Incidental Mutation 'R6105:Zc3hav1l'
ID485464
Institutional Source Beutler Lab
Gene Symbol Zc3hav1l
Ensembl Gene ENSMUSG00000047749
Gene Namezinc finger CCCH-type, antiviral 1-like
SynonymsE430016P22Rik, B130055L09Rik
MMRRC Submission 044255-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R6105 (G1)
Quality Score204.009
Status Not validated
Chromosome6
Chromosomal Location38287396-38299259 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 38293077 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 279 (V279A)
Ref Sequence ENSEMBL: ENSMUSP00000062475 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058524]
Predicted Effect probably benign
Transcript: ENSMUST00000058524
AA Change: V279A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000062475
Gene: ENSMUSG00000047749
AA Change: V279A

DomainStartEndE-ValueType
low complexity region 63 81 N/A INTRINSIC
internal_repeat_1 106 133 4.92e-5 PROSPERO
internal_repeat_1 193 220 4.92e-5 PROSPERO
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 94.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T C 11: 9,397,812 M3555T probably damaging Het
Adam9 A T 8: 24,970,759 C570S probably damaging Het
Adh6b T A 3: 138,357,710 I350K possibly damaging Het
Ahnak G A 19: 9,004,099 V916I probably benign Het
Aldh4a1 C T 4: 139,638,495 P266S possibly damaging Het
Cnot7 C T 8: 40,510,037 R32Q probably benign Het
Cyb5a G A 18: 84,871,593 R49Q possibly damaging Het
Fbxo6 A T 4: 148,149,522 I39N probably damaging Het
Glul T A 1: 153,906,431 Y137* probably null Het
Ipo8 A G 6: 148,798,670 Y570H probably damaging Het
Kif2b A G 11: 91,575,988 S490P probably benign Het
Kxd1 A T 8: 70,519,939 N33K probably benign Het
Man2a2 T C 7: 80,367,001 D355G probably damaging Het
Map6 T C 7: 99,268,107 V29A probably damaging Het
Mtmr3 T C 11: 4,485,432 D1116G probably damaging Het
Olfr1198 T A 2: 88,746,840 H16L probably benign Het
Olfr917 A G 9: 38,665,620 S75P probably damaging Het
Olfr926 T C 9: 38,877,308 L44P possibly damaging Het
Pak1ip1 T A 13: 41,004,885 L78Q probably damaging Het
Phf10 C T 17: 14,954,125 probably null Het
Pikfyve A G 1: 65,264,345 probably null Het
Pkd1l3 A G 8: 109,640,846 D1225G probably damaging Het
Postn A G 3: 54,372,220 probably null Het
Slc22a30 T C 19: 8,337,868 probably null Het
Specc1l T C 10: 75,248,632 S730P probably damaging Het
Steap2 T A 5: 5,675,891 I378F possibly damaging Het
Sult4a1 T A 15: 84,086,620 K195* probably null Het
Tgfb1i1 T A 7: 128,248,417 probably null Het
Thbs4 G T 13: 92,775,485 Q246K possibly damaging Het
Tnfsf10 A G 3: 27,335,549 Y253C probably damaging Het
Tnpo3 G T 6: 29,588,043 C125* probably null Het
Trappc8 A G 18: 20,846,447 probably null Het
Trpm6 C T 19: 18,853,748 R1326* probably null Het
Vmn2r19 A C 6: 123,316,095 E365D possibly damaging Het
Vps18 A G 2: 119,289,062 Y8C probably damaging Het
Zfp111 T C 7: 24,203,366 probably null Het
Zfp618 A T 4: 63,133,241 Q753L probably benign Het
Zkscan17 A T 11: 59,503,575 C67S probably damaging Het
Other mutations in Zc3hav1l
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0070:Zc3hav1l UTSW 6 38295190 missense probably damaging 1.00
R0070:Zc3hav1l UTSW 6 38295190 missense probably damaging 1.00
R1833:Zc3hav1l UTSW 6 38297946 splice site probably benign
R3718:Zc3hav1l UTSW 6 38295125 missense probably damaging 1.00
R6034:Zc3hav1l UTSW 6 38295280 missense probably damaging 1.00
R6034:Zc3hav1l UTSW 6 38295280 missense probably damaging 1.00
R6101:Zc3hav1l UTSW 6 38293077 missense probably benign
R7315:Zc3hav1l UTSW 6 38295147 missense possibly damaging 0.94
R7352:Zc3hav1l UTSW 6 38298981 missense probably benign 0.03
R8021:Zc3hav1l UTSW 6 38297947 splice site probably benign
Predicted Primers PCR Primer
(F):5'- TGCCAATGATACTAAGTGAGGG -3'
(R):5'- GTGGGCAAACTGGTTTTAGC -3'

Sequencing Primer
(F):5'- GAGAGAAAGACCGGCTAAAAACTGC -3'
(R):5'- CATGTTGCTTCCAACAACG -3'
Posted On2017-08-16