Incidental Mutation 'R6105:Zfp618'
ID 485458
Institutional Source Beutler Lab
Gene Symbol Zfp618
Ensembl Gene ENSMUSG00000028358
Gene Name zinc finger protein 618
Synonyms Nedd10, 2810040O04Rik, D430033D05Rik, 2810031P15Rik
MMRRC Submission 044255-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.129) question?
Stock # R6105 (G1)
Quality Score 179.009
Status Not validated
Chromosome 4
Chromosomal Location 62883810-63057945 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 63051478 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 753 (Q753L)
Ref Sequence ENSEMBL: ENSMUSP00000103038 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064814] [ENSMUST00000107415]
AlphaFold Q80YY7
Predicted Effect probably benign
Transcript: ENSMUST00000064814
AA Change: Q660L

PolyPhen 2 Score 0.086 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000069275
Gene: ENSMUSG00000028358
AA Change: Q660L

DomainStartEndE-ValueType
ZnF_C2H2 114 136 5.06e-2 SMART
ZnF_C2H2 155 177 8.81e-2 SMART
ZnF_C2H2 243 265 2.91e-2 SMART
low complexity region 288 295 N/A INTRINSIC
ZnF_C2H2 298 320 2.53e-2 SMART
PDB:2BW3|A 377 690 5e-8 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000107415
AA Change: Q753L

PolyPhen 2 Score 0.086 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000103038
Gene: ENSMUSG00000028358
AA Change: Q753L

DomainStartEndE-ValueType
ZnF_C2H2 146 168 5.06e-2 SMART
ZnF_C2H2 187 209 8.81e-2 SMART
ZnF_C2H2 255 277 2.91e-2 SMART
low complexity region 381 388 N/A INTRINSIC
ZnF_C2H2 391 413 2.53e-2 SMART
PDB:2BW3|A 479 783 9e-8 PDB
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 94.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T C 11: 9,347,812 (GRCm39) M3555T probably damaging Het
Adam9 A T 8: 25,460,775 (GRCm39) C570S probably damaging Het
Adh6b T A 3: 138,063,471 (GRCm39) I350K possibly damaging Het
Ahnak G A 19: 8,981,463 (GRCm39) V916I probably benign Het
Aldh4a1 C T 4: 139,365,806 (GRCm39) P266S possibly damaging Het
Cnot7 C T 8: 40,963,078 (GRCm39) R32Q probably benign Het
Cyb5a G A 18: 84,889,718 (GRCm39) R49Q possibly damaging Het
Fbxo6 A T 4: 148,233,979 (GRCm39) I39N probably damaging Het
Glul T A 1: 153,782,177 (GRCm39) Y137* probably null Het
Ipo8 A G 6: 148,700,168 (GRCm39) Y570H probably damaging Het
Kif2b A G 11: 91,466,814 (GRCm39) S490P probably benign Het
Kxd1 A T 8: 70,972,589 (GRCm39) N33K probably benign Het
Man2a2 T C 7: 80,016,749 (GRCm39) D355G probably damaging Het
Map6 T C 7: 98,917,314 (GRCm39) V29A probably damaging Het
Mtmr3 T C 11: 4,435,432 (GRCm39) D1116G probably damaging Het
Or4p23 T A 2: 88,577,184 (GRCm39) H16L probably benign Het
Or8b52 A G 9: 38,576,916 (GRCm39) S75P probably damaging Het
Or8d2b T C 9: 38,788,604 (GRCm39) L44P possibly damaging Het
Pak1ip1 T A 13: 41,158,361 (GRCm39) L78Q probably damaging Het
Phf10 C T 17: 15,174,387 (GRCm39) probably null Het
Pikfyve A G 1: 65,303,504 (GRCm39) probably null Het
Pkd1l3 A G 8: 110,367,478 (GRCm39) D1225G probably damaging Het
Postn A G 3: 54,279,641 (GRCm39) probably null Het
Slc22a30 T C 19: 8,315,232 (GRCm39) probably null Het
Specc1l T C 10: 75,084,466 (GRCm39) S730P probably damaging Het
Steap2 T A 5: 5,725,891 (GRCm39) I378F possibly damaging Het
Sult4a1 T A 15: 83,970,821 (GRCm39) K195* probably null Het
Tgfb1i1 T A 7: 127,847,589 (GRCm39) probably null Het
Thbs4 G T 13: 92,911,993 (GRCm39) Q246K possibly damaging Het
Tnfsf10 A G 3: 27,389,698 (GRCm39) Y253C probably damaging Het
Tnpo3 G T 6: 29,588,042 (GRCm39) C125* probably null Het
Trappc8 A G 18: 20,979,504 (GRCm39) probably null Het
Trpm6 C T 19: 18,831,112 (GRCm39) R1326* probably null Het
Vmn2r19 A C 6: 123,293,054 (GRCm39) E365D possibly damaging Het
Vps18 A G 2: 119,119,543 (GRCm39) Y8C probably damaging Het
Zc3hav1l A G 6: 38,270,012 (GRCm39) V279A probably benign Het
Zfp111 T C 7: 23,902,791 (GRCm39) probably null Het
Zkscan17 A T 11: 59,394,401 (GRCm39) C67S probably damaging Het
Other mutations in Zfp618
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01301:Zfp618 APN 4 63,051,063 (GRCm39) missense probably damaging 1.00
IGL01563:Zfp618 APN 4 62,998,133 (GRCm39) missense probably benign 0.38
IGL01726:Zfp618 APN 4 63,050,872 (GRCm39) missense probably damaging 1.00
IGL02139:Zfp618 APN 4 63,051,773 (GRCm39) missense probably damaging 1.00
IGL02182:Zfp618 APN 4 63,013,798 (GRCm39) splice site probably benign
IGL02533:Zfp618 APN 4 63,007,642 (GRCm39) missense probably damaging 1.00
IGL03231:Zfp618 APN 4 63,012,716 (GRCm39) missense probably damaging 1.00
IGL03257:Zfp618 APN 4 63,050,908 (GRCm39) missense probably damaging 1.00
ANU18:Zfp618 UTSW 4 63,051,063 (GRCm39) missense probably damaging 1.00
IGL03014:Zfp618 UTSW 4 62,998,325 (GRCm39) missense probably damaging 1.00
R0288:Zfp618 UTSW 4 63,051,171 (GRCm39) missense possibly damaging 0.57
R0408:Zfp618 UTSW 4 63,004,809 (GRCm39) missense probably damaging 0.97
R0685:Zfp618 UTSW 4 63,052,011 (GRCm39) missense probably benign 0.21
R1482:Zfp618 UTSW 4 63,033,685 (GRCm39) missense possibly damaging 0.64
R1585:Zfp618 UTSW 4 63,051,175 (GRCm39) missense probably damaging 1.00
R1649:Zfp618 UTSW 4 63,013,774 (GRCm39) missense probably damaging 1.00
R1744:Zfp618 UTSW 4 63,004,871 (GRCm39) splice site probably benign
R1793:Zfp618 UTSW 4 63,051,474 (GRCm39) missense probably damaging 0.97
R1952:Zfp618 UTSW 4 63,050,555 (GRCm39) splice site probably null
R1996:Zfp618 UTSW 4 63,049,452 (GRCm39) splice site probably null
R3792:Zfp618 UTSW 4 63,033,728 (GRCm39) intron probably benign
R3803:Zfp618 UTSW 4 63,051,256 (GRCm39) missense probably damaging 1.00
R3821:Zfp618 UTSW 4 63,051,801 (GRCm39) missense probably benign 0.00
R3838:Zfp618 UTSW 4 63,051,801 (GRCm39) missense probably benign 0.00
R4009:Zfp618 UTSW 4 63,051,801 (GRCm39) missense probably benign 0.00
R4010:Zfp618 UTSW 4 63,051,801 (GRCm39) missense probably benign 0.00
R4565:Zfp618 UTSW 4 63,039,588 (GRCm39) missense probably damaging 1.00
R4611:Zfp618 UTSW 4 63,051,216 (GRCm39) missense probably damaging 1.00
R5019:Zfp618 UTSW 4 63,021,789 (GRCm39) missense probably damaging 1.00
R5154:Zfp618 UTSW 4 63,051,446 (GRCm39) missense probably damaging 1.00
R5183:Zfp618 UTSW 4 63,017,519 (GRCm39) missense probably benign
R5354:Zfp618 UTSW 4 62,998,265 (GRCm39) missense probably damaging 1.00
R5383:Zfp618 UTSW 4 63,013,729 (GRCm39) missense probably benign 0.33
R5774:Zfp618 UTSW 4 63,050,799 (GRCm39) missense probably damaging 1.00
R5932:Zfp618 UTSW 4 63,036,803 (GRCm39) nonsense probably null
R6101:Zfp618 UTSW 4 63,051,478 (GRCm39) missense probably benign 0.09
R6478:Zfp618 UTSW 4 63,050,943 (GRCm39) missense probably damaging 1.00
R6598:Zfp618 UTSW 4 63,007,636 (GRCm39) missense probably damaging 1.00
R7386:Zfp618 UTSW 4 63,013,622 (GRCm39) critical splice donor site probably null
R7666:Zfp618 UTSW 4 63,050,954 (GRCm39) nonsense probably null
R7678:Zfp618 UTSW 4 63,004,858 (GRCm39) missense probably benign 0.07
R7975:Zfp618 UTSW 4 63,049,352 (GRCm39) missense possibly damaging 0.93
R8276:Zfp618 UTSW 4 63,051,193 (GRCm39) missense probably damaging 1.00
R8421:Zfp618 UTSW 4 63,051,483 (GRCm39) missense probably damaging 1.00
R8988:Zfp618 UTSW 4 63,012,708 (GRCm39) missense probably benign 0.09
R9022:Zfp618 UTSW 4 63,012,687 (GRCm39) missense probably damaging 1.00
R9150:Zfp618 UTSW 4 63,039,603 (GRCm39) nonsense probably null
R9163:Zfp618 UTSW 4 63,051,511 (GRCm39) missense probably damaging 1.00
R9364:Zfp618 UTSW 4 63,036,824 (GRCm39) missense probably damaging 0.99
R9382:Zfp618 UTSW 4 63,051,258 (GRCm39) missense probably damaging 0.97
R9424:Zfp618 UTSW 4 63,051,282 (GRCm39) missense probably benign 0.00
R9462:Zfp618 UTSW 4 63,051,510 (GRCm39) missense possibly damaging 0.94
R9576:Zfp618 UTSW 4 63,051,282 (GRCm39) missense probably benign 0.00
R9587:Zfp618 UTSW 4 63,051,916 (GRCm39) missense
X0011:Zfp618 UTSW 4 62,998,243 (GRCm39) missense probably damaging 0.99
Z1176:Zfp618 UTSW 4 63,051,000 (GRCm39) missense probably benign 0.12
Z1176:Zfp618 UTSW 4 63,013,734 (GRCm39) missense probably benign 0.29
Predicted Primers PCR Primer
(F):5'- CAAGGAGACCTTTGGCTCTCTG -3'
(R):5'- TGCTGAGGATCCAGGATCATG -3'

Sequencing Primer
(F):5'- TGGAACTCAGTGACGGACTC -3'
(R):5'- ATCCAGGATCATGGCCACCTTG -3'
Posted On 2017-08-16