Incidental Mutation 'R6036:Or51a25'
ID 486576
Institutional Source Beutler Lab
Gene Symbol Or51a25
Ensembl Gene ENSMUSG00000066272
Gene Name olfactory receptor family 51 subfamily A member 25
Synonyms MOR11-1, Olfr559, GA_x6K02T2PBJ9-5441154-5440198
MMRRC Submission 043257-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R6036 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 102372739-102373695 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 102373692 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 2 (I2F)
Ref Sequence ENSEMBL: ENSMUSP00000151100 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084816] [ENSMUST00000215657]
AlphaFold Q8VH14
Predicted Effect probably benign
Transcript: ENSMUST00000084816
AA Change: I2F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000095820
Gene: ENSMUSG00000066272
AA Change: I2F

DomainStartEndE-ValueType
Pfam:7tm_4 37 317 1.1e-117 PFAM
Pfam:7TM_GPCR_Srsx 41 215 1e-10 PFAM
Pfam:7tm_1 47 299 3e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215657
AA Change: I2F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3 T C 11: 95,723,684 (GRCm39) probably benign Het
Ago1 C T 4: 126,337,021 (GRCm39) R228H probably damaging Het
Alpk3 G A 7: 80,743,005 (GRCm39) V941M probably benign Het
Ano4 A G 10: 88,818,127 (GRCm39) W588R possibly damaging Het
Atp6v1a A G 16: 43,919,194 (GRCm39) Y464H probably benign Het
Barx2 A T 9: 31,824,304 (GRCm39) D28E probably damaging Het
Cabp5 A T 7: 13,135,260 (GRCm39) M67L probably damaging Het
Col10a1 A G 10: 34,271,278 (GRCm39) T417A probably benign Het
Dnah2 C T 11: 69,349,746 (GRCm39) R2399Q probably benign Het
Ehmt2 C T 17: 35,118,067 (GRCm39) R40* probably null Het
Eif4enif1 T C 11: 3,189,420 (GRCm39) S227P probably damaging Het
Erv3 G A 2: 131,697,925 (GRCm39) H145Y possibly damaging Het
Exoc5 T C 14: 49,251,779 (GRCm39) T591A possibly damaging Het
F5 A T 1: 164,012,565 (GRCm39) E493V probably damaging Het
Gm8444 G T 15: 81,727,794 (GRCm39) probably benign Het
Gria4 T A 9: 4,537,646 (GRCm39) I221L probably benign Het
Gtf2h3 C T 5: 124,722,360 (GRCm39) T121I probably benign Het
H2bc13 A T 13: 21,900,148 (GRCm39) S56T probably damaging Het
Hc T C 2: 34,929,696 (GRCm39) T249A probably benign Het
Herc2 A G 7: 55,717,801 (GRCm39) T48A probably benign Het
Hp A G 8: 110,303,406 (GRCm39) probably null Het
Ifna15 T G 4: 88,476,310 (GRCm39) D58A possibly damaging Het
Kcnj1 A T 9: 32,308,421 (GRCm39) M262L probably benign Het
Krt87 A C 15: 101,385,412 (GRCm39) I320S possibly damaging Het
Megf10 A G 18: 57,375,799 (GRCm39) N242D probably damaging Het
Nup155 A G 15: 8,157,895 (GRCm39) T451A probably benign Het
Or2ag2b A T 7: 106,417,667 (GRCm39) I126F probably damaging Het
Or4g7 T C 2: 111,309,333 (GRCm39) L68P probably damaging Het
Or4k35 C T 2: 111,099,957 (GRCm39) G252R probably damaging Het
Or8d23 A G 9: 38,842,216 (GRCm39) I250V probably damaging Het
Pdzd8 G A 19: 59,293,641 (GRCm39) P403S probably damaging Het
Piezo2 G A 18: 63,248,019 (GRCm39) Q494* probably null Het
Pik3c2b T C 1: 133,018,451 (GRCm39) F966S possibly damaging Het
Plag1 T C 4: 3,904,618 (GRCm39) E191G possibly damaging Het
Pou4f2 A T 8: 79,162,103 (GRCm39) S167T probably damaging Het
Rsf1 G GACGGCGGCT 7: 97,229,116 (GRCm39) probably benign Het
Scd4 G A 19: 44,333,231 (GRCm39) D319N probably damaging Het
Senp2 A T 16: 21,847,308 (GRCm39) R279* probably null Het
Sh3rf3 G A 10: 58,649,806 (GRCm39) G137D probably benign Het
Simc1 C T 13: 54,672,434 (GRCm39) P261S probably benign Het
Skint8 C A 4: 111,807,390 (GRCm39) L359M probably damaging Het
Slc26a1 T A 5: 108,821,436 (GRCm39) D151V probably damaging Het
Snx29 A G 16: 11,556,301 (GRCm39) probably null Het
Stard9 C T 2: 120,530,556 (GRCm39) A2271V probably benign Het
Stat6 A G 10: 127,491,313 (GRCm39) N485D possibly damaging Het
Tpcn2 T C 7: 144,822,606 (GRCm39) T280A possibly damaging Het
Ttc23 A G 7: 67,361,114 (GRCm39) I378V possibly damaging Het
Ttc29 A G 8: 79,052,205 (GRCm39) D362G probably benign Het
Ttll7 A G 3: 146,645,917 (GRCm39) I592V probably benign Het
Ugt3a1 A T 15: 9,306,172 (GRCm39) H107L probably benign Het
Vmn1r70 A G 7: 10,367,830 (GRCm39) Q87R probably damaging Het
Vmn2r-ps129 T C 17: 23,214,146 (GRCm39) noncoding transcript Het
Wdfy4 G T 14: 32,868,947 (GRCm39) S360R probably damaging Het
Zfp780b A G 7: 27,662,993 (GRCm39) Y521H probably damaging Het
Other mutations in Or51a25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02832:Or51a25 APN 7 102,372,858 (GRCm39) missense probably benign 0.01
R0505:Or51a25 UTSW 7 102,373,236 (GRCm39) missense probably damaging 0.97
R1131:Or51a25 UTSW 7 102,372,887 (GRCm39) missense probably damaging 0.99
R1449:Or51a25 UTSW 7 102,373,397 (GRCm39) missense probably damaging 1.00
R3788:Or51a25 UTSW 7 102,372,694 (GRCm39) splice site probably null
R3915:Or51a25 UTSW 7 102,373,409 (GRCm39) missense possibly damaging 0.95
R3980:Or51a25 UTSW 7 102,372,959 (GRCm39) missense probably damaging 0.98
R4647:Or51a25 UTSW 7 102,373,299 (GRCm39) missense probably damaging 1.00
R5242:Or51a25 UTSW 7 102,373,483 (GRCm39) missense probably benign 0.41
R5404:Or51a25 UTSW 7 102,372,807 (GRCm39) missense possibly damaging 0.95
R5464:Or51a25 UTSW 7 102,373,124 (GRCm39) missense possibly damaging 0.85
R5807:Or51a25 UTSW 7 102,373,409 (GRCm39) missense possibly damaging 0.95
R5965:Or51a25 UTSW 7 102,373,467 (GRCm39) missense probably benign 0.00
R6008:Or51a25 UTSW 7 102,373,574 (GRCm39) missense probably damaging 1.00
R6036:Or51a25 UTSW 7 102,373,692 (GRCm39) missense probably benign
R6493:Or51a25 UTSW 7 102,373,287 (GRCm39) missense possibly damaging 0.85
R6756:Or51a25 UTSW 7 102,373,295 (GRCm39) missense probably benign 0.03
R7201:Or51a25 UTSW 7 102,373,692 (GRCm39) missense probably benign
R7460:Or51a25 UTSW 7 102,373,028 (GRCm39) missense probably benign 0.09
R7695:Or51a25 UTSW 7 102,372,866 (GRCm39) missense probably benign 0.37
R8145:Or51a25 UTSW 7 102,372,937 (GRCm39) missense probably damaging 0.98
R8371:Or51a25 UTSW 7 102,372,790 (GRCm39) missense probably damaging 1.00
R8499:Or51a25 UTSW 7 102,372,932 (GRCm39) missense probably damaging 1.00
R9185:Or51a25 UTSW 7 102,373,409 (GRCm39) missense possibly damaging 0.95
R9230:Or51a25 UTSW 7 102,372,795 (GRCm39) missense possibly damaging 0.95
X0025:Or51a25 UTSW 7 102,373,022 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTATGTGTCCTCCTCACAG -3'
(R):5'- TCTTTGGTACTTACTCACAAGGTTG -3'

Sequencing Primer
(F):5'- TGTCCTCCTCACAGCCAGG -3'
(R):5'- GCTAAGGTTTCAATCTTGGCAAC -3'
Posted On 2017-08-16