Incidental Mutation 'R6114:Lpar5'
ID 485012
Institutional Source Beutler Lab
Gene Symbol Lpar5
Ensembl Gene ENSMUSG00000067714
Gene Name lysophosphatidic acid receptor 5
Synonyms Gpr92, LOC381810, GPR93, LPA5
MMRRC Submission 044263-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R6114 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 125044883-125059435 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 125058639 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 120 (N120S)
Ref Sequence ENSEMBL: ENSMUSP00000132511 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088292] [ENSMUST00000140346] [ENSMUST00000171989]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000088292
AA Change: N120S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000085630
Gene: ENSMUSG00000067714
AA Change: N120S

DomainStartEndE-ValueType
low complexity region 15 27 N/A INTRINSIC
Pfam:7tm_1 55 313 7.4e-40 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000140346
AA Change: N120S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000119904
Gene: ENSMUSG00000067714
AA Change: N120S

DomainStartEndE-ValueType
low complexity region 15 27 N/A INTRINSIC
Pfam:7tm_1 55 164 1.5e-30 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000171989
AA Change: N120S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000132511
Gene: ENSMUSG00000067714
AA Change: N120S

DomainStartEndE-ValueType
low complexity region 15 27 N/A INTRINSIC
Pfam:7tm_1 55 313 1.1e-48 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203956
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.0%
Validation Efficiency 94% (60/64)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit resistance to neuropathic pain and myelin sheath alterations. Mice homozygous for a different targeted allele exhibit decreased nociception sensitivity, decreased anxiety-related response and enhanced coordination and spatial learning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamdec1 C A 14: 68,809,252 (GRCm39) V237L probably benign Het
Aff1 T C 5: 103,990,163 (GRCm39) S878P probably damaging Het
Ahcy A C 2: 154,904,079 (GRCm39) L386R probably damaging Het
Ank2 T C 3: 126,804,700 (GRCm39) N607D probably damaging Het
Arid5b T C 10: 67,933,574 (GRCm39) D776G possibly damaging Het
Art4 T A 6: 136,834,211 (GRCm39) T11S unknown Het
Blm T C 7: 80,163,235 (GRCm39) T39A probably damaging Het
Cabin1 T A 10: 75,583,805 (GRCm39) M221L probably benign Het
Cacna1c T C 6: 118,573,101 (GRCm39) T1675A probably benign Het
Cacnb2 A T 2: 14,980,012 (GRCm39) H285L possibly damaging Het
Cchcr1 A G 17: 35,836,227 (GRCm39) E339G probably damaging Het
Cd14 A G 18: 36,859,006 (GRCm39) W150R probably damaging Het
Cep162 A G 9: 87,085,763 (GRCm39) I1187T probably benign Het
Cntnap4 A G 8: 113,568,385 (GRCm39) H807R probably damaging Het
Copb1 T A 7: 113,846,036 (GRCm39) H178L probably benign Het
Cpxm2 A G 7: 131,756,035 (GRCm39) V103A probably benign Het
Egfr A G 11: 16,854,374 (GRCm39) T849A possibly damaging Het
Endou T A 15: 97,611,757 (GRCm39) K294* probably null Het
Hoxd9 A G 2: 74,529,709 (GRCm39) N322D probably damaging Het
Hsph1 C A 5: 149,550,852 (GRCm39) V416L possibly damaging Het
Igkv4-78 T A 6: 69,036,743 (GRCm39) T97S possibly damaging Het
Itga10 G T 3: 96,556,351 (GRCm39) C162F probably damaging Het
Lmod2 A G 6: 24,603,691 (GRCm39) E222G probably damaging Het
Lrrc37 T A 11: 103,508,617 (GRCm39) probably benign Het
Lrrk2 A G 15: 91,632,029 (GRCm39) I1318V probably benign Het
Lst1 T C 17: 35,407,336 (GRCm39) T11A possibly damaging Het
Mfn1 C A 3: 32,617,985 (GRCm39) A106D probably damaging Het
Ms4a12 G T 19: 11,192,654 (GRCm39) N227K probably benign Het
Nr1h4 T A 10: 89,314,678 (GRCm39) N273Y possibly damaging Het
Nrdc A T 4: 108,901,782 (GRCm39) K617M probably damaging Het
Or10a3b A T 7: 108,444,593 (GRCm39) M208K possibly damaging Het
Or1l8 A T 2: 36,817,701 (GRCm39) C142S possibly damaging Het
Or6c202 T A 10: 128,996,202 (GRCm39) H217L probably benign Het
Pcdhgc3 C G 18: 37,940,925 (GRCm39) T442R probably benign Het
Pcnx2 T C 8: 126,500,686 (GRCm39) N1468S probably damaging Het
Pde2a A T 7: 101,160,319 (GRCm39) probably null Het
Pitx2 C G 3: 128,998,062 (GRCm39) probably null Het
Reck T A 4: 43,922,895 (GRCm39) I390N probably damaging Het
Rora A G 9: 69,278,605 (GRCm39) N254S probably benign Het
Samd4b A G 7: 28,222,217 (GRCm39) probably null Het
Scn8a A G 15: 100,938,477 (GRCm39) T1949A probably damaging Het
Slc22a15 A T 3: 101,768,168 (GRCm39) Y346* probably null Het
Slc24a5 A G 2: 124,925,012 (GRCm39) T218A probably benign Het
Slc38a10 G A 11: 120,020,138 (GRCm39) Q305* probably null Het
Slc45a4 G A 15: 73,477,453 (GRCm39) P28S probably damaging Het
Smyd5 A T 6: 85,417,244 (GRCm39) probably benign Het
Sox8 T C 17: 25,786,494 (GRCm39) D403G probably damaging Het
Stx7 A G 10: 24,060,883 (GRCm39) probably null Het
Svil T C 18: 5,108,639 (GRCm39) S1522P probably damaging Het
Sycp2 G C 2: 177,990,038 (GRCm39) R1403G probably benign Het
Tasor2 G A 13: 3,640,081 (GRCm39) T352M probably damaging Het
Tcf25 A T 8: 124,111,114 (GRCm39) K192M probably damaging Het
Tecpr1 C T 5: 144,141,458 (GRCm39) G804S possibly damaging Het
Teddm1a C G 1: 153,767,614 (GRCm39) S26C probably damaging Het
Usp13 C T 3: 32,908,818 (GRCm39) P155S probably damaging Het
Usp17lb T A 7: 104,489,571 (GRCm39) D451V possibly damaging Het
Vmn1r173 A G 7: 23,402,254 (GRCm39) N163S possibly damaging Het
Vmn2r103 G T 17: 20,032,587 (GRCm39) C787F probably damaging Het
Vmn2r106 G A 17: 20,488,638 (GRCm39) P587L probably benign Het
Wdr24 C T 17: 26,043,579 (GRCm39) H134Y probably benign Het
Zbtb40 T A 4: 136,716,002 (GRCm39) I988F probably damaging Het
Zbtb47 T A 9: 121,594,661 (GRCm39) F540Y probably damaging Het
Zfp536 A T 7: 37,179,161 (GRCm39) I84N probably damaging Het
Other mutations in Lpar5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01719:Lpar5 APN 6 125,058,969 (GRCm39) missense possibly damaging 0.94
IGL01830:Lpar5 APN 6 125,058,785 (GRCm39) missense probably benign 0.01
IGL01975:Lpar5 APN 6 125,058,750 (GRCm39) missense probably damaging 0.99
IGL02021:Lpar5 APN 6 125,058,955 (GRCm39) nonsense probably null
IGL02718:Lpar5 APN 6 125,059,207 (GRCm39) missense probably damaging 1.00
IGL03027:Lpar5 APN 6 125,059,203 (GRCm39) missense probably damaging 1.00
IGL03300:Lpar5 APN 6 125,059,203 (GRCm39) missense probably damaging 1.00
F5770:Lpar5 UTSW 6 125,058,690 (GRCm39) missense possibly damaging 0.88
R0633:Lpar5 UTSW 6 125,058,954 (GRCm39) missense probably benign 0.25
R1639:Lpar5 UTSW 6 125,058,564 (GRCm39) missense probably damaging 1.00
R1822:Lpar5 UTSW 6 125,058,378 (GRCm39) missense possibly damaging 0.76
R2227:Lpar5 UTSW 6 125,058,098 (GRCm39) critical splice acceptor site probably null
R4019:Lpar5 UTSW 6 125,058,638 (GRCm39) missense probably damaging 1.00
R4288:Lpar5 UTSW 6 125,058,827 (GRCm39) missense probably benign 0.00
R4705:Lpar5 UTSW 6 125,059,170 (GRCm39) missense possibly damaging 0.64
R4787:Lpar5 UTSW 6 125,059,461 (GRCm39) splice site probably null
R5027:Lpar5 UTSW 6 125,059,110 (GRCm39) missense possibly damaging 0.69
R7197:Lpar5 UTSW 6 125,059,347 (GRCm39) missense probably benign 0.00
R7779:Lpar5 UTSW 6 125,059,207 (GRCm39) missense probably damaging 1.00
R8193:Lpar5 UTSW 6 125,058,302 (GRCm39) missense probably benign
R8264:Lpar5 UTSW 6 125,058,465 (GRCm39) missense probably damaging 1.00
R9460:Lpar5 UTSW 6 125,058,234 (GRCm39) start gained probably benign
R9628:Lpar5 UTSW 6 125,058,948 (GRCm39) missense probably damaging 0.96
V7580:Lpar5 UTSW 6 125,058,690 (GRCm39) missense possibly damaging 0.88
V7581:Lpar5 UTSW 6 125,058,690 (GRCm39) missense possibly damaging 0.88
V7582:Lpar5 UTSW 6 125,058,690 (GRCm39) missense possibly damaging 0.88
Z1176:Lpar5 UTSW 6 125,059,035 (GRCm39) missense probably damaging 1.00
Z1176:Lpar5 UTSW 6 125,058,342 (GRCm39) missense possibly damaging 0.92
Z1177:Lpar5 UTSW 6 125,058,981 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGTCTACAGCCTGGTATTGG -3'
(R):5'- ACAGTGATGTTCTTGTACGTGC -3'

Sequencing Primer
(F):5'- GTATTGGCGACTGGTCTCCC -3'
(R):5'- CTTGTACGTGCAGTGGGAC -3'
Posted On 2017-08-16