|Institutional Source||Beutler Lab|
|Gene Name||chemokine (C-C motif) receptor 4|
|Synonyms||CC CKR-4, Cmkbr4|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R6102 (G1)|
|Chromosomal Location||114490316-114504916 bp(-) (GRCm38)|
|Type of Mutation||splice site (5 bp from exon)|
|DNA Base Change (assembly)||C to T at 114496493 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000062677 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000054414] [ENSMUST00000215425] [ENSMUST00000215959]|
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||97% (65/67)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene results in decreased mortality, decreased tumor necrosis factor production, and decreased IL-1beta production following LPS administration. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ccr4||
(F):5'- TTCTCCAAGACAGAGGCCAG -3'
(R):5'- TTGGGGAAATGAGTCACTCAG -3'
(F):5'- GAGGACACGGCTTCAATTTC -3'
(R):5'- CAGGAAGTCACATACCCT -3'