Incidental Mutation 'R6110:Or5p70'
ID 484787
Institutional Source Beutler Lab
Gene Symbol Or5p70
Ensembl Gene ENSMUSG00000110253
Gene Name olfactory receptor family 5 subfamily P member 70
Synonyms MOR204-37, Olfr495, GA_x6K02T2PBJ9-10725148-10726140
MMRRC Submission 044428-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.168) question?
Stock # R6110 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 107994329-107995321 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 107995035 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Isoleucine at position 236 (S236I)
Ref Sequence ENSEMBL: ENSMUSP00000150689 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000210990] [ENSMUST00000215215]
AlphaFold Q8VF12
Predicted Effect possibly damaging
Transcript: ENSMUST00000210990
AA Change: S236I

PolyPhen 2 Score 0.934 (Sensitivity: 0.80; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215215
AA Change: S236I

PolyPhen 2 Score 0.934 (Sensitivity: 0.80; Specificity: 0.94)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.8%
  • 20x: 93.7%
Validation Efficiency 100% (60/60)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl7b T C 4: 56,740,224 (GRCm39) E378G probably damaging Het
Adam17 A T 12: 21,403,949 (GRCm39) V99E probably damaging Het
Alkal2 G A 12: 30,937,057 (GRCm39) R90Q probably damaging Het
Amy1 C T 3: 113,355,549 (GRCm39) V309M probably damaging Het
Apob T C 12: 8,061,883 (GRCm39) L3455P probably damaging Het
Ash1l T A 3: 88,892,436 (GRCm39) H1438Q probably damaging Het
BC024139 A G 15: 76,003,996 (GRCm39) S757P probably benign Het
Btd G A 14: 31,363,065 (GRCm39) probably benign Het
C2cd3 T A 7: 100,090,283 (GRCm39) F462Y probably damaging Het
C4bp T A 1: 130,566,809 (GRCm39) K177* probably null Het
Cacna1h G T 17: 25,610,250 (GRCm39) P752Q probably benign Het
Cd34 G A 1: 194,631,877 (GRCm39) probably null Het
Cimap1a G T 7: 140,428,554 (GRCm39) R73L possibly damaging Het
Clptm1 G A 7: 19,367,731 (GRCm39) probably benign Het
Dip2c T C 13: 9,673,802 (GRCm39) S1081P probably damaging Het
Dnm3 CAGCCTTCGTTGGGTG C 1: 161,838,637 (GRCm39) probably benign Het
Efcab6 T G 15: 83,763,835 (GRCm39) M1166L possibly damaging Het
Fam151a G A 4: 106,605,395 (GRCm39) V586M probably damaging Het
Fap T G 2: 62,385,114 (GRCm39) Y54S possibly damaging Het
Grhl1 A G 12: 24,630,746 (GRCm39) probably null Het
Hcrtr2 T C 9: 76,167,064 (GRCm39) Y91C probably damaging Het
Ift70b T C 2: 75,768,144 (GRCm39) Y203C probably damaging Het
Kat6b C T 14: 21,720,555 (GRCm39) R1745C probably damaging Het
Kdm5a T C 6: 120,389,267 (GRCm39) L898P probably damaging Het
Lipo5 T C 19: 33,445,317 (GRCm39) Q84R unknown Het
Mfn1 G A 3: 32,617,173 (GRCm39) M18I probably benign Het
Mptx2 G A 1: 173,102,414 (GRCm39) L92F probably benign Het
Mtfmt T C 9: 65,354,586 (GRCm39) probably null Het
Nsun2 C G 13: 69,775,767 (GRCm39) Q404E probably benign Het
Or1j17 T C 2: 36,578,559 (GRCm39) S182P probably benign Het
Or2at4 C T 7: 99,384,377 (GRCm39) S9L possibly damaging Het
Or52d1 A G 7: 103,755,779 (GRCm39) M98V probably damaging Het
Or5b123 C T 19: 13,597,249 (GRCm39) A241V probably benign Het
Or5j3 T A 2: 86,129,019 (GRCm39) N286K probably damaging Het
Or6c215 G A 10: 129,637,689 (GRCm39) A235V probably damaging Het
Or6c215 C A 10: 129,637,690 (GRCm39) A235S probably damaging Het
Parp9 A G 16: 35,773,996 (GRCm39) I90V possibly damaging Het
Pate7 A T 9: 35,688,442 (GRCm39) S48T possibly damaging Het
Pax2 T A 19: 44,779,175 (GRCm39) S183T probably damaging Het
Pcdha11 T C 18: 37,144,509 (GRCm39) L200P probably damaging Het
Pcdhb4 T C 18: 37,441,482 (GRCm39) V264A possibly damaging Het
Plch1 G T 3: 63,606,279 (GRCm39) N1199K possibly damaging Het
Ptpn22 A G 3: 103,819,331 (GRCm39) N795S probably damaging Het
Qars1 T C 9: 108,385,297 (GRCm39) S6P probably benign Het
Sema3a T C 5: 13,630,969 (GRCm39) Y502H probably damaging Het
Sema4f A G 6: 82,914,085 (GRCm39) I91T probably damaging Het
Setx T G 2: 29,030,302 (GRCm39) I247S probably damaging Het
Slc9c1 T C 16: 45,395,731 (GRCm39) L594P probably damaging Het
Tnfrsf19 A T 14: 61,208,588 (GRCm39) M311K probably benign Het
Tubgcp4 T C 2: 121,024,589 (GRCm39) I588T probably benign Het
Tyro3 T C 2: 119,643,304 (GRCm39) V655A probably damaging Het
Uba7 T A 9: 107,856,138 (GRCm39) D504E probably benign Het
Vav3 C T 3: 109,571,681 (GRCm39) T201M probably damaging Het
Vldlr A G 19: 27,215,477 (GRCm39) E117G possibly damaging Het
Vmn2r44 A T 7: 8,381,005 (GRCm39) I296K probably damaging Het
Vmn2r80 T A 10: 79,017,837 (GRCm39) C521S probably damaging Het
Wnk1 A T 6: 119,949,958 (GRCm39) probably benign Het
Xpo1 T C 11: 23,237,434 (GRCm39) S766P probably damaging Het
Zcchc4 A G 5: 52,953,486 (GRCm39) N165S possibly damaging Het
Other mutations in Or5p70
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01382:Or5p70 APN 7 107,994,452 (GRCm39) missense probably benign 0.31
IGL02430:Or5p70 APN 7 107,994,929 (GRCm39) missense probably benign 0.01
IGL02511:Or5p70 APN 7 107,995,265 (GRCm39) missense probably benign 0.06
IGL02932:Or5p70 APN 7 107,994,720 (GRCm39) missense probably benign 0.03
IGL03222:Or5p70 APN 7 107,994,393 (GRCm39) missense possibly damaging 0.77
FR4340:Or5p70 UTSW 7 107,995,105 (GRCm39) missense probably benign
FR4340:Or5p70 UTSW 7 107,995,100 (GRCm39) missense probably benign
FR4342:Or5p70 UTSW 7 107,995,105 (GRCm39) missense probably benign
FR4342:Or5p70 UTSW 7 107,995,100 (GRCm39) missense probably benign
R0141:Or5p70 UTSW 7 107,994,575 (GRCm39) missense probably benign 0.06
R0600:Or5p70 UTSW 7 107,994,438 (GRCm39) missense probably damaging 0.98
R0635:Or5p70 UTSW 7 107,994,971 (GRCm39) missense probably benign 0.01
R0685:Or5p70 UTSW 7 107,994,470 (GRCm39) missense possibly damaging 0.67
R1220:Or5p70 UTSW 7 107,994,539 (GRCm39) missense probably benign 0.03
R1398:Or5p70 UTSW 7 107,994,708 (GRCm39) missense probably damaging 0.98
R1501:Or5p70 UTSW 7 107,995,289 (GRCm39) missense probably benign 0.00
R1990:Or5p70 UTSW 7 107,995,041 (GRCm39) missense probably benign 0.00
R2091:Or5p70 UTSW 7 107,995,068 (GRCm39) missense probably damaging 1.00
R2473:Or5p70 UTSW 7 107,994,711 (GRCm39) missense probably damaging 1.00
R3120:Or5p70 UTSW 7 107,994,930 (GRCm39) missense possibly damaging 0.67
R4771:Or5p70 UTSW 7 107,995,229 (GRCm39) nonsense probably null
R5240:Or5p70 UTSW 7 107,994,909 (GRCm39) missense probably damaging 0.99
R5510:Or5p70 UTSW 7 107,994,332 (GRCm39) missense probably benign 0.01
R5703:Or5p70 UTSW 7 107,994,707 (GRCm39) missense probably benign 0.23
R6102:Or5p70 UTSW 7 107,994,491 (GRCm39) missense probably damaging 0.99
R6782:Or5p70 UTSW 7 107,994,744 (GRCm39) missense probably damaging 1.00
R7062:Or5p70 UTSW 7 107,995,037 (GRCm39) nonsense probably null
R7783:Or5p70 UTSW 7 107,995,296 (GRCm39) missense probably benign 0.15
R8386:Or5p70 UTSW 7 107,994,555 (GRCm39) small deletion probably benign
R9347:Or5p70 UTSW 7 107,995,259 (GRCm39) missense probably benign 0.02
R9468:Or5p70 UTSW 7 107,994,849 (GRCm39) missense possibly damaging 0.56
R9554:Or5p70 UTSW 7 107,994,365 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- ACAGGGTCTCCTTAATGCTTC -3'
(R):5'- TCCTCAGGCTGTAGATGAGG -3'

Sequencing Primer
(F):5'- CCTTGATCTTCTGTGGACCAAATAG -3'
(R):5'- GGGGTTCAACATGGGAATCAC -3'
Posted On 2017-08-16