Incidental Mutation 'R6123:Tnfsf15'
ID 485820
Institutional Source Beutler Lab
Gene Symbol Tnfsf15
Ensembl Gene ENSMUSG00000050395
Gene Name tumor necrosis factor (ligand) superfamily, member 15
Synonyms TL1A, VEGI, TL1
MMRRC Submission 044270-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R6123 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 63642837-63663296 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 63663162 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 54 (S54G)
Ref Sequence ENSEMBL: ENSMUSP00000050144 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062246]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000062246
AA Change: S54G

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000050144
Gene: ENSMUSG00000050395
AA Change: S54G

DomainStartEndE-ValueType
transmembrane domain 56 78 N/A INTRINSIC
TNF 114 270 1.25e-28 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
PHENOTYPE: Homozygous targeted mutants display decreased clinical severity in experimental autoimmune encephalomyelitis (EAE) and collagen-induced arthritis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot7 A G 4: 152,284,402 (GRCm39) E24G probably benign Het
Ankrd34b A G 13: 92,575,584 (GRCm39) E272G probably damaging Het
Arhgef18 A T 8: 3,487,091 (GRCm39) N270I probably damaging Het
AU040320 A G 4: 126,763,179 (GRCm39) probably benign Het
Btnl10 C A 11: 58,811,130 (GRCm39) S151Y probably damaging Het
Ccdc146 C A 5: 21,510,595 (GRCm39) R504I possibly damaging Het
Ckmt1 C G 2: 121,194,060 (GRCm39) R408G probably benign Het
Clba1 T C 12: 112,774,530 (GRCm39) F153L probably damaging Het
Cyp2j6 A T 4: 96,406,266 (GRCm39) *502R probably null Het
Dido1 A T 2: 180,325,760 (GRCm39) V476E probably benign Het
Dnah2 T C 11: 69,409,185 (GRCm39) K398E probably benign Het
E130308A19Rik A G 4: 59,737,565 (GRCm39) Y392C probably damaging Het
Esf1 T A 2: 140,010,309 (GRCm39) D9V probably benign Het
Fam168a A G 7: 100,473,357 (GRCm39) Q82R probably damaging Het
Fastkd3 C T 13: 68,738,337 (GRCm39) Q32* probably null Het
Gm14496 T A 2: 181,633,020 (GRCm39) M1K probably null Het
Gm6665 A G 18: 31,952,937 (GRCm39) M79T probably benign Het
Gna15 A G 10: 81,345,178 (GRCm39) L229P probably damaging Het
Herc1 A G 9: 66,404,532 (GRCm39) T4451A probably damaging Het
Igf2bp1 A G 11: 95,866,122 (GRCm39) V122A probably damaging Het
Ighv5-4 A T 12: 113,561,313 (GRCm39) S36T probably damaging Het
Ints3 A G 3: 90,320,861 (GRCm39) V186A probably benign Het
Jrk A G 15: 74,578,529 (GRCm39) I252T possibly damaging Het
Kcnh5 T C 12: 75,134,365 (GRCm39) S395G probably benign Het
Kcnt2 C T 1: 140,290,718 (GRCm39) P103S probably damaging Het
Klra10 T C 6: 130,256,339 (GRCm39) K105R probably benign Het
P4ha1 A T 10: 59,186,349 (GRCm39) K276I possibly damaging Het
Pcyox1 A G 6: 86,365,910 (GRCm39) S435P possibly damaging Het
Potegl T C 2: 23,120,134 (GRCm39) Y235H possibly damaging Het
Pramel26 A T 4: 143,539,334 (GRCm39) M53K possibly damaging Het
R3hdm1 A T 1: 128,096,773 (GRCm39) N103I probably damaging Het
Rnf213 T C 11: 119,302,339 (GRCm39) V421A probably damaging Het
Rnpc3 A T 3: 113,402,705 (GRCm39) probably null Het
Scaf11 A G 15: 96,318,335 (GRCm39) S410P probably benign Het
Slc16a1 A G 3: 104,560,510 (GRCm39) T272A probably benign Het
Slco3a1 C T 7: 73,968,254 (GRCm39) D489N probably benign Het
Slitrk3 T C 3: 72,957,095 (GRCm39) D559G probably damaging Het
Sntb2 G A 8: 107,707,857 (GRCm39) G207D probably damaging Het
Spata31f1e A G 4: 42,793,065 (GRCm39) S356P possibly damaging Het
Spdye4a T C 5: 143,211,473 (GRCm39) I30M possibly damaging Het
Thumpd1 A T 7: 119,316,232 (GRCm39) V239E probably damaging Het
Tor1aip1 A G 1: 155,882,951 (GRCm39) I299T probably damaging Het
Tpst2 C T 5: 112,456,084 (GRCm39) R208C probably damaging Het
Tubgcp2 T C 7: 139,587,510 (GRCm39) Y285C probably damaging Het
Vav3 C T 3: 109,571,681 (GRCm39) T201M probably damaging Het
Washc5 A G 15: 59,206,959 (GRCm39) S1105P probably damaging Het
Other mutations in Tnfsf15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00674:Tnfsf15 APN 4 63,652,483 (GRCm39) splice site probably benign
IGL00743:Tnfsf15 APN 4 63,652,518 (GRCm39) missense probably benign 0.00
IGL03189:Tnfsf15 APN 4 63,648,289 (GRCm39) splice site probably benign
R0158:Tnfsf15 UTSW 4 63,648,229 (GRCm39) missense possibly damaging 0.95
R1824:Tnfsf15 UTSW 4 63,651,588 (GRCm39) missense probably benign 0.03
R3122:Tnfsf15 UTSW 4 63,652,522 (GRCm39) missense probably benign 0.00
R4595:Tnfsf15 UTSW 4 63,648,180 (GRCm39) nonsense probably null
R5025:Tnfsf15 UTSW 4 63,648,125 (GRCm39) missense probably benign 0.01
R6376:Tnfsf15 UTSW 4 63,663,267 (GRCm39) missense probably damaging 0.98
R7104:Tnfsf15 UTSW 4 63,647,887 (GRCm39) missense probably damaging 1.00
R7173:Tnfsf15 UTSW 4 63,647,889 (GRCm39) missense probably damaging 1.00
R9448:Tnfsf15 UTSW 4 63,663,305 (GRCm39) missense possibly damaging 0.46
Predicted Primers PCR Primer
(F):5'- ATGGCTCTGTCCCAAACTGG -3'
(R):5'- GGACAGTCATTAACTCACTCAGTG -3'

Sequencing Primer
(F):5'- TGGAATACACAGCTGCCTG -3'
(R):5'- ACTCAGTGTGACAGCTGCTC -3'
Posted On 2017-08-16