Mutagenetix > Incidental Mutation

Incidental Mutation 'R6031:Vps13b'

486298

Institutional Source

Beutler Lab

Gene Symbol

Vps13b

Ensembl Gene

ENSMUSG00000037646

Gene Name

vacuolar protein sorting 13B

Synonyms

2310042E16Rik, 1810042B05Rik, Coh1, C330002D13Rik

MMRRC Submission

044203-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6031 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

35371160-35931229 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 35471968 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Methionine at position 806 (L806M)

Ref Sequence

ENSEMBL: ENSMUSP00000045490 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000048646]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000048646
AA Change: L806M

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000045490
Gene: ENSMUSG00000037646
AA Change: L806M

Domain	Start	End	E-Value	Type
Pfam:Chorein_N	2	120	1e-29	PFAM
low complexity region	128	137	N/A	INTRINSIC
low complexity region	143	160	N/A	INTRINSIC
low complexity region	975	984	N/A	INTRINSIC
low complexity region	1007	1018	N/A	INTRINSIC
low complexity region	1876	1883	N/A	INTRINSIC
low complexity region	2042	2054	N/A	INTRINSIC
low complexity region	2414	2423	N/A	INTRINSIC
Pfam:SHR-BD	2601	2700	8.4e-10	PFAM
low complexity region	2954	2964	N/A	INTRINSIC
Pfam:VPS13_C	3539	3706	2.6e-30	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000226579

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.4%
20x: 95.6%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a potential transmembrane protein that may function in vesicle-mediated transport and sorting of proteins within the cell. This protein may play a role in the development and the function of the eye, hematological system, and central nervous system. Mutations in this gene have been associated with Cohen syndrome. Multiple splice variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700010I14Rik	T	C	17: 8,995,252 (GRCm38)	Y304H	possibly damaging	Het
Add2	A	G	6: 86,098,673 (GRCm38)	E268G	probably damaging	Het
Akr1b1	A	C	6: 34,312,674 (GRCm38)	V67G	probably benign	Het
Alms1	A	T	6: 85,622,955 (GRCm38)	N1588Y	probably damaging	Het
Arhgap23	A	T	11: 97,476,139 (GRCm38)	D1082V	probably damaging	Het
Asb6	A	G	2: 30,824,195 (GRCm38)	V301A	probably benign	Het
Ascc3	C	T	10: 50,842,183 (GRCm38)	R1991*	probably null	Het
Atg7	T	A	6: 114,671,233 (GRCm38)	C31S	probably benign	Het
Camsap2	A	T	1: 136,280,438 (GRCm38)	N1105K	possibly damaging	Het
Ccdc125	C	T	13: 100,684,369 (GRCm38)		probably null	Het
Ccdc63	T	C	5: 122,129,736 (GRCm38)	I56V	possibly damaging	Het
Cpd	T	C	11: 76,790,888 (GRCm38)	E1143G	probably benign	Het
Cpt1a	T	A	19: 3,371,556 (GRCm38)		probably null	Het
Creb3l2	A	T	6: 37,334,434 (GRCm38)	D473E	probably benign	Het
Disp2	G	T	2: 118,789,794 (GRCm38)	V336L	probably benign	Het
Efr3b	A	G	12: 3,967,106 (GRCm38)	I782T	possibly damaging	Het
Fam98a	A	G	17: 75,539,432 (GRCm38)	V230A	probably damaging	Het
Fat3	T	A	9: 15,988,492 (GRCm38)	T3082S	probably benign	Het
Frmd3	T	C	4: 74,187,451 (GRCm38)	Y445H	probably damaging	Het
Galt	G	A	4: 41,757,202 (GRCm38)	R185Q	probably benign	Het
Gatb	T	C	3: 85,613,511 (GRCm38)	I309T	possibly damaging	Het
Gfi1b	G	A	2: 28,613,808 (GRCm38)	Q127*	probably null	Het
Gfpt1	C	A	6: 87,086,320 (GRCm38)	T563N	probably damaging	Het
Gria1	A	G	11: 57,217,782 (GRCm38)	D237G	probably damaging	Het
Hspbp1	A	T	7: 4,663,466 (GRCm38)	V305D	probably benign	Het
Hyls1	G	A	9: 35,561,184 (GRCm38)	S312F	probably benign	Het
Iars1	T	C	13: 49,705,831 (GRCm38)	V9A	probably damaging	Het
Ipo4	G	A	14: 55,632,139 (GRCm38)	P355S	probably damaging	Het
Jade2	G	T	11: 51,826,586 (GRCm38)	C314*	probably null	Het
Kri1	T	C	9: 21,275,269 (GRCm38)	E597G	probably benign	Het
Mcub	A	G	3: 129,926,389 (GRCm38)	Y152H	probably damaging	Het
Med23	C	T	10: 24,903,748 (GRCm38)	R542*	probably null	Het
Ndc80	T	C	17: 71,511,488 (GRCm38)	N291S	probably benign	Het
Nop2	T	C	6: 125,133,566 (GRCm38)		probably null	Het
Nrxn1	T	C	17: 90,588,790 (GRCm38)	N984S	probably damaging	Het
Ntm	A	C	9: 29,009,375 (GRCm38)	L86R	probably damaging	Het
Numa1	T	A	7: 102,012,012 (GRCm38)	D1847E	possibly damaging	Het
Odf2l	A	G	3: 145,139,863 (GRCm38)	Q334R	probably damaging	Het
Or10ak11	A	T	4: 118,830,391 (GRCm38)		probably null	Het
Or2ag2	C	T	7: 106,885,927 (GRCm38)	V297I	possibly damaging	Het
Or4a39	T	A	2: 89,406,972 (GRCm38)	T36S	probably damaging	Het
Or5ac17	T	C	16: 59,215,933 (GRCm38)	R227G	probably benign	Het
Or6ae1	A	T	7: 140,162,809 (GRCm38)	V47E	possibly damaging	Het
Or6c203	A	G	10: 129,174,355 (GRCm38)	V222A	probably benign	Het
Pacc1	A	G	1: 191,340,840 (GRCm38)	R153G	probably benign	Het
Pcdhb19	A	T	18: 37,497,723 (GRCm38)	K190N	probably damaging	Het
Pdik1l	A	G	4: 134,279,041 (GRCm38)	F197L	probably damaging	Het
Rnf113a2	T	C	12: 84,417,990 (GRCm38)	F219L	probably damaging	Het
Rnf208	A	C	2: 25,243,764 (GRCm38)	T157P	probably damaging	Het
RP23-145I16.3	A	T	7: 142,376,714 (GRCm38)	C364S	probably damaging	Het
Scn8a	A	T	15: 100,983,984 (GRCm38)	D644V	probably damaging	Het
Thbs3	T	A	3: 89,218,094 (GRCm38)	C204S	probably damaging	Het
Tlr3	A	G	8: 45,398,528 (GRCm38)	I444T	probably damaging	Het
Trpm8	A	T	1: 88,354,469 (GRCm38)	I696F	possibly damaging	Het
Ttn	A	T	2: 76,830,597 (GRCm38)	V7422D	possibly damaging	Het
Ufl1	A	G	4: 25,278,038 (GRCm38)	V139A	probably benign	Het
Uggt2	A	T	14: 119,070,826 (GRCm38)	V381D	probably benign	Het
Vgll3	T	A	16: 65,839,481 (GRCm38)	Y173N	probably damaging	Het
Vmn1r9	A	G	6: 57,071,173 (GRCm38)	T78A	probably benign	Het
Vps13d	A	C	4: 145,168,509 (GRCm38)	H394Q	probably benign	Het
Wdr53	T	A	16: 32,256,718 (GRCm38)	V247D	probably damaging	Het
Wdr81	A	T	11: 75,447,869 (GRCm38)	L1488Q	probably damaging	Het
Zc3h6	A	G	2: 128,967,812 (GRCm38)	D3G	possibly damaging	Het
Zfp93	G	T	7: 24,276,300 (GRCm38)	C570F	probably damaging	Het
Zfp943	C	T	17: 21,993,376 (GRCm38)	T481I	probably benign	Het

Other mutations in Vps13b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00402:Vps13b	APN	15	35,926,226 (GRCm38)	missense	possibly damaging	0.52
IGL00513:Vps13b	APN	15	35,793,884 (GRCm38)	missense	probably damaging	1.00
IGL00516:Vps13b	APN	15	35,640,557 (GRCm38)	missense	probably damaging	1.00
IGL00640:Vps13b	APN	15	35,417,577 (GRCm38)	missense	probably benign
IGL00753:Vps13b	APN	15	35,372,031 (GRCm38)	missense	probably damaging	0.99
IGL00784:Vps13b	APN	15	35,846,900 (GRCm38)	missense	probably damaging	1.00
IGL01138:Vps13b	APN	15	35,446,770 (GRCm38)	splice site	probably benign
IGL01349:Vps13b	APN	15	35,793,945 (GRCm38)	missense	probably benign	0.00
IGL01403:Vps13b	APN	15	35,709,479 (GRCm38)	missense	probably benign	0.00
IGL01535:Vps13b	APN	15	35,454,957 (GRCm38)	missense	possibly damaging	0.67
IGL01571:Vps13b	APN	15	35,877,489 (GRCm38)	splice site	probably benign
IGL01642:Vps13b	APN	15	35,792,072 (GRCm38)	missense	probably benign	0.43
IGL01658:Vps13b	APN	15	35,671,333 (GRCm38)	missense	probably damaging	0.99
IGL01759:Vps13b	APN	15	35,878,789 (GRCm38)	missense	probably damaging	1.00
IGL01763:Vps13b	APN	15	35,709,799 (GRCm38)	missense	possibly damaging	0.72
IGL01906:Vps13b	APN	15	35,639,847 (GRCm38)	splice site	probably benign
IGL01982:Vps13b	APN	15	35,438,904 (GRCm38)	nonsense	probably null
IGL01997:Vps13b	APN	15	35,709,224 (GRCm38)	missense	probably damaging	1.00
IGL02041:Vps13b	APN	15	35,423,245 (GRCm38)	missense	probably damaging	0.98
IGL02073:Vps13b	APN	15	35,875,586 (GRCm38)	missense	possibly damaging	0.52
IGL02077:Vps13b	APN	15	35,910,613 (GRCm38)	missense	possibly damaging	0.68
IGL02141:Vps13b	APN	15	35,572,081 (GRCm38)	missense	probably benign	0.09
IGL02146:Vps13b	APN	15	35,646,333 (GRCm38)	missense	probably benign	0.36
IGL02197:Vps13b	APN	15	35,930,056 (GRCm38)	missense	probably benign	0.02
IGL02311:Vps13b	APN	15	35,709,514 (GRCm38)	missense	probably benign	0.08
IGL02466:Vps13b	APN	15	35,770,741 (GRCm38)	missense	possibly damaging	0.86
IGL02506:Vps13b	APN	15	35,917,162 (GRCm38)	missense	probably damaging	1.00
IGL02550:Vps13b	APN	15	35,572,096 (GRCm38)	missense	probably benign
IGL02553:Vps13b	APN	15	35,646,301 (GRCm38)	missense	probably benign	0.00
IGL02674:Vps13b	APN	15	35,639,958 (GRCm38)	missense	probably benign	0.41
IGL02690:Vps13b	APN	15	35,917,142 (GRCm38)	missense	probably damaging	1.00
IGL02731:Vps13b	APN	15	35,917,128 (GRCm38)	missense	probably benign	0.00
IGL02739:Vps13b	APN	15	35,879,900 (GRCm38)	missense	probably damaging	1.00
IGL02868:Vps13b	APN	15	35,884,519 (GRCm38)	missense	probably benign	0.03
IGL03081:Vps13b	APN	15	35,875,820 (GRCm38)	missense	probably damaging	0.97
IGL03178:Vps13b	APN	15	35,869,300 (GRCm38)	missense	probably damaging	1.00
IGL03343:Vps13b	APN	15	35,917,170 (GRCm38)	missense	possibly damaging	0.76
IGL03407:Vps13b	APN	15	35,639,866 (GRCm38)	missense	possibly damaging	0.95
IGL03410:Vps13b	APN	15	35,910,340 (GRCm38)	missense	probably benign
omlette	UTSW	15	35,671,400 (GRCm38)	missense	probably benign	0.13
swiss	UTSW	15	35,709,673 (GRCm38)	missense	possibly damaging	0.80
FR4449:Vps13b	UTSW	15	35,846,957 (GRCm38)	missense	probably damaging	1.00
FR4548:Vps13b	UTSW	15	35,846,957 (GRCm38)	missense	probably damaging	1.00
FR4737:Vps13b	UTSW	15	35,846,957 (GRCm38)	missense	probably damaging	1.00
FR4976:Vps13b	UTSW	15	35,846,957 (GRCm38)	missense	probably damaging	1.00
LCD18:Vps13b	UTSW	15	35,846,957 (GRCm38)	missense	probably damaging	1.00
PIT4531001:Vps13b	UTSW	15	35,878,825 (GRCm38)	missense	probably damaging	1.00
PIT4581001:Vps13b	UTSW	15	35,534,263 (GRCm38)	missense	probably damaging	1.00
PIT4618001:Vps13b	UTSW	15	35,709,240 (GRCm38)	missense	probably damaging	1.00
R0026:Vps13b	UTSW	15	35,923,301 (GRCm38)	missense	possibly damaging	0.62
R0026:Vps13b	UTSW	15	35,923,301 (GRCm38)	missense	possibly damaging	0.62
R0108:Vps13b	UTSW	15	35,572,119 (GRCm38)	missense	probably benign	0.20
R0109:Vps13b	UTSW	15	35,572,119 (GRCm38)	missense	probably benign	0.20
R0109:Vps13b	UTSW	15	35,572,119 (GRCm38)	missense	probably benign	0.20
R0116:Vps13b	UTSW	15	35,423,155 (GRCm38)	missense	probably damaging	0.99
R0123:Vps13b	UTSW	15	35,887,261 (GRCm38)	missense	probably benign	0.01
R0124:Vps13b	UTSW	15	35,576,528 (GRCm38)	critical splice donor site	probably null
R0134:Vps13b	UTSW	15	35,887,261 (GRCm38)	missense	probably benign	0.01
R0137:Vps13b	UTSW	15	35,926,219 (GRCm38)	missense	probably benign	0.06
R0195:Vps13b	UTSW	15	35,471,899 (GRCm38)	missense	probably benign	0.00
R0225:Vps13b	UTSW	15	35,887,261 (GRCm38)	missense	probably benign	0.01
R0320:Vps13b	UTSW	15	35,674,828 (GRCm38)	missense	probably damaging	0.98
R0333:Vps13b	UTSW	15	35,879,803 (GRCm38)	missense	probably damaging	1.00
R0336:Vps13b	UTSW	15	35,455,133 (GRCm38)	nonsense	probably null
R0463:Vps13b	UTSW	15	35,597,409 (GRCm38)	missense	probably damaging	0.98
R0466:Vps13b	UTSW	15	35,445,602 (GRCm38)	nonsense	probably null
R0472:Vps13b	UTSW	15	35,417,633 (GRCm38)	critical splice donor site	probably null
R0523:Vps13b	UTSW	15	35,472,050 (GRCm38)	missense	probably benign	0.20
R0602:Vps13b	UTSW	15	35,422,368 (GRCm38)	missense	probably damaging	1.00
R0612:Vps13b	UTSW	15	35,623,657 (GRCm38)	missense	probably benign	0.12
R0627:Vps13b	UTSW	15	35,371,999 (GRCm38)	nonsense	probably null
R0679:Vps13b	UTSW	15	35,709,703 (GRCm38)	missense	possibly damaging	0.73
R0742:Vps13b	UTSW	15	35,794,361 (GRCm38)	missense	probably benign	0.22
R1053:Vps13b	UTSW	15	35,652,363 (GRCm38)	missense	probably damaging	1.00
R1355:Vps13b	UTSW	15	35,422,454 (GRCm38)	missense	probably damaging	1.00
R1386:Vps13b	UTSW	15	35,923,312 (GRCm38)	missense	probably damaging	0.99
R1403:Vps13b	UTSW	15	35,709,122 (GRCm38)	splice site	probably benign
R1453:Vps13b	UTSW	15	35,422,444 (GRCm38)	missense	probably damaging	0.97
R1464:Vps13b	UTSW	15	35,709,484 (GRCm38)	missense	probably benign	0.14
R1464:Vps13b	UTSW	15	35,709,484 (GRCm38)	missense	probably benign	0.14
R1511:Vps13b	UTSW	15	35,841,573 (GRCm38)	missense	probably benign	0.00
R1511:Vps13b	UTSW	15	35,839,975 (GRCm38)	missense	probably damaging	0.99
R1513:Vps13b	UTSW	15	35,438,730 (GRCm38)	nonsense	probably null
R1536:Vps13b	UTSW	15	35,875,566 (GRCm38)	missense	probably damaging	0.98
R1537:Vps13b	UTSW	15	35,792,181 (GRCm38)	missense	possibly damaging	0.62
R1558:Vps13b	UTSW	15	35,534,319 (GRCm38)	missense	probably damaging	1.00
R1601:Vps13b	UTSW	15	35,642,436 (GRCm38)	missense	probably benign	0.11
R1653:Vps13b	UTSW	15	35,607,272 (GRCm38)	nonsense	probably null
R1695:Vps13b	UTSW	15	35,576,521 (GRCm38)	missense	probably benign	0.05
R1760:Vps13b	UTSW	15	35,884,619 (GRCm38)	missense	possibly damaging	0.54
R1785:Vps13b	UTSW	15	35,879,791 (GRCm38)	missense	probably damaging	1.00
R1786:Vps13b	UTSW	15	35,879,791 (GRCm38)	missense	probably damaging	1.00
R1803:Vps13b	UTSW	15	35,430,205 (GRCm38)	nonsense	probably null
R1804:Vps13b	UTSW	15	35,917,137 (GRCm38)	missense	probably damaging	1.00
R1808:Vps13b	UTSW	15	35,792,059 (GRCm38)	missense	probably benign	0.00
R1817:Vps13b	UTSW	15	35,910,642 (GRCm38)	missense	possibly damaging	0.86
R1818:Vps13b	UTSW	15	35,877,577 (GRCm38)	missense	probably benign	0.00
R1836:Vps13b	UTSW	15	35,910,232 (GRCm38)	missense	probably damaging	0.99
R1850:Vps13b	UTSW	15	35,674,959 (GRCm38)	splice site	probably benign
R1884:Vps13b	UTSW	15	35,430,291 (GRCm38)	splice site	probably benign
R1938:Vps13b	UTSW	15	35,709,507 (GRCm38)	missense	probably damaging	1.00
R1955:Vps13b	UTSW	15	35,925,408 (GRCm38)	critical splice donor site	probably null
R1956:Vps13b	UTSW	15	35,869,407 (GRCm38)	missense	probably damaging	1.00
R1958:Vps13b	UTSW	15	35,878,689 (GRCm38)	missense	probably damaging	0.99
R2013:Vps13b	UTSW	15	35,607,142 (GRCm38)	missense	probably damaging	0.99
R2014:Vps13b	UTSW	15	35,607,142 (GRCm38)	missense	probably damaging	0.99
R2015:Vps13b	UTSW	15	35,607,142 (GRCm38)	missense	probably damaging	0.99
R2038:Vps13b	UTSW	15	35,884,741 (GRCm38)	missense	probably damaging	1.00
R2058:Vps13b	UTSW	15	35,841,447 (GRCm38)	missense	probably damaging	1.00
R2082:Vps13b	UTSW	15	35,910,746 (GRCm38)	missense	possibly damaging	0.70
R2087:Vps13b	UTSW	15	35,597,493 (GRCm38)	missense	probably damaging	0.99
R2124:Vps13b	UTSW	15	35,646,080 (GRCm38)	missense	probably benign	0.08
R2130:Vps13b	UTSW	15	35,671,400 (GRCm38)	missense	probably benign	0.13
R2168:Vps13b	UTSW	15	35,792,188 (GRCm38)	missense	probably damaging	1.00
R2168:Vps13b	UTSW	15	35,792,189 (GRCm38)	missense	probably damaging	1.00
R2171:Vps13b	UTSW	15	35,887,197 (GRCm38)	missense	probably benign	0.44
R2221:Vps13b	UTSW	15	35,884,597 (GRCm38)	missense	probably benign
R2263:Vps13b	UTSW	15	35,646,181 (GRCm38)	missense	probably benign	0.02
R2289:Vps13b	UTSW	15	35,572,105 (GRCm38)	missense	probably damaging	1.00
R2316:Vps13b	UTSW	15	35,674,899 (GRCm38)	nonsense	probably null
R2351:Vps13b	UTSW	15	35,869,311 (GRCm38)	missense	probably damaging	1.00
R2512:Vps13b	UTSW	15	35,884,555 (GRCm38)	missense	probably benign	0.35
R3054:Vps13b	UTSW	15	35,646,361 (GRCm38)	missense	probably damaging	0.99
R3055:Vps13b	UTSW	15	35,646,361 (GRCm38)	missense	probably damaging	0.99
R3196:Vps13b	UTSW	15	35,869,395 (GRCm38)	missense	probably damaging	1.00
R3236:Vps13b	UTSW	15	35,910,304 (GRCm38)	missense	probably benign	0.40
R3404:Vps13b	UTSW	15	35,926,054 (GRCm38)	missense	probably damaging	1.00
R3722:Vps13b	UTSW	15	35,671,382 (GRCm38)	missense	probably damaging	0.99
R4077:Vps13b	UTSW	15	35,455,128 (GRCm38)	missense	probably damaging	0.99
R4153:Vps13b	UTSW	15	35,792,027 (GRCm38)	splice site	probably null
R4224:Vps13b	UTSW	15	35,876,419 (GRCm38)	missense	probably damaging	0.99
R4408:Vps13b	UTSW	15	35,709,294 (GRCm38)	missense	probably damaging	0.98
R4431:Vps13b	UTSW	15	35,770,753 (GRCm38)	missense	probably damaging	1.00
R4449:Vps13b	UTSW	15	35,876,793 (GRCm38)	missense	possibly damaging	0.86
R4508:Vps13b	UTSW	15	35,709,673 (GRCm38)	missense	possibly damaging	0.80
R4631:Vps13b	UTSW	15	35,646,132 (GRCm38)	missense	possibly damaging	0.95
R4655:Vps13b	UTSW	15	35,770,689 (GRCm38)	missense	probably benign
R4666:Vps13b	UTSW	15	35,640,544 (GRCm38)	missense	probably benign	0.13
R4684:Vps13b	UTSW	15	35,879,821 (GRCm38)	missense	probably benign
R4684:Vps13b	UTSW	15	35,841,341 (GRCm38)	missense	probably benign
R4684:Vps13b	UTSW	15	35,646,178 (GRCm38)	missense	probably damaging	0.98
R4721:Vps13b	UTSW	15	35,910,718 (GRCm38)	nonsense	probably null
R4771:Vps13b	UTSW	15	35,910,800 (GRCm38)	missense	probably damaging	1.00
R4830:Vps13b	UTSW	15	35,452,224 (GRCm38)	missense	possibly damaging	0.94
R4835:Vps13b	UTSW	15	35,869,372 (GRCm38)	missense	probably damaging	1.00
R4835:Vps13b	UTSW	15	35,910,293 (GRCm38)	missense	probably benign
R4857:Vps13b	UTSW	15	35,456,654 (GRCm38)	missense	probably benign	0.01
R4891:Vps13b	UTSW	15	35,640,515 (GRCm38)	splice site	probably null
R5095:Vps13b	UTSW	15	35,923,202 (GRCm38)	missense	probably damaging	1.00
R5110:Vps13b	UTSW	15	35,770,809 (GRCm38)	missense	probably damaging	0.99
R5147:Vps13b	UTSW	15	35,456,678 (GRCm38)	missense	probably benign	0.32
R5153:Vps13b	UTSW	15	35,422,453 (GRCm38)	missense	probably damaging	0.99
R5257:Vps13b	UTSW	15	35,794,421 (GRCm38)	missense	possibly damaging	0.75
R5258:Vps13b	UTSW	15	35,794,421 (GRCm38)	missense	possibly damaging	0.75
R5296:Vps13b	UTSW	15	35,876,413 (GRCm38)	missense	probably damaging	1.00
R5386:Vps13b	UTSW	15	35,640,528 (GRCm38)	critical splice acceptor site	probably null
R5396:Vps13b	UTSW	15	35,886,948 (GRCm38)	missense	probably damaging	0.99
R5412:Vps13b	UTSW	15	35,533,385 (GRCm38)	missense	probably damaging	1.00
R5488:Vps13b	UTSW	15	35,770,542 (GRCm38)	missense	probably benign
R5489:Vps13b	UTSW	15	35,770,542 (GRCm38)	missense	probably benign
R5503:Vps13b	UTSW	15	35,452,166 (GRCm38)	missense	probably damaging	0.97
R5575:Vps13b	UTSW	15	35,929,919 (GRCm38)	missense	probably damaging	1.00
R5781:Vps13b	UTSW	15	35,794,035 (GRCm38)	missense	probably damaging	0.97
R5872:Vps13b	UTSW	15	35,869,351 (GRCm38)	missense	possibly damaging	0.56
R5876:Vps13b	UTSW	15	35,917,061 (GRCm38)	missense	probably damaging	0.99
R5994:Vps13b	UTSW	15	35,875,772 (GRCm38)	missense	probably damaging	1.00
R6031:Vps13b	UTSW	15	35,471,968 (GRCm38)	missense	probably damaging	1.00
R6045:Vps13b	UTSW	15	35,671,316 (GRCm38)	missense	probably damaging	0.99
R6143:Vps13b	UTSW	15	35,668,738 (GRCm38)	missense	probably damaging	0.99
R6147:Vps13b	UTSW	15	35,930,031 (GRCm38)	missense	probably benign	0.16
R6218:Vps13b	UTSW	15	35,770,464 (GRCm38)	missense	probably benign	0.00
R6447:Vps13b	UTSW	15	35,572,126 (GRCm38)	missense	probably benign	0.02
R6555:Vps13b	UTSW	15	35,846,847 (GRCm38)	missense	probably damaging	1.00
R6578:Vps13b	UTSW	15	35,446,101 (GRCm38)	missense	probably damaging	0.99
R6640:Vps13b	UTSW	15	35,617,696 (GRCm38)	missense	possibly damaging	0.93
R6645:Vps13b	UTSW	15	35,910,305 (GRCm38)	missense	probably benign	0.25
R6711:Vps13b	UTSW	15	35,887,249 (GRCm38)	missense	probably damaging	1.00
R6727:Vps13b	UTSW	15	35,770,683 (GRCm38)	missense	probably benign	0.19
R6737:Vps13b	UTSW	15	35,910,611 (GRCm38)	missense	probably damaging	1.00
R6844:Vps13b	UTSW	15	35,877,590 (GRCm38)	missense	probably benign	0.06
R6849:Vps13b	UTSW	15	35,905,309 (GRCm38)	missense	probably damaging	1.00
R6861:Vps13b	UTSW	15	35,576,395 (GRCm38)	missense	probably damaging	0.99
R6938:Vps13b	UTSW	15	35,423,198 (GRCm38)	missense	probably damaging	0.99
R6943:Vps13b	UTSW	15	35,448,689 (GRCm38)	missense	possibly damaging	0.95
R6989:Vps13b	UTSW	15	35,448,581 (GRCm38)	missense	probably benign	0.02
R7092:Vps13b	UTSW	15	35,640,634 (GRCm38)	missense	probably damaging	1.00
R7232:Vps13b	UTSW	15	35,877,557 (GRCm38)	missense	probably damaging	1.00
R7307:Vps13b	UTSW	15	35,841,545 (GRCm38)	missense	probably benign
R7400:Vps13b	UTSW	15	35,378,900 (GRCm38)	missense	probably damaging	1.00
R7414:Vps13b	UTSW	15	35,910,827 (GRCm38)	missense	probably damaging	1.00
R7497:Vps13b	UTSW	15	35,876,697 (GRCm38)	missense	probably benign	0.38
R7500:Vps13b	UTSW	15	35,910,524 (GRCm38)	missense	possibly damaging	0.74
R7603:Vps13b	UTSW	15	35,576,439 (GRCm38)	missense	probably damaging	0.98
R7605:Vps13b	UTSW	15	35,770,646 (GRCm38)	missense	probably damaging	0.97
R7849:Vps13b	UTSW	15	35,423,232 (GRCm38)	missense	probably damaging	0.99
R7984:Vps13b	UTSW	15	35,879,913 (GRCm38)	missense	probably benign
R8094:Vps13b	UTSW	15	35,668,906 (GRCm38)	critical splice donor site	probably null
R8097:Vps13b	UTSW	15	35,709,346 (GRCm38)	missense	probably benign	0.38
R8131:Vps13b	UTSW	15	35,372,109 (GRCm38)	critical splice donor site	probably null
R8139:Vps13b	UTSW	15	35,607,272 (GRCm38)	nonsense	probably null
R8174:Vps13b	UTSW	15	35,709,310 (GRCm38)	nonsense	probably null
R8225:Vps13b	UTSW	15	35,794,382 (GRCm38)	missense	probably damaging	0.99
R8239:Vps13b	UTSW	15	35,597,404 (GRCm38)	missense	probably damaging	1.00
R8244:Vps13b	UTSW	15	35,917,203 (GRCm38)	missense	probably damaging	1.00
R8303:Vps13b	UTSW	15	35,639,917 (GRCm38)	missense	probably damaging	1.00
R8311:Vps13b	UTSW	15	35,886,954 (GRCm38)	missense	probably benign	0.37
R8443:Vps13b	UTSW	15	35,455,100 (GRCm38)	missense	probably benign
R8494:Vps13b	UTSW	15	35,422,448 (GRCm38)	missense	probably damaging	0.99
R8499:Vps13b	UTSW	15	35,841,320 (GRCm38)	missense	probably damaging	1.00
R8506:Vps13b	UTSW	15	35,446,745 (GRCm38)	missense	probably benign	0.31
R8559:Vps13b	UTSW	15	35,876,642 (GRCm38)	missense	probably damaging	1.00
R8686:Vps13b	UTSW	15	35,925,389 (GRCm38)	missense	probably damaging	0.99
R8782:Vps13b	UTSW	15	35,422,337 (GRCm38)	missense	possibly damaging	0.93
R8806:Vps13b	UTSW	15	35,472,066 (GRCm38)	critical splice donor site	probably benign
R8824:Vps13b	UTSW	15	35,533,299 (GRCm38)	missense	probably damaging	0.99
R9024:Vps13b	UTSW	15	35,923,324 (GRCm38)	missense	probably damaging	0.97
R9038:Vps13b	UTSW	15	35,875,785 (GRCm38)	missense	possibly damaging	0.70
R9054:Vps13b	UTSW	15	35,422,391 (GRCm38)	missense	probably damaging	1.00
R9091:Vps13b	UTSW	15	35,770,773 (GRCm38)	missense	probably benign	0.13
R9129:Vps13b	UTSW	15	35,448,647 (GRCm38)	missense	probably damaging	1.00
R9214:Vps13b	UTSW	15	35,623,746 (GRCm38)	missense	probably damaging	0.99
R9237:Vps13b	UTSW	15	35,841,333 (GRCm38)	missense	probably damaging	1.00
R9256:Vps13b	UTSW	15	35,623,779 (GRCm38)	missense	possibly damaging	0.95
R9270:Vps13b	UTSW	15	35,770,773 (GRCm38)	missense	probably benign	0.13
R9279:Vps13b	UTSW	15	35,572,144 (GRCm38)	missense	probably damaging	0.97
R9291:Vps13b	UTSW	15	35,846,913 (GRCm38)	missense	probably damaging	1.00
R9342:Vps13b	UTSW	15	35,455,054 (GRCm38)	missense	possibly damaging	0.94
R9404:Vps13b	UTSW	15	35,876,419 (GRCm38)	missense	probably damaging	1.00
R9488:Vps13b	UTSW	15	35,447,734 (GRCm38)	missense	possibly damaging	0.77
R9509:Vps13b	UTSW	15	35,841,311 (GRCm38)	missense	possibly damaging	0.79
R9610:Vps13b	UTSW	15	35,642,409 (GRCm38)	missense	possibly damaging	0.85
R9611:Vps13b	UTSW	15	35,642,409 (GRCm38)	missense	possibly damaging	0.85
R9658:Vps13b	UTSW	15	35,623,628 (GRCm38)	missense	probably benign	0.00
R9674:Vps13b	UTSW	15	35,607,234 (GRCm38)	missense	probably damaging	0.98
R9696:Vps13b	UTSW	15	35,674,887 (GRCm38)	missense	possibly damaging	0.56
R9767:Vps13b	UTSW	15	35,910,257 (GRCm38)	missense	probably damaging	1.00
R9797:Vps13b	UTSW	15	35,674,876 (GRCm38)	missense	probably damaging	1.00
RF020:Vps13b	UTSW	15	35,925,406 (GRCm38)	missense	probably null	1.00
X0026:Vps13b	UTSW	15	35,910,646 (GRCm38)	missense	probably damaging	1.00
X0028:Vps13b	UTSW	15	35,709,431 (GRCm38)	missense	probably benign	0.00
Z1177:Vps13b	UTSW	15	35,668,885 (GRCm38)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- CAAACCATGTGAATGTATACCTTTCCC -3'
(R):5'- GAAATTACTTTATACTACACAGGCAAC -3'

Sequencing Primer
(F):5'- CCCTTTTGTAGTACAGTTCCTCTAG -3'
(R):5'- CTAAGCAAGATTGACAAGCCTTTAGG -3'

Posted On

2017-08-16