Incidental Mutation 'R6030:Ptprf'
| ID |
486184 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ptprf
|
| Ensembl Gene |
ENSMUSG00000033295 |
| Gene Name |
protein tyrosine phosphatase receptor type F |
| Synonyms |
RPTP-LAR, LAR |
| MMRRC Submission |
044202-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.698)
|
| Stock # |
R6030 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
118065410-118148602 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 118068245 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Aspartic acid
at position 1764
(N1764D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000039368
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000049074]
|
| AlphaFold |
A2A8L5 |
| PDB Structure |
Tandem Ig domains of tyrosine phosphatase LAR [X-RAY DIFFRACTION]
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000049074
AA Change: N1764D
PolyPhen 2
Score 0.189 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000039368
Gene: ENSMUSG00000033295
AA Change: N1764D
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
45 |
114 |
2.64e-12 |
SMART |
|
IGc2
|
147 |
214 |
1.48e-15 |
SMART |
|
IG
|
238 |
316 |
1.06e-11 |
SMART |
|
FN3
|
319 |
398 |
6.9e-14 |
SMART |
|
FN3
|
414 |
497 |
5.73e-11 |
SMART |
|
FN3
|
512 |
591 |
4.06e-11 |
SMART |
|
FN3
|
606 |
693 |
8.69e-11 |
SMART |
|
FN3
|
709 |
797 |
8.83e-12 |
SMART |
|
FN3
|
812 |
892 |
3.2e-9 |
SMART |
|
FN3
|
907 |
988 |
2.53e-12 |
SMART |
|
FN3
|
1003 |
1079 |
3.48e-1 |
SMART |
|
coiled coil region
|
1146 |
1175 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1253 |
1275 |
N/A |
INTRINSIC |
|
PTPc
|
1342 |
1600 |
1.12e-138 |
SMART |
|
PTPc
|
1629 |
1891 |
3.4e-129 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000123484
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000124758
AA Change: N1197D
|
| SMART Domains |
Protein: ENSMUSP00000119954
Gene: ENSMUSG00000033295
AA Change: N1197D
| Domain | Start | End | E-Value | Type |
|---|
|
FN3
|
37 |
116 |
4.06e-11 |
SMART |
|
FN3
|
132 |
220 |
8.83e-12 |
SMART |
|
FN3
|
235 |
315 |
3.2e-9 |
SMART |
|
FN3
|
330 |
411 |
2.53e-12 |
SMART |
|
FN3
|
426 |
502 |
3.48e-1 |
SMART |
|
coiled coil region
|
568 |
597 |
N/A |
INTRINSIC |
|
transmembrane domain
|
676 |
698 |
N/A |
INTRINSIC |
|
PTPc
|
776 |
1034 |
1.12e-138 |
SMART |
|
PTPc
|
1063 |
1325 |
3.4e-129 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127616
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000150096
AA Change: N1156D
|
| SMART Domains |
Protein: ENSMUSP00000117313
Gene: ENSMUSG00000033295
AA Change: N1156D
| Domain | Start | End | E-Value | Type |
|---|
|
FN3
|
14 |
66 |
2.7e1 |
SMART |
|
FN3
|
82 |
165 |
5.73e-11 |
SMART |
|
FN3
|
180 |
259 |
4.06e-11 |
SMART |
|
FN3
|
275 |
372 |
6.69e-12 |
SMART |
|
FN3
|
385 |
461 |
2.83e-1 |
SMART |
|
coiled coil region
|
527 |
556 |
N/A |
INTRINSIC |
|
transmembrane domain
|
635 |
657 |
N/A |
INTRINSIC |
|
PTPc
|
735 |
993 |
1.12e-138 |
SMART |
|
PTPc
|
1022 |
1284 |
3.4e-129 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000184953
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.2%
- 20x: 95.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null females have premature involution of the mammary glands leading to an inability to feed pups. Other characteristics of null mice include defective nerve regeneration and hyperactivity. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca16 |
A |
G |
7: 120,133,021 (GRCm39) |
N1317D |
probably benign |
Het |
| Abhd8 |
T |
A |
8: 71,910,794 (GRCm39) |
Y338F |
possibly damaging |
Het |
| Actg2 |
G |
T |
6: 83,493,346 (GRCm39) |
N297K |
probably damaging |
Het |
| Agap1 |
A |
G |
1: 89,558,156 (GRCm39) |
D148G |
probably damaging |
Het |
| Alox12 |
T |
C |
11: 70,145,417 (GRCm39) |
D52G |
possibly damaging |
Het |
| Ano5 |
T |
A |
7: 51,224,573 (GRCm39) |
S496T |
probably damaging |
Het |
| Arl6ip4 |
T |
C |
5: 124,255,968 (GRCm39) |
|
probably null |
Het |
| Atp4a |
G |
C |
7: 30,421,941 (GRCm39) |
E826Q |
probably damaging |
Het |
| Bbs7 |
T |
C |
3: 36,657,060 (GRCm39) |
D256G |
probably damaging |
Het |
| Bckdha |
T |
A |
7: 25,330,866 (GRCm39) |
D50V |
probably damaging |
Het |
| Cast |
A |
G |
13: 74,844,056 (GRCm39) |
S693P |
possibly damaging |
Het |
| Cfap251 |
C |
T |
5: 123,412,267 (GRCm39) |
T532M |
probably damaging |
Het |
| Col6a1 |
T |
C |
10: 76,545,700 (GRCm39) |
Y924C |
unknown |
Het |
| Crkl |
A |
G |
16: 17,270,604 (GRCm39) |
Y88C |
probably damaging |
Het |
| Cse1l |
T |
C |
2: 166,761,541 (GRCm39) |
F32L |
probably benign |
Het |
| Dmxl2 |
C |
T |
9: 54,300,957 (GRCm39) |
V2385I |
probably benign |
Het |
| Dnah1 |
T |
A |
14: 30,989,984 (GRCm39) |
I3219F |
probably damaging |
Het |
| Dnah17 |
C |
T |
11: 117,916,375 (GRCm39) |
R4266H |
probably benign |
Het |
| Efcab5 |
A |
G |
11: 77,012,088 (GRCm39) |
L722P |
probably damaging |
Het |
| Emilin3 |
C |
A |
2: 160,751,105 (GRCm39) |
V215L |
probably benign |
Het |
| Entr1 |
T |
C |
2: 26,276,983 (GRCm39) |
D249G |
possibly damaging |
Het |
| Esr1 |
A |
T |
10: 4,696,622 (GRCm39) |
N157I |
possibly damaging |
Het |
| Esrrg |
A |
G |
1: 187,930,904 (GRCm39) |
M309V |
probably benign |
Het |
| Fam120b |
G |
A |
17: 15,622,172 (GRCm39) |
R50Q |
probably damaging |
Het |
| Fat2 |
G |
T |
11: 55,201,129 (GRCm39) |
Y648* |
probably null |
Het |
| Gbp2b |
T |
A |
3: 142,309,414 (GRCm39) |
I175N |
probably benign |
Het |
| Gm1043 |
T |
A |
5: 37,311,952 (GRCm39) |
|
probably benign |
Het |
| Gm21060 |
A |
G |
19: 61,285,411 (GRCm39) |
C33R |
possibly damaging |
Het |
| Gpx6 |
C |
T |
13: 21,496,510 (GRCm39) |
S28L |
probably benign |
Het |
| Hyls1 |
G |
A |
9: 35,472,480 (GRCm39) |
S312F |
probably benign |
Het |
| Ifi44 |
T |
C |
3: 151,455,195 (GRCm39) |
Q10R |
probably benign |
Het |
| Impa2 |
T |
C |
18: 67,451,498 (GRCm39) |
V264A |
probably benign |
Het |
| Khdc1a |
A |
T |
1: 21,421,108 (GRCm39) |
M98L |
probably benign |
Het |
| Lrrc45 |
T |
A |
11: 120,611,474 (GRCm39) |
L616* |
probably null |
Het |
| Mios |
A |
T |
6: 8,215,704 (GRCm39) |
H300L |
probably benign |
Het |
| Mllt6 |
A |
T |
11: 97,568,051 (GRCm39) |
T827S |
probably damaging |
Het |
| Mrc1 |
C |
A |
2: 14,321,712 (GRCm39) |
D1068E |
probably benign |
Het |
| Ndst3 |
T |
C |
3: 123,346,168 (GRCm39) |
Y702C |
probably damaging |
Het |
| Nek11 |
T |
A |
9: 105,082,087 (GRCm39) |
|
probably null |
Het |
| Nek4 |
T |
C |
14: 30,678,890 (GRCm39) |
F138S |
probably damaging |
Het |
| Nfatc4 |
T |
A |
14: 56,069,897 (GRCm39) |
Y688* |
probably null |
Het |
| Nlrx1 |
C |
T |
9: 44,175,057 (GRCm39) |
V240M |
probably damaging |
Het |
| Npy6r |
A |
T |
18: 44,409,149 (GRCm39) |
Y190F |
probably benign |
Het |
| Or10ab5 |
A |
C |
7: 108,245,433 (GRCm39) |
S117A |
possibly damaging |
Het |
| Or10d4b |
T |
C |
9: 39,534,637 (GRCm39) |
F71L |
probably damaging |
Het |
| Or1j10 |
T |
G |
2: 36,267,556 (GRCm39) |
L256R |
probably damaging |
Het |
| Or52b4i |
C |
A |
7: 102,191,817 (GRCm39) |
R225S |
probably benign |
Het |
| Or5p52 |
A |
G |
7: 107,502,620 (GRCm39) |
E232G |
probably benign |
Het |
| Or6c68 |
A |
T |
10: 129,158,238 (GRCm39) |
T249S |
probably benign |
Het |
| Osbpl7 |
A |
C |
11: 96,943,087 (GRCm39) |
H113P |
probably benign |
Het |
| Pam16l |
C |
T |
10: 43,400,252 (GRCm39) |
A30V |
probably benign |
Het |
| Pck1 |
A |
G |
2: 172,996,650 (GRCm39) |
E188G |
probably benign |
Het |
| Pimreg |
A |
G |
11: 71,936,576 (GRCm39) |
D213G |
probably benign |
Het |
| Pkd1l2 |
A |
G |
8: 117,769,976 (GRCm39) |
I1160T |
probably damaging |
Het |
| Ppargc1b |
G |
A |
18: 61,441,005 (GRCm39) |
Q622* |
probably null |
Het |
| Ppfia2 |
T |
A |
10: 106,742,338 (GRCm39) |
C1044S |
probably damaging |
Het |
| Ppp4r3a |
A |
G |
12: 101,024,659 (GRCm39) |
V280A |
probably damaging |
Het |
| Pygm |
C |
T |
19: 6,438,842 (GRCm39) |
R311C |
possibly damaging |
Het |
| Rab7b |
A |
G |
1: 131,626,299 (GRCm39) |
K109R |
probably damaging |
Het |
| Rsf1 |
GGCG |
GGCGACGGCTGCG |
7: 97,229,113 (GRCm39) |
|
probably benign |
Homo |
| Setbp1 |
T |
G |
18: 78,900,926 (GRCm39) |
I914L |
probably benign |
Het |
| Shprh |
A |
C |
10: 11,027,735 (GRCm39) |
Q114P |
probably benign |
Het |
| Slc5a9 |
T |
C |
4: 111,742,725 (GRCm39) |
I456V |
possibly damaging |
Het |
| Slc8b1 |
T |
C |
5: 120,657,985 (GRCm39) |
|
probably null |
Het |
| Spin1 |
T |
A |
13: 51,293,552 (GRCm39) |
Y87* |
probably null |
Het |
| Spring1 |
T |
C |
5: 118,393,798 (GRCm39) |
W59R |
probably damaging |
Het |
| Srebf2 |
T |
C |
15: 82,061,477 (GRCm39) |
|
probably null |
Het |
| Sufu |
T |
C |
19: 46,463,978 (GRCm39) |
Y397H |
probably damaging |
Het |
| Tgfb3 |
A |
C |
12: 86,110,624 (GRCm39) |
V242G |
probably benign |
Het |
| Tgm3 |
A |
T |
2: 129,883,920 (GRCm39) |
Y526F |
probably damaging |
Het |
| Tmem209 |
A |
G |
6: 30,482,967 (GRCm39) |
L508P |
probably damaging |
Het |
| Tmem67 |
T |
C |
4: 12,063,799 (GRCm39) |
D454G |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,646,943 (GRCm39) |
E3280G |
possibly damaging |
Het |
| Tusc3 |
G |
C |
8: 39,538,560 (GRCm39) |
G200R |
probably damaging |
Het |
| Umps |
A |
G |
16: 33,782,508 (GRCm39) |
V138A |
probably benign |
Het |
| Ypel1 |
A |
G |
16: 16,902,377 (GRCm39) |
|
probably null |
Het |
| Zdhhc19 |
T |
A |
16: 32,317,860 (GRCm39) |
L63Q |
probably null |
Het |
|
| Other mutations in Ptprf |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00090:Ptprf
|
APN |
4 |
118,080,417 (GRCm39) |
splice site |
probably benign |
|
|
IGL01337:Ptprf
|
APN |
4 |
118,093,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01482:Ptprf
|
APN |
4 |
118,069,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01743:Ptprf
|
APN |
4 |
118,106,095 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01987:Ptprf
|
APN |
4 |
118,134,567 (GRCm39) |
missense |
probably benign |
|
|
IGL02189:Ptprf
|
APN |
4 |
118,070,839 (GRCm39) |
splice site |
probably benign |
|
|
IGL03067:Ptprf
|
APN |
4 |
118,067,910 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
PIT4677001:Ptprf
|
UTSW |
4 |
118,070,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0382:Ptprf
|
UTSW |
4 |
118,080,591 (GRCm39) |
splice site |
probably benign |
|
|
R0788:Ptprf
|
UTSW |
4 |
118,083,663 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1164:Ptprf
|
UTSW |
4 |
118,114,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1478:Ptprf
|
UTSW |
4 |
118,069,302 (GRCm39) |
nonsense |
probably null |
|
|
R1483:Ptprf
|
UTSW |
4 |
118,093,161 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1611:Ptprf
|
UTSW |
4 |
118,093,430 (GRCm39) |
missense |
probably benign |
0.34 |
|
R1721:Ptprf
|
UTSW |
4 |
118,082,096 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R1817:Ptprf
|
UTSW |
4 |
118,080,462 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1818:Ptprf
|
UTSW |
4 |
118,067,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1860:Ptprf
|
UTSW |
4 |
118,081,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2208:Ptprf
|
UTSW |
4 |
118,126,369 (GRCm39) |
splice site |
probably benign |
|
|
R2406:Ptprf
|
UTSW |
4 |
118,126,501 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R2912:Ptprf
|
UTSW |
4 |
118,106,177 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3111:Ptprf
|
UTSW |
4 |
118,068,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3498:Ptprf
|
UTSW |
4 |
118,082,127 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3499:Ptprf
|
UTSW |
4 |
118,082,127 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3615:Ptprf
|
UTSW |
4 |
118,095,080 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3616:Ptprf
|
UTSW |
4 |
118,095,080 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4038:Ptprf
|
UTSW |
4 |
118,114,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4243:Ptprf
|
UTSW |
4 |
118,083,649 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4260:Ptprf
|
UTSW |
4 |
118,083,280 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R4693:Ptprf
|
UTSW |
4 |
118,068,219 (GRCm39) |
missense |
probably benign |
0.16 |
|
R4726:Ptprf
|
UTSW |
4 |
118,069,414 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4746:Ptprf
|
UTSW |
4 |
118,082,236 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4802:Ptprf
|
UTSW |
4 |
118,067,526 (GRCm39) |
intron |
probably benign |
|
|
R4857:Ptprf
|
UTSW |
4 |
118,074,394 (GRCm39) |
splice site |
probably benign |
|
|
R5071:Ptprf
|
UTSW |
4 |
118,069,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5221:Ptprf
|
UTSW |
4 |
118,082,305 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5327:Ptprf
|
UTSW |
4 |
118,093,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5336:Ptprf
|
UTSW |
4 |
118,092,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5356:Ptprf
|
UTSW |
4 |
118,083,535 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5373:Ptprf
|
UTSW |
4 |
118,083,238 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5555:Ptprf
|
UTSW |
4 |
118,082,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5693:Ptprf
|
UTSW |
4 |
118,093,374 (GRCm39) |
nonsense |
probably null |
|
|
R5860:Ptprf
|
UTSW |
4 |
118,068,486 (GRCm39) |
intron |
probably benign |
|
|
R5869:Ptprf
|
UTSW |
4 |
118,067,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5890:Ptprf
|
UTSW |
4 |
118,081,932 (GRCm39) |
missense |
probably benign |
|
|
R5932:Ptprf
|
UTSW |
4 |
118,068,964 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6028:Ptprf
|
UTSW |
4 |
118,070,826 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6030:Ptprf
|
UTSW |
4 |
118,068,245 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6088:Ptprf
|
UTSW |
4 |
118,067,952 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6089:Ptprf
|
UTSW |
4 |
118,068,281 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6108:Ptprf
|
UTSW |
4 |
118,080,453 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6320:Ptprf
|
UTSW |
4 |
118,070,011 (GRCm39) |
missense |
probably benign |
|
|
R6741:Ptprf
|
UTSW |
4 |
118,080,565 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6744:Ptprf
|
UTSW |
4 |
118,093,562 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6750:Ptprf
|
UTSW |
4 |
118,088,928 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6906:Ptprf
|
UTSW |
4 |
118,126,474 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7021:Ptprf
|
UTSW |
4 |
118,081,101 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7153:Ptprf
|
UTSW |
4 |
118,088,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7326:Ptprf
|
UTSW |
4 |
118,088,866 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7337:Ptprf
|
UTSW |
4 |
118,068,322 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7374:Ptprf
|
UTSW |
4 |
118,114,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7375:Ptprf
|
UTSW |
4 |
118,070,011 (GRCm39) |
missense |
probably benign |
|
|
R7399:Ptprf
|
UTSW |
4 |
118,083,720 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7417:Ptprf
|
UTSW |
4 |
118,069,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7448:Ptprf
|
UTSW |
4 |
118,092,864 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7530:Ptprf
|
UTSW |
4 |
118,069,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7593:Ptprf
|
UTSW |
4 |
118,069,593 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8172:Ptprf
|
UTSW |
4 |
118,068,275 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8239:Ptprf
|
UTSW |
4 |
118,069,309 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8257:Ptprf
|
UTSW |
4 |
118,083,476 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8331:Ptprf
|
UTSW |
4 |
118,083,263 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8441:Ptprf
|
UTSW |
4 |
118,075,255 (GRCm39) |
splice site |
probably benign |
|
|
R8681:Ptprf
|
UTSW |
4 |
118,088,844 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8771:Ptprf
|
UTSW |
4 |
118,068,987 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8815:Ptprf
|
UTSW |
4 |
118,095,125 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8998:Ptprf
|
UTSW |
4 |
118,083,671 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8999:Ptprf
|
UTSW |
4 |
118,083,671 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9389:Ptprf
|
UTSW |
4 |
118,093,236 (GRCm39) |
missense |
probably benign |
|
|
R9508:Ptprf
|
UTSW |
4 |
118,126,776 (GRCm39) |
nonsense |
probably null |
|
|
R9581:Ptprf
|
UTSW |
4 |
118,092,257 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0067:Ptprf
|
UTSW |
4 |
118,093,223 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
Z1177:Ptprf
|
UTSW |
4 |
118,126,812 (GRCm39) |
missense |
probably benign |
0.04 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACTAGGCCCTCTAAACCAGGAG -3'
(R):5'- TTTACCAACACCTGAGGCAC -3'
Sequencing Primer
(F):5'- CTCTCAAGGACACTCTAGGAGG -3'
(R):5'- ACCTGAGGCACCCCTTC -3'
|
| Posted On |
2017-08-16 |
Incidental Mutation