Incidental Mutation 'R6087:Or4f17-ps1'
ID 484594
Institutional Source Beutler Lab
Gene Symbol Or4f17-ps1
Ensembl Gene ENSMUSG00000108908
Gene Name olfactory receptor family 4 subfamily F member 17, pseudogene 1
Synonyms Olfr1293-ps, MOR245-24P, OTTMUSG00000015076, GA_x6K02T2Q125-72578807-72579745
MMRRC Submission 044244-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.111) question?
Stock # R6087 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 111357649-111358587 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 111358526 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Valine at position 289 (E289V)
Ref Sequence ENSEMBL: ENSMUSP00000099611 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102551] [ENSMUST00000120021] [ENSMUST00000215245] [ENSMUST00000217845]
AlphaFold A0A1L1SVB5
Predicted Effect possibly damaging
Transcript: ENSMUST00000102551
AA Change: E289V

PolyPhen 2 Score 0.806 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000099611
Gene: ENSMUSG00000108908
AA Change: E289V

DomainStartEndE-ValueType
Pfam:7tm_4 17 289 6e-45 PFAM
Pfam:7TM_GPCR_Srsx 20 288 1.4e-7 PFAM
Pfam:7tm_1 27 273 7e-24 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000120021
AA Change: E292V
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208680
Predicted Effect probably benign
Transcript: ENSMUST00000215245
AA Change: E307V

PolyPhen 2 Score 0.362 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000217845
AA Change: E307V

PolyPhen 2 Score 0.362 (Sensitivity: 0.90; Specificity: 0.89)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310003L06Rik A G 5: 88,119,621 (GRCm39) K126R possibly damaging Het
Adam7 A T 14: 68,748,206 (GRCm39) C548S probably damaging Het
Adar C A 3: 89,652,897 (GRCm39) H260N probably benign Het
Ak9 A G 10: 41,258,828 (GRCm39) E775G probably benign Het
Arhgap35 T C 7: 16,297,568 (GRCm39) Y499C probably damaging Het
Bank1 A G 3: 135,772,190 (GRCm39) L480P probably damaging Het
Cep135 G T 5: 76,763,638 (GRCm39) probably null Het
Cnga1 G T 5: 72,768,155 (GRCm39) A177E probably damaging Het
Cubn T A 2: 13,432,658 (GRCm39) D1221V probably damaging Het
Cyp2d40 T C 15: 82,648,205 (GRCm39) Y36C possibly damaging Het
Dock8 C A 19: 25,138,438 (GRCm39) N1254K probably benign Het
Elapor2 T C 5: 9,449,255 (GRCm39) S128P probably damaging Het
Fam13b C T 18: 34,620,192 (GRCm39) V231I possibly damaging Het
Fbxo8 T A 8: 57,022,353 (GRCm39) Y122N probably damaging Het
Fmo2 T A 1: 162,708,002 (GRCm39) I378F probably benign Het
Golga3 A T 5: 110,352,812 (GRCm39) Q861L probably damaging Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Ighv3-8 G T 12: 114,286,000 (GRCm39) A114E probably damaging Het
Itga3 C T 11: 94,943,269 (GRCm39) probably null Het
Kank1 G A 19: 25,387,088 (GRCm39) V254I probably benign Het
Lipo5 A T 19: 33,443,375 (GRCm39) I147K unknown Het
Lrfn2 A G 17: 49,378,154 (GRCm39) S412G probably benign Het
Lrrn3 T C 12: 41,503,534 (GRCm39) N261S possibly damaging Het
Mical2 C T 7: 111,917,692 (GRCm39) Q350* probably null Het
Nras T C 3: 102,967,637 (GRCm39) F78L probably damaging Het
Nudt9 A G 5: 104,198,679 (GRCm39) I65V probably benign Het
Or10ag59 A G 2: 87,406,259 (GRCm39) D277G probably benign Het
Oscar G A 7: 3,614,311 (GRCm39) P143S probably benign Het
Pla2g4d C T 2: 120,100,487 (GRCm39) G615D probably damaging Het
Plekha1 T G 7: 130,502,301 (GRCm39) S175A probably benign Het
Psg27 T C 7: 18,290,869 (GRCm39) K445E probably benign Het
Rad51c A G 11: 87,271,705 (GRCm39) Y318H probably benign Het
Ret G T 6: 118,153,252 (GRCm39) T472K possibly damaging Het
Tarbp1 T C 8: 127,155,709 (GRCm39) D1343G probably benign Het
Top2b C A 14: 16,409,864 (GRCm38) R844S probably benign Het
Vmn1r171 T A 7: 23,332,429 (GRCm39) M218K probably damaging Het
Vmn2r89 A T 14: 51,695,033 (GRCm39) probably null Het
Zc3h13 T A 14: 75,568,149 (GRCm39) D1147E probably damaging Het
Zgrf1 T A 3: 127,409,135 (GRCm39) L1703H probably damaging Het
Other mutations in Or4f17-ps1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R3933:Or4f17-ps1 UTSW 2 111,358,300 (GRCm39) missense probably damaging 1.00
R4231:Or4f17-ps1 UTSW 2 111,358,546 (GRCm39) missense probably damaging 1.00
R4364:Or4f17-ps1 UTSW 2 111,357,985 (GRCm39) missense probably benign 0.24
R4935:Or4f17-ps1 UTSW 2 111,357,793 (GRCm39) missense probably damaging 1.00
R4957:Or4f17-ps1 UTSW 2 111,358,569 (GRCm39) missense probably benign 0.00
R4959:Or4f17-ps1 UTSW 2 111,357,969 (GRCm39) missense probably damaging 1.00
R4973:Or4f17-ps1 UTSW 2 111,357,969 (GRCm39) missense probably damaging 1.00
R5333:Or4f17-ps1 UTSW 2 111,358,048 (GRCm39) missense probably benign
R6431:Or4f17-ps1 UTSW 2 111,358,001 (GRCm39) missense probably damaging 1.00
R8189:Or4f17-ps1 UTSW 2 111,358,118 (GRCm39) missense
R8345:Or4f17-ps1 UTSW 2 111,357,864 (GRCm39) nonsense probably null
R9260:Or4f17-ps1 UTSW 2 111,358,271 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- AGGCTCTGTCTACACTGACTGC -3'
(R):5'- TGTAGACAGAGCCTTAGATGACC -3'

Sequencing Primer
(F):5'- ACTGACTGCTCATATCACAGTAG -3'
(R):5'- CACATAAGGTCAGCTGCATA -3'
Posted On 2017-08-16