Incidental Mutation 'R6090:Clasp2'
ID 486150
Institutional Source Beutler Lab
Gene Symbol Clasp2
Ensembl Gene ENSMUSG00000033392
Gene Name CLIP associating protein 2
Synonyms CLASP2alpha, 1500004F14Rik, CLASP2gamma, CLASP2, CLASP2beta, 8030404L10Rik
MMRRC Submission 044247-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6090 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 113570541-113748750 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 113681803 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 320 (V320L)
Ref Sequence ENSEMBL: ENSMUSP00000149670 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111838] [ENSMUST00000163895] [ENSMUST00000166734] [ENSMUST00000213663] [ENSMUST00000214522] [ENSMUST00000215022]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000111838
AA Change: V320L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000107469
Gene: ENSMUSG00000033392
AA Change: V320L

DomainStartEndE-ValueType
TOG 90 323 1.17e-8 SMART
low complexity region 382 395 N/A INTRINSIC
low complexity region 459 472 N/A INTRINSIC
low complexity region 473 484 N/A INTRINSIC
low complexity region 562 572 N/A INTRINSIC
low complexity region 614 634 N/A INTRINSIC
TOG 640 877 2.03e-1 SMART
low complexity region 995 1009 N/A INTRINSIC
TOG 1043 1274 1.49e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000163895
AA Change: V320L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000128460
Gene: ENSMUSG00000033392
AA Change: V320L

DomainStartEndE-ValueType
TOG 90 323 1.17e-8 SMART
low complexity region 382 395 N/A INTRINSIC
low complexity region 459 472 N/A INTRINSIC
low complexity region 473 484 N/A INTRINSIC
low complexity region 583 593 N/A INTRINSIC
low complexity region 635 655 N/A INTRINSIC
TOG 661 898 2.03e-1 SMART
low complexity region 1016 1030 N/A INTRINSIC
TOG 1064 1295 1.49e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000166734
AA Change: V320L

PolyPhen 2 Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000130201
Gene: ENSMUSG00000033392
AA Change: V320L

DomainStartEndE-ValueType
TOG 90 323 1.17e-8 SMART
low complexity region 382 395 N/A INTRINSIC
low complexity region 459 472 N/A INTRINSIC
low complexity region 473 484 N/A INTRINSIC
low complexity region 562 572 N/A INTRINSIC
low complexity region 614 634 N/A INTRINSIC
TOG 640 878 7.51e-1 SMART
low complexity region 996 1010 N/A INTRINSIC
TOG 1044 1275 1.49e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000213663
Predicted Effect probably benign
Transcript: ENSMUST00000214522
AA Change: V320L

PolyPhen 2 Score 0.062 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214860
Predicted Effect probably benign
Transcript: ENSMUST00000215022
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.8%
  • 20x: 93.6%
Validation Efficiency
MGI Phenotype PHENOTYPE: Targeted deletion of this gene leads to impaired formation of stable microtubules in a wound healing assay, and results in a 2-fold reduction of directionally persistent migration in mutant embryonic fibroblasts. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m C T 6: 121,624,972 (GRCm39) A450V probably benign Het
Abca8a T C 11: 109,954,048 (GRCm39) probably null Het
Adgrl3 A T 5: 81,660,173 (GRCm39) N246I probably damaging Het
Bmal2 T A 6: 146,731,194 (GRCm39) S500T possibly damaging Het
Cdipt A T 7: 126,576,131 (GRCm39) M29L possibly damaging Het
Chml G T 1: 175,514,624 (GRCm39) Y432* probably null Het
Col12a1 G A 9: 79,599,675 (GRCm39) T826M probably damaging Het
Cpsf3 A G 12: 21,345,194 (GRCm39) I169V probably damaging Het
Dhx36 G A 3: 62,404,241 (GRCm39) T234M probably damaging Het
Dhx57 A G 17: 80,571,375 (GRCm39) probably null Het
Dnah1 A T 14: 30,991,382 (GRCm39) I3132N possibly damaging Het
Fbxw20 G T 9: 109,052,431 (GRCm39) Q231K probably benign Het
Gfod1 G T 13: 43,354,437 (GRCm39) Y179* probably null Het
Glg1 T A 8: 111,907,667 (GRCm39) I510F probably damaging Het
Gm10801 TC TCGGC 2: 98,494,151 (GRCm39) probably benign Het
Gse1 C A 8: 121,297,908 (GRCm39) probably benign Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Klrd1 T C 6: 129,572,499 (GRCm39) L97P probably damaging Het
Lgmn A T 12: 102,366,413 (GRCm39) M240K probably damaging Het
Lrp1b A G 2: 41,075,880 (GRCm39) probably null Het
Notch2 A T 3: 98,042,693 (GRCm39) R1353* probably null Het
Or2d2b A G 7: 106,705,456 (GRCm39) V204A possibly damaging Het
Or5t18 A C 2: 86,636,701 (GRCm39) V214G possibly damaging Het
Pcdhb14 G A 18: 37,581,659 (GRCm39) S255N probably benign Het
Pcgf2 C T 11: 97,581,817 (GRCm39) M25I possibly damaging Het
Poll G T 19: 45,544,436 (GRCm39) D328E probably benign Het
Pomgnt2 A T 9: 121,811,863 (GRCm39) L306Q probably damaging Het
Proser1 A T 3: 53,386,088 (GRCm39) M657L probably benign Het
Rbm47 G C 5: 66,183,626 (GRCm39) R326G probably damaging Het
Rdh11 G T 12: 79,235,838 (GRCm39) P37T probably benign Het
Rsph10b A T 5: 143,913,946 (GRCm39) I286L probably benign Het
Septin4 G A 11: 87,480,343 (GRCm39) R238K possibly damaging Het
Sptan1 C T 2: 29,883,899 (GRCm39) R580C probably damaging Het
Stard9 T A 2: 120,524,135 (GRCm39) W777R probably damaging Het
Timd2 T C 11: 46,578,063 (GRCm39) T23A probably benign Het
Tmc4 A G 7: 3,674,052 (GRCm39) Y376H probably damaging Het
Tmem143 A G 7: 45,558,950 (GRCm39) I297M probably benign Het
Togaram1 A G 12: 65,014,575 (GRCm39) T609A probably benign Het
Tyw3 T C 3: 154,302,704 (GRCm39) H10R probably benign Het
Unc13b C A 4: 43,239,306 (GRCm39) H3456Q probably damaging Het
Zfp131 A T 13: 120,237,532 (GRCm39) H275Q probably damaging Het
Other mutations in Clasp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00772:Clasp2 APN 9 113,735,060 (GRCm39) splice site probably benign
IGL00885:Clasp2 APN 9 113,740,484 (GRCm39) missense probably damaging 1.00
IGL01314:Clasp2 APN 9 113,735,195 (GRCm39) missense possibly damaging 0.89
IGL01344:Clasp2 APN 9 113,642,360 (GRCm39) splice site probably null
IGL01567:Clasp2 APN 9 113,709,164 (GRCm39) missense probably damaging 1.00
IGL02238:Clasp2 APN 9 113,709,088 (GRCm39) missense probably damaging 1.00
IGL02299:Clasp2 APN 9 113,709,057 (GRCm39) missense probably damaging 1.00
IGL02323:Clasp2 APN 9 113,697,794 (GRCm39) splice site probably benign
IGL02635:Clasp2 APN 9 113,737,910 (GRCm39) missense probably damaging 0.98
IGL02645:Clasp2 APN 9 113,719,129 (GRCm39) missense probably damaging 1.00
IGL02976:Clasp2 APN 9 113,735,204 (GRCm39) missense probably damaging 1.00
IGL03190:Clasp2 APN 9 113,673,208 (GRCm39) nonsense probably null
IGL03219:Clasp2 APN 9 113,677,545 (GRCm39) splice site probably benign
PIT4810001:Clasp2 UTSW 9 113,735,135 (GRCm39) missense probably damaging 1.00
R0067:Clasp2 UTSW 9 113,689,209 (GRCm39) splice site probably benign
R0067:Clasp2 UTSW 9 113,689,209 (GRCm39) splice site probably benign
R0421:Clasp2 UTSW 9 113,683,370 (GRCm39) missense probably benign 0.02
R0432:Clasp2 UTSW 9 113,738,487 (GRCm39) missense probably benign 0.00
R0458:Clasp2 UTSW 9 113,735,292 (GRCm39) splice site probably null
R0865:Clasp2 UTSW 9 113,740,568 (GRCm39) missense possibly damaging 0.57
R0972:Clasp2 UTSW 9 113,676,773 (GRCm39) missense possibly damaging 0.58
R1037:Clasp2 UTSW 9 113,725,702 (GRCm39) splice site probably benign
R1925:Clasp2 UTSW 9 113,735,265 (GRCm39) missense possibly damaging 0.88
R2015:Clasp2 UTSW 9 113,740,568 (GRCm39) missense possibly damaging 0.57
R2066:Clasp2 UTSW 9 113,735,225 (GRCm39) missense possibly damaging 0.86
R2330:Clasp2 UTSW 9 113,705,372 (GRCm39) missense probably damaging 1.00
R2568:Clasp2 UTSW 9 113,707,832 (GRCm39) missense probably benign
R3011:Clasp2 UTSW 9 113,730,581 (GRCm39) missense probably damaging 1.00
R3879:Clasp2 UTSW 9 113,719,029 (GRCm39) missense probably damaging 0.98
R3915:Clasp2 UTSW 9 113,737,805 (GRCm39) missense probably damaging 0.99
R3928:Clasp2 UTSW 9 113,735,173 (GRCm39) missense probably benign 0.28
R4323:Clasp2 UTSW 9 113,719,027 (GRCm39) missense possibly damaging 0.91
R4571:Clasp2 UTSW 9 113,676,789 (GRCm39) missense probably damaging 1.00
R4975:Clasp2 UTSW 9 113,732,984 (GRCm39) missense probably damaging 1.00
R5445:Clasp2 UTSW 9 113,733,014 (GRCm39) missense probably damaging 1.00
R5564:Clasp2 UTSW 9 113,641,836 (GRCm39) critical splice donor site probably null
R5697:Clasp2 UTSW 9 113,689,190 (GRCm39) missense probably benign 0.01
R5780:Clasp2 UTSW 9 113,679,220 (GRCm39) missense probably damaging 0.99
R5787:Clasp2 UTSW 9 113,691,310 (GRCm39) missense probably damaging 1.00
R6011:Clasp2 UTSW 9 113,705,315 (GRCm39) missense probably benign 0.07
R6026:Clasp2 UTSW 9 113,740,646 (GRCm39) missense probably benign 0.13
R6262:Clasp2 UTSW 9 113,705,420 (GRCm39) critical splice donor site probably null
R6427:Clasp2 UTSW 9 113,721,512 (GRCm39) missense probably damaging 1.00
R6464:Clasp2 UTSW 9 113,602,785 (GRCm39) missense probably damaging 1.00
R6586:Clasp2 UTSW 9 113,642,332 (GRCm39) missense probably damaging 1.00
R6628:Clasp2 UTSW 9 113,725,788 (GRCm39) missense probably damaging 1.00
R6745:Clasp2 UTSW 9 113,704,338 (GRCm39) nonsense probably null
R7032:Clasp2 UTSW 9 113,683,391 (GRCm39) missense probably benign 0.04
R7165:Clasp2 UTSW 9 113,615,467 (GRCm39) splice site probably null
R7221:Clasp2 UTSW 9 113,681,825 (GRCm39) missense probably damaging 0.99
R7336:Clasp2 UTSW 9 113,705,421 (GRCm39) splice site probably null
R7583:Clasp2 UTSW 9 113,737,755 (GRCm39) missense probably benign 0.02
R7774:Clasp2 UTSW 9 113,677,804 (GRCm39) splice site probably null
R7895:Clasp2 UTSW 9 113,733,016 (GRCm39) missense probably benign 0.03
R8084:Clasp2 UTSW 9 113,676,823 (GRCm39) missense probably benign 0.16
R8109:Clasp2 UTSW 9 113,740,588 (GRCm39) missense probably damaging 1.00
R8171:Clasp2 UTSW 9 113,732,974 (GRCm39) missense possibly damaging 0.88
R8230:Clasp2 UTSW 9 113,721,482 (GRCm39) missense possibly damaging 0.73
R8810:Clasp2 UTSW 9 113,728,649 (GRCm39) missense probably damaging 1.00
R8879:Clasp2 UTSW 9 113,602,773 (GRCm39) missense probably benign 0.39
R8888:Clasp2 UTSW 9 113,732,936 (GRCm39) missense possibly damaging 0.54
R8889:Clasp2 UTSW 9 113,709,251 (GRCm39) missense probably damaging 1.00
R8892:Clasp2 UTSW 9 113,709,251 (GRCm39) missense probably damaging 1.00
R8922:Clasp2 UTSW 9 113,725,728 (GRCm39) nonsense probably null
R9042:Clasp2 UTSW 9 113,735,065 (GRCm39) missense probably benign
R9195:Clasp2 UTSW 9 113,671,045 (GRCm39) missense probably benign 0.06
R9355:Clasp2 UTSW 9 113,664,309 (GRCm39) missense probably damaging 1.00
R9481:Clasp2 UTSW 9 113,670,669 (GRCm39) missense probably damaging 1.00
R9502:Clasp2 UTSW 9 113,737,866 (GRCm39) missense probably benign 0.01
R9523:Clasp2 UTSW 9 113,705,372 (GRCm39) missense probably damaging 0.98
R9525:Clasp2 UTSW 9 113,740,677 (GRCm39) missense probably damaging 1.00
R9653:Clasp2 UTSW 9 113,670,993 (GRCm39) missense probably benign 0.01
R9699:Clasp2 UTSW 9 113,738,614 (GRCm39) critical splice donor site probably null
R9738:Clasp2 UTSW 9 113,590,665 (GRCm39) nonsense probably null
R9775:Clasp2 UTSW 9 113,725,740 (GRCm39) missense probably benign
X0022:Clasp2 UTSW 9 113,681,740 (GRCm39) missense probably damaging 1.00
Z1177:Clasp2 UTSW 9 113,599,289 (GRCm39) missense probably damaging 1.00
Z1177:Clasp2 UTSW 9 113,737,863 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GATTGGTTCAGTTTACCCAGTTTC -3'
(R):5'- TGTGACTCATTAACCCTAACCG -3'

Sequencing Primer
(F):5'- CAGTTTCTACTCAACATGGATACTGC -3'
(R):5'- TGACTCATTAACCCTAACCGCAGAG -3'
Posted On 2017-08-16