Mutagenetix > Incidental Mutation

Incidental Mutation 'R6114:Gm884'

485035

Institutional Source

Beutler Lab

Gene Symbol

Gm884

Ensembl Gene

ENSMUSG00000034239

Gene Name

predicted gene 884

Synonyms

LOC380730

MMRRC Submission

044263-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.154) question?

Stock #

R6114 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

103534577-103621140 bp(-) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

T to A at 103617791 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000129662 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059279] [ENSMUST00000167262]

AlphaFold

no structure available at present

Predicted Effect

unknown
Transcript: ENSMUST00000059279
AA Change: Y1117F

SMART Domains

Protein: ENSMUSP00000058511
Gene: ENSMUSG00000034239
AA Change: Y1117F

Domain	Start	End	E-Value	Type
Pfam:LRRC37	149	223	5.4e-10	PFAM
low complexity region	244	264	N/A	INTRINSIC
low complexity region	298	308	N/A	INTRINSIC
Pfam:LRRC37	335	403	1.9e-14	PFAM
Pfam:LRRC37	419	514	1.2e-8	PFAM
Pfam:LRRC37	565	620	2e-10	PFAM
Pfam:LRRC37	669	739	7.6e-18	PFAM
Pfam:LRRC37	741	792	1.6e-9	PFAM
Pfam:LRRC37	789	860	1.4e-23	PFAM
Pfam:LRRC37	861	914	2.8e-9	PFAM
Pfam:LRRC37	911	983	1.9e-23	PFAM
Pfam:LRRC37	979	1038	1e-8	PFAM
Pfam:LRRC37	1034	1105	2.7e-24	PFAM
Pfam:LRRC37	1105	1158	2.3e-9	PFAM
Pfam:LRRC37	1155	1219	2.4e-17	PFAM
Pfam:LRRC37	1222	1265	9.2e-7	PFAM
Pfam:LRRC37	1263	1330	4.9e-24	PFAM
Pfam:LRRC37	1331	1384	1.4e-10	PFAM
Pfam:LRRC37	1380	1451	4.3e-15	PFAM
Pfam:LRRC37	1487	1558	1.9e-15	PFAM
Pfam:LRRC37	1594	1665	2.9e-18	PFAM
Pfam:LRRC37	1701	1772	5.6e-23	PFAM
Pfam:LRRC37	1808	1910	2.8e-18	PFAM
Pfam:LRRC37	1915	1986	7.2e-17	PFAM
Pfam:LRRC37	2022	2093	4.9e-22	PFAM
Pfam:LRRC37	2129	2200	4.4e-22	PFAM
Pfam:LRRC37	2236	2307	2.1e-21	PFAM
Pfam:LRRC37	2343	2414	3.8e-17	PFAM
Pfam:LRRC37	2449	2519	1.6e-19	PFAM
LRR	2777	2796	3.09e1	SMART
LRR_TYP	2797	2820	2.09e-3	SMART
LRR	2821	2844	4.44e0	SMART
LRR	2848	2872	8.26e1	SMART
low complexity region	2991	3002	N/A	INTRINSIC
low complexity region	3220	3230	N/A	INTRINSIC
low complexity region	3382	3393	N/A	INTRINSIC
Pfam:LRRC37AB_C	3424	3570	7.7e-76	PFAM
low complexity region	3571	3589	N/A	INTRINSIC
low complexity region	3622	3640	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000167262

SMART Domains

Protein: ENSMUSP00000129662
Gene: ENSMUSG00000034239

Domain	Start	End	E-Value	Type
internal_repeat_1	1	70	1.46e-11	PROSPERO
internal_repeat_1	108	290	1.46e-11	PROSPERO
LRR	601	620	3.09e1	SMART
LRR_TYP	621	644	2.09e-3	SMART
LRR	645	668	4.44e0	SMART
LRR	672	696	8.26e1	SMART
low complexity region	815	826	N/A	INTRINSIC
low complexity region	1044	1054	N/A	INTRINSIC
low complexity region	1206	1217	N/A	INTRINSIC
Pfam:LRRC37AB_C	1243	1396	1.2e-92	PFAM
low complexity region	1446	1464	N/A	INTRINSIC

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.0%
20x: 94.0%

Validation Efficiency

94% (60/64)

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamdec1	C	A	14: 68,571,803 (GRCm38)	V237L	probably benign	Het
Aff1	T	C	5: 103,842,297 (GRCm38)	S878P	probably damaging	Het
Ahcy	A	C	2: 155,062,159 (GRCm38)	L386R	probably damaging	Het
Ank2	T	C	3: 127,011,051 (GRCm38)	N607D	probably damaging	Het
Arid5b	T	C	10: 68,097,744 (GRCm38)	D776G	possibly damaging	Het
Art4	T	A	6: 136,857,213 (GRCm38)	T11S	unknown	Het
Blm	T	C	7: 80,513,487 (GRCm38)	T39A	probably damaging	Het
Cabin1	T	A	10: 75,747,971 (GRCm38)	M221L	probably benign	Het
Cacna1c	T	C	6: 118,596,140 (GRCm38)	T1675A	probably benign	Het
Cacnb2	A	T	2: 14,975,201 (GRCm38)	H285L	possibly damaging	Het
Cchcr1	A	G	17: 35,525,330 (GRCm38)	E339G	probably damaging	Het
Cd14	A	G	18: 36,725,953 (GRCm38)	W150R	probably damaging	Het
Cep162	A	G	9: 87,203,710 (GRCm38)	I1187T	probably benign	Het
Cntnap4	A	G	8: 112,841,753 (GRCm38)	H807R	probably damaging	Het
Copb1	T	A	7: 114,246,801 (GRCm38)	H178L	probably benign	Het
Cpxm2	A	G	7: 132,154,306 (GRCm38)	V103A	probably benign	Het
Egfr	A	G	11: 16,904,374 (GRCm38)	T849A	possibly damaging	Het
Endou	T	A	15: 97,713,876 (GRCm38)	K294*	probably null	Het
Fam208b	G	A	13: 3,590,081 (GRCm38)	T352M	probably damaging	Het
Hoxd9	A	G	2: 74,699,365 (GRCm38)	N322D	probably damaging	Het
Hsph1	C	A	5: 149,627,387 (GRCm38)	V416L	possibly damaging	Het
Igkv4-78	T	A	6: 69,059,759 (GRCm38)	T97S	possibly damaging	Het
Itga10	G	T	3: 96,649,035 (GRCm38)	C162F	probably damaging	Het
Lmod2	A	G	6: 24,603,692 (GRCm38)	E222G	probably damaging	Het
Lpar5	A	G	6: 125,081,676 (GRCm38)	N120S	probably damaging	Het
Lrrk2	A	G	15: 91,747,826 (GRCm38)	I1318V	probably benign	Het
Lst1	T	C	17: 35,188,360 (GRCm38)	T11A	possibly damaging	Het
Mfn1	C	A	3: 32,563,836 (GRCm38)	A106D	probably damaging	Het
Ms4a12	G	T	19: 11,215,290 (GRCm38)	N227K	probably benign	Het
Nr1h4	T	A	10: 89,478,816 (GRCm38)	N273Y	possibly damaging	Het
Nrd1	A	T	4: 109,044,585 (GRCm38)	K617M	probably damaging	Het
Olfr355	A	T	2: 36,927,689 (GRCm38)	C142S	possibly damaging	Het
Olfr516	A	T	7: 108,845,386 (GRCm38)	M208K	possibly damaging	Het
Olfr771	T	A	10: 129,160,333 (GRCm38)	H217L	probably benign	Het
Pcdhgc3	C	G	18: 37,807,872 (GRCm38)	T442R	probably benign	Het
Pcnx2	T	C	8: 125,773,947 (GRCm38)	N1468S	probably damaging	Het
Pde2a	A	T	7: 101,511,112 (GRCm38)		probably null	Het
Pitx2	C	G	3: 129,204,413 (GRCm38)		probably null	Het
Reck	T	A	4: 43,922,895 (GRCm38)	I390N	probably damaging	Het
Rora	A	G	9: 69,371,323 (GRCm38)	N254S	probably benign	Het
Samd4b	A	G	7: 28,522,792 (GRCm38)		probably null	Het
Scn8a	A	G	15: 101,040,596 (GRCm38)	T1949A	probably damaging	Het
Slc22a15	A	T	3: 101,860,852 (GRCm38)	Y346*	probably null	Het
Slc24a5	A	G	2: 125,083,092 (GRCm38)	T218A	probably benign	Het
Slc38a10	G	A	11: 120,129,312 (GRCm38)	Q305*	probably null	Het
Slc45a4	G	A	15: 73,605,604 (GRCm38)	P28S	probably damaging	Het
Smyd5	A	T	6: 85,440,262 (GRCm38)		probably benign	Het
Sox8	T	C	17: 25,567,520 (GRCm38)	D403G	probably damaging	Het
Stx7	A	G	10: 24,184,985 (GRCm38)		probably null	Het
Svil	T	C	18: 5,108,639 (GRCm38)	S1522P	probably damaging	Het
Sycp2	G	C	2: 178,348,245 (GRCm38)	R1403G	probably benign	Het
Tcf25	A	T	8: 123,384,375 (GRCm38)	K192M	probably damaging	Het
Tecpr1	C	T	5: 144,204,640 (GRCm38)	G804S	possibly damaging	Het
Teddm1a	C	G	1: 153,891,868 (GRCm38)	S26C	probably damaging	Het
Usp13	C	T	3: 32,854,669 (GRCm38)	P155S	probably damaging	Het
Usp17lb	T	A	7: 104,840,364 (GRCm38)	D451V	possibly damaging	Het
Vmn1r173	A	G	7: 23,702,829 (GRCm38)	N163S	possibly damaging	Het
Vmn2r103	G	T	17: 19,812,325 (GRCm38)	C787F	probably damaging	Het
Vmn2r106	G	A	17: 20,268,376 (GRCm38)	P587L	probably benign	Het
Wdr24	C	T	17: 25,824,605 (GRCm38)	H134Y	probably benign	Het
Zbtb40	T	A	4: 136,988,691 (GRCm38)	I988F	probably damaging	Het
Zfp536	A	T	7: 37,479,736 (GRCm38)	I84N	probably damaging	Het
Zfp651	T	A	9: 121,765,595 (GRCm38)	F540Y	probably damaging	Het

Other mutations in Gm884

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00572:Gm884	APN	11	103,615,410 (GRCm38)	missense	probably benign	0.01
IGL00576:Gm884	APN	11	103,617,386 (GRCm38)	unclassified	probably benign
IGL00813:Gm884	APN	11	103,614,498 (GRCm38)	missense	probably benign	0.05
IGL01311:Gm884	APN	11	103,534,676 (GRCm38)	missense	unknown
IGL01946:Gm884	APN	11	103,612,933 (GRCm38)	missense	probably benign	0.28
IGL02217:Gm884	APN	11	103,612,871 (GRCm38)	splice site	probably benign
IGL02556:Gm884	APN	11	103,613,283 (GRCm38)	missense	probably benign	0.01
IGL02825:Gm884	APN	11	103,617,068 (GRCm38)	unclassified	probably benign
IGL02868:Gm884	APN	11	103,615,139 (GRCm38)	missense	probably benign	0.10
IGL02904:Gm884	APN	11	103,616,361 (GRCm38)	unclassified	probably benign
IGL03008:Gm884	APN	11	103,620,467 (GRCm38)	missense	unknown
IGL03120:Gm884	APN	11	103,616,975 (GRCm38)	unclassified	probably benign
IGL03159:Gm884	APN	11	103,604,502 (GRCm38)	splice site	probably benign
IGL03181:Gm884	APN	11	103,616,416 (GRCm38)	unclassified	probably benign
IGL03202:Gm884	APN	11	103,615,373 (GRCm38)	missense	probably benign	0.03
IGL03263:Gm884	APN	11	103,613,699 (GRCm38)	missense	possibly damaging	0.86
esteemed	UTSW	11	103,618,830 (GRCm38)	missense	unknown
lauded	UTSW	11	103,613,103 (GRCm38)	missense	possibly damaging	0.62
PIT4486001:Gm884	UTSW	11	103,618,201 (GRCm38)	missense	unknown
R0040:Gm884	UTSW	11	103,542,990 (GRCm38)	missense	probably damaging	0.99
R0135:Gm884	UTSW	11	103,618,047 (GRCm38)	unclassified	probably benign
R0141:Gm884	UTSW	11	103,613,686 (GRCm38)	missense	probably damaging	1.00
R0226:Gm884	UTSW	11	103,603,241 (GRCm38)	missense	probably benign	0.08
R0547:Gm884	UTSW	11	103,620,164 (GRCm38)	missense	unknown
R0646:Gm884	UTSW	11	103,613,160 (GRCm38)	nonsense	probably null
R0685:Gm884	UTSW	11	103,616,888 (GRCm38)	unclassified	probably benign
R0732:Gm884	UTSW	11	103,619,838 (GRCm38)	missense	unknown
R1015:Gm884	UTSW	11	103,545,796 (GRCm38)	missense	probably benign	0.01
R1166:Gm884	UTSW	11	103,615,383 (GRCm38)	missense	probably benign	0.21
R1168:Gm884	UTSW	11	103,618,950 (GRCm38)	unclassified	probably benign
R1257:Gm884	UTSW	11	103,534,641 (GRCm38)	missense	unknown
R1545:Gm884	UTSW	11	103,608,919 (GRCm38)	missense	probably benign	0.16
R1570:Gm884	UTSW	11	103,609,938 (GRCm38)	missense	possibly damaging	0.76
R1677:Gm884	UTSW	11	103,614,942 (GRCm38)	missense	probably benign	0.19
R1703:Gm884	UTSW	11	103,540,874 (GRCm38)	missense	probably benign	0.39
R1719:Gm884	UTSW	11	103,617,071 (GRCm38)	unclassified	probably benign
R1752:Gm884	UTSW	11	103,614,555 (GRCm38)	missense	possibly damaging	0.67
R1870:Gm884	UTSW	11	103,620,605 (GRCm38)	missense	unknown
R2155:Gm884	UTSW	11	103,620,459 (GRCm38)	missense	unknown
R2191:Gm884	UTSW	11	103,618,967 (GRCm38)	unclassified	probably benign
R2271:Gm884	UTSW	11	103,614,207 (GRCm38)	missense	possibly damaging	0.53
R2378:Gm884	UTSW	11	103,619,711 (GRCm38)	unclassified	probably benign
R2405:Gm884	UTSW	11	103,620,984 (GRCm38)	missense	unknown
R2864:Gm884	UTSW	11	103,540,918 (GRCm38)	missense	probably benign	0.34
R3011:Gm884	UTSW	11	103,613,103 (GRCm38)	missense	possibly damaging	0.62
R3415:Gm884	UTSW	11	103,614,609 (GRCm38)	missense	possibly damaging	0.82
R3417:Gm884	UTSW	11	103,614,609 (GRCm38)	missense	possibly damaging	0.82
R3835:Gm884	UTSW	11	103,620,010 (GRCm38)	missense	unknown
R3974:Gm884	UTSW	11	103,619,101 (GRCm38)	unclassified	probably benign
R4019:Gm884	UTSW	11	103,615,293 (GRCm38)	missense	probably benign	0.19
R4020:Gm884	UTSW	11	103,615,293 (GRCm38)	missense	probably benign	0.19
R4176:Gm884	UTSW	11	103,536,600 (GRCm38)	missense	unknown
R4361:Gm884	UTSW	11	103,617,501 (GRCm38)	frame shift	probably null
R4418:Gm884	UTSW	11	103,618,314 (GRCm38)	unclassified	probably benign
R4633:Gm884	UTSW	11	103,619,131 (GRCm38)	unclassified	probably benign
R4693:Gm884	UTSW	11	103,619,860 (GRCm38)	missense	unknown
R4758:Gm884	UTSW	11	103,614,464 (GRCm38)	missense	possibly damaging	0.48
R4878:Gm884	UTSW	11	103,617,891 (GRCm38)	unclassified	probably benign
R4887:Gm884	UTSW	11	103,614,872 (GRCm38)	missense	probably benign	0.03
R4944:Gm884	UTSW	11	103,613,460 (GRCm38)	missense	possibly damaging	0.68
R4952:Gm884	UTSW	11	103,614,207 (GRCm38)	missense	possibly damaging	0.53
R5030:Gm884	UTSW	11	103,534,849 (GRCm38)	missense	unknown
R5183:Gm884	UTSW	11	103,543,121 (GRCm38)	missense	probably damaging	0.99
R5294:Gm884	UTSW	11	103,616,231 (GRCm38)	unclassified	probably benign
R5317:Gm884	UTSW	11	103,614,145 (GRCm38)	missense	possibly damaging	0.73
R5334:Gm884	UTSW	11	103,613,873 (GRCm38)	missense	probably benign	0.18
R5426:Gm884	UTSW	11	103,620,760 (GRCm38)	missense	unknown
R5467:Gm884	UTSW	11	103,603,265 (GRCm38)	nonsense	probably null
R5518:Gm884	UTSW	11	103,615,253 (GRCm38)	missense	probably benign	0.03
R5634:Gm884	UTSW	11	103,542,014 (GRCm38)	missense	possibly damaging	0.95
R5647:Gm884	UTSW	11	103,617,474 (GRCm38)	unclassified	probably benign
R5663:Gm884	UTSW	11	103,613,123 (GRCm38)	missense	probably benign	0.01
R5668:Gm884	UTSW	11	103,617,054 (GRCm38)	unclassified	probably benign
R5763:Gm884	UTSW	11	103,613,643 (GRCm38)	missense	probably damaging	0.97
R5829:Gm884	UTSW	11	103,541,886 (GRCm38)	missense	possibly damaging	0.95
R5871:Gm884	UTSW	11	103,616,454 (GRCm38)	unclassified	probably benign
R5905:Gm884	UTSW	11	103,614,255 (GRCm38)	missense	probably damaging	0.98
R5940:Gm884	UTSW	11	103,613,886 (GRCm38)	missense	probably benign	0.18
R5964:Gm884	UTSW	11	103,542,120 (GRCm38)	missense	possibly damaging	0.92
R5988:Gm884	UTSW	11	103,615,896 (GRCm38)	unclassified	probably benign
R5992:Gm884	UTSW	11	103,613,792 (GRCm38)	missense	possibly damaging	0.81
R6154:Gm884	UTSW	11	103,614,143 (GRCm38)	missense	probably benign	0.33
R6233:Gm884	UTSW	11	103,613,388 (GRCm38)	missense	probably damaging	0.98
R6301:Gm884	UTSW	11	103,618,930 (GRCm38)	unclassified	probably benign
R6362:Gm884	UTSW	11	103,620,652 (GRCm38)	missense	unknown
R6471:Gm884	UTSW	11	103,619,622 (GRCm38)	unclassified	probably benign
R6806:Gm884	UTSW	11	103,621,124 (GRCm38)	missense	unknown
R6962:Gm884	UTSW	11	103,614,300 (GRCm38)	missense	possibly damaging	0.67
R6996:Gm884	UTSW	11	103,618,757 (GRCm38)	nonsense	probably null
R7028:Gm884	UTSW	11	103,614,537 (GRCm38)	missense	probably benign	0.28
R7034:Gm884	UTSW	11	103,615,812 (GRCm38)	unclassified	probably benign
R7036:Gm884	UTSW	11	103,615,812 (GRCm38)	unclassified	probably benign
R7113:Gm884	UTSW	11	103,618,799 (GRCm38)	missense	unknown
R7405:Gm884	UTSW	11	103,615,161 (GRCm38)	missense	probably benign	0.02
R7420:Gm884	UTSW	11	103,613,625 (GRCm38)	missense	probably benign	0.11
R7461:Gm884	UTSW	11	103,616,290 (GRCm38)	missense	unknown
R7544:Gm884	UTSW	11	103,615,448 (GRCm38)	missense	probably benign	0.01
R7613:Gm884	UTSW	11	103,616,290 (GRCm38)	missense	unknown
R7711:Gm884	UTSW	11	103,614,912 (GRCm38)	missense	probably benign	0.02
R7714:Gm884	UTSW	11	103,616,893 (GRCm38)	missense	unknown
R7747:Gm884	UTSW	11	103,614,255 (GRCm38)	missense	probably damaging	0.98
R7814:Gm884	UTSW	11	103,614,173 (GRCm38)	missense	possibly damaging	0.53
R8053:Gm884	UTSW	11	103,604,566 (GRCm38)	missense	unknown
R8063:Gm884	UTSW	11	103,542,261 (GRCm38)	missense	unknown
R8116:Gm884	UTSW	11	103,543,289 (GRCm38)	missense	unknown
R8124:Gm884	UTSW	11	103,620,431 (GRCm38)	missense	unknown
R8141:Gm884	UTSW	11	103,621,029 (GRCm38)	missense	unknown
R8163:Gm884	UTSW	11	103,615,862 (GRCm38)	missense	unknown
R8270:Gm884	UTSW	11	103,543,315 (GRCm38)	missense	unknown
R8348:Gm884	UTSW	11	103,620,900 (GRCm38)	missense	unknown
R8362:Gm884	UTSW	11	103,615,337 (GRCm38)	missense	probably benign	0.34
R8448:Gm884	UTSW	11	103,620,900 (GRCm38)	missense	unknown
R8465:Gm884	UTSW	11	103,616,121 (GRCm38)	unclassified	probably benign
R8473:Gm884	UTSW	11	103,543,440 (GRCm38)	missense	unknown
R8781:Gm884	UTSW	11	103,618,132 (GRCm38)	missense	unknown
R8821:Gm884	UTSW	11	103,619,644 (GRCm38)	missense	unknown
R8859:Gm884	UTSW	11	103,615,544 (GRCm38)	missense	unknown
R8888:Gm884	UTSW	11	103,618,830 (GRCm38)	missense	unknown
R8895:Gm884	UTSW	11	103,618,830 (GRCm38)	missense	unknown
R9083:Gm884	UTSW	11	103,619,004 (GRCm38)	missense	unknown
R9085:Gm884	UTSW	11	103,616,739 (GRCm38)	missense	unknown
R9088:Gm884	UTSW	11	103,620,936 (GRCm38)	missense	unknown
R9124:Gm884	UTSW	11	103,618,895 (GRCm38)	missense	unknown
R9177:Gm884	UTSW	11	103,617,437 (GRCm38)	missense	unknown
R9238:Gm884	UTSW	11	103,619,033 (GRCm38)	missense	unknown
R9267:Gm884	UTSW	11	103,604,580 (GRCm38)	missense	unknown
R9444:Gm884	UTSW	11	103,618,020 (GRCm38)	nonsense	probably null
R9517:Gm884	UTSW	11	103,542,590 (GRCm38)	missense	unknown
R9564:Gm884	UTSW	11	103,612,996 (GRCm38)	missense	unknown
R9632:Gm884	UTSW	11	103,542,426 (GRCm38)	missense	unknown
R9741:Gm884	UTSW	11	103,613,429 (GRCm38)	missense	possibly damaging	0.68
Z1176:Gm884	UTSW	11	103,613,681 (GRCm38)	missense	probably benign	0.45

Predicted Primers

PCR Primer
(F):5'- AGGTGTTGGAACTGTTACCTCC -3'
(R):5'- GGTTGCAATTCCAGTCCCAGTC -3'

Sequencing Primer
(F):5'- GGAACTGTTACCTCCTGAAATACAG -3'
(R):5'- CAGTCTATCTGGATATGACAGTTCC -3'

Posted On

2017-08-16