Mutagenetix > Incidental Mutation

Incidental Mutation 'R6056:Mtor'

484382

Institutional Source

Beutler Lab

Gene Symbol

Mtor

Ensembl Gene

ENSMUSG00000028991

Gene Name

mechanistic target of rapamycin kinase

Synonyms

RAPT1, FKBP-rapamycin-associated protein FRAP, RAFT1, flat, Frap1, 2610315D21Rik

MMRRC Submission

044223-MU

Accession Numbers

Ncbi RefSeq: NM_020009.2; MGI:1928394

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R6056 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

148448611-148557683 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 148537435 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Lysine at position 1896 (R1896K)

Ref Sequence

ENSEMBL: ENSMUSP00000099510 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103221]

AlphaFold

Q9JLN9

Predicted Effect

probably benign
Transcript: ENSMUST00000103221
AA Change: R1896K

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000099510
Gene: ENSMUSG00000028991
AA Change: R1896K

Domain	Start	End	E-Value	Type
low complexity region	7	21	N/A	INTRINSIC
low complexity region	179	191	N/A	INTRINSIC
low complexity region	277	288	N/A	INTRINSIC
low complexity region	774	790	N/A	INTRINSIC
DUF3385	854	1024	1.51e-93	SMART
low complexity region	1279	1300	N/A	INTRINSIC
Pfam:FAT	1513	1908	2.3e-134	PFAM
Rapamycin_bind	2015	2114	7.94e-61	SMART
PI3Kc	2183	2484	8.84e-121	SMART
FATC	2517	2549	2.11e-15	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000158456

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.4%
20x: 95.4%

Validation Efficiency

96% (99/103)

MGI Phenotype

Strain: 3529989; 4820819; 3512186; 5425404; 3052669
Lethality: E11-E12
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
PHENOTYPE: Mice homozygous for targeted, gene trap and ENU-induced null alleles exhibit embryonic lethality by E12.5 with abnormal embryogenesis. Mice homozygous for the ENU mutation further exhibit abnormal brain development. [provided by MGI curators]

Allele List at MGI

All alleles(25) : Targeted(12) Gene trapped(12) Chemically induced(1)

Other mutations in this stock

Total: 101 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310002L09Rik	A	T	4: 73,942,878 (GRCm38)	W162R	probably benign	Het
2610507B11Rik	C	A	11: 78,271,384 (GRCm38)	L691I	possibly damaging	Het
4930438A08Rik	C	A	11: 58,293,638 (GRCm38)	P394H	probably damaging	Het
Aggf1	C	T	13: 95,371,615 (GRCm38)	C81Y	probably benign	Het
Agxt2	A	T	15: 10,378,877 (GRCm38)	D188V	probably damaging	Het
Angpt2	T	C	8: 18,698,116 (GRCm38)	K376R	probably benign	Het
Anxa5	A	G	3: 36,450,691 (GRCm38)	S241P	probably damaging	Het
Aox3	A	T	1: 58,169,859 (GRCm38)	K850N	probably damaging	Het
Arid5a	T	C	1: 36,319,392 (GRCm38)	M415T	probably benign	Het
Aspa	T	A	11: 73,308,752 (GRCm38)	N233I	probably damaging	Het
Atp4b	C	T	8: 13,388,782 (GRCm38)	R198Q	probably damaging	Het
Atp8b2	A	T	3: 89,946,221 (GRCm38)	V719E	possibly damaging	Het
Cacna1s	T	G	1: 136,105,836 (GRCm38)	V1017G	probably damaging	Het
Chrna4	G	T	2: 181,029,442 (GRCm38)	Q174K	probably damaging	Het
Chrnb1	A	T	11: 69,786,939 (GRCm38)	V329D	probably damaging	Het
Chst14	T	C	2: 118,927,733 (GRCm38)	L336P	probably damaging	Het
Clec2e	T	C	6: 129,100,809 (GRCm38)	D22G	probably benign	Het
Csrnp2	A	C	15: 100,482,382 (GRCm38)	S343A	probably benign	Het
Dapl1	C	A	2: 59,484,713 (GRCm38)	A2E	probably damaging	Het
Dlec1	G	T	9: 119,121,923 (GRCm38)	R519L	probably damaging	Het
Dmgdh	T	A	13: 93,708,743 (GRCm38)	F415I	possibly damaging	Het
Dmgdh	T	C	13: 93,752,326 (GRCm38)	V824A	probably damaging	Het
Dnah11	T	G	12: 117,928,456 (GRCm38)	T3661P	probably benign	Het
Dnah3	A	G	7: 120,030,031 (GRCm38)	F1434L	probably damaging	Het
Dnajc11	C	A	4: 151,978,126 (GRCm38)		probably benign	Het
Dot1l	A	G	10: 80,786,095 (GRCm38)	E527G	probably damaging	Het
Drc7	T	C	8: 95,075,051 (GRCm38)	L680P	probably damaging	Het
Dysf	T	C	6: 84,106,862 (GRCm38)	Y742H	probably benign	Het
Ece1	A	G	4: 137,961,647 (GRCm38)	Y665C	probably damaging	Het
Emc1	A	G	4: 139,354,222 (GRCm38)	K54E	possibly damaging	Het
Enoph1	C	T	5: 100,067,901 (GRCm38)	T247M	probably damaging	Het
Exoc2	T	C	13: 30,900,829 (GRCm38)	K383R	probably benign	Het
Fam227b	A	T	2: 126,121,052 (GRCm38)	H181Q	probably damaging	Het
Fsip2	A	T	2: 82,985,673 (GRCm38)	M3917L	probably benign	Het
Gtf3a	T	A	5: 146,955,528 (GRCm38)		probably benign	Het
Hgfac	T	A	5: 35,041,629 (GRCm38)	C11*	probably null	Het
Hmcn1	C	A	1: 150,663,909 (GRCm38)	A2944S	probably damaging	Het
Hps5	T	A	7: 46,767,097 (GRCm38)	Y947F	probably benign	Het
Ighv2-5	A	T	12: 113,685,500 (GRCm38)	I111K	probably benign	Het
Inpp5e	A	T	2: 26,407,848 (GRCm38)	L247*	probably null	Het
Kbtbd11	T	C	8: 15,027,577 (GRCm38)	S59P	probably benign	Het
Kctd19	G	A	8: 105,396,450 (GRCm38)	H111Y	probably damaging	Het
Kif1a	T	C	1: 93,024,648 (GRCm38)	D1303G	probably damaging	Het
Kif7	A	G	7: 79,714,094 (GRCm38)	V22A	possibly damaging	Het
Lrit3	A	T	3: 129,789,355 (GRCm38)	C328S	probably damaging	Het
Lrrc37a	G	T	11: 103,497,658 (GRCm38)	Q2314K	unknown	Het
Lurap1	G	T	4: 116,137,402 (GRCm38)	P211T	possibly damaging	Het
Mbd2	T	A	18: 70,580,803 (GRCm38)	N5K	possibly damaging	Het
Mbtps1	A	C	8: 119,515,602 (GRCm38)	L894V	probably benign	Het
Mefv	G	A	16: 3,708,042 (GRCm38)	S787F	possibly damaging	Het
Miip	T	A	4: 147,862,335 (GRCm38)	I289F	probably damaging	Het
Mogat2	T	A	7: 99,223,513 (GRCm38)	I155F	possibly damaging	Het
Mpp3	C	A	11: 102,011,689 (GRCm38)		probably null	Het
Mrrf	A	G	2: 36,177,221 (GRCm38)	K220E	probably damaging	Het
Mtmr6	C	T	14: 60,298,170 (GRCm38)	P485L	probably damaging	Het
Myh3	C	T	11: 67,087,545 (GRCm38)	P453S	probably benign	Het
Nebl	A	G	2: 17,450,234 (GRCm38)	V112A	probably benign	Het
Nmnat2	G	A	1: 153,074,734 (GRCm38)	W55*	probably null	Het
Nprl3	A	G	11: 32,267,432 (GRCm38)	S37P	probably damaging	Het
Olfr1246	T	C	2: 89,591,101 (GRCm38)	N5D	possibly damaging	Het
Oraov1	G	T	7: 144,915,286 (GRCm38)	V17L	possibly damaging	Het
Pcdhga4	T	G	18: 37,686,330 (GRCm38)	S311A	probably benign	Het
Pcdhgb6	T	C	18: 37,743,112 (GRCm38)	V291A	probably benign	Het
Peg10	GAT	GATCAT	6: 4,756,449 (GRCm38)		probably benign	Het
Peg3	T	C	7: 6,709,571 (GRCm38)	E884G	probably damaging	Het
Pgpep1	G	A	8: 70,652,451 (GRCm38)	T53M	probably damaging	Het
Phf12	A	G	11: 78,009,515 (GRCm38)	T146A	probably benign	Het
Polr3k	C	G	2: 181,864,488 (GRCm38)	N10K	probably damaging	Het
Prickle4	C	A	17: 47,690,210 (GRCm38)	G144C	probably damaging	Het
Ptpn6	T	C	6: 124,732,435 (GRCm38)	Y25C	probably damaging	Het
Rad1	A	G	15: 10,488,074 (GRCm38)	I95V	probably damaging	Het
Rad23b	A	G	4: 55,382,540 (GRCm38)	T248A	probably benign	Het
Rapgef3	T	C	15: 97,758,861 (GRCm38)	D299G	probably damaging	Het
Rcc2	T	G	4: 140,717,024 (GRCm38)	V342G	possibly damaging	Het
Rgs3	G	T	4: 62,625,906 (GRCm38)	R136L	probably damaging	Het
Scube2	A	T	7: 109,833,013 (GRCm38)	C399*	probably null	Het
Serpinb3d	T	C	1: 107,079,722 (GRCm38)	Y178C	probably damaging	Het
Slc1a7	A	G	4: 108,012,261 (GRCm38)	T508A	probably benign	Het
Slc29a4	C	T	5: 142,720,077 (GRCm38)	R439C	probably damaging	Het
Sntg2	A	G	12: 30,312,561 (GRCm38)	I62T	probably benign	Het
Sowaha	G	A	11: 53,479,087 (GRCm38)	P274L	probably damaging	Het
Sptan1	A	G	2: 29,996,782 (GRCm38)	N869S	probably benign	Het
Stx18	C	A	5: 38,106,564 (GRCm38)	A64D	probably damaging	Het
Stxbp5	A	G	10: 9,770,686 (GRCm38)	V94A	probably benign	Het
Sult1a1	T	A	7: 126,676,452 (GRCm38)		probably null	Het
Susd1	G	T	4: 59,379,687 (GRCm38)	H313Q	possibly damaging	Het
Tdrd9	A	T	12: 111,985,041 (GRCm38)	K88N	probably damaging	Het
Tlr5	A	C	1: 182,974,038 (GRCm38)	R302S	possibly damaging	Het
Tnr	C	T	1: 159,886,909 (GRCm38)	T786I	probably damaging	Het
Tprgl	A	G	4: 154,160,095 (GRCm38)	S148P	probably damaging	Het
Trpc4ap	T	A	2: 155,671,074 (GRCm38)	N127I	probably damaging	Het
Tulp2	T	A	7: 45,490,373 (GRCm38)		probably null	Het
Uggt2	C	T	14: 119,035,969 (GRCm38)		probably null	Het
Ulk4	T	A	9: 121,272,955 (GRCm38)	Y19F	probably damaging	Het
Upf1	T	C	8: 70,333,037 (GRCm38)	Y1053C	probably damaging	Het
Vars2	A	T	17: 35,665,788 (GRCm38)	H223Q	probably benign	Het
Vmn2r106	T	A	17: 20,267,544 (GRCm38)		probably null	Het
Ythdc2	T	A	18: 44,840,210 (GRCm38)	F305I	probably damaging	Het
Zfp281	T	C	1: 136,625,440 (GRCm38)	F52S	possibly damaging	Het
Zfp292	A	T	4: 34,809,784 (GRCm38)	C1087S	probably damaging	Het
Zfp335	A	T	2: 164,895,098 (GRCm38)		probably null	Het

Other mutations in Mtor

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01123:Mtor	APN	4	148,453,037 (GRCm38)	missense	probably benign	0.06
IGL01447:Mtor	APN	4	148,530,757 (GRCm38)	missense	possibly damaging	0.62
IGL01551:Mtor	APN	4	148,472,037 (GRCm38)	missense	probably damaging	0.99
IGL01661:Mtor	APN	4	148,514,851 (GRCm38)	missense	possibly damaging	0.61
IGL01675:Mtor	APN	4	148,484,654 (GRCm38)	missense	probably benign	0.00
IGL01743:Mtor	APN	4	148,530,613 (GRCm38)	splice site	probably benign
IGL02015:Mtor	APN	4	148,540,113 (GRCm38)	nonsense	probably null
IGL02084:Mtor	APN	4	148,470,680 (GRCm38)	missense	probably damaging	0.98
IGL02095:Mtor	APN	4	148,544,541 (GRCm38)	missense	probably damaging	1.00
IGL02129:Mtor	APN	4	148,549,845 (GRCm38)	missense	possibly damaging	0.91
IGL02260:Mtor	APN	4	148,538,301 (GRCm38)	missense	probably damaging	1.00
IGL02329:Mtor	APN	4	148,534,939 (GRCm38)	missense	probably benign	0.16
IGL02440:Mtor	APN	4	148,491,647 (GRCm38)	missense	probably benign	0.04
IGL02440:Mtor	APN	4	148,546,429 (GRCm38)	missense	probably benign	0.24
IGL02449:Mtor	APN	4	148,533,921 (GRCm38)	missense	possibly damaging	0.65
IGL02479:Mtor	APN	4	148,470,584 (GRCm38)	missense	probably damaging	1.00
IGL02904:Mtor	APN	4	148,491,612 (GRCm38)	splice site	probably benign
IGL02904:Mtor	APN	4	148,452,394 (GRCm38)	missense	possibly damaging	0.55
IGL02931:Mtor	APN	4	148,464,964 (GRCm38)	missense	probably benign	0.22
IGL03048:Mtor	APN	4	148,546,390 (GRCm38)	splice site	probably benign
IGL03133:Mtor	APN	4	148,484,319 (GRCm38)	missense	probably benign	0.01
IGL03142:Mtor	APN	4	148,453,899 (GRCm38)	missense	probably benign	0.00
Brushes	UTSW	4	148,463,748 (GRCm38)	missense	probably benign	0.00
Dynamo	UTSW	4	148,462,910 (GRCm38)	missense	probably benign	0.00
engine	UTSW	4	148,556,855 (GRCm38)	splice site	probably null
Erg	UTSW	4	148,545,596 (GRCm38)	missense	probably damaging	1.00
Lindor	UTSW	4	148,454,646 (GRCm38)	missense	probably damaging	1.00
motor	UTSW	4	148,491,360 (GRCm38)	missense	possibly damaging	0.76
R4858_Mtor_211	UTSW	4	148,454,816 (GRCm38)	makesense	probably null
Vigor	UTSW	4	148,538,899 (GRCm38)	missense	probably damaging	1.00
Vim	UTSW	4	148,525,803 (GRCm38)	critical splice donor site	probably null
PIT4519001:Mtor	UTSW	4	148,524,500 (GRCm38)	missense	probably damaging	1.00
R0045:Mtor	UTSW	4	148,464,949 (GRCm38)	missense	probably benign	0.42
R0048:Mtor	UTSW	4	148,538,881 (GRCm38)	nonsense	probably null
R0048:Mtor	UTSW	4	148,538,881 (GRCm38)	nonsense	probably null
R0103:Mtor	UTSW	4	148,533,902 (GRCm38)	missense	probably benign	0.05
R0112:Mtor	UTSW	4	148,480,923 (GRCm38)	missense	probably damaging	1.00
R0137:Mtor	UTSW	4	148,470,624 (GRCm38)	missense	possibly damaging	0.78
R0184:Mtor	UTSW	4	148,464,971 (GRCm38)	missense	probably benign	0.05
R0208:Mtor	UTSW	4	148,464,975 (GRCm38)	missense	probably benign	0.43
R0329:Mtor	UTSW	4	148,484,380 (GRCm38)	missense	probably benign
R0330:Mtor	UTSW	4	148,484,380 (GRCm38)	missense	probably benign
R0365:Mtor	UTSW	4	148,486,050 (GRCm38)	missense	probably benign	0.01
R0537:Mtor	UTSW	4	148,538,360 (GRCm38)	missense	probably damaging	1.00
R0542:Mtor	UTSW	4	148,540,450 (GRCm38)	missense	probably benign	0.02
R0556:Mtor	UTSW	4	148,469,380 (GRCm38)	missense	possibly damaging	0.88
R0613:Mtor	UTSW	4	148,526,046 (GRCm38)	missense	possibly damaging	0.95
R0646:Mtor	UTSW	4	148,484,354 (GRCm38)	nonsense	probably null
R0710:Mtor	UTSW	4	148,464,391 (GRCm38)	missense	possibly damaging	0.73
R0791:Mtor	UTSW	4	148,462,910 (GRCm38)	missense	probably benign	0.00
R0792:Mtor	UTSW	4	148,462,910 (GRCm38)	missense	probably benign	0.00
R0866:Mtor	UTSW	4	148,486,056 (GRCm38)	missense	probably benign	0.04
R0973:Mtor	UTSW	4	148,550,188 (GRCm38)	missense	probably damaging	1.00
R1027:Mtor	UTSW	4	148,539,999 (GRCm38)	missense	probably benign	0.03
R1028:Mtor	UTSW	4	148,538,830 (GRCm38)	missense	possibly damaging	0.88
R1289:Mtor	UTSW	4	148,470,307 (GRCm38)	missense	probably benign	0.10
R1416:Mtor	UTSW	4	148,491,414 (GRCm38)	nonsense	probably null
R1465:Mtor	UTSW	4	148,525,993 (GRCm38)	splice site	probably benign
R1506:Mtor	UTSW	4	148,536,505 (GRCm38)	splice site	probably benign
R1624:Mtor	UTSW	4	148,547,676 (GRCm38)	missense	probably damaging	1.00
R1695:Mtor	UTSW	4	148,538,907 (GRCm38)	missense	probably benign	0.08
R1771:Mtor	UTSW	4	148,470,624 (GRCm38)	missense	possibly damaging	0.78
R1800:Mtor	UTSW	4	148,462,892 (GRCm38)	missense	probably benign	0.00
R1855:Mtor	UTSW	4	148,553,089 (GRCm38)	missense	probably benign	0.02
R1857:Mtor	UTSW	4	148,480,879 (GRCm38)	missense	probably damaging	1.00
R1867:Mtor	UTSW	4	148,454,632 (GRCm38)	missense	probably damaging	0.97
R1954:Mtor	UTSW	4	148,468,273 (GRCm38)	missense	probably damaging	1.00
R2054:Mtor	UTSW	4	148,466,025 (GRCm38)	missense	probably benign	0.00
R2054:Mtor	UTSW	4	148,462,852 (GRCm38)	missense	probably benign	0.05
R2099:Mtor	UTSW	4	148,550,192 (GRCm38)	nonsense	probably null
R2148:Mtor	UTSW	4	148,456,012 (GRCm38)	missense	possibly damaging	0.56
R2214:Mtor	UTSW	4	148,538,870 (GRCm38)	missense	probably benign	0.39
R2281:Mtor	UTSW	4	148,489,555 (GRCm38)	missense	probably benign	0.02
R2512:Mtor	UTSW	4	148,530,491 (GRCm38)	missense	possibly damaging	0.95
R2870:Mtor	UTSW	4	148,540,030 (GRCm38)	missense	probably benign	0.00
R2870:Mtor	UTSW	4	148,540,030 (GRCm38)	missense	probably benign	0.00
R2871:Mtor	UTSW	4	148,540,030 (GRCm38)	missense	probably benign	0.00
R2871:Mtor	UTSW	4	148,540,030 (GRCm38)	missense	probably benign	0.00
R2872:Mtor	UTSW	4	148,540,030 (GRCm38)	missense	probably benign	0.00
R2872:Mtor	UTSW	4	148,540,030 (GRCm38)	missense	probably benign	0.00
R2873:Mtor	UTSW	4	148,540,030 (GRCm38)	missense	probably benign	0.00
R4032:Mtor	UTSW	4	148,536,752 (GRCm38)	missense	probably benign	0.03
R4073:Mtor	UTSW	4	148,549,375 (GRCm38)	missense	probably damaging	0.99
R4273:Mtor	UTSW	4	148,550,152 (GRCm38)	missense	probably benign	0.21
R4611:Mtor	UTSW	4	148,486,119 (GRCm38)	missense	probably benign	0.03
R4858:Mtor	UTSW	4	148,454,816 (GRCm38)	makesense	probably null
R4942:Mtor	UTSW	4	148,472,142 (GRCm38)	missense	probably benign	0.03
R4967:Mtor	UTSW	4	148,491,360 (GRCm38)	missense	possibly damaging	0.76
R4995:Mtor	UTSW	4	148,525,752 (GRCm38)	missense	probably damaging	1.00
R5054:Mtor	UTSW	4	148,556,855 (GRCm38)	splice site	probably null
R5215:Mtor	UTSW	4	148,453,983 (GRCm38)	missense	probably benign
R5249:Mtor	UTSW	4	148,463,732 (GRCm38)	missense	probably damaging	1.00
R5289:Mtor	UTSW	4	148,466,092 (GRCm38)	missense	possibly damaging	0.88
R5365:Mtor	UTSW	4	148,550,130 (GRCm38)	missense	probably damaging	0.99
R5498:Mtor	UTSW	4	148,540,364 (GRCm38)	missense	possibly damaging	0.71
R5514:Mtor	UTSW	4	148,546,444 (GRCm38)	missense	probably damaging	1.00
R5540:Mtor	UTSW	4	148,454,708 (GRCm38)	missense	probably benign	0.01
R5600:Mtor	UTSW	4	148,491,470 (GRCm38)	missense	probably damaging	1.00
R5615:Mtor	UTSW	4	148,538,276 (GRCm38)	missense	possibly damaging	0.95
R5632:Mtor	UTSW	4	148,469,006 (GRCm38)	missense	possibly damaging	0.94
R5641:Mtor	UTSW	4	148,546,425 (GRCm38)	missense	probably damaging	0.98
R5834:Mtor	UTSW	4	148,536,536 (GRCm38)	missense	possibly damaging	0.95
R5984:Mtor	UTSW	4	148,538,827 (GRCm38)	missense	probably benign	0.02
R6225:Mtor	UTSW	4	148,521,337 (GRCm38)	missense	probably benign	0.04
R6262:Mtor	UTSW	4	148,526,095 (GRCm38)	missense	possibly damaging	0.46
R6335:Mtor	UTSW	4	148,465,927 (GRCm38)	missense	probably damaging	1.00
R6479:Mtor	UTSW	4	148,551,000 (GRCm38)	missense	probably benign	0.16
R6543:Mtor	UTSW	4	148,545,596 (GRCm38)	missense	probably damaging	1.00
R6711:Mtor	UTSW	4	148,452,367 (GRCm38)	missense	possibly damaging	0.49
R6715:Mtor	UTSW	4	148,538,547 (GRCm38)	missense	probably benign	0.00
R6744:Mtor	UTSW	4	148,458,655 (GRCm38)	missense	probably benign	0.01
R6748:Mtor	UTSW	4	148,550,184 (GRCm38)	missense	probably damaging	1.00
R6762:Mtor	UTSW	4	148,538,481 (GRCm38)	missense	possibly damaging	0.47
R6836:Mtor	UTSW	4	148,489,498 (GRCm38)	missense	possibly damaging	0.94
R6948:Mtor	UTSW	4	148,536,752 (GRCm38)	missense	probably benign	0.12
R6979:Mtor	UTSW	4	148,524,473 (GRCm38)	missense	possibly damaging	0.60
R6992:Mtor	UTSW	4	148,464,475 (GRCm38)	missense	probably benign
R7271:Mtor	UTSW	4	148,546,485 (GRCm38)	missense	possibly damaging	0.70
R7423:Mtor	UTSW	4	148,556,344 (GRCm38)	missense	possibly damaging	0.77
R7434:Mtor	UTSW	4	148,464,959 (GRCm38)	missense	probably benign	0.39
R7619:Mtor	UTSW	4	148,462,795 (GRCm38)	missense	probably damaging	0.98
R7634:Mtor	UTSW	4	148,452,350 (GRCm38)	missense	possibly damaging	0.53
R7697:Mtor	UTSW	4	148,540,308 (GRCm38)	nonsense	probably null
R7737:Mtor	UTSW	4	148,538,738 (GRCm38)	missense	possibly damaging	0.95
R7791:Mtor	UTSW	4	148,462,940 (GRCm38)	missense	probably benign	0.00
R7858:Mtor	UTSW	4	148,454,646 (GRCm38)	missense	probably damaging	1.00
R8035:Mtor	UTSW	4	148,546,399 (GRCm38)	missense	probably benign	0.29
R8076:Mtor	UTSW	4	148,525,803 (GRCm38)	critical splice donor site	probably null
R8078:Mtor	UTSW	4	148,468,287 (GRCm38)	missense	probably benign
R8928:Mtor	UTSW	4	148,538,899 (GRCm38)	missense	probably damaging	1.00
R9040:Mtor	UTSW	4	148,463,748 (GRCm38)	missense	probably benign	0.00
R9116:Mtor	UTSW	4	148,552,741 (GRCm38)	missense	probably benign
R9284:Mtor	UTSW	4	148,459,080 (GRCm38)	missense	probably benign	0.03
R9310:Mtor	UTSW	4	148,469,377 (GRCm38)	missense	probably benign	0.03
R9374:Mtor	UTSW	4	148,514,940 (GRCm38)	missense	probably damaging	1.00
R9417:Mtor	UTSW	4	148,538,319 (GRCm38)	nonsense	probably null
R9465:Mtor	UTSW	4	148,540,382 (GRCm38)	missense	possibly damaging	0.92
R9492:Mtor	UTSW	4	148,484,344 (GRCm38)	missense	probably damaging	1.00
R9499:Mtor	UTSW	4	148,514,940 (GRCm38)	missense	probably damaging	1.00
R9516:Mtor	UTSW	4	148,484,646 (GRCm38)	missense	probably benign	0.23
R9600:Mtor	UTSW	4	148,547,635 (GRCm38)	missense	possibly damaging	0.82
R9622:Mtor	UTSW	4	148,483,712 (GRCm38)	missense	probably damaging	0.99
X0025:Mtor	UTSW	4	148,530,714 (GRCm38)	missense	probably benign	0.09
Z1176:Mtor	UTSW	4	148,550,130 (GRCm38)	missense	possibly damaging	0.69
Z1176:Mtor	UTSW	4	148,550,125 (GRCm38)	missense	probably benign	0.08

Predicted Primers

PCR Primer
(F):5'- TCCTCAAGCATCAGTGTCTCAC -3'
(R):5'- ACTTGGCTGTAGAAGTGAGC -3'

Posted On

2017-07-14