Mutagenetix > Incidental Mutations

Incidental Mutation 'R5541:Vmn2r97'

486855

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r97

Ensembl Gene

ENSMUSG00000091491

Gene Name

vomeronasal 2, receptor 97

Synonyms

EG627367

MMRRC Submission

043099-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

R5541 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

18914300-18958087 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 18928355 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 171 (Q171*)

Ref Sequence

ENSEMBL: ENSMUSP00000156141 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168710] [ENSMUST00000232219]

AlphaFold

K7N6Z2

Predicted Effect

probably null
Transcript: ENSMUST00000168710
AA Change: Q171*

SMART Domains

Protein: ENSMUSP00000129313
Gene: ENSMUSG00000091491
AA Change: Q171*

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	82	442	2.9e-36	PFAM
Pfam:NCD3G	513	566	4.9e-21	PFAM
Pfam:7tm_3	599	834	1.7e-52	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000232219
AA Change: Q171*

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000232325

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.4%
20x: 95.2%

Validation Efficiency

100% (63/63)

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610009B22Rik	T	C	11: 51,685,969	H34R	probably benign	Het
1700113H08Rik	A	G	10: 87,225,946	K86R	probably benign	Het
Abca13	T	C	11: 9,291,545	V1136A	probably benign	Het
Als2cr12	A	G	1: 58,658,429	M384T	probably benign	Het
Arfgap2	G	A	2: 91,275,769	R530H	probably benign	Het
Arhgap30	T	C	1: 171,404,139		probably null	Het
Asb7	T	C	7: 66,679,269	R8G	probably benign	Het
Bod1l	T	C	5: 41,791,933	N2949D	probably benign	Het
Ccdc86	T	C	19: 10,948,554	E227G	probably damaging	Het
Cercam	A	G	2: 29,875,629	D261G	probably benign	Het
Chd9	A	T	8: 91,051,504	E2714D	probably benign	Het
Dcp1a	T	A	14: 30,502,839	S126R	probably damaging	Het
Defa17	T	A	8: 21,656,549	C64S	probably damaging	Het
Depdc5	A	T	5: 32,864,629		probably benign	Het
Dhx29	A	G	13: 112,940,374	N259S	possibly damaging	Het
Dnah6	A	T	6: 73,192,988	L323Q	possibly damaging	Het
Dnah9	T	C	11: 66,145,336	Y416C	probably damaging	Het
Faap100	T	A	11: 120,377,632	E105V	possibly damaging	Het
Fbxw15	T	G	9: 109,565,430	I106L	probably benign	Het
Gm10610	A	G	7: 83,549,406		noncoding transcript	Het
Gpr22	A	G	12: 31,709,349	F258S	probably damaging	Het
Grip1	A	T	10: 120,072,718	I618F	probably damaging	Het
H2afy2	T	C	10: 61,747,717	I215V	probably benign	Het
Hspg2	C	T	4: 137,520,551	T1233I	probably damaging	Het
Hspg2	C	A	4: 137,542,825	Q2365K	probably benign	Het
Intu	A	G	3: 40,692,587		probably null	Het
Kdm1b	T	C	13: 47,079,196	M714T	probably damaging	Het
Kif21a	A	G	15: 90,968,113	M924T	probably damaging	Het
Klb	A	T	5: 65,379,234	M636L	probably benign	Het
Klrb1a	G	A	6: 128,609,736	H219Y	probably benign	Het
March10	C	T	11: 105,390,131	D443N	probably damaging	Het
Nos1	A	G	5: 117,905,394	E578G	probably damaging	Het
Olfr1502	T	C	19: 13,861,964	I57T	probably benign	Het
Olfr887	T	C	9: 38,085,123	C96R	probably damaging	Het
Pard3b	A	G	1: 61,639,343	Y34C	probably damaging	Het
Pcdh17	T	A	14: 84,447,416	V441E	probably damaging	Het
Pde6g	A	T	11: 120,448,172	I64N	probably damaging	Het
Pdia4	C	T	6: 47,796,637	V593M	probably damaging	Het
Pnn	T	G	12: 59,071,930	V433G	possibly damaging	Het
Rbak	G	A	5: 143,173,990	S436F	probably damaging	Het
Rpl11	A	G	4: 136,052,732		probably benign	Het
Ryr1	G	T	7: 29,086,185	Q1701K	probably damaging	Het
Scn1a	T	A	2: 66,324,633	T661S	probably benign	Het
Smg1	T	A	7: 118,157,163		probably benign	Het
St8sia2	T	C	7: 73,966,900	D109G	probably benign	Het
Stk-ps1	T	A	17: 36,398,213		noncoding transcript	Het
Stxbp3-ps	C	T	19: 9,557,970		noncoding transcript	Het
Taf1d	T	A	9: 15,308,850	F132I	probably damaging	Het
Tfap2b	A	G	1: 19,214,026	S35G	possibly damaging	Het
Tnk2	C	T	16: 32,669,523	T198I	probably benign	Het
Ube2q2	T	A	9: 55,191,879	V168E	possibly damaging	Het
Ucma	A	G	2: 4,981,330	R105G	probably benign	Het
Wapl	T	C	14: 34,730,662		probably null	Het
Zfand4	T	A	6: 116,314,295	C397S	possibly damaging	Het
Zfhx3	A	G	8: 108,948,951	N2211S	probably damaging	Het
Zfp143	G	T	7: 110,070,480	G39C	probably benign	Het
Zfp568	T	A	7: 30,022,876	D414E	possibly damaging	Het
Zfp574	C	T	7: 25,081,950	A799V	probably damaging	Het

Other mutations in Vmn2r97

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r97	APN	17	18947659	missense	probably benign	0.37
IGL00962:Vmn2r97	APN	17	18929228	missense	probably damaging	1.00
IGL01704:Vmn2r97	APN	17	18947811	missense	probably damaging	0.99
IGL01888:Vmn2r97	APN	17	18929024	nonsense	probably null
IGL02429:Vmn2r97	APN	17	18930334	missense	possibly damaging	0.94
IGL02742:Vmn2r97	APN	17	18929170	missense	probably damaging	0.97
IGL02934:Vmn2r97	APN	17	18929685	missense	probably benign	0.00
IGL02978:Vmn2r97	APN	17	18948036	missense	probably benign	0.01
IGL03230:Vmn2r97	APN	17	18929406	missense	probably benign	0.10
IGL03241:Vmn2r97	APN	17	18928176	missense	probably benign	0.11
IGL03050:Vmn2r97	UTSW	17	18947638	missense	possibly damaging	0.84
PIT4469001:Vmn2r97	UTSW	17	18929616	missense	probably benign	0.00
R0482:Vmn2r97	UTSW	17	18947668	missense	probably damaging	1.00
R0514:Vmn2r97	UTSW	17	18914472	missense	probably benign	0.25
R0944:Vmn2r97	UTSW	17	18947403	missense	probably benign	0.13
R1061:Vmn2r97	UTSW	17	18928178	nonsense	probably null
R1546:Vmn2r97	UTSW	17	18947848	missense	probably damaging	1.00
R1725:Vmn2r97	UTSW	17	18929135	missense	probably benign	0.43
R1860:Vmn2r97	UTSW	17	18947386	missense	probably benign	0.01
R1938:Vmn2r97	UTSW	17	18929331	missense	probably benign	0.01
R1944:Vmn2r97	UTSW	17	18940238	missense	probably benign	0.00
R2027:Vmn2r97	UTSW	17	18929682	missense	unknown
R2106:Vmn2r97	UTSW	17	18947838	missense	probably damaging	1.00
R2151:Vmn2r97	UTSW	17	18947322	nonsense	probably null
R2153:Vmn2r97	UTSW	17	18947322	nonsense	probably null
R2154:Vmn2r97	UTSW	17	18947322	nonsense	probably null
R2516:Vmn2r97	UTSW	17	18947552	missense	probably benign
R3739:Vmn2r97	UTSW	17	18928151	missense	probably damaging	1.00
R3744:Vmn2r97	UTSW	17	18929628	missense	probably benign
R3885:Vmn2r97	UTSW	17	18928334	missense	possibly damaging	0.90
R3899:Vmn2r97	UTSW	17	18947611	missense	probably damaging	0.96
R4115:Vmn2r97	UTSW	17	18928070	missense	probably benign	0.01
R4247:Vmn2r97	UTSW	17	18947280	missense	possibly damaging	0.83
R4287:Vmn2r97	UTSW	17	18948075	intron	probably benign
R4439:Vmn2r97	UTSW	17	18930354	missense	probably benign	0.00
R4523:Vmn2r97	UTSW	17	18929071	missense	probably benign	0.03
R4783:Vmn2r97	UTSW	17	18929288	missense	probably benign
R4948:Vmn2r97	UTSW	17	18947299	missense	possibly damaging	0.95
R4981:Vmn2r97	UTSW	17	18940174	nonsense	probably null
R5029:Vmn2r97	UTSW	17	18947911	missense	probably damaging	1.00
R5200:Vmn2r97	UTSW	17	18928353	missense	probably damaging	1.00
R5637:Vmn2r97	UTSW	17	18947366	nonsense	probably null
R5765:Vmn2r97	UTSW	17	18947180	nonsense	probably null
R5885:Vmn2r97	UTSW	17	18947773	missense	possibly damaging	0.50
R6272:Vmn2r97	UTSW	17	18947599	missense	possibly damaging	0.70
R6553:Vmn2r97	UTSW	17	18930304	nonsense	probably null
R6818:Vmn2r97	UTSW	17	18947931	missense	possibly damaging	0.95
R6880:Vmn2r97	UTSW	17	18914508	missense	probably benign	0.00
R7012:Vmn2r97	UTSW	17	18947494	missense	probably damaging	0.99
R7023:Vmn2r97	UTSW	17	18914401	missense	probably damaging	1.00
R7044:Vmn2r97	UTSW	17	18914367	missense	probably benign	0.05
R7191:Vmn2r97	UTSW	17	18930286	missense	probably damaging	1.00
R7503:Vmn2r97	UTSW	17	18928208	missense	probably benign
R7862:Vmn2r97	UTSW	17	18947154	missense	probably damaging	1.00
R7876:Vmn2r97	UTSW	17	18929064	missense	probably damaging	0.97
R7890:Vmn2r97	UTSW	17	18929540	missense	probably benign	0.00
R7936:Vmn2r97	UTSW	17	18930400	missense	probably damaging	1.00
R7978:Vmn2r97	UTSW	17	18947592	missense	probably damaging	1.00
R8405:Vmn2r97	UTSW	17	18914540	critical splice donor site	probably null
R8755:Vmn2r97	UTSW	17	18947842	missense	probably damaging	1.00
R8790:Vmn2r97	UTSW	17	18940210	missense	probably damaging	1.00
R8850:Vmn2r97	UTSW	17	18929345	missense	probably benign	0.00
R9060:Vmn2r97	UTSW	17	18914323	start codon destroyed	probably null	0.94
R9079:Vmn2r97	UTSW	17	18929378	missense	probably benign
R9252:Vmn2r97	UTSW	17	18947587	missense	probably benign	0.00
R9278:Vmn2r97	UTSW	17	18914500	missense	probably benign	0.00
R9342:Vmn2r97	UTSW	17	18929106	missense	probably benign
R9422:Vmn2r97	UTSW	17	18929071	missense	probably benign	0.03

Predicted Primers

PCR Primer
(F):5'- TGAGGAGATCAATGGGAACCCC -3'
(R):5'- AGAACTTACCTGGCTTCATTTACTGC -3'

Sequencing Primer
(F):5'- CTACAATGTCAGATTCACTGGGAAG -3'
(R):5'- GAAACCTGGATTGAACTCT -3'

Posted On

2017-08-28