Incidental Mutation 'R6114:Adamdec1'
ID 485038
Institutional Source Beutler Lab
Gene Symbol Adamdec1
Ensembl Gene ENSMUSG00000022057
Gene Name ADAM-like, decysin 1
Synonyms Dcsn, 2210414L24Rik
MMRRC Submission 044263-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R6114 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 68800829-68819535 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 68809252 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 237 (V237L)
Ref Sequence ENSEMBL: ENSMUSP00000022641 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022641]
AlphaFold Q9R0X2
Predicted Effect probably benign
Transcript: ENSMUST00000022641
AA Change: V237L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000022641
Gene: ENSMUSG00000022057
AA Change: V237L

DomainStartEndE-ValueType
signal peptide 1 33 N/A INTRINSIC
Pfam:Pep_M12B_propep 37 175 3.9e-29 PFAM
Pfam:Reprolysin_5 215 389 9.8e-17 PFAM
Pfam:Reprolysin_4 216 407 7.3e-12 PFAM
Pfam:Reprolysin 217 411 1.5e-57 PFAM
Pfam:Reprolysin_3 242 360 1e-11 PFAM
DISIN 427 465 1.12e-3 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.0%
Validation Efficiency 94% (60/64)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during dendritic cells maturation. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aff1 T C 5: 103,990,163 (GRCm39) S878P probably damaging Het
Ahcy A C 2: 154,904,079 (GRCm39) L386R probably damaging Het
Ank2 T C 3: 126,804,700 (GRCm39) N607D probably damaging Het
Arid5b T C 10: 67,933,574 (GRCm39) D776G possibly damaging Het
Art4 T A 6: 136,834,211 (GRCm39) T11S unknown Het
Blm T C 7: 80,163,235 (GRCm39) T39A probably damaging Het
Cabin1 T A 10: 75,583,805 (GRCm39) M221L probably benign Het
Cacna1c T C 6: 118,573,101 (GRCm39) T1675A probably benign Het
Cacnb2 A T 2: 14,980,012 (GRCm39) H285L possibly damaging Het
Cchcr1 A G 17: 35,836,227 (GRCm39) E339G probably damaging Het
Cd14 A G 18: 36,859,006 (GRCm39) W150R probably damaging Het
Cep162 A G 9: 87,085,763 (GRCm39) I1187T probably benign Het
Cntnap4 A G 8: 113,568,385 (GRCm39) H807R probably damaging Het
Copb1 T A 7: 113,846,036 (GRCm39) H178L probably benign Het
Cpxm2 A G 7: 131,756,035 (GRCm39) V103A probably benign Het
Egfr A G 11: 16,854,374 (GRCm39) T849A possibly damaging Het
Endou T A 15: 97,611,757 (GRCm39) K294* probably null Het
Hoxd9 A G 2: 74,529,709 (GRCm39) N322D probably damaging Het
Hsph1 C A 5: 149,550,852 (GRCm39) V416L possibly damaging Het
Igkv4-78 T A 6: 69,036,743 (GRCm39) T97S possibly damaging Het
Itga10 G T 3: 96,556,351 (GRCm39) C162F probably damaging Het
Lmod2 A G 6: 24,603,691 (GRCm39) E222G probably damaging Het
Lpar5 A G 6: 125,058,639 (GRCm39) N120S probably damaging Het
Lrrc37 T A 11: 103,508,617 (GRCm39) probably benign Het
Lrrk2 A G 15: 91,632,029 (GRCm39) I1318V probably benign Het
Lst1 T C 17: 35,407,336 (GRCm39) T11A possibly damaging Het
Mfn1 C A 3: 32,617,985 (GRCm39) A106D probably damaging Het
Ms4a12 G T 19: 11,192,654 (GRCm39) N227K probably benign Het
Nr1h4 T A 10: 89,314,678 (GRCm39) N273Y possibly damaging Het
Nrdc A T 4: 108,901,782 (GRCm39) K617M probably damaging Het
Or10a3b A T 7: 108,444,593 (GRCm39) M208K possibly damaging Het
Or1l8 A T 2: 36,817,701 (GRCm39) C142S possibly damaging Het
Or6c202 T A 10: 128,996,202 (GRCm39) H217L probably benign Het
Pcdhgc3 C G 18: 37,940,925 (GRCm39) T442R probably benign Het
Pcnx2 T C 8: 126,500,686 (GRCm39) N1468S probably damaging Het
Pde2a A T 7: 101,160,319 (GRCm39) probably null Het
Pitx2 C G 3: 128,998,062 (GRCm39) probably null Het
Reck T A 4: 43,922,895 (GRCm39) I390N probably damaging Het
Rora A G 9: 69,278,605 (GRCm39) N254S probably benign Het
Samd4b A G 7: 28,222,217 (GRCm39) probably null Het
Scn8a A G 15: 100,938,477 (GRCm39) T1949A probably damaging Het
Slc22a15 A T 3: 101,768,168 (GRCm39) Y346* probably null Het
Slc24a5 A G 2: 124,925,012 (GRCm39) T218A probably benign Het
Slc38a10 G A 11: 120,020,138 (GRCm39) Q305* probably null Het
Slc45a4 G A 15: 73,477,453 (GRCm39) P28S probably damaging Het
Smyd5 A T 6: 85,417,244 (GRCm39) probably benign Het
Sox8 T C 17: 25,786,494 (GRCm39) D403G probably damaging Het
Stx7 A G 10: 24,060,883 (GRCm39) probably null Het
Svil T C 18: 5,108,639 (GRCm39) S1522P probably damaging Het
Sycp2 G C 2: 177,990,038 (GRCm39) R1403G probably benign Het
Tasor2 G A 13: 3,640,081 (GRCm39) T352M probably damaging Het
Tcf25 A T 8: 124,111,114 (GRCm39) K192M probably damaging Het
Tecpr1 C T 5: 144,141,458 (GRCm39) G804S possibly damaging Het
Teddm1a C G 1: 153,767,614 (GRCm39) S26C probably damaging Het
Usp13 C T 3: 32,908,818 (GRCm39) P155S probably damaging Het
Usp17lb T A 7: 104,489,571 (GRCm39) D451V possibly damaging Het
Vmn1r173 A G 7: 23,402,254 (GRCm39) N163S possibly damaging Het
Vmn2r103 G T 17: 20,032,587 (GRCm39) C787F probably damaging Het
Vmn2r106 G A 17: 20,488,638 (GRCm39) P587L probably benign Het
Wdr24 C T 17: 26,043,579 (GRCm39) H134Y probably benign Het
Zbtb40 T A 4: 136,716,002 (GRCm39) I988F probably damaging Het
Zbtb47 T A 9: 121,594,661 (GRCm39) F540Y probably damaging Het
Zfp536 A T 7: 37,179,161 (GRCm39) I84N probably damaging Het
Other mutations in Adamdec1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01691:Adamdec1 APN 14 68,810,556 (GRCm39) missense probably damaging 1.00
IGL02026:Adamdec1 APN 14 68,809,251 (GRCm39) missense possibly damaging 0.81
IGL02068:Adamdec1 APN 14 68,814,558 (GRCm39) missense probably benign 0.21
IGL02416:Adamdec1 APN 14 68,810,282 (GRCm39) missense probably null 0.99
IGL02739:Adamdec1 APN 14 68,807,605 (GRCm39) nonsense probably null
IGL03078:Adamdec1 APN 14 68,806,299 (GRCm39) missense possibly damaging 0.53
IGL03115:Adamdec1 APN 14 68,808,802 (GRCm39) missense probably damaging 1.00
R0201:Adamdec1 UTSW 14 68,819,406 (GRCm39) critical splice donor site probably null
R0243:Adamdec1 UTSW 14 68,819,407 (GRCm39) critical splice donor site probably null
R0244:Adamdec1 UTSW 14 68,806,172 (GRCm39) nonsense probably null
R0416:Adamdec1 UTSW 14 68,806,161 (GRCm39) missense possibly damaging 0.79
R1373:Adamdec1 UTSW 14 68,808,400 (GRCm39) missense probably damaging 1.00
R1856:Adamdec1 UTSW 14 68,808,397 (GRCm39) missense probably damaging 1.00
R2570:Adamdec1 UTSW 14 68,816,657 (GRCm39) missense probably damaging 0.98
R3684:Adamdec1 UTSW 14 68,819,447 (GRCm39) missense probably benign 0.04
R3755:Adamdec1 UTSW 14 68,814,587 (GRCm39) missense probably damaging 1.00
R4450:Adamdec1 UTSW 14 68,810,568 (GRCm39) missense probably benign 0.00
R4661:Adamdec1 UTSW 14 68,807,562 (GRCm39) missense probably damaging 1.00
R4672:Adamdec1 UTSW 14 68,815,353 (GRCm39) nonsense probably null
R4673:Adamdec1 UTSW 14 68,815,353 (GRCm39) nonsense probably null
R4902:Adamdec1 UTSW 14 68,809,215 (GRCm39) missense probably damaging 0.99
R5017:Adamdec1 UTSW 14 68,810,694 (GRCm39) missense probably benign 0.01
R5018:Adamdec1 UTSW 14 68,809,228 (GRCm39) missense probably damaging 1.00
R5141:Adamdec1 UTSW 14 68,810,577 (GRCm39) missense probably benign 0.00
R5329:Adamdec1 UTSW 14 68,807,612 (GRCm39) missense probably damaging 1.00
R5395:Adamdec1 UTSW 14 68,808,352 (GRCm39) missense probably benign 0.04
R5864:Adamdec1 UTSW 14 68,807,551 (GRCm39) missense probably damaging 1.00
R6032:Adamdec1 UTSW 14 68,816,633 (GRCm39) missense probably damaging 1.00
R6032:Adamdec1 UTSW 14 68,816,633 (GRCm39) missense probably damaging 1.00
R6633:Adamdec1 UTSW 14 68,810,601 (GRCm39) missense probably benign 0.03
R7243:Adamdec1 UTSW 14 68,809,203 (GRCm39) missense probably benign 0.06
R7580:Adamdec1 UTSW 14 68,802,980 (GRCm39) missense probably benign 0.00
R8388:Adamdec1 UTSW 14 68,810,684 (GRCm39) nonsense probably null
R9133:Adamdec1 UTSW 14 68,814,547 (GRCm39) nonsense probably null
X0025:Adamdec1 UTSW 14 68,807,607 (GRCm39) missense probably damaging 1.00
X0050:Adamdec1 UTSW 14 68,807,607 (GRCm39) missense probably damaging 1.00
X0062:Adamdec1 UTSW 14 68,810,701 (GRCm39) missense probably benign 0.12
Z1177:Adamdec1 UTSW 14 68,818,092 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CCACAAGTGATAGATAAAGGGATGT -3'
(R):5'- TACCTGAAAGCAATCAACTGTAAAA -3'

Sequencing Primer
(F):5'- TGATAGAAAAAGGCTTTGTTACTGTC -3'
(R):5'- CAATCCTTGGAAAGTTTCACTGGG -3'
Posted On 2017-08-16