Incidental Mutation 'R0520:Wdr64'
ID 48440
Institutional Source Beutler Lab
Gene Symbol Wdr64
Ensembl Gene ENSMUSG00000026523
Gene Name WD repeat domain 64
Synonyms 4930415O10Rik, 4930511H01Rik
MMRRC Submission 038713-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R0520 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 175526159-175643300 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 175553958 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 173 (T173A)
Ref Sequence ENSEMBL: ENSMUSP00000091846 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094288] [ENSMUST00000171939] [ENSMUST00000194087]
AlphaFold Q9D565
Predicted Effect probably damaging
Transcript: ENSMUST00000094288
AA Change: T173A

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000091846
Gene: ENSMUSG00000026523
AA Change: T173A

DomainStartEndE-ValueType
WD40 118 159 2.65e1 SMART
WD40 162 200 2.13e1 SMART
low complexity region 259 271 N/A INTRINSIC
Blast:WD40 277 316 5e-19 BLAST
WD40 323 361 2.4e-1 SMART
WD40 365 404 8.29e-1 SMART
WD40 407 449 1.7e2 SMART
WD40 457 493 1.19e1 SMART
WD40 497 538 4.55e-3 SMART
WD40 643 684 3.31e0 SMART
WD40 742 806 7.4e0 SMART
Blast:WD40 811 851 7e-17 BLAST
WD40 864 903 4.62e-4 SMART
Blast:XPGN 921 964 9e-19 BLAST
Predicted Effect probably damaging
Transcript: ENSMUST00000171939
AA Change: T163A

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000128678
Gene: ENSMUSG00000026523
AA Change: T163A

DomainStartEndE-ValueType
WD40 151 190 5.73e0 SMART
low complexity region 249 261 N/A INTRINSIC
Blast:WD40 267 306 4e-19 BLAST
WD40 313 351 2.4e-1 SMART
WD40 355 394 8.29e-1 SMART
WD40 397 439 1.7e2 SMART
WD40 447 483 1.19e1 SMART
WD40 487 528 4.55e-3 SMART
WD40 633 674 3.31e0 SMART
WD40 732 796 7.4e0 SMART
Blast:WD40 801 841 5e-17 BLAST
WD40 854 893 4.62e-4 SMART
Blast:XPGN 911 954 1e-18 BLAST
Predicted Effect probably damaging
Transcript: ENSMUST00000194087
AA Change: T163A

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000141740
Gene: ENSMUSG00000026523
AA Change: T163A

DomainStartEndE-ValueType
WD40 151 190 3.6e-2 SMART
low complexity region 249 261 N/A INTRINSIC
Blast:WD40 267 305 5e-19 BLAST
WD40 313 351 1.5e-3 SMART
WD40 355 394 5.2e-3 SMART
WD40 397 439 1.1e0 SMART
WD40 447 483 7.6e-2 SMART
WD40 487 528 2.9e-5 SMART
WD40 633 674 2.1e-2 SMART
WD40 732 796 4.7e-2 SMART
Blast:WD40 801 841 6e-17 BLAST
WD40 854 893 2.9e-6 SMART
Blast:XPGN 911 954 1e-18 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195794
Meta Mutation Damage Score 0.1757 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.2%
Validation Efficiency 100% (72/72)
Allele List at MGI

All alleles(1) : Gene trapped(1)

Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acod1 T C 14: 103,288,952 (GRCm39) I154T possibly damaging Het
Acr G T 15: 89,457,430 (GRCm39) C226F probably damaging Het
Aff1 C T 5: 103,995,617 (GRCm39) R1070* probably null Het
Aldh9a1 C T 1: 167,188,960 (GRCm39) probably benign Het
Apaf1 A T 10: 90,915,851 (GRCm39) H12Q probably damaging Het
Asic1 A T 15: 99,593,416 (GRCm39) I291F probably damaging Het
Aspm T A 1: 139,406,558 (GRCm39) M1815K possibly damaging Het
Asxl3 A T 18: 22,656,043 (GRCm39) D1351V probably damaging Het
Atg9a C T 1: 75,163,178 (GRCm39) W299* probably null Het
B3gntl1 C A 11: 121,514,314 (GRCm39) V313F possibly damaging Het
B4galnt4 T A 7: 140,647,286 (GRCm39) C345* probably null Het
Bicc1 A T 10: 70,793,020 (GRCm39) F211L probably damaging Het
Cachd1 T G 4: 100,754,900 (GRCm39) V117G probably damaging Het
Cdc16 G A 8: 13,810,569 (GRCm39) probably null Het
Cers6 C T 2: 68,935,435 (GRCm39) Q312* probably null Het
Csta2 A G 16: 36,073,461 (GRCm39) I16V probably benign Het
Dclre1c A G 2: 3,437,512 (GRCm39) H115R probably damaging Het
Ddx20 T C 3: 105,594,692 (GRCm39) T18A probably benign Het
Dhx57 A G 17: 80,565,604 (GRCm39) V816A possibly damaging Het
Dlgap1 C T 17: 70,823,989 (GRCm39) Q325* probably null Het
Dnaja1 A T 4: 40,728,072 (GRCm39) M178L probably benign Het
Ecd A T 14: 20,378,732 (GRCm39) S454T probably benign Het
Efcab6 G A 15: 83,834,247 (GRCm39) H454Y probably benign Het
Exo1 T A 1: 175,727,031 (GRCm39) D447E probably benign Het
F5 T G 1: 164,037,156 (GRCm39) I1965S probably benign Het
Fbn2 A G 18: 58,146,821 (GRCm39) C2692R probably damaging Het
Fggy T A 4: 95,489,340 (GRCm39) L152Q probably damaging Het
Glb1 ACCC ACC 9: 114,250,812 (GRCm39) probably null Het
Gm9871 A G 6: 101,778,540 (GRCm39) noncoding transcript Het
Gnai2 A T 9: 107,497,372 (GRCm39) D7E probably benign Het
Gon7 C T 12: 102,724,047 (GRCm39) probably benign Het
H2-K2 A T 17: 34,216,390 (GRCm39) V272E probably damaging Het
Hectd4 G T 5: 121,469,770 (GRCm39) R2555L possibly damaging Het
Hexb T C 13: 97,317,618 (GRCm39) R360G probably benign Het
Igsf9b C A 9: 27,234,546 (GRCm39) S470R probably benign Het
Inpp5d T C 1: 87,633,642 (GRCm39) probably benign Het
Inpp5k C A 11: 75,530,356 (GRCm39) Y265* probably null Het
Klhl33 T G 14: 51,129,140 (GRCm39) E436D probably damaging Het
Krt80 A G 15: 101,267,898 (GRCm39) L13P probably benign Het
Krtap19-2 C T 16: 88,670,749 (GRCm39) probably benign Het
Marchf10 T C 11: 105,280,708 (GRCm39) T526A probably benign Het
Mcrs1 A G 15: 99,146,336 (GRCm39) probably null Het
Msh2 G T 17: 88,024,972 (GRCm39) V617F possibly damaging Het
Nckap1 A C 2: 80,371,874 (GRCm39) probably benign Het
Nek4 T A 14: 30,681,263 (GRCm39) probably benign Het
Or7h8 G A 9: 20,123,791 (GRCm39) V49I probably benign Het
Or8b12b T C 9: 37,684,849 (GRCm39) V298A probably benign Het
Or8k22 G T 2: 86,163,475 (GRCm39) T75K probably damaging Het
Or9s14 T A 1: 92,536,471 (GRCm39) V304E probably damaging Het
Osgin1 A G 8: 120,169,247 (GRCm39) H48R probably damaging Het
Pam T A 1: 97,811,920 (GRCm39) T369S probably benign Het
Pclo C T 5: 14,763,844 (GRCm39) Q821* probably null Het
Plekhm1 T C 11: 103,285,770 (GRCm39) I222V probably benign Het
Ptprg T G 14: 12,199,783 (GRCm38) N65K possibly damaging Het
Pum2 T A 12: 8,771,710 (GRCm39) V351E probably damaging Het
Slc25a54 T A 3: 109,014,546 (GRCm39) probably benign Het
Smchd1 A T 17: 71,736,538 (GRCm39) D587E possibly damaging Het
Stap1 A G 5: 86,238,823 (GRCm39) M164V probably benign Het
Stat5a T C 11: 100,752,252 (GRCm39) V30A probably damaging Het
Stk36 T G 1: 74,641,365 (GRCm39) probably benign Het
Tiam1 G T 16: 89,614,839 (GRCm39) probably benign Het
Tmc5 T C 7: 118,265,799 (GRCm39) M553T probably damaging Het
Tmem14a T A 1: 21,299,636 (GRCm39) Y89N possibly damaging Het
Tpp2 A G 1: 44,029,690 (GRCm39) Y991C probably damaging Het
Ttc7 A G 17: 87,666,579 (GRCm39) K615E possibly damaging Het
Ubac2 C T 14: 122,231,754 (GRCm39) P227S probably damaging Het
Vit A C 17: 78,932,588 (GRCm39) K565T probably damaging Het
Vps13c T C 9: 67,853,133 (GRCm39) F2409L possibly damaging Het
Zfp759 T C 13: 67,285,419 (GRCm39) I60T probably benign Het
Zfp81 A G 17: 33,553,351 (GRCm39) S488P probably damaging Het
Zic2 CCCACCACCACCATCACCACCACCACC CCCACCATCACCACCACCACC 14: 122,713,776 (GRCm39) probably benign Het
Other mutations in Wdr64
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00563:Wdr64 APN 1 175,526,366 (GRCm39) missense probably benign 0.00
IGL00902:Wdr64 APN 1 175,556,391 (GRCm39) missense probably damaging 1.00
IGL01347:Wdr64 APN 1 175,547,899 (GRCm39) missense probably benign 0.12
IGL01353:Wdr64 APN 1 175,559,151 (GRCm39) missense probably damaging 0.96
IGL01583:Wdr64 APN 1 175,594,722 (GRCm39) critical splice donor site probably null
IGL01643:Wdr64 APN 1 175,599,877 (GRCm39) missense probably damaging 1.00
IGL01673:Wdr64 APN 1 175,627,922 (GRCm39) missense possibly damaging 0.68
IGL01992:Wdr64 APN 1 175,533,637 (GRCm39) missense probably damaging 1.00
IGL02613:Wdr64 APN 1 175,594,613 (GRCm39) nonsense probably null
IGL02834:Wdr64 APN 1 175,633,415 (GRCm39) splice site probably benign
IGL03214:Wdr64 APN 1 175,571,201 (GRCm39) splice site probably benign
IGL03305:Wdr64 APN 1 175,583,152 (GRCm39) missense possibly damaging 0.94
IGL03308:Wdr64 APN 1 175,594,562 (GRCm39) unclassified probably benign
PIT4418001:Wdr64 UTSW 1 175,571,160 (GRCm39) nonsense probably null
R0036:Wdr64 UTSW 1 175,556,496 (GRCm39) nonsense probably null
R0041:Wdr64 UTSW 1 175,554,037 (GRCm39) nonsense probably null
R0041:Wdr64 UTSW 1 175,554,037 (GRCm39) nonsense probably null
R0079:Wdr64 UTSW 1 175,622,668 (GRCm39) missense probably benign 0.02
R0380:Wdr64 UTSW 1 175,597,208 (GRCm39) splice site probably benign
R0486:Wdr64 UTSW 1 175,622,769 (GRCm39) splice site probably benign
R0598:Wdr64 UTSW 1 175,633,465 (GRCm39) missense probably damaging 1.00
R0711:Wdr64 UTSW 1 175,599,751 (GRCm39) missense probably benign 0.39
R0746:Wdr64 UTSW 1 175,620,539 (GRCm39) missense possibly damaging 0.92
R0927:Wdr64 UTSW 1 175,620,647 (GRCm39) missense probably damaging 0.97
R0947:Wdr64 UTSW 1 175,603,315 (GRCm39) missense probably benign
R1014:Wdr64 UTSW 1 175,583,192 (GRCm39) missense probably damaging 1.00
R1332:Wdr64 UTSW 1 175,622,706 (GRCm39) missense possibly damaging 0.82
R1416:Wdr64 UTSW 1 175,633,568 (GRCm39) missense probably benign 0.01
R1421:Wdr64 UTSW 1 175,594,716 (GRCm39) missense possibly damaging 0.85
R1467:Wdr64 UTSW 1 175,603,288 (GRCm39) missense probably benign 0.00
R1467:Wdr64 UTSW 1 175,603,288 (GRCm39) missense probably benign 0.00
R1796:Wdr64 UTSW 1 175,544,897 (GRCm39) missense probably damaging 1.00
R1797:Wdr64 UTSW 1 175,639,585 (GRCm39) missense probably damaging 1.00
R2145:Wdr64 UTSW 1 175,594,661 (GRCm39) missense probably benign 0.01
R2321:Wdr64 UTSW 1 175,622,653 (GRCm39) missense possibly damaging 0.57
R2449:Wdr64 UTSW 1 175,526,479 (GRCm39) missense probably benign
R4049:Wdr64 UTSW 1 175,633,422 (GRCm39) missense probably benign 0.21
R4155:Wdr64 UTSW 1 175,597,172 (GRCm39) missense probably benign 0.03
R4624:Wdr64 UTSW 1 175,599,829 (GRCm39) missense probably benign
R4661:Wdr64 UTSW 1 175,554,060 (GRCm39) missense probably damaging 1.00
R4711:Wdr64 UTSW 1 175,626,795 (GRCm39) missense probably damaging 1.00
R4891:Wdr64 UTSW 1 175,526,345 (GRCm39) unclassified probably benign
R4925:Wdr64 UTSW 1 175,552,268 (GRCm39) splice site probably null
R4943:Wdr64 UTSW 1 175,547,882 (GRCm39) missense probably benign 0.01
R5000:Wdr64 UTSW 1 175,553,941 (GRCm39) splice site probably null
R5001:Wdr64 UTSW 1 175,620,525 (GRCm39) critical splice acceptor site probably null
R5143:Wdr64 UTSW 1 175,553,979 (GRCm39) missense probably damaging 1.00
R5395:Wdr64 UTSW 1 175,583,164 (GRCm39) missense probably damaging 1.00
R5813:Wdr64 UTSW 1 175,639,623 (GRCm39) missense possibly damaging 0.89
R6014:Wdr64 UTSW 1 175,633,556 (GRCm39) missense possibly damaging 0.56
R6417:Wdr64 UTSW 1 175,553,956 (GRCm39) missense probably damaging 1.00
R6456:Wdr64 UTSW 1 175,613,175 (GRCm39) critical splice donor site probably null
R6555:Wdr64 UTSW 1 175,547,856 (GRCm39) missense probably damaging 1.00
R6576:Wdr64 UTSW 1 175,633,494 (GRCm39) missense possibly damaging 0.82
R6797:Wdr64 UTSW 1 175,638,176 (GRCm39) critical splice donor site probably null
R6891:Wdr64 UTSW 1 175,533,634 (GRCm39) missense probably damaging 1.00
R6959:Wdr64 UTSW 1 175,533,555 (GRCm39) missense probably damaging 1.00
R7205:Wdr64 UTSW 1 175,617,499 (GRCm39) missense probably benign 0.34
R7252:Wdr64 UTSW 1 175,603,240 (GRCm39) missense probably benign 0.00
R7552:Wdr64 UTSW 1 175,613,147 (GRCm39) missense possibly damaging 0.71
R7732:Wdr64 UTSW 1 175,617,495 (GRCm39) missense probably benign
R7777:Wdr64 UTSW 1 175,617,564 (GRCm39) missense possibly damaging 0.71
R7780:Wdr64 UTSW 1 175,556,542 (GRCm39) missense probably damaging 1.00
R7810:Wdr64 UTSW 1 175,559,092 (GRCm39) missense probably benign 0.01
R7833:Wdr64 UTSW 1 175,591,511 (GRCm39) missense probably damaging 1.00
R7843:Wdr64 UTSW 1 175,639,668 (GRCm39) missense probably benign 0.00
R7887:Wdr64 UTSW 1 175,613,111 (GRCm39) missense not run
R7991:Wdr64 UTSW 1 175,554,051 (GRCm39) missense probably benign 0.36
R8124:Wdr64 UTSW 1 175,626,844 (GRCm39) splice site probably null
R8129:Wdr64 UTSW 1 175,603,154 (GRCm39) missense probably damaging 0.96
R8673:Wdr64 UTSW 1 175,633,584 (GRCm39) missense probably damaging 1.00
R8728:Wdr64 UTSW 1 175,559,079 (GRCm39) missense probably benign 0.01
R8786:Wdr64 UTSW 1 175,636,327 (GRCm39) nonsense probably null
R8822:Wdr64 UTSW 1 175,544,920 (GRCm39) missense probably damaging 1.00
R8842:Wdr64 UTSW 1 175,599,893 (GRCm39) missense probably benign 0.02
R8887:Wdr64 UTSW 1 175,599,850 (GRCm39) missense probably benign 0.17
R9014:Wdr64 UTSW 1 175,526,395 (GRCm39) missense probably benign
R9330:Wdr64 UTSW 1 175,554,024 (GRCm39) missense possibly damaging 0.93
R9332:Wdr64 UTSW 1 175,599,871 (GRCm39) missense possibly damaging 0.71
R9465:Wdr64 UTSW 1 175,618,823 (GRCm39) missense possibly damaging 0.53
R9716:Wdr64 UTSW 1 175,622,658 (GRCm39) missense probably benign
R9717:Wdr64 UTSW 1 175,544,854 (GRCm39) missense probably damaging 1.00
Z1088:Wdr64 UTSW 1 175,533,551 (GRCm39) missense possibly damaging 0.71
Predicted Primers PCR Primer
(F):5'- AAGCTTTGCTGCCAGATGGGAC -3'
(R):5'- AGACTGTGCCGTGTGAAAAGACC -3'

Sequencing Primer
(F):5'- CTGCCAGATGGGACTTCTAATATC -3'
(R):5'- GGCCAGGCTCATATCCTTAATGG -3'
Posted On 2013-06-12