K209E)
Ref Sequence ENSEMBL: ENSMUSP00000046380 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000013910] [ENSMUST00000038507] [ENSMUST00000172494] [ENSMUST00000172678] [ENSMUST00000172959]
AlphaFold B2RXM6
Predicted Effect probably benign
Transcript: ENSMUST00000013910
SMART Domains Protein: ENSMUSP00000013910
Gene: ENSMUSG00000013766

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LU 28 117 1.65e-2 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000038507
AA Change: K209E

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000046380
Gene: ENSMUSG00000034923
AA Change: K209E

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
IG 21 127 6.02e-7 SMART
transmembrane domain 237 259 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000172494
SMART Domains Protein: ENSMUSP00000133645
Gene: ENSMUSG00000013766

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Blast:LU 28 50 1e-8 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000172639
Predicted Effect probably benign
Transcript: ENSMUST00000172678
SMART Domains Protein: ENSMUSP00000134073
Gene: ENSMUSG00000013766

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LU 28 117 1.65e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000172745
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173120
Predicted Effect probably benign
Transcript: ENSMUST00000172959
SMART Domains Protein: ENSMUSP00000133753
Gene: ENSMUSG00000013766

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:Activin_recp 82 143 2.3e-7 PFAM
Meta Mutation Damage Score 0.0901 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 98.8%
  • 10x: 96.6%
  • 20x: 93.2%
Validation Efficiency 99% (74/75)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The human G6f protein is a type I transmembrane protein belonging to the immunoglobin (Ig) superfamily, which is comprised of cell-surface proteins involved in the immune system and cellular recognition (de Vet et al., 2003 [PubMed 12852788]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700028K03Rik A G 5: 107,696,067 (GRCm39) R168G probably benign Het
2810004N23Rik C T 8: 125,566,668 (GRCm39) G251R possibly damaging Het
3425401B19Rik A G 14: 32,384,919 (GRCm39) S349P possibly damaging Het
Ackr4 A G 9: 103,976,650 (GRCm39) V99A probably benign Het
Acsbg3 T A 17: 57,192,169 (GRCm39) Y577* probably null Het
Asxl3 A G 18: 22,656,577 (GRCm39) Q1529R possibly damaging Het
Atg12 T C 18: 46,874,477 (GRCm39) E46G probably benign Het
Cdcp2 A G 4: 106,964,389 (GRCm39) probably benign Het
Clasrp A G 7: 19,318,089 (GRCm39) probably benign Het
Clip2 A G 5: 134,545,005 (GRCm39) V383A probably benign Het
Cntln C T 4: 84,923,290 (GRCm39) probably benign Het
Colgalt2 G T 1: 152,384,312 (GRCm39) A551S possibly damaging Het
Csmd2 A C 4: 128,380,798 (GRCm39) Y2118S possibly damaging Het
Dip2c T A 13: 9,613,244 (GRCm39) V415E probably damaging Het
Dpy19l2 C T 9: 24,469,391 (GRCm39) R755Q probably benign Het
Dsn1 A T 2: 156,840,633 (GRCm39) probably benign Het
Dtd2 T C 12: 52,051,742 (GRCm39) probably benign Het
Dync1i1 A G 6: 6,027,399 (GRCm39) T602A probably benign Het
Ercc6 A C 14: 32,248,799 (GRCm39) D450A probably damaging Het
Fgf12 A T 16: 28,008,380 (GRCm39) V104D probably benign Het
Frem1 A T 4: 82,888,870 (GRCm39) probably null Het
Gcgr G T 11: 120,426,982 (GRCm39) W88L probably damaging Het
Glb1 ACCC ACC 9: 114,250,812 (GRCm39) probably null Het
Hapln1 A G 13: 89,732,835 (GRCm39) probably benign Het
Hmgn3 T C 9: 82,994,301 (GRCm39) E40G probably damaging Het
Hsdl1 G A 8: 120,292,450 (GRCm39) A255V probably damaging Het
Hyls1 T C 9: 35,472,499 (GRCm39) K306E probably damaging Het
Jcad C T 18: 4,649,122 (GRCm39) probably benign Het
Kif14 C A 1: 136,396,885 (GRCm39) A397E probably damaging Het
Lcmt2 A T 2: 120,969,825 (GRCm39) probably null Het
Lifr T C 15: 7,207,061 (GRCm39) L524P probably damaging Het
Macf1 G A 4: 123,365,113 (GRCm39) T1651I probably benign Het
Mapk4 T C 18: 74,103,392 (GRCm39) D39G probably damaging Het
Mbl1 A G 14: 40,880,522 (GRCm39) M137V probably damaging Het
Mcm10 G A 2: 5,013,356 (GRCm39) S92L probably benign Het
Mug1 A G 6: 121,828,383 (GRCm39) K265R possibly damaging Het
Mxra7 A G 11: 116,701,612 (GRCm39) probably null Het
Neu3 G A 7: 99,472,524 (GRCm39) probably benign Het
Nsd1 A G 13: 55,460,648 (GRCm39) T2395A probably benign Het
Or1j1 T A 2: 36,702,627 (GRCm39) H159L probably damaging Het
Or5m9 A T 2: 85,877,411 (GRCm39) Y195F probably benign Het
Or6s1 T A 14: 51,308,614 (GRCm39) I79F probably damaging Het
Or7g34 A T 9: 19,478,245 (GRCm39) I145N probably benign Het
Osgepl1 T C 1: 53,360,255 (GRCm39) V327A probably damaging Het
Pcdhb21 T C 18: 37,649,085 (GRCm39) V738A possibly damaging Het
Plekha8 A T 6: 54,599,092 (GRCm39) probably benign Het
Ptprq A C 10: 107,374,781 (GRCm39) probably benign Het
Pus10 T A 11: 23,661,201 (GRCm39) F263Y probably benign Het
Rad54b A T 4: 11,599,809 (GRCm39) I338F probably damaging Het
Rad54l2 A G 9: 106,585,498 (GRCm39) F756L probably damaging Het
Scn11a A G 9: 119,619,185 (GRCm39) L719P probably damaging Het
Slc2a2 G A 3: 28,772,965 (GRCm39) V253I possibly damaging Het
Slc39a4 A T 15: 76,499,338 (GRCm39) N192K probably benign Het
Soat1 T A 1: 156,268,816 (GRCm39) I245F probably damaging Het
Sorcs2 G A 5: 36,188,534 (GRCm39) A858V probably benign Het
Tcim T C 8: 24,928,651 (GRCm39) T88A possibly damaging Het
Tecta G A 9: 42,259,188 (GRCm39) probably benign Het
Tgm5 C A 2: 120,879,376 (GRCm39) L553F probably damaging Het
Tjp1 A G 7: 64,952,669 (GRCm39) V1555A probably benign Het
Tmem214 A C 5: 31,027,012 (GRCm39) M1L probably null Het
Togaram1 T C 12: 65,012,776 (GRCm39) probably benign Het
Topaz1 C A 9: 122,578,544 (GRCm39) L485I possibly damaging Het
Ttn T C 2: 76,548,626 (GRCm39) probably benign Het
Ube2o A G 11: 116,437,285 (GRCm39) probably null Het
Ubr7 T A 12: 102,734,465 (GRCm39) D246E probably benign Het
Vcpkmt T C 12: 69,629,102 (GRCm39) D132G probably benign Het
Vmn2r111 T A 17: 22,792,102 (GRCm39) Q51H probably benign Het
Vmn2r95 C T 17: 18,659,765 (GRCm39) P170S probably damaging Het
Zbtb38 A G 9: 96,567,826 (GRCm39) I1086T probably damaging Het
Zfp444 G A 7: 6,191,172 (GRCm39) A118T probably benign Het
Zp2 A G 7: 119,737,372 (GRCm39) I272T probably damaging Het
Other mutations in Ly6g6f
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01647:Ly6g6f APN 17 35,299,817 (GRCm39) unclassified probably benign
IGL01804:Ly6g6f APN 17 35,300,146 (GRCm39) missense possibly damaging 0.85
IGL02280:Ly6g6f APN 17 35,302,194 (GRCm39) missense probably benign 0.06
IGL02455:Ly6g6f APN 17 35,301,866 (GRCm39) missense possibly damaging 0.91
IGL02694:Ly6g6f APN 17 35,300,144 (GRCm39) missense possibly damaging 0.96
R1169:Ly6g6f UTSW 17 35,302,240 (GRCm39) missense probably damaging 0.99
R1796:Ly6g6f UTSW 17 35,302,478 (GRCm39) missense probably benign 0.02
R5549:Ly6g6f UTSW 17 35,302,333 (GRCm39) missense possibly damaging 0.51
R6717:Ly6g6f UTSW 17 35,304,550 (GRCm39) start codon destroyed probably benign 0.01
R8012:Ly6g6f UTSW 17 35,300,060 (GRCm39) missense possibly damaging 0.53
R9443:Ly6g6f UTSW 17 35,299,826 (GRCm39) missense possibly damaging 0.96
X0017:Ly6g6f UTSW 17 35,304,514 (GRCm39) missense probably benign 0.17
X0027:Ly6g6f UTSW 17 35,300,096 (GRCm39) missense probably benign 0.03
Z1177:Ly6g6f UTSW 17 35,302,008 (GRCm39) missense possibly damaging 0.96
Predicted Primers PCR Primer
(F):5'- TGTGATAGATGTGGTCAATGAGGGAGAT -3'
(R):5'- CAAGTACCAGAACTGGAGGGTGTATGA -3'

Sequencing Primer
(F):5'- TGAGGGAGATGGGGAAGCC -3'
(R):5'- GGTCTGAAGACCTCTCTGGATAC -3'
Posted On 2013-06-12