Mutagenetix > Incidental Mutations

Incidental Mutation 'R6101:Olfr1303'

485235

Institutional Source

Beutler Lab

Gene Symbol

Olfr1303

Ensembl Gene

ENSMUSG00000093804

Gene Name

olfactory receptor 1303

Synonyms

MOR245-7, MOR245-7, Olfr276, GA_x6K02T2N82Q-3465-3764, GA_x6K02T2Q125-72882187-72881249, MOR245-28_p

MMRRC Submission

044251-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.101) question?

Stock #

R6101 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

111812247-111820340 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 111814253 bp

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 158 (F158L)

Ref Sequence

ENSEMBL: ENSMUSP00000149015 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099609] [ENSMUST00000216114]

Predicted Effect

probably benign
Transcript: ENSMUST00000099609
AA Change: F158L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000097204
Gene: ENSMUSG00000093804
AA Change: F158L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	305	2.3e-43	PFAM
Pfam:7TM_GPCR_Srsx	35	302	2.5e-6	PFAM
Pfam:7tm_1	41	287	2.4e-19	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000216114
AA Change: F158L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.2%
20x: 95.0%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam9	A	T	8: 24,970,759	C570S	probably damaging	Het
Adh6b	T	A	3: 138,357,710	I350K	possibly damaging	Het
Ahnak	G	A	19: 9,004,099	V916I	probably benign	Het
Aldh4a1	C	T	4: 139,638,495	P266S	possibly damaging	Het
Arhgap11a	G	A	2: 113,834,874	R460*	probably null	Het
Chl1	A	T	6: 103,693,032	D477V	probably damaging	Het
Clstn3	A	T	6: 124,461,670	L45Q	probably damaging	Het
Cnot7	C	T	8: 40,510,037	R32Q	probably benign	Het
Csrnp1	T	C	9: 119,973,485	D220G	probably damaging	Het
Cyb5a	G	A	18: 84,871,593	R49Q	possibly damaging	Het
Fblim1	G	A	4: 141,584,722	R231C	probably damaging	Het
Glul	T	A	1: 153,906,431	Y137*	probably null	Het
Gm10549	C	A	18: 33,464,305		probably benign	Het
Igha	T	A	12: 113,256,397		probably benign	Het
Kif2b	A	G	11: 91,575,988	S490P	probably benign	Het
Kxd1	A	T	8: 70,519,939	N33K	probably benign	Het
Lrrk2	T	C	15: 91,723,135	I567T	probably benign	Het
Man2a2	T	C	7: 80,367,001	D355G	probably damaging	Het
Map6	T	C	7: 99,268,107	V29A	probably damaging	Het
Mical3	A	T	6: 121,033,710	V437D	probably damaging	Het
Mief1	T	C	15: 80,249,740	Y333H	probably benign	Het
Olfr533	T	A	7: 140,466,519	V106D	probably benign	Het
Olfr917	A	G	9: 38,665,620	S75P	probably damaging	Het
Olfr926	T	C	9: 38,877,308	L44P	possibly damaging	Het
Pak1ip1	T	A	13: 41,004,885	L78Q	probably damaging	Het
Pikfyve	A	G	1: 65,264,345		probably null	Het
Pinlyp	C	T	7: 24,545,980	R5K	possibly damaging	Het
Pkd1l3	A	G	8: 109,640,846	D1225G	probably damaging	Het
Pnmal2	T	A	7: 16,946,568	S492R	probably benign	Het
Postn	A	G	3: 54,372,220		probably null	Het
Ptprq	A	G	10: 107,580,266	Y1724H	possibly damaging	Het
Rpn2	T	A	2: 157,310,188		probably null	Het
Scn5a	A	G	9: 119,522,650	V755A	probably damaging	Het
Slc22a30	T	C	19: 8,337,868		probably null	Het
Specc1l	T	C	10: 75,248,632	S730P	probably damaging	Het
Steap2	T	A	5: 5,675,891	I378F	possibly damaging	Het
Tdrd12	A	T	7: 35,481,133	Y818*	probably null	Het
Thbs4	G	T	13: 92,775,485	Q246K	possibly damaging	Het
Tnfsf10	A	G	3: 27,335,549	Y253C	probably damaging	Het
Tnpo3	G	T	6: 29,588,043	C125*	probably null	Het
Trim58	A	G	11: 58,651,615	N467S	probably benign	Het
Trpm6	C	T	19: 18,853,748	R1326*	probably null	Het
Zc3hav1l	A	G	6: 38,293,077	V279A	probably benign	Het
Zfp618	A	T	4: 63,133,241	Q753L	probably benign	Het
Zfp647	G	A	15: 76,912,085	P125L	probably damaging	Het
Zkscan17	A	T	11: 59,503,575	C67S	probably damaging	Het

Other mutations in Olfr1303

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00163:Olfr1303	APN	2	111813781	utr 3 prime	probably benign
IGL02442:Olfr1303	APN	2	111813991	missense	probably benign	0.26
IGL02563:Olfr1303	APN	2	111813817	missense	probably benign
IGL03064:Olfr1303	APN	2	111814423	missense	possibly damaging	0.86
R0081:Olfr1303	UTSW	2	111813868	missense	probably damaging	1.00
R0139:Olfr1303	UTSW	2	111814354	missense	possibly damaging	0.54
R0624:Olfr1303	UTSW	2	111814711	missense	probably damaging	1.00
R0926:Olfr1303	UTSW	2	111814547	missense	probably damaging	1.00
R1436:Olfr1303	UTSW	2	111814561	missense	probably damaging	1.00
R2099:Olfr1303	UTSW	2	111813832	missense	probably benign	0.18
R5255:Olfr1303	UTSW	2	111814178	missense	probably benign	0.02
R6034:Olfr1303	UTSW	2	111814357	missense	probably damaging	1.00
R6034:Olfr1303	UTSW	2	111814357	missense	probably damaging	1.00
R6385:Olfr1303	UTSW	2	111814619	missense	probably benign
R6489:Olfr1303	UTSW	2	111814060	missense	probably damaging	1.00
R6978:Olfr1303	UTSW	2	111813810	missense	probably benign	0.03
R7410:Olfr1303	UTSW	2	111813926	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- CCACCTGAAGAATGTTTCCAGAC -3'
(R):5'- GGAGGCTGTATCACTCAGATCTTC -3'

Sequencing Primer
(F):5'- GTTTCCAGACACTAAACAAGATGAAG -3'
(R):5'- CTTCTTTATCCATTTAGTTGGTGGAG -3'

Posted On

2017-08-16