Incidental Mutation 'R6114:Vmn2r106'
| ID |
485044 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r106
|
| Ensembl Gene |
ENSMUSG00000091656 |
| Gene Name |
vomeronasal 2, receptor 106 |
| Synonyms |
EG224576 |
| MMRRC Submission |
044263-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.127)
|
| Stock # |
R6114 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
20267547-20285430 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 20268376 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Leucine
at position 587
(P587L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126534
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167464]
|
| AlphaFold |
E9PY92 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167464
AA Change: P587L
PolyPhen 2
Score 0.107 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000126534
Gene: ENSMUSG00000091656
AA Change: P587L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
471 |
3.8e-37 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
5.7e-22 |
PFAM |
|
Pfam:7tm_3
|
596 |
835 |
1.3e-49 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.0%
- 20x: 94.0%
|
| Validation Efficiency |
94% (60/64) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 63 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamdec1 |
C |
A |
14: 68,571,803 (GRCm38) |
V237L |
probably benign |
Het |
| Aff1 |
T |
C |
5: 103,842,297 (GRCm38) |
S878P |
probably damaging |
Het |
| Ahcy |
A |
C |
2: 155,062,159 (GRCm38) |
L386R |
probably damaging |
Het |
| Ank2 |
T |
C |
3: 127,011,051 (GRCm38) |
N607D |
probably damaging |
Het |
| Arid5b |
T |
C |
10: 68,097,744 (GRCm38) |
D776G |
possibly damaging |
Het |
| Art4 |
T |
A |
6: 136,857,213 (GRCm38) |
T11S |
unknown |
Het |
| Blm |
T |
C |
7: 80,513,487 (GRCm38) |
T39A |
probably damaging |
Het |
| Cabin1 |
T |
A |
10: 75,747,971 (GRCm38) |
M221L |
probably benign |
Het |
| Cacna1c |
T |
C |
6: 118,596,140 (GRCm38) |
T1675A |
probably benign |
Het |
| Cacnb2 |
A |
T |
2: 14,975,201 (GRCm38) |
H285L |
possibly damaging |
Het |
| Cchcr1 |
A |
G |
17: 35,525,330 (GRCm38) |
E339G |
probably damaging |
Het |
| Cd14 |
A |
G |
18: 36,725,953 (GRCm38) |
W150R |
probably damaging |
Het |
| Cep162 |
A |
G |
9: 87,203,710 (GRCm38) |
I1187T |
probably benign |
Het |
| Cntnap4 |
A |
G |
8: 112,841,753 (GRCm38) |
H807R |
probably damaging |
Het |
| Copb1 |
T |
A |
7: 114,246,801 (GRCm38) |
H178L |
probably benign |
Het |
| Cpxm2 |
A |
G |
7: 132,154,306 (GRCm38) |
V103A |
probably benign |
Het |
| Egfr |
A |
G |
11: 16,904,374 (GRCm38) |
T849A |
possibly damaging |
Het |
| Endou |
T |
A |
15: 97,713,876 (GRCm38) |
K294* |
probably null |
Het |
| Fam208b |
G |
A |
13: 3,590,081 (GRCm38) |
T352M |
probably damaging |
Het |
| Gm884 |
T |
A |
11: 103,617,791 (GRCm38) |
|
probably benign |
Het |
| Hoxd9 |
A |
G |
2: 74,699,365 (GRCm38) |
N322D |
probably damaging |
Het |
| Hsph1 |
C |
A |
5: 149,627,387 (GRCm38) |
V416L |
possibly damaging |
Het |
| Igkv4-78 |
T |
A |
6: 69,059,759 (GRCm38) |
T97S |
possibly damaging |
Het |
| Itga10 |
G |
T |
3: 96,649,035 (GRCm38) |
C162F |
probably damaging |
Het |
| Lmod2 |
A |
G |
6: 24,603,692 (GRCm38) |
E222G |
probably damaging |
Het |
| Lpar5 |
A |
G |
6: 125,081,676 (GRCm38) |
N120S |
probably damaging |
Het |
| Lrrk2 |
A |
G |
15: 91,747,826 (GRCm38) |
I1318V |
probably benign |
Het |
| Lst1 |
T |
C |
17: 35,188,360 (GRCm38) |
T11A |
possibly damaging |
Het |
| Mfn1 |
C |
A |
3: 32,563,836 (GRCm38) |
A106D |
probably damaging |
Het |
| Ms4a12 |
G |
T |
19: 11,215,290 (GRCm38) |
N227K |
probably benign |
Het |
| Nr1h4 |
T |
A |
10: 89,478,816 (GRCm38) |
N273Y |
possibly damaging |
Het |
| Nrd1 |
A |
T |
4: 109,044,585 (GRCm38) |
K617M |
probably damaging |
Het |
| Olfr355 |
A |
T |
2: 36,927,689 (GRCm38) |
C142S |
possibly damaging |
Het |
| Olfr516 |
A |
T |
7: 108,845,386 (GRCm38) |
M208K |
possibly damaging |
Het |
| Olfr771 |
T |
A |
10: 129,160,333 (GRCm38) |
H217L |
probably benign |
Het |
| Pcdhgc3 |
C |
G |
18: 37,807,872 (GRCm38) |
T442R |
probably benign |
Het |
| Pcnx2 |
T |
C |
8: 125,773,947 (GRCm38) |
N1468S |
probably damaging |
Het |
| Pde2a |
A |
T |
7: 101,511,112 (GRCm38) |
|
probably null |
Het |
| Pitx2 |
C |
G |
3: 129,204,413 (GRCm38) |
|
probably null |
Het |
| Reck |
T |
A |
4: 43,922,895 (GRCm38) |
I390N |
probably damaging |
Het |
| Rora |
A |
G |
9: 69,371,323 (GRCm38) |
N254S |
probably benign |
Het |
| Samd4b |
A |
G |
7: 28,522,792 (GRCm38) |
|
probably null |
Het |
| Scn8a |
A |
G |
15: 101,040,596 (GRCm38) |
T1949A |
probably damaging |
Het |
| Slc22a15 |
A |
T |
3: 101,860,852 (GRCm38) |
Y346* |
probably null |
Het |
| Slc24a5 |
A |
G |
2: 125,083,092 (GRCm38) |
T218A |
probably benign |
Het |
| Slc38a10 |
G |
A |
11: 120,129,312 (GRCm38) |
Q305* |
probably null |
Het |
| Slc45a4 |
G |
A |
15: 73,605,604 (GRCm38) |
P28S |
probably damaging |
Het |
| Smyd5 |
A |
T |
6: 85,440,262 (GRCm38) |
|
probably benign |
Het |
| Sox8 |
T |
C |
17: 25,567,520 (GRCm38) |
D403G |
probably damaging |
Het |
| Stx7 |
A |
G |
10: 24,184,985 (GRCm38) |
|
probably null |
Het |
| Svil |
T |
C |
18: 5,108,639 (GRCm38) |
S1522P |
probably damaging |
Het |
| Sycp2 |
G |
C |
2: 178,348,245 (GRCm38) |
R1403G |
probably benign |
Het |
| Tcf25 |
A |
T |
8: 123,384,375 (GRCm38) |
K192M |
probably damaging |
Het |
| Tecpr1 |
C |
T |
5: 144,204,640 (GRCm38) |
G804S |
possibly damaging |
Het |
| Teddm1a |
C |
G |
1: 153,891,868 (GRCm38) |
S26C |
probably damaging |
Het |
| Usp13 |
C |
T |
3: 32,854,669 (GRCm38) |
P155S |
probably damaging |
Het |
| Usp17lb |
T |
A |
7: 104,840,364 (GRCm38) |
D451V |
possibly damaging |
Het |
| Vmn1r173 |
A |
G |
7: 23,702,829 (GRCm38) |
N163S |
possibly damaging |
Het |
| Vmn2r103 |
G |
T |
17: 19,812,325 (GRCm38) |
C787F |
probably damaging |
Het |
| Wdr24 |
C |
T |
17: 25,824,605 (GRCm38) |
H134Y |
probably benign |
Het |
| Zbtb40 |
T |
A |
4: 136,988,691 (GRCm38) |
I988F |
probably damaging |
Het |
| Zfp536 |
A |
T |
7: 37,479,736 (GRCm38) |
I84N |
probably damaging |
Het |
| Zfp651 |
T |
A |
9: 121,765,595 (GRCm38) |
F540Y |
probably damaging |
Het |
|
| Other mutations in Vmn2r106 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00979:Vmn2r106
|
APN |
17 |
20,277,575 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
IGL01313:Vmn2r106
|
APN |
17 |
20,278,389 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01419:Vmn2r106
|
APN |
17 |
20,279,545 (GRCm38) |
missense |
probably benign |
0.06 |
|
IGL01574:Vmn2r106
|
APN |
17 |
20,268,310 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL01796:Vmn2r106
|
APN |
17 |
20,268,052 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
IGL01893:Vmn2r106
|
APN |
17 |
20,277,468 (GRCm38) |
missense |
probably benign |
0.06 |
|
IGL01895:Vmn2r106
|
APN |
17 |
20,278,965 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL02378:Vmn2r106
|
APN |
17 |
20,277,529 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02430:Vmn2r106
|
APN |
17 |
20,278,896 (GRCm38) |
missense |
probably benign |
0.38 |
|
IGL02664:Vmn2r106
|
APN |
17 |
20,268,082 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
IGL03308:Vmn2r106
|
APN |
17 |
20,278,523 (GRCm38) |
nonsense |
probably null |
|
|
IGL03384:Vmn2r106
|
APN |
17 |
20,268,143 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0401:Vmn2r106
|
UTSW |
17 |
20,279,019 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R0842:Vmn2r106
|
UTSW |
17 |
20,268,203 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0964:Vmn2r106
|
UTSW |
17 |
20,267,597 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1235:Vmn2r106
|
UTSW |
17 |
20,279,479 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1709:Vmn2r106
|
UTSW |
17 |
20,279,111 (GRCm38) |
missense |
probably benign |
0.12 |
|
R1712:Vmn2r106
|
UTSW |
17 |
20,278,735 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1770:Vmn2r106
|
UTSW |
17 |
20,268,298 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2049:Vmn2r106
|
UTSW |
17 |
20,268,304 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R2245:Vmn2r106
|
UTSW |
17 |
20,268,161 (GRCm38) |
missense |
probably benign |
0.13 |
|
R2336:Vmn2r106
|
UTSW |
17 |
20,268,208 (GRCm38) |
missense |
probably benign |
0.18 |
|
R2910:Vmn2r106
|
UTSW |
17 |
20,278,684 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3025:Vmn2r106
|
UTSW |
17 |
20,278,885 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3944:Vmn2r106
|
UTSW |
17 |
20,267,651 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4081:Vmn2r106
|
UTSW |
17 |
20,267,556 (GRCm38) |
nonsense |
probably null |
|
|
R4153:Vmn2r106
|
UTSW |
17 |
20,267,818 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4356:Vmn2r106
|
UTSW |
17 |
20,279,648 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4426:Vmn2r106
|
UTSW |
17 |
20,285,379 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4590:Vmn2r106
|
UTSW |
17 |
20,277,466 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4661:Vmn2r106
|
UTSW |
17 |
20,267,623 (GRCm38) |
missense |
probably benign |
0.10 |
|
R5106:Vmn2r106
|
UTSW |
17 |
20,279,133 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R5341:Vmn2r106
|
UTSW |
17 |
20,277,526 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5509:Vmn2r106
|
UTSW |
17 |
20,278,422 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5826:Vmn2r106
|
UTSW |
17 |
20,278,871 (GRCm38) |
missense |
probably benign |
|
|
R5859:Vmn2r106
|
UTSW |
17 |
20,285,321 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R5937:Vmn2r106
|
UTSW |
17 |
20,285,405 (GRCm38) |
nonsense |
probably null |
|
|
R5972:Vmn2r106
|
UTSW |
17 |
20,278,476 (GRCm38) |
missense |
probably benign |
|
|
R6056:Vmn2r106
|
UTSW |
17 |
20,267,544 (GRCm38) |
splice site |
probably null |
|
|
R6108:Vmn2r106
|
UTSW |
17 |
20,268,376 (GRCm38) |
missense |
probably benign |
0.11 |
|
R6115:Vmn2r106
|
UTSW |
17 |
20,268,376 (GRCm38) |
missense |
probably benign |
0.11 |
|
R6132:Vmn2r106
|
UTSW |
17 |
20,268,404 (GRCm38) |
missense |
probably benign |
|
|
R6208:Vmn2r106
|
UTSW |
17 |
20,268,329 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6217:Vmn2r106
|
UTSW |
17 |
20,268,239 (GRCm38) |
missense |
probably benign |
0.10 |
|
R6289:Vmn2r106
|
UTSW |
17 |
20,268,463 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6378:Vmn2r106
|
UTSW |
17 |
20,278,405 (GRCm38) |
missense |
probably benign |
0.19 |
|
R6390:Vmn2r106
|
UTSW |
17 |
20,268,463 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6391:Vmn2r106
|
UTSW |
17 |
20,268,463 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6392:Vmn2r106
|
UTSW |
17 |
20,268,463 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6405:Vmn2r106
|
UTSW |
17 |
20,279,099 (GRCm38) |
missense |
probably benign |
0.22 |
|
R6427:Vmn2r106
|
UTSW |
17 |
20,268,463 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6428:Vmn2r106
|
UTSW |
17 |
20,268,463 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6435:Vmn2r106
|
UTSW |
17 |
20,268,463 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6436:Vmn2r106
|
UTSW |
17 |
20,268,463 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6437:Vmn2r106
|
UTSW |
17 |
20,268,463 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6511:Vmn2r106
|
UTSW |
17 |
20,268,463 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6512:Vmn2r106
|
UTSW |
17 |
20,268,463 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6587:Vmn2r106
|
UTSW |
17 |
20,268,463 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6703:Vmn2r106
|
UTSW |
17 |
20,268,463 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6730:Vmn2r106
|
UTSW |
17 |
20,278,834 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
R6961:Vmn2r106
|
UTSW |
17 |
20,268,384 (GRCm38) |
nonsense |
probably null |
|
|
R7054:Vmn2r106
|
UTSW |
17 |
20,278,920 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R7379:Vmn2r106
|
UTSW |
17 |
20,267,775 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R7402:Vmn2r106
|
UTSW |
17 |
20,267,621 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7497:Vmn2r106
|
UTSW |
17 |
20,267,939 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7692:Vmn2r106
|
UTSW |
17 |
20,285,228 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
R8539:Vmn2r106
|
UTSW |
17 |
20,279,009 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8827:Vmn2r106
|
UTSW |
17 |
20,267,606 (GRCm38) |
missense |
probably benign |
0.05 |
|
R8872:Vmn2r106
|
UTSW |
17 |
20,268,139 (GRCm38) |
missense |
probably benign |
0.19 |
|
R9118:Vmn2r106
|
UTSW |
17 |
20,285,405 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9254:Vmn2r106
|
UTSW |
17 |
20,275,804 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9379:Vmn2r106
|
UTSW |
17 |
20,275,804 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9571:Vmn2r106
|
UTSW |
17 |
20,285,379 (GRCm38) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGCAACTCCAAATGTGGTCTG -3'
(R):5'- GTGACAGTCCTTGTACATAGAAATG -3'
Sequencing Primer
(F):5'- CAACTCCAAATGTGGTCTGTTGTAG -3'
(R):5'- GTCCTTGTACATAGAAATGACTCAG -3'
|
| Posted On |
2017-08-16 |
Incidental Mutation