Incidental Mutation 'R6114:Olfr771'
ID485033
Institutional Source Beutler Lab
Gene Symbol Olfr771
Ensembl Gene ENSMUSG00000061367
Gene Nameolfactory receptor 771
SynonymsMOR114-8, GA_x6K02T2PULF-10846420-10845467
MMRRC Submission 044263-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.062) question?
Stock #R6114 (G1)
Quality Score225.009
Status Validated
Chromosome10
Chromosomal Location129160003-129164751 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 129160333 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Leucine at position 217 (H217L)
Ref Sequence ENSEMBL: ENSMUSP00000151108 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078914] [ENSMUST00000214271]
Predicted Effect probably benign
Transcript: ENSMUST00000078914
AA Change: H217L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000077948
Gene: ENSMUSG00000061367
AA Change: H217L

DomainStartEndE-ValueType
Pfam:7tm_4 28 304 8.9e-48 PFAM
Pfam:7tm_1 38 287 3e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214271
AA Change: H217L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.0%
Validation Efficiency 94% (60/64)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamdec1 C A 14: 68,571,803 V237L probably benign Het
Aff1 T C 5: 103,842,297 S878P probably damaging Het
Ahcy A C 2: 155,062,159 L386R probably damaging Het
Ank2 T C 3: 127,011,051 N607D probably damaging Het
Arid5b T C 10: 68,097,744 D776G possibly damaging Het
Art4 T A 6: 136,857,213 T11S unknown Het
Blm T C 7: 80,513,487 T39A probably damaging Het
Cabin1 T A 10: 75,747,971 M221L probably benign Het
Cacna1c T C 6: 118,596,140 T1675A probably benign Het
Cacnb2 A T 2: 14,975,201 H285L possibly damaging Het
Cchcr1 A G 17: 35,525,330 E339G probably damaging Het
Cd14 A G 18: 36,725,953 W150R probably damaging Het
Cep162 A G 9: 87,203,710 I1187T probably benign Het
Cntnap4 A G 8: 112,841,753 H807R probably damaging Het
Copb1 T A 7: 114,246,801 H178L probably benign Het
Cpxm2 A G 7: 132,154,306 V103A probably benign Het
Egfr A G 11: 16,904,374 T849A possibly damaging Het
Endou T A 15: 97,713,876 K294* probably null Het
Fam208b G A 13: 3,590,081 T352M probably damaging Het
Gm884 T A 11: 103,617,791 probably benign Het
Hoxd9 A G 2: 74,699,365 N322D probably damaging Het
Hsph1 C A 5: 149,627,387 V416L possibly damaging Het
Igkv4-78 T A 6: 69,059,759 T97S possibly damaging Het
Itga10 G T 3: 96,649,035 C162F probably damaging Het
Lmod2 A G 6: 24,603,692 E222G probably damaging Het
Lpar5 A G 6: 125,081,676 N120S probably damaging Het
Lrrk2 A G 15: 91,747,826 I1318V probably benign Het
Lst1 T C 17: 35,188,360 T11A possibly damaging Het
Mfn1 C A 3: 32,563,836 A106D probably damaging Het
Ms4a12 G T 19: 11,215,290 N227K probably benign Het
Nr1h4 T A 10: 89,478,816 N273Y possibly damaging Het
Nrd1 A T 4: 109,044,585 K617M probably damaging Het
Olfr355 A T 2: 36,927,689 C142S possibly damaging Het
Olfr516 A T 7: 108,845,386 M208K possibly damaging Het
Pcdhgc3 C G 18: 37,807,872 T442R probably benign Het
Pcnx2 T C 8: 125,773,947 N1468S probably damaging Het
Pde2a A T 7: 101,511,112 probably null Het
Pitx2 C G 3: 129,204,413 probably null Het
Reck T A 4: 43,922,895 I390N probably damaging Het
Rora A G 9: 69,371,323 N254S probably benign Het
Samd4b A G 7: 28,522,792 probably null Het
Scn8a A G 15: 101,040,596 T1949A probably damaging Het
Slc22a15 A T 3: 101,860,852 Y346* probably null Het
Slc24a5 A G 2: 125,083,092 T218A probably benign Het
Slc38a10 G A 11: 120,129,312 Q305* probably null Het
Slc45a4 G A 15: 73,605,604 P28S probably damaging Het
Smyd5 A T 6: 85,440,262 probably benign Het
Sox8 T C 17: 25,567,520 D403G probably damaging Het
Stx7 A G 10: 24,184,985 probably null Het
Svil T C 18: 5,108,639 S1522P probably damaging Het
Sycp2 G C 2: 178,348,245 R1403G probably benign Het
Tcf25 A T 8: 123,384,375 K192M probably damaging Het
Tecpr1 C T 5: 144,204,640 G804S possibly damaging Het
Teddm1a C G 1: 153,891,868 S26C probably damaging Het
Usp13 C T 3: 32,854,669 P155S probably damaging Het
Usp17lb T A 7: 104,840,364 D451V possibly damaging Het
Vmn1r173 A G 7: 23,702,829 N163S possibly damaging Het
Vmn2r103 G T 17: 19,812,325 C787F probably damaging Het
Vmn2r106 G A 17: 20,268,376 P587L probably benign Het
Wdr24 C T 17: 25,824,605 H134Y probably benign Het
Zbtb40 T A 4: 136,988,691 I988F probably damaging Het
Zfp536 A T 7: 37,479,736 I84N probably damaging Het
Zfp651 T A 9: 121,765,595 F540Y probably damaging Het
Other mutations in Olfr771
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02341:Olfr771 APN 10 129160433 missense probably benign 0.30
IGL02366:Olfr771 APN 10 129160625 missense probably damaging 1.00
IGL02947:Olfr771 APN 10 129160570 missense probably damaging 1.00
R0040:Olfr771 UTSW 10 129160739 missense probably benign 0.10
R0081:Olfr771 UTSW 10 129160838 missense possibly damaging 0.55
R1179:Olfr771 UTSW 10 129160058 missense probably benign 0.00
R1328:Olfr771 UTSW 10 129160424 missense possibly damaging 0.54
R1701:Olfr771 UTSW 10 129160105 missense probably damaging 1.00
R4470:Olfr771 UTSW 10 129160514 missense probably benign 0.16
R4814:Olfr771 UTSW 10 129160376 missense possibly damaging 0.77
R5106:Olfr771 UTSW 10 129160237 missense probably damaging 0.99
R5109:Olfr771 UTSW 10 129160237 missense probably damaging 0.99
R5209:Olfr771 UTSW 10 129160932 missense possibly damaging 0.74
R5646:Olfr771 UTSW 10 129160837 missense possibly damaging 0.55
R6133:Olfr771 UTSW 10 129160883 missense possibly damaging 0.55
R6879:Olfr771 UTSW 10 129160979 missense probably benign 0.04
R7358:Olfr771 UTSW 10 129160070 missense probably benign
R7426:Olfr771 UTSW 10 129160751 missense possibly damaging 0.67
R7699:Olfr771 UTSW 10 129160055 missense probably benign
R7700:Olfr771 UTSW 10 129160055 missense probably benign
Z1177:Olfr771 UTSW 10 129160402 missense probably benign 0.07
Predicted Primers PCR Primer
(F):5'- ACATGGGAGCAATCGATGTC -3'
(R):5'- GGCTGGCTTGCTCATCATAC -3'

Sequencing Primer
(F):5'- CATGGGAGCAATCGATGTCATCAG -3'
(R):5'- ACTCACTCTGTTCCTAAACTTGAG -3'
Posted On2017-08-16