Incidental Mutation 'R6030:Shprh'
| ID |
486210 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Shprh
|
| Ensembl Gene |
ENSMUSG00000090112 |
| Gene Name |
SNF2 histone linker PHD RING helicase |
| Synonyms |
2610103K11Rik, D230017O13Rik |
| MMRRC Submission |
044202-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R6030 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
11025171-11093339 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 11027735 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Proline
at position 114
(Q114P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125457
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044053]
[ENSMUST00000054814]
[ENSMUST00000159541]
[ENSMUST00000159810]
|
| AlphaFold |
Q7TPQ3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000044053
AA Change: Q114P
PolyPhen 2
Score 0.366 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000039422
Gene: ENSMUSG00000090112
AA Change: Q114P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
Pfam:Helicase_C
|
1500 |
1613 |
1.6e-8 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000054814
AA Change: Q114P
PolyPhen 2
Score 0.366 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000125849
Gene: ENSMUSG00000090112
AA Change: Q114P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
SCOP:d1fuka_
|
1504 |
1616 |
6e-8 |
SMART |
|
Blast:HELICc
|
1533 |
1613 |
4e-46 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159541
AA Change: Q114P
PolyPhen 2
Score 0.366 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000132870
Gene: ENSMUSG00000090112
AA Change: Q114P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
SCOP:d1fuka_
|
1504 |
1619 |
4e-8 |
SMART |
|
Blast:HELICc
|
1533 |
1613 |
6e-46 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159810
AA Change: Q114P
PolyPhen 2
Score 0.366 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000125457
Gene: ENSMUSG00000090112
AA Change: Q114P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
2e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
Blast:DEXDc
|
948 |
1026 |
2e-9 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161858
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.2%
- 20x: 95.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]
PHENOTYPE: The gene product is an E3 ligase involved in poly-ubiquitination of Pcna. Neither homozygous truncation nor KO affect B cell somatic hypermutation or class switching. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca16 |
A |
G |
7: 120,133,021 (GRCm39) |
N1317D |
probably benign |
Het |
| Abhd8 |
T |
A |
8: 71,910,794 (GRCm39) |
Y338F |
possibly damaging |
Het |
| Actg2 |
G |
T |
6: 83,493,346 (GRCm39) |
N297K |
probably damaging |
Het |
| Agap1 |
A |
G |
1: 89,558,156 (GRCm39) |
D148G |
probably damaging |
Het |
| Alox12 |
T |
C |
11: 70,145,417 (GRCm39) |
D52G |
possibly damaging |
Het |
| Ano5 |
T |
A |
7: 51,224,573 (GRCm39) |
S496T |
probably damaging |
Het |
| Arl6ip4 |
T |
C |
5: 124,255,968 (GRCm39) |
|
probably null |
Het |
| Atp4a |
G |
C |
7: 30,421,941 (GRCm39) |
E826Q |
probably damaging |
Het |
| Bbs7 |
T |
C |
3: 36,657,060 (GRCm39) |
D256G |
probably damaging |
Het |
| Bckdha |
T |
A |
7: 25,330,866 (GRCm39) |
D50V |
probably damaging |
Het |
| Cast |
A |
G |
13: 74,844,056 (GRCm39) |
S693P |
possibly damaging |
Het |
| Cfap251 |
C |
T |
5: 123,412,267 (GRCm39) |
T532M |
probably damaging |
Het |
| Col6a1 |
T |
C |
10: 76,545,700 (GRCm39) |
Y924C |
unknown |
Het |
| Crkl |
A |
G |
16: 17,270,604 (GRCm39) |
Y88C |
probably damaging |
Het |
| Cse1l |
T |
C |
2: 166,761,541 (GRCm39) |
F32L |
probably benign |
Het |
| Dmxl2 |
C |
T |
9: 54,300,957 (GRCm39) |
V2385I |
probably benign |
Het |
| Dnah1 |
T |
A |
14: 30,989,984 (GRCm39) |
I3219F |
probably damaging |
Het |
| Dnah17 |
C |
T |
11: 117,916,375 (GRCm39) |
R4266H |
probably benign |
Het |
| Efcab5 |
A |
G |
11: 77,012,088 (GRCm39) |
L722P |
probably damaging |
Het |
| Emilin3 |
C |
A |
2: 160,751,105 (GRCm39) |
V215L |
probably benign |
Het |
| Entr1 |
T |
C |
2: 26,276,983 (GRCm39) |
D249G |
possibly damaging |
Het |
| Esr1 |
A |
T |
10: 4,696,622 (GRCm39) |
N157I |
possibly damaging |
Het |
| Esrrg |
A |
G |
1: 187,930,904 (GRCm39) |
M309V |
probably benign |
Het |
| Fam120b |
G |
A |
17: 15,622,172 (GRCm39) |
R50Q |
probably damaging |
Het |
| Fat2 |
G |
T |
11: 55,201,129 (GRCm39) |
Y648* |
probably null |
Het |
| Gbp2b |
T |
A |
3: 142,309,414 (GRCm39) |
I175N |
probably benign |
Het |
| Gm1043 |
T |
A |
5: 37,311,952 (GRCm39) |
|
probably benign |
Het |
| Gm21060 |
A |
G |
19: 61,285,411 (GRCm39) |
C33R |
possibly damaging |
Het |
| Gpx6 |
C |
T |
13: 21,496,510 (GRCm39) |
S28L |
probably benign |
Het |
| Hyls1 |
G |
A |
9: 35,472,480 (GRCm39) |
S312F |
probably benign |
Het |
| Ifi44 |
T |
C |
3: 151,455,195 (GRCm39) |
Q10R |
probably benign |
Het |
| Impa2 |
T |
C |
18: 67,451,498 (GRCm39) |
V264A |
probably benign |
Het |
| Khdc1a |
A |
T |
1: 21,421,108 (GRCm39) |
M98L |
probably benign |
Het |
| Lrrc45 |
T |
A |
11: 120,611,474 (GRCm39) |
L616* |
probably null |
Het |
| Mios |
A |
T |
6: 8,215,704 (GRCm39) |
H300L |
probably benign |
Het |
| Mllt6 |
A |
T |
11: 97,568,051 (GRCm39) |
T827S |
probably damaging |
Het |
| Mrc1 |
C |
A |
2: 14,321,712 (GRCm39) |
D1068E |
probably benign |
Het |
| Ndst3 |
T |
C |
3: 123,346,168 (GRCm39) |
Y702C |
probably damaging |
Het |
| Nek11 |
T |
A |
9: 105,082,087 (GRCm39) |
|
probably null |
Het |
| Nek4 |
T |
C |
14: 30,678,890 (GRCm39) |
F138S |
probably damaging |
Het |
| Nfatc4 |
T |
A |
14: 56,069,897 (GRCm39) |
Y688* |
probably null |
Het |
| Nlrx1 |
C |
T |
9: 44,175,057 (GRCm39) |
V240M |
probably damaging |
Het |
| Npy6r |
A |
T |
18: 44,409,149 (GRCm39) |
Y190F |
probably benign |
Het |
| Or10ab5 |
A |
C |
7: 108,245,433 (GRCm39) |
S117A |
possibly damaging |
Het |
| Or10d4b |
T |
C |
9: 39,534,637 (GRCm39) |
F71L |
probably damaging |
Het |
| Or1j10 |
T |
G |
2: 36,267,556 (GRCm39) |
L256R |
probably damaging |
Het |
| Or52b4i |
C |
A |
7: 102,191,817 (GRCm39) |
R225S |
probably benign |
Het |
| Or5p52 |
A |
G |
7: 107,502,620 (GRCm39) |
E232G |
probably benign |
Het |
| Or6c68 |
A |
T |
10: 129,158,238 (GRCm39) |
T249S |
probably benign |
Het |
| Osbpl7 |
A |
C |
11: 96,943,087 (GRCm39) |
H113P |
probably benign |
Het |
| Pam16l |
C |
T |
10: 43,400,252 (GRCm39) |
A30V |
probably benign |
Het |
| Pck1 |
A |
G |
2: 172,996,650 (GRCm39) |
E188G |
probably benign |
Het |
| Pimreg |
A |
G |
11: 71,936,576 (GRCm39) |
D213G |
probably benign |
Het |
| Pkd1l2 |
A |
G |
8: 117,769,976 (GRCm39) |
I1160T |
probably damaging |
Het |
| Ppargc1b |
G |
A |
18: 61,441,005 (GRCm39) |
Q622* |
probably null |
Het |
| Ppfia2 |
T |
A |
10: 106,742,338 (GRCm39) |
C1044S |
probably damaging |
Het |
| Ppp4r3a |
A |
G |
12: 101,024,659 (GRCm39) |
V280A |
probably damaging |
Het |
| Ptprf |
T |
C |
4: 118,068,245 (GRCm39) |
N1764D |
probably benign |
Het |
| Pygm |
C |
T |
19: 6,438,842 (GRCm39) |
R311C |
possibly damaging |
Het |
| Rab7b |
A |
G |
1: 131,626,299 (GRCm39) |
K109R |
probably damaging |
Het |
| Rsf1 |
GGCG |
GGCGACGGCTGCG |
7: 97,229,113 (GRCm39) |
|
probably benign |
Homo |
| Setbp1 |
T |
G |
18: 78,900,926 (GRCm39) |
I914L |
probably benign |
Het |
| Slc5a9 |
T |
C |
4: 111,742,725 (GRCm39) |
I456V |
possibly damaging |
Het |
| Slc8b1 |
T |
C |
5: 120,657,985 (GRCm39) |
|
probably null |
Het |
| Spin1 |
T |
A |
13: 51,293,552 (GRCm39) |
Y87* |
probably null |
Het |
| Spring1 |
T |
C |
5: 118,393,798 (GRCm39) |
W59R |
probably damaging |
Het |
| Srebf2 |
T |
C |
15: 82,061,477 (GRCm39) |
|
probably null |
Het |
| Sufu |
T |
C |
19: 46,463,978 (GRCm39) |
Y397H |
probably damaging |
Het |
| Tgfb3 |
A |
C |
12: 86,110,624 (GRCm39) |
V242G |
probably benign |
Het |
| Tgm3 |
A |
T |
2: 129,883,920 (GRCm39) |
Y526F |
probably damaging |
Het |
| Tmem209 |
A |
G |
6: 30,482,967 (GRCm39) |
L508P |
probably damaging |
Het |
| Tmem67 |
T |
C |
4: 12,063,799 (GRCm39) |
D454G |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,646,943 (GRCm39) |
E3280G |
possibly damaging |
Het |
| Tusc3 |
G |
C |
8: 39,538,560 (GRCm39) |
G200R |
probably damaging |
Het |
| Umps |
A |
G |
16: 33,782,508 (GRCm39) |
V138A |
probably benign |
Het |
| Ypel1 |
A |
G |
16: 16,902,377 (GRCm39) |
|
probably null |
Het |
| Zdhhc19 |
T |
A |
16: 32,317,860 (GRCm39) |
L63Q |
probably null |
Het |
|
| Other mutations in Shprh |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00492:Shprh
|
APN |
10 |
11,063,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00583:Shprh
|
APN |
10 |
11,063,764 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00684:Shprh
|
APN |
10 |
11,038,781 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL01295:Shprh
|
APN |
10 |
11,059,612 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01387:Shprh
|
APN |
10 |
11,045,998 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01635:Shprh
|
APN |
10 |
11,045,763 (GRCm39) |
nonsense |
probably null |
|
|
IGL01833:Shprh
|
APN |
10 |
11,066,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02013:Shprh
|
APN |
10 |
11,057,246 (GRCm39) |
splice site |
probably benign |
|
|
IGL02502:Shprh
|
APN |
10 |
11,070,101 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL02819:Shprh
|
APN |
10 |
11,030,509 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
PIT4581001:Shprh
|
UTSW |
10 |
11,068,238 (GRCm39) |
frame shift |
probably null |
|
|
R0010:Shprh
|
UTSW |
10 |
11,027,675 (GRCm39) |
missense |
probably benign |
|
|
R0010:Shprh
|
UTSW |
10 |
11,027,675 (GRCm39) |
missense |
probably benign |
|
|
R0053:Shprh
|
UTSW |
10 |
11,070,116 (GRCm39) |
splice site |
probably null |
|
|
R0053:Shprh
|
UTSW |
10 |
11,070,116 (GRCm39) |
splice site |
probably null |
|
|
R0255:Shprh
|
UTSW |
10 |
11,062,135 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0325:Shprh
|
UTSW |
10 |
11,045,853 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0331:Shprh
|
UTSW |
10 |
11,069,914 (GRCm39) |
splice site |
probably benign |
|
|
R0494:Shprh
|
UTSW |
10 |
11,032,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0532:Shprh
|
UTSW |
10 |
11,038,556 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0546:Shprh
|
UTSW |
10 |
11,059,631 (GRCm39) |
splice site |
probably benign |
|
|
R0574:Shprh
|
UTSW |
10 |
11,038,821 (GRCm39) |
unclassified |
probably benign |
|
|
R0605:Shprh
|
UTSW |
10 |
11,082,856 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0662:Shprh
|
UTSW |
10 |
11,062,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1148:Shprh
|
UTSW |
10 |
11,089,226 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1148:Shprh
|
UTSW |
10 |
11,089,226 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1263:Shprh
|
UTSW |
10 |
11,035,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1588:Shprh
|
UTSW |
10 |
11,040,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1638:Shprh
|
UTSW |
10 |
11,032,822 (GRCm39) |
missense |
probably benign |
|
|
R1830:Shprh
|
UTSW |
10 |
11,062,655 (GRCm39) |
splice site |
probably null |
|
|
R1898:Shprh
|
UTSW |
10 |
11,062,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1903:Shprh
|
UTSW |
10 |
11,059,541 (GRCm39) |
nonsense |
probably null |
|
|
R2060:Shprh
|
UTSW |
10 |
11,027,864 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2225:Shprh
|
UTSW |
10 |
11,037,979 (GRCm39) |
unclassified |
probably benign |
|
|
R2363:Shprh
|
UTSW |
10 |
11,047,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2509:Shprh
|
UTSW |
10 |
11,042,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2891:Shprh
|
UTSW |
10 |
11,040,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3077:Shprh
|
UTSW |
10 |
11,046,157 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3150:Shprh
|
UTSW |
10 |
11,045,774 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3796:Shprh
|
UTSW |
10 |
11,054,501 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4196:Shprh
|
UTSW |
10 |
11,083,604 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4423:Shprh
|
UTSW |
10 |
11,062,262 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4488:Shprh
|
UTSW |
10 |
11,036,215 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4748:Shprh
|
UTSW |
10 |
11,046,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4768:Shprh
|
UTSW |
10 |
11,057,284 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4867:Shprh
|
UTSW |
10 |
11,040,301 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4937:Shprh
|
UTSW |
10 |
11,032,863 (GRCm39) |
missense |
probably benign |
|
|
R5140:Shprh
|
UTSW |
10 |
11,030,449 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5318:Shprh
|
UTSW |
10 |
11,042,301 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5323:Shprh
|
UTSW |
10 |
11,046,041 (GRCm39) |
splice site |
probably null |
|
|
R5450:Shprh
|
UTSW |
10 |
11,088,074 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R5872:Shprh
|
UTSW |
10 |
11,063,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6030:Shprh
|
UTSW |
10 |
11,027,735 (GRCm39) |
missense |
probably benign |
0.37 |
|
R6392:Shprh
|
UTSW |
10 |
11,054,485 (GRCm39) |
nonsense |
probably null |
|
|
R6416:Shprh
|
UTSW |
10 |
11,043,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6470:Shprh
|
UTSW |
10 |
11,047,681 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6513:Shprh
|
UTSW |
10 |
11,062,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6530:Shprh
|
UTSW |
10 |
11,070,011 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6678:Shprh
|
UTSW |
10 |
11,042,289 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6757:Shprh
|
UTSW |
10 |
11,057,252 (GRCm39) |
splice site |
probably null |
|
|
R6971:Shprh
|
UTSW |
10 |
11,042,437 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7158:Shprh
|
UTSW |
10 |
11,042,474 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7582:Shprh
|
UTSW |
10 |
11,040,449 (GRCm39) |
missense |
probably benign |
|
|
R7757:Shprh
|
UTSW |
10 |
11,037,924 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7812:Shprh
|
UTSW |
10 |
11,027,735 (GRCm39) |
missense |
probably benign |
|
|
R7998:Shprh
|
UTSW |
10 |
11,061,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8061:Shprh
|
UTSW |
10 |
11,088,077 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8082:Shprh
|
UTSW |
10 |
11,027,555 (GRCm39) |
missense |
probably benign |
0.22 |
|
R8116:Shprh
|
UTSW |
10 |
11,089,205 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8390:Shprh
|
UTSW |
10 |
11,063,727 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8445:Shprh
|
UTSW |
10 |
11,057,313 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8530:Shprh
|
UTSW |
10 |
11,027,678 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8759:Shprh
|
UTSW |
10 |
11,032,908 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8937:Shprh
|
UTSW |
10 |
11,061,181 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8995:Shprh
|
UTSW |
10 |
11,040,574 (GRCm39) |
nonsense |
probably null |
|
|
R9053:Shprh
|
UTSW |
10 |
11,030,446 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9131:Shprh
|
UTSW |
10 |
11,038,589 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R9176:Shprh
|
UTSW |
10 |
11,036,320 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9391:Shprh
|
UTSW |
10 |
11,038,633 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9423:Shprh
|
UTSW |
10 |
11,081,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9563:Shprh
|
UTSW |
10 |
11,042,235 (GRCm39) |
nonsense |
probably null |
|
|
R9668:Shprh
|
UTSW |
10 |
11,082,076 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9709:Shprh
|
UTSW |
10 |
11,038,574 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9718:Shprh
|
UTSW |
10 |
11,089,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9750:Shprh
|
UTSW |
10 |
11,040,204 (GRCm39) |
missense |
probably damaging |
0.98 |
|
RF012:Shprh
|
UTSW |
10 |
11,040,585 (GRCm39) |
missense |
probably benign |
0.02 |
|
V8831:Shprh
|
UTSW |
10 |
11,062,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Shprh
|
UTSW |
10 |
11,062,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Shprh
|
UTSW |
10 |
11,040,297 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Shprh
|
UTSW |
10 |
11,027,506 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ATCATCGATGAAGGCCCTCCTG -3'
(R):5'- TCTGTAGCCAGGCCAAATCC -3'
Sequencing Primer
(F):5'- ATGAAGGCCCTCCTGAGAGTG -3'
(R):5'- CATGTCACTACTGAAGGAGGATTCC -3'
|
| Posted On |
2017-08-16 |
Incidental Mutation