Incidental Mutation 'R6090:Or5t18'
ID 486128
Institutional Source Beutler Lab
Gene Symbol Or5t18
Ensembl Gene ENSMUSG00000078420
Gene Name olfactory receptor family 5 subfamily T member 18
Synonyms MOR179-5, K17, GA_x6K02T2Q125-48299679-48298702, Olfr141
MMRRC Submission 044247-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R6090 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 86636365-86637341 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 86636701 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glycine at position 214 (V214G)
Gene Model predicted gene model for transcript(s): [ENSMUST00000216117]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000105212
AA Change: V214G

PolyPhen 2 Score 0.851 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000100847
Gene: ENSMUSG00000078420
AA Change: V214G

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 3.3e-48 PFAM
Pfam:7tm_1 39 288 2.7e-18 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216117
AA Change: V214G

PolyPhen 2 Score 0.736 (Sensitivity: 0.85; Specificity: 0.92)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.8%
  • 20x: 93.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m C T 6: 121,624,972 (GRCm39) A450V probably benign Het
Abca8a T C 11: 109,954,048 (GRCm39) probably null Het
Adgrl3 A T 5: 81,660,173 (GRCm39) N246I probably damaging Het
Bmal2 T A 6: 146,731,194 (GRCm39) S500T possibly damaging Het
Cdipt A T 7: 126,576,131 (GRCm39) M29L possibly damaging Het
Chml G T 1: 175,514,624 (GRCm39) Y432* probably null Het
Clasp2 G T 9: 113,681,803 (GRCm39) V320L probably benign Het
Col12a1 G A 9: 79,599,675 (GRCm39) T826M probably damaging Het
Cpsf3 A G 12: 21,345,194 (GRCm39) I169V probably damaging Het
Dhx36 G A 3: 62,404,241 (GRCm39) T234M probably damaging Het
Dhx57 A G 17: 80,571,375 (GRCm39) probably null Het
Dnah1 A T 14: 30,991,382 (GRCm39) I3132N possibly damaging Het
Fbxw20 G T 9: 109,052,431 (GRCm39) Q231K probably benign Het
Gfod1 G T 13: 43,354,437 (GRCm39) Y179* probably null Het
Glg1 T A 8: 111,907,667 (GRCm39) I510F probably damaging Het
Gm10801 TC TCGGC 2: 98,494,151 (GRCm39) probably benign Het
Gse1 C A 8: 121,297,908 (GRCm39) probably benign Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Klrd1 T C 6: 129,572,499 (GRCm39) L97P probably damaging Het
Lgmn A T 12: 102,366,413 (GRCm39) M240K probably damaging Het
Lrp1b A G 2: 41,075,880 (GRCm39) probably null Het
Notch2 A T 3: 98,042,693 (GRCm39) R1353* probably null Het
Or2d2b A G 7: 106,705,456 (GRCm39) V204A possibly damaging Het
Pcdhb14 G A 18: 37,581,659 (GRCm39) S255N probably benign Het
Pcgf2 C T 11: 97,581,817 (GRCm39) M25I possibly damaging Het
Poll G T 19: 45,544,436 (GRCm39) D328E probably benign Het
Pomgnt2 A T 9: 121,811,863 (GRCm39) L306Q probably damaging Het
Proser1 A T 3: 53,386,088 (GRCm39) M657L probably benign Het
Rbm47 G C 5: 66,183,626 (GRCm39) R326G probably damaging Het
Rdh11 G T 12: 79,235,838 (GRCm39) P37T probably benign Het
Rsph10b A T 5: 143,913,946 (GRCm39) I286L probably benign Het
Septin4 G A 11: 87,480,343 (GRCm39) R238K possibly damaging Het
Sptan1 C T 2: 29,883,899 (GRCm39) R580C probably damaging Het
Stard9 T A 2: 120,524,135 (GRCm39) W777R probably damaging Het
Timd2 T C 11: 46,578,063 (GRCm39) T23A probably benign Het
Tmc4 A G 7: 3,674,052 (GRCm39) Y376H probably damaging Het
Tmem143 A G 7: 45,558,950 (GRCm39) I297M probably benign Het
Togaram1 A G 12: 65,014,575 (GRCm39) T609A probably benign Het
Tyw3 T C 3: 154,302,704 (GRCm39) H10R probably benign Het
Unc13b C A 4: 43,239,306 (GRCm39) H3456Q probably damaging Het
Zfp131 A T 13: 120,237,532 (GRCm39) H275Q probably damaging Het
Other mutations in Or5t18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01608:Or5t18 APN 2 86,636,769 (GRCm39) nonsense probably null
R0400:Or5t18 UTSW 2 86,636,995 (GRCm39) missense probably damaging 1.00
R0609:Or5t18 UTSW 2 86,637,205 (GRCm39) missense probably damaging 0.98
R1650:Or5t18 UTSW 2 86,637,091 (GRCm39) missense possibly damaging 0.62
R1918:Or5t18 UTSW 2 86,637,171 (GRCm39) missense probably damaging 1.00
R3975:Or5t18 UTSW 2 86,636,804 (GRCm39) missense possibly damaging 0.95
R4567:Or5t18 UTSW 2 86,637,146 (GRCm39) missense probably damaging 0.99
R7286:Or5t18 UTSW 2 86,636,967 (GRCm39) missense possibly damaging 0.62
R7910:Or5t18 UTSW 2 86,637,191 (GRCm39) missense probably benign 0.00
R8048:Or5t18 UTSW 2 86,636,515 (GRCm39) missense probably damaging 0.99
R8193:Or5t18 UTSW 2 86,637,209 (GRCm39) missense noncoding transcript
R8799:Or5t18 UTSW 2 86,636,575 (GRCm39) missense probably damaging 0.98
R8973:Or5t18 UTSW 2 86,637,200 (GRCm39) missense probably benign
R9398:Or5t18 UTSW 2 86,637,160 (GRCm39) missense possibly damaging 0.54
R9444:Or5t18 UTSW 2 86,636,486 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- TCTCAGACTGTAGATGATGGGG -3'
(R):5'- ACACAGTGGCCACTTTCAG -3'

Sequencing Primer
(F):5'- GGTTGAGCATGGGAATCCC -3'
(R):5'- GGCCACTTTCAGCCTGTC -3'
Posted On 2017-08-16