Incidental Mutation 'R6092:Zfp109'
ID 485984
Institutional Source Beutler Lab
Gene Symbol Zfp109
Ensembl Gene ENSMUSG00000074283
Gene Name zinc finger protein 109
Synonyms
MMRRC Submission 044249-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R6092 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 23926997-23936985 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 23928978 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 152 (S152P)
Ref Sequence ENSEMBL: ENSMUSP00000145925 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037448] [ENSMUST00000206362] [ENSMUST00000206960]
AlphaFold A0A0U1RPC5
Predicted Effect probably benign
Transcript: ENSMUST00000037448
AA Change: S144P

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000045498
Gene: ENSMUSG00000074283
AA Change: S144P

DomainStartEndE-ValueType
KRAB 8 74 8.77e-20 SMART
ZnF_C2H2 283 305 2.91e-2 SMART
ZnF_C2H2 311 333 4.47e-3 SMART
ZnF_C2H2 339 361 4.11e-2 SMART
ZnF_C2H2 367 387 5.54e1 SMART
ZnF_C2H2 393 415 1.98e-4 SMART
ZnF_C2H2 421 443 8.67e-1 SMART
ZnF_C2H2 449 471 4.87e-4 SMART
ZnF_C2H2 477 499 7.49e-5 SMART
ZnF_C2H2 505 527 1.47e-3 SMART
ZnF_C2H2 533 555 3.21e-4 SMART
ZnF_C2H2 561 583 8.47e-4 SMART
ZnF_C2H2 589 611 2.57e-3 SMART
ZnF_C2H2 617 639 4.4e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000206362
AA Change: S144P

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Predicted Effect possibly damaging
Transcript: ENSMUST00000206960
AA Change: S152P

PolyPhen 2 Score 0.572 (Sensitivity: 0.88; Specificity: 0.91)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.1%
Validation Efficiency 98% (61/62)
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik C T 3: 137,774,701 (GRCm39) P1297S probably benign Het
4930486L24Rik C T 13: 61,001,461 (GRCm39) V89M probably benign Het
Abhd16a T C 17: 35,317,786 (GRCm39) probably null Het
Abtb1 A C 6: 88,815,433 (GRCm39) C264G probably benign Het
Ank3 G A 10: 69,838,395 (GRCm39) R1566K possibly damaging Het
Arid1a C T 4: 133,421,163 (GRCm39) G881R unknown Het
Asb8 A G 15: 98,034,123 (GRCm39) V144A possibly damaging Het
Atm A C 9: 53,435,714 (GRCm39) C199G probably damaging Het
Atxn1 C A 13: 45,720,288 (GRCm39) V536L probably benign Het
Baz1a C T 12: 54,955,868 (GRCm39) V1074M possibly damaging Het
BC034090 T A 1: 155,100,659 (GRCm39) D535V probably damaging Het
Casp8ap2 C A 4: 32,639,380 (GRCm39) H145N probably damaging Het
Ccdc24 T A 4: 117,729,645 (GRCm39) K25* probably null Het
Ccdc91 A G 6: 147,437,114 (GRCm39) N100S possibly damaging Het
Cdh20 A T 1: 110,026,036 (GRCm39) Y424F probably benign Het
Clasp1 T C 1: 118,438,028 (GRCm39) S612P probably damaging Het
Cxcl14 T C 13: 56,443,646 (GRCm39) M55V possibly damaging Het
Dnah11 T C 12: 117,892,191 (GRCm39) T3661A probably benign Het
Dnah14 T A 1: 181,449,398 (GRCm39) D574E probably benign Het
Dnah6 C T 6: 73,091,680 (GRCm39) V2204M possibly damaging Het
Ercc4 A T 16: 12,943,125 (GRCm39) H178L probably benign Het
Far2 T C 6: 148,076,581 (GRCm39) F475L probably benign Het
Ggt7 A G 2: 155,359,959 (GRCm39) probably null Het
Gm4131 T A 14: 62,718,364 (GRCm39) T81S possibly damaging Het
Gprc6a A G 10: 51,491,173 (GRCm39) S788P probably damaging Het
Hmgxb3 C A 18: 61,270,672 (GRCm39) G884V possibly damaging Het
Homer1 T A 13: 93,502,945 (GRCm39) probably benign Het
Iars1 T C 13: 49,861,897 (GRCm39) S483P probably damaging Het
Kansl1l C G 1: 66,812,643 (GRCm39) E457Q probably damaging Het
Krtap4-9 G A 11: 99,676,481 (GRCm39) probably benign Het
Lepr C A 4: 101,649,220 (GRCm39) P874T probably damaging Het
Mad2l2 T A 4: 148,228,067 (GRCm39) F100L probably damaging Het
Mavs A T 2: 131,087,518 (GRCm39) R339* probably null Het
Mettl1 G A 10: 126,877,843 (GRCm39) probably benign Het
Mfsd8 A G 3: 40,774,031 (GRCm39) V493A possibly damaging Het
Mtmr9 C T 14: 63,779,901 (GRCm39) V63M possibly damaging Het
Mto1 T C 9: 78,368,131 (GRCm39) I425T possibly damaging Het
Or2av9 A T 11: 58,380,900 (GRCm39) M227K probably damaging Het
Or5g29 A G 2: 85,420,950 (GRCm39) Y22C probably benign Het
Or8b36 ATTGCTGTTT ATTGCTGTTTGCTGTTT 9: 37,937,836 (GRCm39) probably null Het
Pclo C T 5: 14,727,937 (GRCm39) probably benign Het
Phf2 T C 13: 48,969,533 (GRCm39) D608G unknown Het
Plch2 T C 4: 155,068,829 (GRCm39) T1266A probably benign Het
Prdm12 A G 2: 31,533,889 (GRCm39) N169D probably damaging Het
Rimbp3 A G 16: 17,030,134 (GRCm39) Y1186C probably damaging Het
Serpinb3d T C 1: 107,006,989 (GRCm39) M240V probably damaging Het
Slc25a38 C T 9: 119,945,658 (GRCm39) R74C probably damaging Het
Slc25a39 A T 11: 102,295,719 (GRCm39) Y109* probably null Het
Slc26a8 T C 17: 28,867,129 (GRCm39) N564S probably damaging Het
Spag4 G A 2: 155,907,696 (GRCm39) probably benign Het
Stx1b A G 7: 127,407,035 (GRCm39) M74T possibly damaging Het
Tbc1d1 A G 5: 64,507,242 (GRCm39) D1153G probably benign Het
Tert T C 13: 73,776,700 (GRCm39) F484L probably benign Het
Tet1 A G 10: 62,649,494 (GRCm39) V72A probably benign Het
Tnfrsf13c T C 15: 82,107,355 (GRCm39) T147A probably damaging Het
Trpa1 A T 1: 14,959,710 (GRCm39) Y659N probably damaging Het
Trpm2 A G 10: 77,761,516 (GRCm39) F1045L probably benign Het
Ttc13 T C 8: 125,405,772 (GRCm39) H529R probably benign Het
Ttn T C 2: 76,545,614 (GRCm39) T32570A probably damaging Het
Uba7 A G 9: 107,860,359 (GRCm39) T892A possibly damaging Het
Uty A T Y: 1,174,836 (GRCm39) M195K probably benign Het
Zfp532 T C 18: 65,777,281 (GRCm39) V846A probably damaging Het
Zfp658 A T 7: 43,223,951 (GRCm39) H742L possibly damaging Het
Zfp831 C A 2: 174,547,299 (GRCm39) P1494Q probably damaging Het
Other mutations in Zfp109
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00646:Zfp109 APN 7 23,928,237 (GRCm39) nonsense probably null
IGL01082:Zfp109 APN 7 23,933,784 (GRCm39) missense probably damaging 1.00
IGL02129:Zfp109 APN 7 23,936,054 (GRCm39) missense possibly damaging 0.76
PIT4585001:Zfp109 UTSW 7 23,928,779 (GRCm39) missense probably benign 0.35
R0319:Zfp109 UTSW 7 23,933,895 (GRCm39) missense probably damaging 1.00
R1502:Zfp109 UTSW 7 23,927,588 (GRCm39) missense probably damaging 1.00
R1912:Zfp109 UTSW 7 23,927,676 (GRCm39) missense probably damaging 0.97
R1930:Zfp109 UTSW 7 23,928,161 (GRCm39) missense probably damaging 1.00
R1931:Zfp109 UTSW 7 23,928,161 (GRCm39) missense probably damaging 1.00
R1994:Zfp109 UTSW 7 23,928,743 (GRCm39) missense probably benign 0.04
R2105:Zfp109 UTSW 7 23,936,041 (GRCm39) critical splice donor site probably null
R2219:Zfp109 UTSW 7 23,927,886 (GRCm39) missense probably damaging 1.00
R2353:Zfp109 UTSW 7 23,928,806 (GRCm39) missense probably benign 0.06
R3754:Zfp109 UTSW 7 23,929,181 (GRCm39) missense probably benign 0.34
R4434:Zfp109 UTSW 7 23,928,771 (GRCm39) missense probably benign 0.02
R4884:Zfp109 UTSW 7 23,928,570 (GRCm39) missense probably benign 0.06
R5056:Zfp109 UTSW 7 23,928,162 (GRCm39) missense possibly damaging 0.75
R5220:Zfp109 UTSW 7 23,928,179 (GRCm39) missense probably benign 0.03
R5472:Zfp109 UTSW 7 23,928,046 (GRCm39) nonsense probably null
R5715:Zfp109 UTSW 7 23,928,995 (GRCm39) missense possibly damaging 0.92
R5801:Zfp109 UTSW 7 23,928,126 (GRCm39) missense probably damaging 0.99
R6093:Zfp109 UTSW 7 23,928,558 (GRCm39) missense probably benign 0.03
R6334:Zfp109 UTSW 7 23,928,308 (GRCm39) missense probably damaging 0.96
R6458:Zfp109 UTSW 7 23,927,870 (GRCm39) missense probably benign 0.01
R6856:Zfp109 UTSW 7 23,928,823 (GRCm39) missense probably benign 0.03
R6879:Zfp109 UTSW 7 23,928,615 (GRCm39) missense probably benign 0.02
R7069:Zfp109 UTSW 7 23,928,785 (GRCm39) missense probably benign 0.01
R7151:Zfp109 UTSW 7 23,929,231 (GRCm39) missense probably benign 0.01
R7822:Zfp109 UTSW 7 23,928,570 (GRCm39) missense probably benign 0.06
R8205:Zfp109 UTSW 7 23,928,635 (GRCm39) missense probably damaging 0.99
R8492:Zfp109 UTSW 7 23,927,499 (GRCm39) missense possibly damaging 0.79
Z1088:Zfp109 UTSW 7 23,928,360 (GRCm39) missense probably benign 0.08
Z1177:Zfp109 UTSW 7 23,928,212 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTATCAAAGTCACTGTTGCTCTGG -3'
(R):5'- GCCATGATGCCAACAAGCTG -3'

Sequencing Primer
(F):5'- GGCCTTTGTCTCCTTTATGCAGTG -3'
(R):5'- TGGCCAGAGCTCCAGAAG -3'
Posted On 2017-08-16