Incidental Mutation 'R5505:Prdm15'
ID 486826
Institutional Source Beutler Lab
Gene Symbol Prdm15
Ensembl Gene ENSMUSG00000014039
Gene Name PR domain containing 15
Synonyms Zfp298, E130018M06Rik
MMRRC Submission 043066-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5505 (G1)
Quality Score 31
Status Validated
Chromosome 16
Chromosomal Location 97592667-97653050 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 97618183 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 325 (H325L)
Ref Sequence ENSEMBL: ENSMUSP00000120497 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095849] [ENSMUST00000121584] [ENSMUST00000142295]
AlphaFold E9Q8T2
Predicted Effect possibly damaging
Transcript: ENSMUST00000095849
AA Change: H385L

PolyPhen 2 Score 0.539 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000093533
Gene: ENSMUSG00000014039
AA Change: H385L

DomainStartEndE-ValueType
SET 75 191 5.96e-1 SMART
ZnF_C2H2 223 245 3.99e0 SMART
low complexity region 290 303 N/A INTRINSIC
ZnF_C2H2 402 424 3.89e-3 SMART
ZnF_C2H2 434 457 2.75e-3 SMART
ZnF_C2H2 468 488 1.88e2 SMART
ZnF_C2H2 495 517 5.42e-2 SMART
ZnF_C2H2 522 544 1.36e-2 SMART
ZnF_C2H2 571 593 6.23e-2 SMART
ZnF_C2H2 598 620 2.75e-3 SMART
low complexity region 642 657 N/A INTRINSIC
ZnF_C2H2 661 684 2.17e-1 SMART
ZnF_C2H2 689 711 3.24e0 SMART
ZnF_C2H2 725 747 1.38e-3 SMART
ZnF_C2H2 753 775 5.67e-5 SMART
ZnF_C2H2 781 803 3.11e-2 SMART
ZnF_C2H2 809 831 8.34e-3 SMART
ZnF_C2H2 837 859 4.79e-3 SMART
ZnF_C2H2 865 888 4.79e-3 SMART
ZnF_C2H2 894 917 5.06e-2 SMART
low complexity region 948 959 N/A INTRINSIC
low complexity region 1148 1170 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000121584
AA Change: H359L

PolyPhen 2 Score 0.539 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000113791
Gene: ENSMUSG00000014039
AA Change: H359L

DomainStartEndE-ValueType
SET 49 165 5.96e-1 SMART
ZnF_C2H2 197 219 3.99e0 SMART
low complexity region 264 277 N/A INTRINSIC
ZnF_C2H2 376 398 3.89e-3 SMART
ZnF_C2H2 408 431 2.75e-3 SMART
ZnF_C2H2 442 462 1.88e2 SMART
ZnF_C2H2 469 491 5.42e-2 SMART
ZnF_C2H2 496 518 1.36e-2 SMART
ZnF_C2H2 545 567 6.23e-2 SMART
ZnF_C2H2 572 594 2.75e-3 SMART
low complexity region 616 631 N/A INTRINSIC
ZnF_C2H2 635 658 2.17e-1 SMART
ZnF_C2H2 663 685 3.24e0 SMART
ZnF_C2H2 699 721 1.38e-3 SMART
ZnF_C2H2 727 749 5.67e-5 SMART
ZnF_C2H2 755 777 3.11e-2 SMART
ZnF_C2H2 783 805 8.34e-3 SMART
ZnF_C2H2 811 833 4.79e-3 SMART
ZnF_C2H2 839 862 4.79e-3 SMART
ZnF_C2H2 868 891 5.06e-2 SMART
low complexity region 922 933 N/A INTRINSIC
low complexity region 1122 1144 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128917
Predicted Effect possibly damaging
Transcript: ENSMUST00000142295
AA Change: H325L

PolyPhen 2 Score 0.759 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000120497
Gene: ENSMUSG00000014039
AA Change: H325L

DomainStartEndE-ValueType
SET 49 165 5.96e-1 SMART
low complexity region 230 243 N/A INTRINSIC
ZnF_C2H2 342 364 3.89e-3 SMART
ZnF_C2H2 369 392 2.75e-3 SMART
ZnF_C2H2 403 423 1.88e2 SMART
Meta Mutation Damage Score 0.1921 question?
Coding Region Coverage
  • 1x: 98.3%
  • 3x: 97.3%
  • 10x: 95.2%
  • 20x: 90.9%
Validation Efficiency 98% (47/48)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb8 T A 5: 24,606,036 (GRCm39) D240E probably damaging Het
Alpk3 G A 7: 80,728,309 (GRCm39) E480K possibly damaging Het
Arhgap20 A G 9: 51,750,248 (GRCm39) E372G probably damaging Het
Atp23 G T 10: 126,723,499 (GRCm39) A201D probably damaging Het
Bpifb1 A G 2: 154,046,699 (GRCm39) D73G probably benign Het
Ccdc7a A G 8: 129,706,655 (GRCm39) S325P possibly damaging Het
Cckar A G 5: 53,860,410 (GRCm39) Y140H probably damaging Het
Cd46 A T 1: 194,767,688 (GRCm39) D124E possibly damaging Het
Cep290 T C 10: 100,335,048 (GRCm39) probably null Het
Cmklr1 C G 5: 113,752,990 (GRCm39) D4H possibly damaging Het
Eif2ak1 T C 5: 143,803,745 (GRCm39) S34P probably benign Het
Enah T A 1: 181,734,018 (GRCm39) probably benign Het
Gad2 C G 2: 22,514,845 (GRCm39) L108V probably benign Het
Gpr22 T C 12: 31,759,724 (GRCm39) I133V probably damaging Het
Hdac4 T C 1: 91,903,187 (GRCm39) T13A probably benign Het
Ighv1-4 A G 12: 114,451,057 (GRCm39) V17A possibly damaging Het
Ints8 T A 4: 11,221,143 (GRCm39) Q744L probably benign Het
Lrit3 C T 3: 129,585,087 (GRCm39) V224I possibly damaging Het
Mgat4a T C 1: 37,535,035 (GRCm39) I108V probably benign Het
Mmp9 T C 2: 164,795,528 (GRCm39) I682T probably benign Het
Myh7b G A 2: 155,474,592 (GRCm39) A1742T probably benign Het
Nlrp12 C T 7: 3,298,015 (GRCm39) G52D probably damaging Het
Or5t9 T C 2: 86,659,845 (GRCm39) F250L possibly damaging Het
Pcnx1 T C 12: 81,996,927 (GRCm39) L941P probably damaging Het
Pla2g4e T C 2: 120,075,256 (GRCm39) R45G probably benign Het
Plcz1 C G 6: 139,961,942 (GRCm39) G203A probably damaging Het
Poldip2 A G 11: 78,406,001 (GRCm39) T76A probably benign Het
Ralyl A T 3: 13,841,980 (GRCm39) I39F probably damaging Het
Rnf220 A C 4: 117,153,288 (GRCm39) probably benign Het
Rnpc3 T C 3: 113,409,102 (GRCm39) K318E probably damaging Het
Rsbn1 T A 3: 103,836,259 (GRCm39) N432K probably damaging Het
Sh3yl1 T A 12: 30,992,072 (GRCm39) Y176N probably damaging Het
Slc25a30 G A 14: 76,000,789 (GRCm39) L272F probably damaging Het
Spag1 T C 15: 36,234,772 (GRCm39) V844A probably damaging Het
Srsf5 T C 12: 80,995,857 (GRCm39) probably benign Het
Tle2 T A 10: 81,417,574 (GRCm39) D223E probably benign Het
Tmem192 A G 8: 65,416,898 (GRCm39) E39G possibly damaging Het
Trpc6 T A 9: 8,626,736 (GRCm39) L362H probably damaging Het
Tuba4a A G 1: 75,193,060 (GRCm39) Y185H probably damaging Het
Uba6 A G 5: 86,268,405 (GRCm39) V941A probably benign Het
Vmn2r35 A T 7: 7,789,479 (GRCm39) Y753N probably damaging Het
Zfp941 C T 7: 140,391,830 (GRCm39) V510I probably benign Het
Other mutations in Prdm15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00973:Prdm15 APN 16 97,607,367 (GRCm39) splice site probably benign
IGL01325:Prdm15 APN 16 97,607,717 (GRCm39) missense probably damaging 1.00
IGL02195:Prdm15 APN 16 97,637,029 (GRCm39) missense probably damaging 1.00
IGL02473:Prdm15 APN 16 97,638,805 (GRCm39) splice site probably null
IGL02502:Prdm15 APN 16 97,640,539 (GRCm39) missense probably damaging 1.00
IGL02604:Prdm15 APN 16 97,623,142 (GRCm39) missense probably benign
R0408:Prdm15 UTSW 16 97,636,986 (GRCm39) missense possibly damaging 0.92
R0437:Prdm15 UTSW 16 97,613,759 (GRCm39) missense probably benign 0.00
R0497:Prdm15 UTSW 16 97,595,534 (GRCm39) missense possibly damaging 0.63
R0590:Prdm15 UTSW 16 97,598,961 (GRCm39) missense possibly damaging 0.95
R0630:Prdm15 UTSW 16 97,638,907 (GRCm39) missense probably null 1.00
R0661:Prdm15 UTSW 16 97,630,882 (GRCm39) missense probably benign 0.34
R0718:Prdm15 UTSW 16 97,613,833 (GRCm39) missense possibly damaging 0.89
R1144:Prdm15 UTSW 16 97,609,908 (GRCm39) missense probably damaging 1.00
R1240:Prdm15 UTSW 16 97,638,800 (GRCm39) missense probably damaging 0.98
R1605:Prdm15 UTSW 16 97,640,506 (GRCm39) missense probably damaging 1.00
R1908:Prdm15 UTSW 16 97,638,885 (GRCm39) missense probably benign 0.27
R2081:Prdm15 UTSW 16 97,604,980 (GRCm39) nonsense probably null
R2208:Prdm15 UTSW 16 97,600,464 (GRCm39) splice site probably null
R3787:Prdm15 UTSW 16 97,598,945 (GRCm39) missense probably benign 0.00
R3890:Prdm15 UTSW 16 97,600,771 (GRCm39) missense probably damaging 1.00
R4326:Prdm15 UTSW 16 97,607,715 (GRCm39) missense probably damaging 1.00
R4728:Prdm15 UTSW 16 97,622,986 (GRCm39) missense probably benign 0.04
R4952:Prdm15 UTSW 16 97,607,277 (GRCm39) missense probably damaging 0.99
R4998:Prdm15 UTSW 16 97,595,689 (GRCm39) missense probably damaging 0.97
R5225:Prdm15 UTSW 16 97,609,875 (GRCm39) missense probably damaging 1.00
R5628:Prdm15 UTSW 16 97,600,823 (GRCm39) missense probably damaging 0.98
R5721:Prdm15 UTSW 16 97,608,296 (GRCm39) missense possibly damaging 0.74
R5873:Prdm15 UTSW 16 97,609,889 (GRCm39) missense probably damaging 1.00
R5980:Prdm15 UTSW 16 97,613,770 (GRCm39) nonsense probably null
R6311:Prdm15 UTSW 16 97,600,255 (GRCm39) missense probably null 0.08
R6540:Prdm15 UTSW 16 97,637,005 (GRCm39) missense probably benign 0.13
R7053:Prdm15 UTSW 16 97,595,742 (GRCm39) nonsense probably null
R7241:Prdm15 UTSW 16 97,596,941 (GRCm39) missense possibly damaging 0.50
R7468:Prdm15 UTSW 16 97,636,842 (GRCm39) nonsense probably null
R7473:Prdm15 UTSW 16 97,623,046 (GRCm39) missense possibly damaging 0.68
R7762:Prdm15 UTSW 16 97,619,473 (GRCm39) missense probably benign 0.00
R7911:Prdm15 UTSW 16 97,613,792 (GRCm39) missense probably benign 0.35
R8053:Prdm15 UTSW 16 97,636,807 (GRCm39) missense probably benign 0.17
R8127:Prdm15 UTSW 16 97,638,910 (GRCm39) missense probably benign 0.24
R8213:Prdm15 UTSW 16 97,608,260 (GRCm39) missense probably damaging 1.00
R8708:Prdm15 UTSW 16 97,618,066 (GRCm39) missense unknown
R8768:Prdm15 UTSW 16 97,638,888 (GRCm39) missense probably benign
R9000:Prdm15 UTSW 16 97,595,470 (GRCm39) missense probably benign 0.03
R9513:Prdm15 UTSW 16 97,607,704 (GRCm39) missense probably damaging 1.00
R9583:Prdm15 UTSW 16 97,623,142 (GRCm39) missense probably benign
RF002:Prdm15 UTSW 16 97,600,829 (GRCm39) missense probably damaging 1.00
RF021:Prdm15 UTSW 16 97,609,956 (GRCm39) missense probably damaging 1.00
Z1177:Prdm15 UTSW 16 97,618,159 (GRCm39) missense possibly damaging 0.54
Predicted Primers PCR Primer
(F):5'- AAACGTGAGGCCTCTGTCTG -3'
(R):5'- TCATAGCTGGGAAATGTGGCTG -3'

Sequencing Primer
(F):5'- ATGGACACACACCTTCTTGG -3'
(R):5'- AAATGTGGCTGATGAGCTTTC -3'
Posted On 2017-08-18