Mutagenetix > Incidental Mutation

Incidental Mutation 'R6089:Vmn2r98'

484690

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r98

Ensembl Gene

ENSMUSG00000096717

Gene Name

vomeronasal 2, receptor 98

Synonyms

EG224552

MMRRC Submission

044246-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.139) question?

Stock #

R6089 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

19053460-19082411 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19066074 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 278 (D278G)

Ref Sequence

ENSEMBL: ENSMUSP00000131261 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170424]

AlphaFold

E9PZ56

Predicted Effect

probably benign
Transcript: ENSMUST00000170424
AA Change: D278G

PolyPhen 2 Score 0.293 (Sensitivity: 0.91; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: D278G

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	460	2.6e-35	PFAM
Pfam:NCD3G	509	562	7.4e-22	PFAM
Pfam:7tm_3	594	830	1.4e-52	PFAM
low complexity region	844	856	N/A	INTRINSIC

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 97.8%
20x: 93.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9030624J02Rik	T	G	7: 118,746,435	S59A	possibly damaging	Het
A830010M20Rik	C	T	5: 107,507,029	A386V	probably damaging	Het
Actr3	A	G	1: 125,407,395	V95A	probably damaging	Het
Ankrd40	A	T	11: 94,333,925	K53N	probably damaging	Het
Ash1l	C	T	3: 89,053,143	Q2338*	probably null	Het
Astn2	A	G	4: 65,794,573	F610S	probably damaging	Het
Baz2a	TCTCCTC	TCTC	10: 128,114,642		probably benign	Het
Calm4	A	T	13: 3,837,874		probably benign	Het
Card10	T	C	15: 78,802,414	T68A	probably benign	Het
Cars2	A	G	8: 11,530,301	M245T	probably damaging	Het
Cat	C	A	2: 103,472,951	L160F	probably null	Het
Cers5	G	T	15: 99,741,002	T144K	probably benign	Het
Cyp3a13	T	A	5: 137,909,953	L211F	probably benign	Het
Defb4	A	T	8: 19,201,305	R63*	probably null	Het
Dnah14	G	T	1: 181,750,154	W3012L	probably damaging	Het
Dusp18	A	G	11: 3,897,555	T182A	probably benign	Het
Dzip1l	C	A	9: 99,642,684	T286K	possibly damaging	Het
Eif2ak3	A	T	6: 70,896,934	T944S	possibly damaging	Het
Fbn1	A	T	2: 125,321,225	I2119N	possibly damaging	Het
Gabbr2	A	G	4: 46,846,448	S154P	probably damaging	Het
Gm15440	A	T	13: 51,691,401	H107Q	unknown	Het
Grm2	G	A	9: 106,653,891	P133L	probably damaging	Het
Gsdme	A	G	6: 50,251,305	V61A	probably damaging	Het
Gtpbp1	A	G	15: 79,706,997	T23A	probably benign	Het
Helz	A	T	11: 107,595,137		probably null	Het
Herc1	A	C	9: 66,445,532	H2100P	probably damaging	Het
Hjurp	GT	GTT	1: 88,266,524		probably null	Het
Ifngr1	T	C	10: 19,606,300	S213P	probably benign	Het
Itgb7	T	C	15: 102,217,286	D636G	probably benign	Het
Mre11a	G	A	9: 14,819,464	D491N	probably benign	Het
Muc16	A	G	9: 18,643,252	L3915P	unknown	Het
Myh1	T	A	11: 67,202,167		probably null	Het
Myh1	T	G	11: 67,220,787		probably null	Het
Myh7b	C	T	2: 155,622,489	T608M	probably damaging	Het
Myof	T	C	19: 37,967,060	K23E	probably benign	Het
Nacad	A	G	11: 6,601,331	V620A	probably benign	Het
Pbrm1	T	C	14: 31,087,585	Y1121H	probably damaging	Het
Pcdha9	T	C	18: 36,998,498	F207L	probably benign	Het
Pcdhb10	T	C	18: 37,413,626	V585A	possibly damaging	Het
Pigg	A	T	5: 108,341,922	M798L	probably benign	Het
Poc5	G	T	13: 96,396,671	M102I	probably damaging	Het
Ppp2r3a	T	A	9: 101,211,636	Q496L	probably benign	Het
Ptprf	A	G	4: 118,211,084	Y1752H	probably damaging	Het
Ptpru	G	C	4: 131,772,630	S1244R	possibly damaging	Het
Rnf213	A	G	11: 119,416,559	K682E	probably benign	Het
Rtp3	T	C	9: 110,986,973	D170G	probably benign	Het
Sall4	T	C	2: 168,755,486	D478G	possibly damaging	Het
Scai	A	T	2: 39,083,554	Y58*	probably null	Het
Simc1	G	A	13: 54,528,490	V1007M	probably benign	Het
Tcf20	G	T	15: 82,853,208	D1347E	probably benign	Het
Tdo2	T	C	3: 81,962,728	Y279C	probably damaging	Het
Trdn	C	T	10: 33,464,575	P602S	probably benign	Het
Txndc5	A	T	13: 38,523,416	M1K	probably null	Het
Ubr2	A	C	17: 46,982,292	M356R	possibly damaging	Het
Uqcrc2	A	T	7: 120,654,009	D332V	probably damaging	Het
Usp48	T	C	4: 137,605,818	F108L	probably damaging	Het
Vill	A	G	9: 119,057,799	N4S	probably benign	Het
Vmn1r11	T	C	6: 57,137,660	V103A	possibly damaging	Het
Wfdc15a	A	T	2: 164,199,666	L79*	probably null	Het
Xxylt1	C	T	16: 31,080,981	V119M	probably damaging	Het
Zfp26	G	T	9: 20,437,693	A525D	probably damaging	Het
Zgrf1	G	A	3: 127,595,993	G396D	probably damaging	Het
Zkscan16	A	G	4: 58,948,889	D148G	possibly damaging	Het
Zscan26	G	T	13: 21,448,329	S77R	probably damaging	Het

Other mutations in Vmn2r98

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r98	APN	17	19065745	splice site	probably benign
IGL01296:Vmn2r98	APN	17	19065185	missense	probably damaging	1.00
IGL01363:Vmn2r98	APN	17	19065758	missense	probably benign	0.01
IGL01618:Vmn2r98	APN	17	19065259	missense	possibly damaging	0.93
IGL01746:Vmn2r98	APN	17	19066451	missense	probably damaging	1.00
IGL01747:Vmn2r98	APN	17	19066440	missense	probably damaging	1.00
IGL01770:Vmn2r98	APN	17	19066440	missense	probably damaging	1.00
IGL01868:Vmn2r98	APN	17	19066286	missense	probably benign
IGL02123:Vmn2r98	APN	17	19080679	missense	probably damaging	1.00
IGL02323:Vmn2r98	APN	17	19065851	missense	probably damaging	0.99
IGL02543:Vmn2r98	APN	17	19065821	missense	probably benign
IGL02650:Vmn2r98	APN	17	19080961	missense	probably benign	0.00
IGL02676:Vmn2r98	APN	17	19065259	missense	probably benign	0.00
IGL02803:Vmn2r98	APN	17	19066013	missense	probably benign
IGL02807:Vmn2r98	APN	17	19081021	missense	probably damaging	1.00
IGL03307:Vmn2r98	APN	17	19065980	missense	possibly damaging	0.62
IGL03396:Vmn2r98	APN	17	19069845	missense	possibly damaging	0.92
PIT4131001:Vmn2r98	UTSW	17	19080961	missense	probably benign	0.00
R0122:Vmn2r98	UTSW	17	19066400	missense	probably benign	0.06
R0329:Vmn2r98	UTSW	17	19066347	missense	probably benign	0.21
R0330:Vmn2r98	UTSW	17	19066347	missense	probably benign	0.21
R0368:Vmn2r98	UTSW	17	19065827	nonsense	probably null
R0545:Vmn2r98	UTSW	17	19053613	missense	probably benign	0.15
R0635:Vmn2r98	UTSW	17	19080497	missense	probably benign	0.00
R0689:Vmn2r98	UTSW	17	19080520	missense	possibly damaging	0.83
R1035:Vmn2r98	UTSW	17	19080749	missense	possibly damaging	0.90
R1243:Vmn2r98	UTSW	17	19065948	missense	possibly damaging	0.52
R1421:Vmn2r98	UTSW	17	19065178	missense	probably damaging	1.00
R1629:Vmn2r98	UTSW	17	19067383	missense	possibly damaging	0.94
R1643:Vmn2r98	UTSW	17	19080908	missense	probably damaging	1.00
R1795:Vmn2r98	UTSW	17	19066440	missense	probably damaging	1.00
R1958:Vmn2r98	UTSW	17	19066418	missense	possibly damaging	0.70
R1962:Vmn2r98	UTSW	17	19065333	nonsense	probably null
R2165:Vmn2r98	UTSW	17	19081291	missense	unknown
R2238:Vmn2r98	UTSW	17	19065951	missense	probably damaging	1.00
R2252:Vmn2r98	UTSW	17	19080436	missense	probably benign	0.00
R2323:Vmn2r98	UTSW	17	19065819	missense	probably benign	0.18
R2887:Vmn2r98	UTSW	17	19081177	missense	possibly damaging	0.83
R2909:Vmn2r98	UTSW	17	19067402	missense	probably damaging	1.00
R3001:Vmn2r98	UTSW	17	19065863	missense	probably benign	0.01
R3002:Vmn2r98	UTSW	17	19065863	missense	probably benign	0.01
R3003:Vmn2r98	UTSW	17	19065863	missense	probably benign	0.01
R3788:Vmn2r98	UTSW	17	19080625	missense	probably benign	0.31
R4570:Vmn2r98	UTSW	17	19066092	missense	probably benign	0.11
R4706:Vmn2r98	UTSW	17	19069745	missense	probably damaging	1.00
R4723:Vmn2r98	UTSW	17	19066340	missense	probably benign	0.01
R5036:Vmn2r98	UTSW	17	19066157	missense	probably benign	0.00
R5072:Vmn2r98	UTSW	17	19066044	missense	probably benign	0.07
R5121:Vmn2r98	UTSW	17	19053553	missense	probably benign	0.13
R5283:Vmn2r98	UTSW	17	19080719	missense	probably benign	0.05
R5294:Vmn2r98	UTSW	17	19069754	nonsense	probably null
R5371:Vmn2r98	UTSW	17	19069753	missense	probably damaging	1.00
R5532:Vmn2r98	UTSW	17	19067383	missense	possibly damaging	0.94
R5598:Vmn2r98	UTSW	17	19080899	missense	probably benign	0.37
R5800:Vmn2r98	UTSW	17	19065998	missense	probably benign	0.17
R6155:Vmn2r98	UTSW	17	19065881	missense	possibly damaging	0.87
R6853:Vmn2r98	UTSW	17	19065801	missense	probably benign	0.00
R6920:Vmn2r98	UTSW	17	19065248	missense	probably damaging	0.98
R7012:Vmn2r98	UTSW	17	19066268	missense	probably benign	0.06
R7042:Vmn2r98	UTSW	17	19080922	missense	probably benign
R7068:Vmn2r98	UTSW	17	19065313	missense	probably benign
R7607:Vmn2r98	UTSW	17	19067308	missense	possibly damaging	0.95
R7763:Vmn2r98	UTSW	17	19080535	missense	probably benign	0.00
R7771:Vmn2r98	UTSW	17	19067198	splice site	probably null
R7915:Vmn2r98	UTSW	17	19067231	missense	probably benign	0.10
R8028:Vmn2r98	UTSW	17	19053650	missense	probably benign	0.00
R8205:Vmn2r98	UTSW	17	19081163	missense	probably damaging	0.99
R8241:Vmn2r98	UTSW	17	19080769	missense	probably damaging	0.99
R8906:Vmn2r98	UTSW	17	19066270	missense	probably benign
R8952:Vmn2r98	UTSW	17	19065269	missense	possibly damaging	0.76
R9147:Vmn2r98	UTSW	17	19066121	missense	probably benign	0.04
R9148:Vmn2r98	UTSW	17	19066121	missense	probably benign	0.04
R9187:Vmn2r98	UTSW	17	19081219	missense	probably damaging	1.00
R9344:Vmn2r98	UTSW	17	19066515	missense	probably benign	0.14
R9467:Vmn2r98	UTSW	17	19067255	missense	probably benign	0.01
R9487:Vmn2r98	UTSW	17	19081234	missense	possibly damaging	0.78
R9753:Vmn2r98	UTSW	17	19065403	missense	probably benign	0.27
Z1177:Vmn2r98	UTSW	17	19065136	critical splice acceptor site	probably null
Z1177:Vmn2r98	UTSW	17	19067423	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- GGTCTAATCCTCCCCAATGACC -3'
(R):5'- CCACAGCTTAGGAAGATAAACGTC -3'

Sequencing Primer
(F):5'- TAATCCTCCCCAATGACCACAAAGG -3'
(R):5'- ATAAACGTCTTCTGGGTATTTATTGG -3'

Posted On

2017-08-16