Mutagenetix > Incidental Mutations

Incidental Mutation 'R6114:Vmn1r173'

485014

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r173

Ensembl Gene

ENSMUSG00000115021

Gene Name

vomeronasal 1 receptor 173

Synonyms

Gm5892

MMRRC Submission

044263-MU

Accession Numbers

Is this an essential gene?

Possibly essential (E-score: 0.512) question?

Stock #

R6114 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

23700703-23711009 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23702829 bp

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 163 (N163S)

Ref Sequence

ENSEMBL: ENSMUSP00000153884 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000174055] [ENSMUST00000226233] [ENSMUST00000227987]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000174055
AA Change: N163S

PolyPhen 2 Score 0.534 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000134645
Gene: ENSMUSG00000115021
AA Change: N163S

Domain	Start	End	E-Value	Type
transmembrane domain	13	35	N/A	INTRINSIC
Pfam:V1R	43	301	5.3e-20	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000226233
AA Change: N163S

PolyPhen 2 Score 0.534 (Sensitivity: 0.88; Specificity: 0.90)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000227987
AA Change: N163S

PolyPhen 2 Score 0.534 (Sensitivity: 0.88; Specificity: 0.90)

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.0%
20x: 94.0%

Validation Efficiency

94% (60/64)

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamdec1	C	A	14: 68,571,803	V237L	probably benign	Het
Aff1	T	C	5: 103,842,297	S878P	probably damaging	Het
Ahcy	A	C	2: 155,062,159	L386R	probably damaging	Het
Ank2	T	C	3: 127,011,051	N607D	probably damaging	Het
Arid5b	T	C	10: 68,097,744	D776G	possibly damaging	Het
Art4	T	A	6: 136,857,213	T11S	unknown	Het
Blm	T	C	7: 80,513,487	T39A	probably damaging	Het
Cabin1	T	A	10: 75,747,971	M221L	probably benign	Het
Cacna1c	T	C	6: 118,596,140	T1675A	probably benign	Het
Cacnb2	A	T	2: 14,975,201	H285L	possibly damaging	Het
Cchcr1	A	G	17: 35,525,330	E339G	probably damaging	Het
Cd14	A	G	18: 36,725,953	W150R	probably damaging	Het
Cep162	A	G	9: 87,203,710	I1187T	probably benign	Het
Cntnap4	A	G	8: 112,841,753	H807R	probably damaging	Het
Copb1	T	A	7: 114,246,801	H178L	probably benign	Het
Cpxm2	A	G	7: 132,154,306	V103A	probably benign	Het
Egfr	A	G	11: 16,904,374	T849A	possibly damaging	Het
Endou	T	A	15: 97,713,876	K294*	probably null	Het
Fam208b	G	A	13: 3,590,081	T352M	probably damaging	Het
Gm884	T	A	11: 103,617,791		probably benign	Het
Hoxd9	A	G	2: 74,699,365	N322D	probably damaging	Het
Hsph1	C	A	5: 149,627,387	V416L	possibly damaging	Het
Igkv4-78	T	A	6: 69,059,759	T97S	possibly damaging	Het
Itga10	G	T	3: 96,649,035	C162F	probably damaging	Het
Lmod2	A	G	6: 24,603,692	E222G	probably damaging	Het
Lpar5	A	G	6: 125,081,676	N120S	probably damaging	Het
Lrrk2	A	G	15: 91,747,826	I1318V	probably benign	Het
Lst1	T	C	17: 35,188,360	T11A	possibly damaging	Het
Mfn1	C	A	3: 32,563,836	A106D	probably damaging	Het
Ms4a12	G	T	19: 11,215,290	N227K	probably benign	Het
Nr1h4	T	A	10: 89,478,816	N273Y	possibly damaging	Het
Nrd1	A	T	4: 109,044,585	K617M	probably damaging	Het
Olfr355	A	T	2: 36,927,689	C142S	possibly damaging	Het
Olfr516	A	T	7: 108,845,386	M208K	possibly damaging	Het
Olfr771	T	A	10: 129,160,333	H217L	probably benign	Het
Pcdhgc3	C	G	18: 37,807,872	T442R	probably benign	Het
Pcnx2	T	C	8: 125,773,947	N1468S	probably damaging	Het
Pde2a	A	T	7: 101,511,112		probably null	Het
Pitx2	C	G	3: 129,204,413		probably null	Het
Reck	T	A	4: 43,922,895	I390N	probably damaging	Het
Rora	A	G	9: 69,371,323	N254S	probably benign	Het
Samd4b	A	G	7: 28,522,792		probably null	Het
Scn8a	A	G	15: 101,040,596	T1949A	probably damaging	Het
Slc22a15	A	T	3: 101,860,852	Y346*	probably null	Het
Slc24a5	A	G	2: 125,083,092	T218A	probably benign	Het
Slc38a10	G	A	11: 120,129,312	Q305*	probably null	Het
Slc45a4	G	A	15: 73,605,604	P28S	probably damaging	Het
Smyd5	A	T	6: 85,440,262		probably benign	Het
Sox8	T	C	17: 25,567,520	D403G	probably damaging	Het
Stx7	A	G	10: 24,184,985		probably null	Het
Svil	T	C	18: 5,108,639	S1522P	probably damaging	Het
Sycp2	G	C	2: 178,348,245	R1403G	probably benign	Het
Tcf25	A	T	8: 123,384,375	K192M	probably damaging	Het
Tecpr1	C	T	5: 144,204,640	G804S	possibly damaging	Het
Teddm1a	C	G	1: 153,891,868	S26C	probably damaging	Het
Usp13	C	T	3: 32,854,669	P155S	probably damaging	Het
Usp17lb	T	A	7: 104,840,364	D451V	possibly damaging	Het
Vmn2r103	G	T	17: 19,812,325	C787F	probably damaging	Het
Vmn2r106	G	A	17: 20,268,376	P587L	probably benign	Het
Wdr24	C	T	17: 25,824,605	H134Y	probably benign	Het
Zbtb40	T	A	4: 136,988,691	I988F	probably damaging	Het
Zfp536	A	T	7: 37,479,736	I84N	probably damaging	Het
Zfp651	T	A	9: 121,765,595	F540Y	probably damaging	Het

Other mutations in Vmn1r173

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01490:Vmn1r173	APN	7	23702707	missense	probably benign	0.01
IGL01637:Vmn1r173	APN	7	23702948	missense	probably damaging	0.96
IGL01878:Vmn1r173	APN	7	23702452	missense	probably damaging	1.00
IGL02036:Vmn1r173	APN	7	23702896	missense	probably benign	0.04
IGL02039:Vmn1r173	APN	7	23702896	missense	probably benign	0.04
IGL02171:Vmn1r173	APN	7	23702896	missense	probably benign	0.04
IGL02209:Vmn1r173	APN	7	23703161	missense	probably benign	0.25
PIT4515001:Vmn1r173	UTSW	7	23702486	nonsense	probably null
R0157:Vmn1r173	UTSW	7	23702397	missense	probably damaging	0.99
R0226:Vmn1r173	UTSW	7	23703083	missense	possibly damaging	0.65
R0482:Vmn1r173	UTSW	7	23702791	missense	probably damaging	0.99
R0792:Vmn1r173	UTSW	7	23702735	missense	probably benign	0.01
R1242:Vmn1r173	UTSW	7	23703225	missense	probably damaging	1.00
R1390:Vmn1r173	UTSW	7	23702898	missense	possibly damaging	0.82
R1641:Vmn1r173	UTSW	7	23703108	missense	probably benign	0.06
R1867:Vmn1r173	UTSW	7	23703235	missense	unknown
R2325:Vmn1r173	UTSW	7	23703112	nonsense	probably null
R3863:Vmn1r173	UTSW	7	23702552	missense	probably damaging	1.00
R4407:Vmn1r173	UTSW	7	23703016	missense	probably damaging	1.00
R4717:Vmn1r173	UTSW	7	23703212	missense	probably damaging	1.00
R4841:Vmn1r173	UTSW	7	23702936	missense	probably damaging	1.00
R4842:Vmn1r173	UTSW	7	23702936	missense	probably damaging	1.00
R5966:Vmn1r173	UTSW	7	23702687	missense	probably benign	0.00
R6022:Vmn1r173	UTSW	7	23702835	missense	probably benign	0.07
R6657:Vmn1r173	UTSW	7	23702895	missense	probably damaging	0.98
R7165:Vmn1r173	UTSW	7	23702651	missense	probably benign	0.00
R7195:Vmn1r173	UTSW	7	23702459	missense	probably damaging	0.99
R7201:Vmn1r173	UTSW	7	23702158	start gained	probably benign
R7533:Vmn1r173	UTSW	7	23702646	missense	probably benign	0.05
X0022:Vmn1r173	UTSW	7	23702587	missense	probably benign	0.06

Predicted Primers

PCR Primer
(F):5'- GCAAACATGTGTACTACTTGTGTCC -3'
(R):5'- TCTGGCCTCTGGTTGAAGTC -3'

Sequencing Primer
(F):5'- GTGTCCTGAGCACTTACCAG -3'
(R):5'- GCTCCCATTGGACCTGTGAATG -3'

Posted On

2017-08-16