Incidental Mutation 'R5241:Dok6'
ID486804
Institutional Source Beutler Lab
Gene Symbol Dok6
Ensembl Gene ENSMUSG00000073514
Gene Namedocking protein 6
SynonymsDok-6
MMRRC Submission 042812-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.071) question?
Stock #R5241 (G1)
Quality Score225
Status Not validated
Chromosome18
Chromosomal Location89301082-89769528 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 89598789 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Methionine at position 23 (I23M)
Ref Sequence ENSEMBL: ENSMUSP00000095103 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097495]
Predicted Effect possibly damaging
Transcript: ENSMUST00000097495
AA Change: I23M

PolyPhen 2 Score 0.770 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000095103
Gene: ENSMUSG00000073514
AA Change: I23M

DomainStartEndE-ValueType
PH 8 114 8.99e-7 SMART
PTBI 130 232 4.39e-45 SMART
IRS 135 232 4.87e-41 SMART
low complexity region 316 328 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.2%
  • 20x: 91.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930033H14Rik A G 10: 69,212,751 probably null Het
Adgrb3 T C 1: 25,111,790 T881A possibly damaging Het
Adgrv1 A T 13: 81,488,929 C3464* probably null Het
Afp A G 5: 90,501,614 M347V probably benign Het
Apc2 A G 10: 80,312,234 T1041A probably benign Het
Atl1 T C 12: 69,959,113 S398P possibly damaging Het
Atp8b4 G A 2: 126,383,726 P528L probably benign Het
Bahcc1 C A 11: 120,271,403 P176T probably damaging Het
Bsnd A G 4: 106,487,985 V88A probably benign Het
Dnah7c T A 1: 46,530,500 F687Y probably benign Het
Fcgbp A T 7: 28,085,199 D228V probably damaging Het
Gatad2a G A 8: 69,918,017 Q107* probably null Het
Glis3 G T 19: 28,350,023 T663K probably benign Het
Gm10784 T A 13: 49,945,093 noncoding transcript Het
Gsdmc2 C T 15: 63,824,894 R476H probably benign Het
Gsdmc3 A G 15: 63,864,146 S202P possibly damaging Het
Map3k8 T C 18: 4,340,750 E188G probably damaging Het
Mccc1 T A 3: 35,974,196 Q487L probably benign Het
Msantd1 A G 5: 34,921,469 D116G probably damaging Het
Myh1 T A 11: 67,204,449 S212T probably benign Het
Nr1h4 A G 10: 89,483,489 Y158H probably damaging Het
Olfr1180 T C 2: 88,412,098 T187A possibly damaging Het
Olfr421-ps1 T A 1: 174,152,101 I195N probably benign Het
Olfr585 T C 7: 103,098,317 V192A probably benign Het
Pcnt A T 10: 76,433,617 H272Q probably benign Het
Pdia5 T C 16: 35,429,775 N242S probably benign Het
Pkd1l2 A T 8: 117,035,118 D1441E probably damaging Het
Runx2 G T 17: 44,639,777 Y203* probably null Het
Sdr9c7 T G 10: 127,909,790 I257S probably benign Het
Slitrk1 A G 14: 108,913,012 M89T probably benign Het
St14 G T 9: 31,100,418 C397* probably null Het
Tas2r123 T C 6: 132,847,218 I26T probably benign Het
Tmem144 A T 3: 79,814,124 M329K probably benign Het
Tmem252 T C 19: 24,674,127 M20T probably benign Het
Umodl1 T C 17: 30,984,092 V473A probably benign Het
Wdr70 A G 15: 8,079,216 C149R probably benign Het
Xirp2 C T 2: 67,482,360 R58* probably null Het
Zer1 A C 2: 30,104,970 L471R probably damaging Het
Zfp101 C T 17: 33,382,236 C182Y probably benign Het
Other mutations in Dok6
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1884:Dok6 UTSW 18 89474006 missense probably damaging 1.00
R1984:Dok6 UTSW 18 89560110 missense probably damaging 1.00
R2369:Dok6 UTSW 18 89414864 missense probably null 0.00
R2372:Dok6 UTSW 18 89414864 missense probably null 0.00
R4572:Dok6 UTSW 18 89473947 missense possibly damaging 0.95
R4587:Dok6 UTSW 18 89301196 missense probably benign 0.06
R4658:Dok6 UTSW 18 89473847 splice site probably benign
R5995:Dok6 UTSW 18 89421018 missense possibly damaging 0.89
R7498:Dok6 UTSW 18 89769319 start gained probably benign
R7614:Dok6 UTSW 18 89473943 missense probably damaging 1.00
R7840:Dok6 UTSW 18 89560058 missense probably benign 0.00
R8041:Dok6 UTSW 18 89560089 missense possibly damaging 0.93
R8158:Dok6 UTSW 18 89473947 missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- CAGGAGCGTTTTATCTTGGC -3'
(R):5'- TGACACATTGACTTTCTCATGATGC -3'

Sequencing Primer
(F):5'- GGCCATGAATTTTTCCCTCTGTAG -3'
(R):5'- ATGTTTTCAAGTTGTGCTGCAATTTC -3'
Posted On2017-08-17