Mutagenetix > Incidental Mutation

Incidental Mutation 'R6120:Vmn2r115'

485738

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r115

Ensembl Gene

ENSMUSG00000091076

Gene Name

vomeronasal 2, receptor 115

Synonyms

V2Rp4, EG638102

MMRRC Submission

044268-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.094) question?

Stock #

R6120 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

23562951-23579102 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 23565003 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Arginine at position 297 (W297R)

Ref Sequence

ENSEMBL: ENSMUSP00000131447 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168175]

AlphaFold

E9Q0E7

Predicted Effect

probably damaging
Transcript: ENSMUST00000168175
AA Change: W297R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000131447
Gene: ENSMUSG00000091076
AA Change: W297R

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	1.4e-28	PFAM
Pfam:NCD3G	512	565	2.9e-20	PFAM
Pfam:7tm_3	598	833	5e-55	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.3%
20x: 95.6%

Validation Efficiency

98% (55/56)

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921524L21Rik	T	A	18: 6,638,795 (GRCm39)	V398E	possibly damaging	Het
Ankef1	A	G	2: 136,392,296 (GRCm39)	N495S	probably benign	Het
Bpifb3	G	T	2: 153,773,363 (GRCm39)	V428L	probably benign	Het
Btd	G	A	14: 31,363,065 (GRCm39)		probably benign	Het
Ccdc178	A	G	18: 22,230,785 (GRCm39)	L362S	probably benign	Het
Ccdc33	G	A	9: 57,993,883 (GRCm39)	P88S	probably damaging	Het
Cdk14	A	T	5: 4,944,029 (GRCm39)	D385E	probably damaging	Het
Chrna4	A	G	2: 180,666,599 (GRCm39)	L613P	probably damaging	Het
Cnot3	T	A	7: 3,648,335 (GRCm39)		probably null	Het
Csf1	T	A	3: 107,661,170 (GRCm39)	I116L	probably damaging	Het
Csrp2	G	T	10: 110,775,140 (GRCm39)	A192S	probably benign	Het
Dnah9	T	C	11: 66,038,225 (GRCm39)	T104A	probably benign	Het
Eml1	C	T	12: 108,493,983 (GRCm39)	P593S	probably damaging	Het
Entpd2	T	A	2: 25,289,478 (GRCm39)	I320N	probably benign	Het
Exosc9	A	T	3: 36,608,821 (GRCm39)	N140I	probably damaging	Het
Fam186a	T	C	15: 99,838,244 (GRCm39)	T2667A	probably benign	Het
Fes	T	C	7: 80,030,615 (GRCm39)	D558G	probably damaging	Het
Fgfr2	G	T	7: 129,830,420 (GRCm39)	T186K	probably benign	Het
Fnip1	A	G	11: 54,400,826 (GRCm39)	E1075G	probably benign	Het
Gbf1	A	G	19: 46,267,760 (GRCm39)	I1203V	possibly damaging	Het
Gja1	T	A	10: 56,264,601 (GRCm39)	M320K	probably benign	Het
Gm5431	A	G	11: 48,785,608 (GRCm39)	Y256H	probably benign	Het
Gpr20	C	T	15: 73,567,853 (GRCm39)	V179M	probably damaging	Het
Greb1	T	G	12: 16,758,622 (GRCm39)	D698A	probably damaging	Het
Hook2	A	G	8: 85,724,754 (GRCm39)	E500G	probably damaging	Het
Kif13b	A	T	14: 64,989,007 (GRCm39)	N796I	probably damaging	Het
Kif1a	C	T	1: 92,952,296 (GRCm39)		probably null	Het
Lama1	T	C	17: 68,087,612 (GRCm39)		probably null	Het
Mfsd1	C	T	3: 67,501,718 (GRCm39)	Q246*	probably null	Het
Mkrn3	A	G	7: 62,069,282 (GRCm39)	S170P	probably benign	Het
Ms4a6b	A	G	19: 11,499,059 (GRCm39)	M58V	probably benign	Het
Muc4	T	C	16: 32,577,169 (GRCm39)	V2223A	unknown	Het
Mycbp2	A	T	14: 103,513,323 (GRCm39)	V811D	probably benign	Het
Or5p59	A	T	7: 107,703,340 (GRCm39)	N275Y	probably damaging	Het
Or6c215	G	A	10: 129,637,689 (GRCm39)	A235V	probably damaging	Het
Or6c215	C	A	10: 129,637,690 (GRCm39)	A235S	probably damaging	Het
Or9g4b	T	C	2: 85,616,685 (GRCm39)	F277L	probably damaging	Het
Pcsk2	A	G	2: 143,643,031 (GRCm39)	E436G	probably damaging	Het
Pet100	T	G	8: 3,671,764 (GRCm39)		probably null	Het
Pira2	A	G	7: 3,844,553 (GRCm39)	Y493H	probably damaging	Het
Prkdc	C	A	16: 15,557,335 (GRCm39)	R2213S	probably benign	Het
Prmt2	A	G	10: 76,045,280 (GRCm39)	I342T	possibly damaging	Het
Psmc6	A	G	14: 45,586,130 (GRCm39)	E381G	possibly damaging	Het
Rrm1	G	A	7: 102,110,063 (GRCm39)		probably null	Het
Sema3c	A	G	5: 17,932,630 (GRCm39)	D711G	probably benign	Het
Sgcb	T	C	5: 73,798,153 (GRCm39)	E103G	possibly damaging	Het
Sh3pxd2a	A	G	19: 47,255,848 (GRCm39)	S957P	probably damaging	Het
Slc26a2	A	G	18: 61,332,489 (GRCm39)	V314A	possibly damaging	Het
Smarca5	G	T	8: 81,438,372 (GRCm39)	H655N	probably damaging	Het
Sspo	T	A	6: 48,442,510 (GRCm39)	S2002T	probably damaging	Het
Sync	T	C	4: 129,187,544 (GRCm39)	L192P	probably damaging	Het
Ush2a	T	C	1: 188,090,800 (GRCm39)	M477T	probably benign	Het
Vav3	C	T	3: 109,571,681 (GRCm39)	T201M	probably damaging	Het
Vcam1	A	G	3: 115,918,049 (GRCm39)	V304A	probably damaging	Het
Vmn2r120	T	A	17: 57,832,973 (GRCm39)	M69L	probably benign	Het
Wdr11	A	G	7: 129,226,515 (GRCm39)	D771G	probably damaging	Het

Other mutations in Vmn2r115

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r115	APN	17	23,575,934 (GRCm39)	missense	probably benign	0.00
IGL00990:Vmn2r115	APN	17	23,565,345 (GRCm39)	nonsense	probably null
IGL00990:Vmn2r115	APN	17	23,578,371 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,565,135 (GRCm39)	missense	probably benign	0.03
IGL00990:Vmn2r115	APN	17	23,565,252 (GRCm39)	missense	probably benign	0.14
IGL00990:Vmn2r115	APN	17	23,565,313 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,578,323 (GRCm39)	missense	probably benign	0.22
IGL00990:Vmn2r115	APN	17	23,565,150 (GRCm39)	missense	probably benign	0.00
IGL00990:Vmn2r115	APN	17	23,565,180 (GRCm39)	missense	possibly damaging	0.90
IGL00990:Vmn2r115	APN	17	23,567,008 (GRCm39)	nonsense	probably null
IGL00990:Vmn2r115	APN	17	23,578,798 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,578,753 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,565,238 (GRCm39)	missense	probably benign	0.19
IGL00990:Vmn2r115	APN	17	23,565,346 (GRCm39)	missense	probably benign	0.30
IGL01073:Vmn2r115	APN	17	23,564,971 (GRCm39)	missense	probably benign	0.12
IGL01101:Vmn2r115	APN	17	23,564,971 (GRCm39)	missense	probably benign	0.12
IGL01300:Vmn2r115	APN	17	23,578,755 (GRCm39)	missense	probably damaging	1.00
IGL01415:Vmn2r115	APN	17	23,578,755 (GRCm39)	missense	probably damaging	1.00
IGL02309:Vmn2r115	APN	17	23,564,113 (GRCm39)	missense	probably benign	0.01
IGL02863:Vmn2r115	APN	17	23,578,257 (GRCm39)	missense	probably damaging	0.97
R0023:Vmn2r115	UTSW	17	23,565,252 (GRCm39)	missense	probably benign	0.14
R0197:Vmn2r115	UTSW	17	23,578,755 (GRCm39)	missense	probably damaging	1.00
R0361:Vmn2r115	UTSW	17	23,564,196 (GRCm39)	missense	probably benign	0.11
R0601:Vmn2r115	UTSW	17	23,579,074 (GRCm39)	missense	probably null	0.51
R0676:Vmn2r115	UTSW	17	23,565,238 (GRCm39)	missense	probably benign	0.19
R0685:Vmn2r115	UTSW	17	23,578,249 (GRCm39)	missense	probably benign
R0865:Vmn2r115	UTSW	17	23,565,382 (GRCm39)	missense	possibly damaging	0.65
R1124:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1145:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1146:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1207:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1266:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1318:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1367:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1376:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1376:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1420:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1469:Vmn2r115	UTSW	17	23,564,992 (GRCm39)	missense	probably damaging	0.99
R1469:Vmn2r115	UTSW	17	23,564,992 (GRCm39)	missense	probably damaging	0.99
R1604:Vmn2r115	UTSW	17	23,564,245 (GRCm39)	missense	probably benign	0.12
R1645:Vmn2r115	UTSW	17	23,565,192 (GRCm39)	missense	possibly damaging	0.69
R1646:Vmn2r115	UTSW	17	23,578,513 (GRCm39)	missense	probably damaging	1.00
R1650:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1678:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1716:Vmn2r115	UTSW	17	23,566,795 (GRCm39)	missense	probably benign
R1846:Vmn2r115	UTSW	17	23,578,357 (GRCm39)	missense	probably damaging	1.00
R1847:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1885:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1887:Vmn2r115	UTSW	17	23,565,007 (GRCm39)	missense	possibly damaging	0.91
R1937:Vmn2r115	UTSW	17	23,578,388 (GRCm39)	missense	probably damaging	1.00
R2007:Vmn2r115	UTSW	17	23,566,927 (GRCm39)	missense	possibly damaging	0.94
R2120:Vmn2r115	UTSW	17	23,578,297 (GRCm39)	missense	probably damaging	1.00
R3161:Vmn2r115	UTSW	17	23,575,998 (GRCm39)	missense	possibly damaging	0.82
R3780:Vmn2r115	UTSW	17	23,564,146 (GRCm39)	missense	probably damaging	1.00
R3806:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R3982:Vmn2r115	UTSW	17	23,578,948 (GRCm39)	missense	probably damaging	1.00
R4019:Vmn2r115	UTSW	17	23,579,017 (GRCm39)	missense	probably damaging	1.00
R4039:Vmn2r115	UTSW	17	23,564,077 (GRCm39)	missense	probably benign	0.26
R4087:Vmn2r115	UTSW	17	23,565,358 (GRCm39)	missense	probably benign	0.35
R4089:Vmn2r115	UTSW	17	23,565,358 (GRCm39)	missense	probably benign	0.35
R4379:Vmn2r115	UTSW	17	23,564,197 (GRCm39)	missense	possibly damaging	0.95
R4417:Vmn2r115	UTSW	17	23,564,854 (GRCm39)	missense	probably benign	0.02
R4601:Vmn2r115	UTSW	17	23,565,373 (GRCm39)	missense	probably benign	0.01
R4874:Vmn2r115	UTSW	17	23,578,825 (GRCm39)	missense	probably damaging	1.00
R5466:Vmn2r115	UTSW	17	23,579,030 (GRCm39)	missense	probably damaging	1.00
R5613:Vmn2r115	UTSW	17	23,564,307 (GRCm39)	missense	probably benign
R5821:Vmn2r115	UTSW	17	23,566,937 (GRCm39)	missense	probably damaging	0.99
R6193:Vmn2r115	UTSW	17	23,575,983 (GRCm39)	missense	probably benign	0.01
R6213:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R6290:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R6319:Vmn2r115	UTSW	17	23,566,877 (GRCm39)	missense	possibly damaging	0.70
R6495:Vmn2r115	UTSW	17	23,578,572 (GRCm39)	missense	probably benign	0.02
R6599:Vmn2r115	UTSW	17	23,565,006 (GRCm39)	missense	probably benign	0.00
R6764:Vmn2r115	UTSW	17	23,565,046 (GRCm39)	missense	probably damaging	1.00
R6970:Vmn2r115	UTSW	17	23,564,989 (GRCm39)	missense	probably benign	0.23
R7023:Vmn2r115	UTSW	17	23,578,785 (GRCm39)	missense	probably damaging	1.00
R7236:Vmn2r115	UTSW	17	23,578,576 (GRCm39)	missense	probably benign	0.01
R7353:Vmn2r115	UTSW	17	23,564,887 (GRCm39)	missense	possibly damaging	0.65
R7483:Vmn2r115	UTSW	17	23,565,371 (GRCm39)	missense	possibly damaging	0.95
R7743:Vmn2r115	UTSW	17	23,564,772 (GRCm39)	nonsense	probably null
R8005:Vmn2r115	UTSW	17	23,563,124 (GRCm39)	nonsense	probably null
R8191:Vmn2r115	UTSW	17	23,578,530 (GRCm39)	missense	probably damaging	1.00
R8544:Vmn2r115	UTSW	17	23,564,773 (GRCm39)	missense	possibly damaging	0.88
R8890:Vmn2r115	UTSW	17	23,578,497 (GRCm39)	missense	probably damaging	0.98
R9098:Vmn2r115	UTSW	17	23,564,803 (GRCm39)	missense	probably benign
R9114:Vmn2r115	UTSW	17	23,564,307 (GRCm39)	missense	probably benign
R9189:Vmn2r115	UTSW	17	23,564,784 (GRCm39)	missense	probably damaging	1.00
R9351:Vmn2r115	UTSW	17	23,578,482 (GRCm39)	missense	probably benign	0.05
R9397:Vmn2r115	UTSW	17	23,564,152 (GRCm39)	nonsense	probably null
R9410:Vmn2r115	UTSW	17	23,578,915 (GRCm39)	missense	possibly damaging	0.67
R9593:Vmn2r115	UTSW	17	23,578,184 (GRCm39)	missense	probably damaging	0.99
V5622:Vmn2r115	UTSW	17	23,578,333 (GRCm39)	missense	probably benign
V5622:Vmn2r115	UTSW	17	23,565,201 (GRCm39)	missense	probably damaging	1.00
X0023:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
X0033:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign

Predicted Primers

PCR Primer
(F):5'- AGGGTTGGTCATCTCAGACAATG -3'
(R):5'- GCATCCATTCCAGCTTTACCAG -3'

Sequencing Primer
(F):5'- TGGTCATCTCAGACAATGATCAAGG -3'
(R):5'- GATACTCATCTGGGCATTTGACAGAG -3'

Posted On

2017-08-16