Incidental Mutation 'R6115:Vmn2r18'
ID 485069
Institutional Source Beutler Lab
Gene Symbol Vmn2r18
Ensembl Gene ENSMUSG00000091794
Gene Name vomeronasal 2, receptor 18
Synonyms EG632671
MMRRC Submission 044264-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R6115 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 151485126-151529232 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 151508462 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 221 (S221T)
Ref Sequence ENSEMBL: ENSMUSP00000127506 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165928]
AlphaFold A0A3B2WB67
Predicted Effect possibly damaging
Transcript: ENSMUST00000165928
AA Change: S221T

PolyPhen 2 Score 0.814 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000127506
Gene: ENSMUSG00000091794
AA Change: S221T

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 403 5.7e-39 PFAM
Pfam:NCD3G 446 499 5.5e-20 PFAM
Pfam:7tm_3 531 767 5e-53 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.9%
Validation Efficiency 98% (51/52)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik C G 5: 64,055,317 (GRCm39) Q18E probably damaging Het
Acsf3 T A 8: 123,517,411 (GRCm39) H402Q probably damaging Het
Adam34 T G 8: 44,105,098 (GRCm39) Q182H probably benign Het
Alx1 G A 10: 102,864,304 (GRCm39) P55L possibly damaging Het
Arhgef38 A T 3: 132,838,374 (GRCm39) probably null Het
Ccdc102a T C 8: 95,629,999 (GRCm39) N514S probably benign Het
Corin T A 5: 72,518,072 (GRCm39) T317S probably damaging Het
Ctnna2 A G 6: 77,613,822 (GRCm39) V256A probably benign Het
Dhx29 A T 13: 113,089,335 (GRCm39) probably null Het
Dnah2 C A 11: 69,337,475 (GRCm39) D3209Y probably damaging Het
Dnhd1 A G 7: 105,363,194 (GRCm39) T3919A probably benign Het
F7 T A 8: 13,083,958 (GRCm39) N214K probably benign Het
Fam3b T G 16: 97,276,568 (GRCm39) Q177H possibly damaging Het
Fign T C 2: 63,809,654 (GRCm39) I539V probably benign Het
Hc T G 2: 34,903,050 (GRCm39) D1067A probably damaging Het
Herc6 A G 6: 57,560,191 (GRCm39) D77G probably benign Het
Hmg20a A T 9: 56,397,116 (GRCm39) E305D possibly damaging Het
Il16 G A 7: 83,301,775 (GRCm39) Q116* probably null Het
Kif13a T A 13: 46,954,789 (GRCm39) I648F probably damaging Het
Lactb G T 9: 66,874,969 (GRCm39) N374K possibly damaging Het
Lmx1b T C 2: 33,459,118 (GRCm39) D145G probably damaging Het
Lrfn4 T C 19: 4,663,937 (GRCm39) D199G probably damaging Het
Lrrc49 A T 9: 60,522,444 (GRCm39) V307E possibly damaging Het
Magi1 A C 6: 93,685,051 (GRCm39) S776A possibly damaging Het
Mthfsl T A 9: 88,570,807 (GRCm39) *147L probably null Het
Nsmce4a G T 7: 130,148,722 (GRCm39) Q95K probably benign Het
Or1j15 A T 2: 36,458,963 (GRCm39) M118L probably damaging Het
Or4k37 A G 2: 111,159,558 (GRCm39) T265A probably benign Het
Or4k49 A T 2: 111,494,987 (GRCm39) K139* probably null Het
Or5b24 T C 19: 12,912,948 (GRCm39) V282A possibly damaging Het
Pcdha7 A G 18: 37,107,788 (GRCm39) E271G probably damaging Het
Pcdhga8 T A 18: 37,860,596 (GRCm39) F551I possibly damaging Het
Prpf31 T C 7: 3,642,705 (GRCm39) probably null Het
Qrfpr C T 3: 36,236,742 (GRCm39) V220I possibly damaging Het
Rnf170 T C 8: 26,615,994 (GRCm39) F95S possibly damaging Het
Scn9a T A 2: 66,393,973 (GRCm39) Y200F possibly damaging Het
Sfpq A T 4: 126,915,141 (GRCm39) probably null Het
Slc9c1 A T 16: 45,376,132 (GRCm39) Y406F probably damaging Het
Stk32c G T 7: 138,700,628 (GRCm39) Y200* probably null Het
Svil A G 18: 5,108,675 (GRCm39) R1938G probably damaging Het
Sycp2 G C 2: 177,990,038 (GRCm39) R1403G probably benign Het
Tm9sf4 T C 2: 153,024,409 (GRCm39) probably null Het
Tmc3 A T 7: 83,264,170 (GRCm39) M633L possibly damaging Het
Tmem163 T C 1: 127,605,185 (GRCm39) D61G possibly damaging Het
Unc5b C A 10: 60,613,325 (GRCm39) A304S probably benign Het
Vmn2r106 G A 17: 20,488,638 (GRCm39) P587L probably benign Het
Vmn2r85 T G 10: 130,258,672 (GRCm39) Y461S probably damaging Het
Yod1 T C 1: 130,646,800 (GRCm39) F226L possibly damaging Het
Zbtb4 T C 11: 69,667,148 (GRCm39) I151T probably damaging Het
Zfp110 A T 7: 12,583,701 (GRCm39) Q783L probably damaging Het
Other mutations in Vmn2r18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01098:Vmn2r18 APN 5 151,496,296 (GRCm39) missense probably damaging 0.99
IGL01564:Vmn2r18 APN 5 151,508,633 (GRCm39) missense possibly damaging 0.69
IGL01602:Vmn2r18 APN 5 151,510,106 (GRCm39) missense possibly damaging 0.64
IGL01605:Vmn2r18 APN 5 151,510,106 (GRCm39) missense possibly damaging 0.64
IGL01619:Vmn2r18 APN 5 151,510,229 (GRCm39) missense probably benign 0.25
IGL02177:Vmn2r18 APN 5 151,510,274 (GRCm39) missense possibly damaging 0.76
IGL02682:Vmn2r18 APN 5 151,508,102 (GRCm39) missense probably damaging 0.99
IGL02751:Vmn2r18 APN 5 151,508,072 (GRCm39) missense probably benign 0.09
IGL02977:Vmn2r18 APN 5 151,510,149 (GRCm39) missense probably damaging 1.00
R0089:Vmn2r18 UTSW 5 151,508,269 (GRCm39) missense probably benign 0.00
R0282:Vmn2r18 UTSW 5 151,508,668 (GRCm39) missense probably benign 0.02
R0529:Vmn2r18 UTSW 5 151,485,988 (GRCm39) missense probably damaging 0.99
R0812:Vmn2r18 UTSW 5 151,496,395 (GRCm39) splice site probably benign
R1467:Vmn2r18 UTSW 5 151,510,301 (GRCm39) missense possibly damaging 0.48
R1467:Vmn2r18 UTSW 5 151,510,301 (GRCm39) missense possibly damaging 0.48
R1506:Vmn2r18 UTSW 5 151,499,099 (GRCm39) splice site probably null
R1562:Vmn2r18 UTSW 5 151,510,301 (GRCm39) missense probably benign 0.12
R1637:Vmn2r18 UTSW 5 151,508,222 (GRCm39) missense probably damaging 1.00
R1651:Vmn2r18 UTSW 5 151,485,464 (GRCm39) missense probably damaging 1.00
R1883:Vmn2r18 UTSW 5 151,499,190 (GRCm39) missense probably benign 0.37
R1884:Vmn2r18 UTSW 5 151,499,190 (GRCm39) missense probably benign 0.37
R1914:Vmn2r18 UTSW 5 151,499,286 (GRCm39) missense probably benign 0.02
R2051:Vmn2r18 UTSW 5 151,486,016 (GRCm39) missense possibly damaging 0.90
R2056:Vmn2r18 UTSW 5 151,508,160 (GRCm39) missense probably damaging 0.98
R2252:Vmn2r18 UTSW 5 151,508,441 (GRCm39) missense possibly damaging 0.59
R2265:Vmn2r18 UTSW 5 151,510,127 (GRCm39) missense probably damaging 1.00
R2266:Vmn2r18 UTSW 5 151,510,127 (GRCm39) missense probably damaging 1.00
R2267:Vmn2r18 UTSW 5 151,510,127 (GRCm39) missense probably damaging 1.00
R2843:Vmn2r18 UTSW 5 151,485,749 (GRCm39) missense probably damaging 1.00
R3023:Vmn2r18 UTSW 5 151,485,148 (GRCm39) missense probably benign 0.13
R3694:Vmn2r18 UTSW 5 151,508,033 (GRCm39) missense probably benign 0.00
R3763:Vmn2r18 UTSW 5 151,508,644 (GRCm39) missense probably damaging 1.00
R3816:Vmn2r18 UTSW 5 151,485,148 (GRCm39) missense probably benign 0.13
R4007:Vmn2r18 UTSW 5 151,508,711 (GRCm39) missense probably damaging 0.99
R4152:Vmn2r18 UTSW 5 151,485,730 (GRCm39) missense probably damaging 1.00
R4308:Vmn2r18 UTSW 5 151,508,268 (GRCm39) nonsense probably null
R4362:Vmn2r18 UTSW 5 151,496,368 (GRCm39) missense probably damaging 1.00
R4618:Vmn2r18 UTSW 5 151,508,424 (GRCm39) missense possibly damaging 0.64
R4716:Vmn2r18 UTSW 5 151,485,602 (GRCm39) missense possibly damaging 0.87
R4817:Vmn2r18 UTSW 5 151,508,897 (GRCm39) splice site probably null
R5111:Vmn2r18 UTSW 5 151,485,913 (GRCm39) missense possibly damaging 0.85
R5692:Vmn2r18 UTSW 5 151,485,724 (GRCm39) missense possibly damaging 0.65
R6244:Vmn2r18 UTSW 5 151,508,116 (GRCm39) missense probably damaging 1.00
R6595:Vmn2r18 UTSW 5 151,485,889 (GRCm39) missense probably damaging 1.00
R6997:Vmn2r18 UTSW 5 151,485,338 (GRCm39) missense possibly damaging 0.95
R7227:Vmn2r18 UTSW 5 151,496,264 (GRCm39) missense probably damaging 1.00
R7349:Vmn2r18 UTSW 5 151,485,682 (GRCm39) nonsense probably null
R7506:Vmn2r18 UTSW 5 151,508,485 (GRCm39) missense possibly damaging 0.51
R7590:Vmn2r18 UTSW 5 151,485,194 (GRCm39) missense probably damaging 1.00
R7721:Vmn2r18 UTSW 5 151,510,158 (GRCm39) missense possibly damaging 0.53
R7877:Vmn2r18 UTSW 5 151,508,437 (GRCm39) missense probably damaging 1.00
R7882:Vmn2r18 UTSW 5 151,485,329 (GRCm39) missense probably damaging 1.00
R7984:Vmn2r18 UTSW 5 151,485,526 (GRCm39) missense probably damaging 1.00
R8295:Vmn2r18 UTSW 5 151,508,621 (GRCm39) missense probably damaging 0.97
R8353:Vmn2r18 UTSW 5 151,485,373 (GRCm39) missense probably damaging 1.00
R8453:Vmn2r18 UTSW 5 151,485,373 (GRCm39) missense probably damaging 1.00
R8670:Vmn2r18 UTSW 5 151,485,854 (GRCm39) missense probably damaging 1.00
R8725:Vmn2r18 UTSW 5 151,508,462 (GRCm39) missense probably damaging 0.99
R8727:Vmn2r18 UTSW 5 151,508,462 (GRCm39) missense probably damaging 0.99
R8895:Vmn2r18 UTSW 5 151,485,140 (GRCm39) missense possibly damaging 0.46
R9286:Vmn2r18 UTSW 5 151,499,175 (GRCm39) missense probably benign 0.00
R9339:Vmn2r18 UTSW 5 151,485,132 (GRCm39) missense probably damaging 0.99
Z1176:Vmn2r18 UTSW 5 151,508,498 (GRCm39) missense probably damaging 0.99
Z1187:Vmn2r18 UTSW 5 151,508,497 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGGTGCGCAATCAAACTTGTC -3'
(R):5'- ACCTGAAAGCAGAGATGGTATC -3'

Sequencing Primer
(F):5'- GTGCGCAATCAAACTTGTCAATCC -3'
(R):5'- GCAGAGATGGTATCAGAAGACATC -3'
Posted On 2017-08-16