Incidental Mutation 'R5254:Lrrk1'
| ID |
486786 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrrk1
|
| Ensembl Gene |
ENSMUSG00000015133 |
| Gene Name |
leucine-rich repeat kinase 1 |
| Synonyms |
|
| MMRRC Submission |
042825-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R5254 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
66226912-66388350 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 66307107 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Isoleucine
at position 372
(N372I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000015277
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000015277]
|
| AlphaFold |
Q3UHC2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000015277
AA Change: N372I
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000015277
Gene: ENSMUSG00000015133
AA Change: N372I
| Domain | Start | End | E-Value | Type |
|---|
|
ANK
|
86 |
116 |
9.33e2 |
SMART |
|
ANK
|
119 |
148 |
1.14e2 |
SMART |
|
ANK
|
152 |
182 |
8.36e1 |
SMART |
|
ANK
|
193 |
223 |
2.6e1 |
SMART |
|
LRR
|
278 |
300 |
2.84e2 |
SMART |
|
LRR
|
301 |
325 |
7.79e0 |
SMART |
|
LRR
|
328 |
351 |
3.27e1 |
SMART |
|
LRR_TYP
|
379 |
401 |
2.53e-2 |
SMART |
|
LRR
|
403 |
427 |
5.89e1 |
SMART |
|
LRR
|
472 |
493 |
5.27e1 |
SMART |
|
LRR
|
548 |
569 |
2.92e2 |
SMART |
|
LRR
|
570 |
594 |
5.88e0 |
SMART |
|
Pfam:Arf
|
625 |
786 |
2e-8 |
PFAM |
|
Pfam:Roc
|
640 |
761 |
3.1e-24 |
PFAM |
|
Pfam:Ras
|
640 |
782 |
2.2e-7 |
PFAM |
|
Pfam:COR
|
844 |
1046 |
4.7e-26 |
PFAM |
|
low complexity region
|
1109 |
1119 |
N/A |
INTRINSIC |
|
low complexity region
|
1209 |
1222 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
1243 |
1521 |
7.8e-40 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1244 |
1520 |
9.4e-39 |
PFAM |
|
low complexity region
|
1642 |
1654 |
N/A |
INTRINSIC |
|
low complexity region
|
1839 |
1846 |
N/A |
INTRINSIC |
|
low complexity region
|
1852 |
1871 |
N/A |
INTRINSIC |
|
low complexity region
|
1957 |
1970 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000207140
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.6%
|
| Validation Efficiency |
98% (82/84) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit preweaning lethality. Mice homozygous for another knock-out allele exhibit severe osteopetrosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abhd8 |
G |
T |
8: 71,458,398 (GRCm38) |
C296* |
probably null |
Het |
| Adam11 |
T |
A |
11: 102,774,272 (GRCm38) |
Y413* |
probably null |
Het |
| Ankhd1 |
A |
G |
18: 36,656,715 (GRCm38) |
I907V |
probably benign |
Het |
| Arrdc5 |
A |
G |
17: 56,297,897 (GRCm38) |
I130T |
probably benign |
Het |
| Asic5 |
T |
A |
3: 82,020,987 (GRCm38) |
I419K |
probably damaging |
Het |
| Atp4a |
A |
T |
7: 30,715,530 (GRCm38) |
E248V |
probably damaging |
Het |
| Avil |
C |
A |
10: 127,011,761 (GRCm38) |
V154L |
probably benign |
Het |
| Bclaf1 |
T |
A |
10: 20,323,536 (GRCm38) |
H226Q |
possibly damaging |
Het |
| Cald1 |
A |
G |
6: 34,746,416 (GRCm38) |
|
probably benign |
Het |
| Cd200r4 |
A |
C |
16: 44,832,090 (GRCm38) |
D27A |
possibly damaging |
Het |
| Cdsn |
T |
A |
17: 35,552,202 (GRCm38) |
M1K |
probably null |
Het |
| Cfap46 |
T |
A |
7: 139,678,514 (GRCm38) |
H281L |
possibly damaging |
Het |
| Chaf1a |
T |
C |
17: 56,062,606 (GRCm38) |
F533L |
probably benign |
Het |
| Chil4 |
T |
A |
3: 106,219,452 (GRCm38) |
I5F |
probably benign |
Het |
| Ctu2 |
A |
T |
8: 122,476,588 (GRCm38) |
R48W |
probably damaging |
Het |
| Daam1 |
A |
T |
12: 71,946,576 (GRCm38) |
H373L |
unknown |
Het |
| Dcaf10 |
T |
A |
4: 45,370,415 (GRCm38) |
Y328N |
possibly damaging |
Het |
| Dst |
A |
T |
1: 34,177,931 (GRCm38) |
K1151* |
probably null |
Het |
| Ect2 |
T |
C |
3: 27,130,070 (GRCm38) |
D503G |
probably damaging |
Het |
| Epm2a |
C |
A |
10: 11,457,345 (GRCm38) |
D307E |
probably benign |
Het |
| Exph5 |
A |
T |
9: 53,337,930 (GRCm38) |
D73V |
probably damaging |
Het |
| Fam20b |
C |
T |
1: 156,705,740 (GRCm38) |
G102D |
probably damaging |
Het |
| Fat2 |
T |
C |
11: 55,281,175 (GRCm38) |
N2904S |
probably damaging |
Het |
| Flt3 |
T |
A |
5: 147,375,690 (GRCm38) |
Q147L |
possibly damaging |
Het |
| Fndc11 |
A |
G |
2: 181,222,163 (GRCm38) |
T254A |
possibly damaging |
Het |
| Galnt15 |
C |
T |
14: 32,058,287 (GRCm38) |
R514* |
probably null |
Het |
| Gbgt1 |
A |
G |
2: 28,505,208 (GRCm38) |
D286G |
probably damaging |
Het |
| Ggt1 |
T |
A |
10: 75,579,198 (GRCm38) |
|
probably null |
Het |
| Gm26526 |
A |
T |
7: 39,589,234 (GRCm38) |
|
noncoding transcript |
Het |
| H2-K1 |
T |
C |
17: 33,997,462 (GRCm38) |
T237A |
probably damaging |
Het |
| Igf1r |
T |
A |
7: 68,207,319 (GRCm38) |
S1010T |
probably damaging |
Het |
| Il21 |
T |
C |
3: 37,227,735 (GRCm38) |
T87A |
possibly damaging |
Het |
| Kmt2b |
G |
A |
7: 30,569,175 (GRCm38) |
R2010C |
probably damaging |
Het |
| Kmt2c |
G |
A |
5: 25,314,594 (GRCm38) |
P2173S |
probably benign |
Het |
| Krt1 |
A |
T |
15: 101,846,368 (GRCm38) |
S512T |
unknown |
Het |
| Krtap16-1 |
G |
A |
11: 99,985,598 (GRCm38) |
R327* |
probably null |
Het |
| Lama1 |
T |
A |
17: 67,756,716 (GRCm38) |
I745N |
probably benign |
Het |
| Lyst |
A |
T |
13: 13,683,070 (GRCm38) |
E2481D |
probably benign |
Het |
| Map2k1 |
A |
T |
9: 64,187,745 (GRCm38) |
|
probably benign |
Het |
| Mbip |
A |
G |
12: 56,337,443 (GRCm38) |
V215A |
probably damaging |
Het |
| Mdc1 |
T |
A |
17: 35,847,922 (GRCm38) |
V398D |
probably benign |
Het |
| Mog |
T |
G |
17: 37,012,372 (GRCm38) |
I225L |
probably benign |
Het |
| Mrgprx3-ps |
T |
A |
7: 47,309,436 (GRCm38) |
|
noncoding transcript |
Het |
| Muc5b |
C |
T |
7: 141,864,540 (GRCm38) |
S3741L |
probably benign |
Het |
| Myo5a |
A |
T |
9: 75,130,120 (GRCm38) |
I202F |
probably damaging |
Het |
| Myo5b |
A |
T |
18: 74,700,606 (GRCm38) |
I818F |
possibly damaging |
Het |
| Nfia |
T |
A |
4: 98,014,297 (GRCm38) |
M262K |
probably damaging |
Het |
| Nisch |
C |
T |
14: 31,206,567 (GRCm38) |
|
probably null |
Het |
| Nkd1 |
A |
G |
8: 88,589,194 (GRCm38) |
D64G |
probably damaging |
Het |
| Nt5c2 |
T |
A |
19: 46,893,560 (GRCm38) |
K284* |
probably null |
Het |
| Or14a259 |
A |
T |
7: 86,364,190 (GRCm38) |
V49E |
possibly damaging |
Het |
| Or4k15b |
C |
A |
14: 50,034,678 (GRCm38) |
A242S |
possibly damaging |
Het |
| Or4l1 |
A |
T |
14: 49,928,779 (GRCm38) |
I255N |
probably damaging |
Het |
| Or52z14 |
T |
G |
7: 103,603,789 (GRCm38) |
I45R |
probably benign |
Het |
| Or5an1c |
A |
G |
19: 12,241,248 (GRCm38) |
S138P |
probably damaging |
Het |
| Or5j3 |
A |
T |
2: 86,297,921 (GRCm38) |
Y35F |
probably damaging |
Het |
| Or8g55 |
A |
T |
9: 39,873,445 (GRCm38) |
T57S |
possibly damaging |
Het |
| Or8k24 |
A |
T |
2: 86,386,140 (GRCm38) |
S93T |
possibly damaging |
Het |
| Pcdhb17 |
A |
T |
18: 37,486,825 (GRCm38) |
D556V |
probably damaging |
Het |
| Pcdhga8 |
A |
T |
18: 37,726,620 (GRCm38) |
D243V |
probably benign |
Het |
| Polq |
A |
T |
16: 37,089,319 (GRCm38) |
Q2355L |
probably damaging |
Het |
| Slc22a30 |
G |
A |
19: 8,344,393 (GRCm38) |
Q436* |
probably null |
Het |
| Slc5a4a |
C |
A |
10: 76,182,738 (GRCm38) |
Y506* |
probably null |
Het |
| Sp110 |
G |
C |
1: 85,577,202 (GRCm38) |
|
probably benign |
Het |
| Tarbp1 |
G |
A |
8: 126,467,156 (GRCm38) |
H336Y |
probably damaging |
Het |
| Tas2r134 |
T |
G |
2: 51,627,547 (GRCm38) |
F13V |
probably benign |
Het |
| Tgfb2 |
A |
G |
1: 186,704,483 (GRCm38) |
Y98H |
probably damaging |
Het |
| Tmprss11a |
C |
A |
5: 86,411,806 (GRCm38) |
V376L |
probably damaging |
Het |
| Tmprss11f |
T |
A |
5: 86,538,033 (GRCm38) |
K158N |
probably benign |
Het |
| Tnip2 |
G |
T |
5: 34,503,578 (GRCm38) |
Q177K |
probably damaging |
Het |
| Trp53inp1 |
T |
A |
4: 11,165,075 (GRCm38) |
|
probably null |
Het |
| Ttc28 |
C |
T |
5: 111,271,238 (GRCm38) |
P1398S |
probably benign |
Het |
| Umodl1 |
T |
G |
17: 30,980,359 (GRCm38) |
I308S |
possibly damaging |
Het |
| Vcan |
A |
T |
13: 89,691,600 (GRCm38) |
S1942T |
probably damaging |
Het |
| Vmn2r124 |
T |
A |
17: 18,063,077 (GRCm38) |
N344K |
probably benign |
Het |
| Vmn2r25 |
C |
G |
6: 123,825,318 (GRCm38) |
C542S |
probably damaging |
Het |
| Wiz |
T |
A |
17: 32,378,496 (GRCm38) |
|
probably benign |
Het |
| Wrap73 |
A |
G |
4: 154,155,346 (GRCm38) |
Y343C |
probably benign |
Het |
|
| Other mutations in Lrrk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01365:Lrrk1
|
APN |
7 |
66,287,701 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01511:Lrrk1
|
APN |
7 |
66,265,450 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
IGL02337:Lrrk1
|
APN |
7 |
66,279,416 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
IGL02636:Lrrk1
|
APN |
7 |
66,308,659 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL02679:Lrrk1
|
APN |
7 |
66,274,872 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02711:Lrrk1
|
APN |
7 |
66,330,767 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02742:Lrrk1
|
APN |
7 |
66,308,691 (GRCm38) |
missense |
probably benign |
0.12 |
|
IGL02878:Lrrk1
|
APN |
7 |
66,262,563 (GRCm38) |
missense |
probably benign |
|
|
IGL03135:Lrrk1
|
APN |
7 |
66,262,890 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03191:Lrrk1
|
APN |
7 |
66,259,959 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03198:Lrrk1
|
APN |
7 |
66,306,894 (GRCm38) |
missense |
probably damaging |
1.00 |
|
combustion
|
UTSW |
7 |
66,262,665 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
fluorine
|
UTSW |
7 |
66,302,710 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
halide
|
UTSW |
7 |
66,265,474 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
Heiland
|
UTSW |
7 |
66,262,733 (GRCm38) |
missense |
probably damaging |
0.96 |
|
liebster
|
UTSW |
7 |
66,294,981 (GRCm38) |
missense |
probably damaging |
1.00 |
|
magi
|
UTSW |
7 |
66,281,648 (GRCm38) |
missense |
probably damaging |
1.00 |
|
oxidation
|
UTSW |
7 |
66,279,372 (GRCm38) |
missense |
probably benign |
0.00 |
|
phlogiston
|
UTSW |
7 |
66,278,520 (GRCm38) |
splice site |
probably benign |
|
|
Savior
|
UTSW |
7 |
66,262,487 (GRCm38) |
missense |
probably damaging |
1.00 |
|
wenig
|
UTSW |
7 |
66,273,001 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
66,292,341 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
66,292,341 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0276:Lrrk1
|
UTSW |
7 |
66,296,263 (GRCm38) |
splice site |
probably benign |
|
|
R0505:Lrrk1
|
UTSW |
7 |
66,290,908 (GRCm38) |
splice site |
probably null |
|
|
R0609:Lrrk1
|
UTSW |
7 |
66,266,615 (GRCm38) |
splice site |
probably null |
|
|
R0650:Lrrk1
|
UTSW |
7 |
66,292,336 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0676:Lrrk1
|
UTSW |
7 |
66,294,981 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1157:Lrrk1
|
UTSW |
7 |
66,262,283 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1435:Lrrk1
|
UTSW |
7 |
66,273,028 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
66,259,974 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
66,259,974 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1498:Lrrk1
|
UTSW |
7 |
66,302,671 (GRCm38) |
nonsense |
probably null |
|
|
R1620:Lrrk1
|
UTSW |
7 |
66,381,538 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1884:Lrrk1
|
UTSW |
7 |
66,262,437 (GRCm38) |
missense |
probably benign |
|
|
R1891:Lrrk1
|
UTSW |
7 |
66,279,300 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1989:Lrrk1
|
UTSW |
7 |
66,281,684 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2107:Lrrk1
|
UTSW |
7 |
66,279,282 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2140:Lrrk1
|
UTSW |
7 |
66,330,750 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2144:Lrrk1
|
UTSW |
7 |
66,296,163 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2147:Lrrk1
|
UTSW |
7 |
66,285,411 (GRCm38) |
splice site |
probably null |
|
|
R3176:Lrrk1
|
UTSW |
7 |
66,305,521 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R3276:Lrrk1
|
UTSW |
7 |
66,305,521 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R3886:Lrrk1
|
UTSW |
7 |
66,292,364 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3893:Lrrk1
|
UTSW |
7 |
66,278,520 (GRCm38) |
splice site |
probably benign |
|
|
R3906:Lrrk1
|
UTSW |
7 |
66,294,903 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R4259:Lrrk1
|
UTSW |
7 |
66,330,764 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4649:Lrrk1
|
UTSW |
7 |
66,273,053 (GRCm38) |
missense |
probably benign |
0.12 |
|
R4653:Lrrk1
|
UTSW |
7 |
66,273,053 (GRCm38) |
missense |
probably benign |
0.12 |
|
R4672:Lrrk1
|
UTSW |
7 |
66,279,372 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4693:Lrrk1
|
UTSW |
7 |
66,262,487 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4729:Lrrk1
|
UTSW |
7 |
66,262,293 (GRCm38) |
missense |
probably benign |
|
|
R4737:Lrrk1
|
UTSW |
7 |
66,306,873 (GRCm38) |
missense |
probably benign |
0.09 |
|
R4795:Lrrk1
|
UTSW |
7 |
66,262,665 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R4911:Lrrk1
|
UTSW |
7 |
66,295,454 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R5002:Lrrk1
|
UTSW |
7 |
66,332,363 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5407:Lrrk1
|
UTSW |
7 |
66,270,797 (GRCm38) |
missense |
probably benign |
0.20 |
|
R5482:Lrrk1
|
UTSW |
7 |
66,330,670 (GRCm38) |
missense |
probably benign |
|
|
R5600:Lrrk1
|
UTSW |
7 |
66,307,215 (GRCm38) |
missense |
probably benign |
0.31 |
|
R5615:Lrrk1
|
UTSW |
7 |
66,287,615 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6041:Lrrk1
|
UTSW |
7 |
66,262,133 (GRCm38) |
missense |
probably benign |
|
|
R6211:Lrrk1
|
UTSW |
7 |
66,302,710 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R6271:Lrrk1
|
UTSW |
7 |
66,307,103 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6276:Lrrk1
|
UTSW |
7 |
66,306,839 (GRCm38) |
splice site |
probably null |
|
|
R6447:Lrrk1
|
UTSW |
7 |
66,302,728 (GRCm38) |
missense |
probably benign |
0.19 |
|
R6478:Lrrk1
|
UTSW |
7 |
66,262,733 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R6615:Lrrk1
|
UTSW |
7 |
66,281,648 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6745:Lrrk1
|
UTSW |
7 |
66,273,001 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6836:Lrrk1
|
UTSW |
7 |
66,342,779 (GRCm38) |
missense |
probably benign |
0.05 |
|
R6995:Lrrk1
|
UTSW |
7 |
66,292,342 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7107:Lrrk1
|
UTSW |
7 |
66,287,443 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7137:Lrrk1
|
UTSW |
7 |
66,285,279 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7203:Lrrk1
|
UTSW |
7 |
66,270,825 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7224:Lrrk1
|
UTSW |
7 |
66,332,386 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7239:Lrrk1
|
UTSW |
7 |
66,262,155 (GRCm38) |
missense |
probably benign |
|
|
R7440:Lrrk1
|
UTSW |
7 |
66,290,854 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7515:Lrrk1
|
UTSW |
7 |
66,262,562 (GRCm38) |
missense |
probably benign |
|
|
R7593:Lrrk1
|
UTSW |
7 |
66,308,691 (GRCm38) |
missense |
probably benign |
0.12 |
|
R7728:Lrrk1
|
UTSW |
7 |
66,262,715 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7984:Lrrk1
|
UTSW |
7 |
66,300,729 (GRCm38) |
splice site |
probably null |
|
|
R7993:Lrrk1
|
UTSW |
7 |
66,262,454 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8009:Lrrk1
|
UTSW |
7 |
66,265,474 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R8037:Lrrk1
|
UTSW |
7 |
66,285,341 (GRCm38) |
missense |
probably benign |
|
|
R8101:Lrrk1
|
UTSW |
7 |
66,342,782 (GRCm38) |
missense |
probably benign |
|
|
R8116:Lrrk1
|
UTSW |
7 |
66,262,623 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R8126:Lrrk1
|
UTSW |
7 |
66,292,315 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8278:Lrrk1
|
UTSW |
7 |
66,278,684 (GRCm38) |
missense |
probably benign |
0.37 |
|
R8559:Lrrk1
|
UTSW |
7 |
66,282,327 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R8669:Lrrk1
|
UTSW |
7 |
66,262,596 (GRCm38) |
missense |
probably benign |
0.20 |
|
R8690:Lrrk1
|
UTSW |
7 |
66,302,729 (GRCm38) |
missense |
probably benign |
0.02 |
|
R8955:Lrrk1
|
UTSW |
7 |
66,269,825 (GRCm38) |
missense |
probably benign |
0.09 |
|
R9135:Lrrk1
|
UTSW |
7 |
66,278,609 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9380:Lrrk1
|
UTSW |
7 |
66,278,583 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9625:Lrrk1
|
UTSW |
7 |
66,259,918 (GRCm38) |
makesense |
probably null |
|
|
R9721:Lrrk1
|
UTSW |
7 |
66,274,875 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF018:Lrrk1
|
UTSW |
7 |
66,381,502 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCATAAATTGGACAGGGAGCTC -3'
(R):5'- TGTGTGCAGAGAGAACGCAC -3'
Sequencing Primer
(F):5'- CTGTCAGCCTGTTGTCAGCTAG -3'
(R):5'- CACACCTTGTCTAGTGAGAGATCG -3'
|
| Posted On |
2017-08-17 |
Incidental Mutation