Incidental Mutation 'R0523:Oas3'
ID 48693
Institutional Source Beutler Lab
Gene Symbol Oas3
Ensembl Gene ENSMUSG00000032661
Gene Name 2'-5' oligoadenylate synthetase 3
Synonyms Oasl10, 2'-5' oligoadenylate synthetase-like 10
MMRRC Submission 038716-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R0523 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 120891163-120915726 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 120904209 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Arginine at position 555 (Q555R)
Ref Sequence ENSEMBL: ENSMUSP00000035588 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044833]
AlphaFold Q8VI93
Predicted Effect unknown
Transcript: ENSMUST00000044833
AA Change: Q555R
SMART Domains Protein: ENSMUSP00000035588
Gene: ENSMUSG00000032661
AA Change: Q555R

DomainStartEndE-ValueType
Pfam:OAS1_C 159 341 6.3e-83 PFAM
Pfam:OAS1_C 610 795 3.1e-78 PFAM
Pfam:NTP_transf_2 831 920 4.5e-11 PFAM
Pfam:OAS1_C 954 1136 9e-85 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000166703
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 T C 6: 128,535,289 (GRCm39) D807G possibly damaging Het
Actl9 T A 17: 33,652,323 (GRCm39) W128R probably damaging Het
Aggf1 T C 13: 95,492,924 (GRCm39) I562V probably damaging Het
Ano3 T A 2: 110,715,200 (GRCm39) E79D probably benign Het
Apobec1 T A 6: 122,558,504 (GRCm39) I84F probably damaging Het
Atp6v1b2 T C 8: 69,562,637 (GRCm39) F458L possibly damaging Het
Bco2 A T 9: 50,445,926 (GRCm39) V490E probably damaging Het
Catsperg1 G A 7: 28,884,615 (GRCm39) probably benign Het
Cdc37 T C 9: 21,054,292 (GRCm39) K111R probably damaging Het
Cfap54 T C 10: 92,744,745 (GRCm39) probably benign Het
Cfap91 G A 16: 38,148,736 (GRCm39) P231S probably damaging Het
Cplane1 T A 15: 8,223,870 (GRCm39) Y878N probably damaging Het
Cpox T A 16: 58,495,608 (GRCm39) C308* probably null Het
Cracdl A T 1: 37,683,710 (GRCm39) M1K probably null Het
Ctnna3 T G 10: 64,511,688 (GRCm39) M626R probably damaging Het
Cyp2c68 T C 19: 39,727,873 (GRCm39) E93G probably benign Het
Cyp2s1 G A 7: 25,505,475 (GRCm39) R330W probably damaging Het
Diaph1 C T 18: 37,989,553 (GRCm39) V860I possibly damaging Het
Dicer1 A G 12: 104,668,750 (GRCm39) S1311P probably damaging Het
Dpyd G A 3: 118,692,852 (GRCm39) R332K probably benign Het
E130308A19Rik G A 4: 59,719,716 (GRCm39) R416H probably damaging Het
Eef1d T C 15: 75,775,005 (GRCm39) D218G probably benign Het
Eif2ak1 T C 5: 143,818,984 (GRCm39) V215A probably damaging Het
Eif2ak4 T C 2: 118,272,577 (GRCm39) probably null Het
Fcrl5 T C 3: 87,365,099 (GRCm39) S583P possibly damaging Het
Garin5b A G 7: 4,762,392 (GRCm39) S246P possibly damaging Het
Grid2ip C A 5: 143,358,798 (GRCm39) Q29K possibly damaging Het
Htr1f A T 16: 64,746,262 (GRCm39) N343K probably damaging Het
Hvcn1 T C 5: 122,354,428 (GRCm39) probably null Het
Igf2r T C 17: 12,910,951 (GRCm39) I1956V probably benign Het
Impdh2 A T 9: 108,439,018 (GRCm39) probably null Het
Impdh2 C T 9: 108,439,019 (GRCm39) T96I possibly damaging Het
Lactb C G 9: 66,877,974 (GRCm39) G285A probably benign Het
Lrrc43 T C 5: 123,639,305 (GRCm39) S445P probably damaging Het
Mapk12 T G 15: 89,019,848 (GRCm39) M120L probably benign Het
Mroh8 C G 2: 157,065,956 (GRCm39) A669P probably damaging Het
Mrpl38 A C 11: 116,022,844 (GRCm39) H373Q probably benign Het
Myocd A G 11: 65,071,728 (GRCm39) V740A probably damaging Het
Naprt A G 15: 75,764,314 (GRCm39) F300S probably damaging Het
Ncam2 T C 16: 81,258,531 (GRCm39) I271T probably damaging Het
Nek4 A G 14: 30,701,995 (GRCm39) T582A probably benign Het
Notch2 G A 3: 98,018,914 (GRCm39) R692H probably benign Het
Notch2 C T 3: 97,978,286 (GRCm39) T89I probably benign Het
Nt5c3 A T 6: 56,860,666 (GRCm39) N296K probably damaging Het
Nt5c3b T A 11: 100,327,036 (GRCm39) I87F probably damaging Het
Or2ag17 A G 7: 106,389,533 (GRCm39) V225A probably damaging Het
Or5p69 A T 7: 107,967,438 (GRCm39) H247L probably damaging Het
Or9g19 T A 2: 85,600,273 (GRCm39) S43T probably benign Het
P3h1 C A 4: 119,098,727 (GRCm39) Q410K probably benign Het
Pax3 A G 1: 78,172,078 (GRCm39) V44A possibly damaging Het
Pde1c T A 6: 56,151,926 (GRCm39) L252F probably damaging Het
Pdzd7 T A 19: 45,024,529 (GRCm39) T497S probably benign Het
Piezo2 T C 18: 63,155,552 (GRCm39) T253A probably damaging Het
Pipox T C 11: 77,782,965 (GRCm39) E79G probably damaging Het
Pole G T 5: 110,451,459 (GRCm39) M829I probably damaging Het
Ppp1r12c A T 7: 4,492,771 (GRCm39) L156Q probably damaging Het
Psme2b T G 11: 48,836,609 (GRCm39) T113P probably damaging Het
Ptprq A G 10: 107,416,081 (GRCm39) I1739T possibly damaging Het
Qser1 T C 2: 104,620,021 (GRCm39) T174A probably damaging Het
Rcor3 T G 1: 191,814,736 (GRCm39) D81A probably damaging Het
Rev3l T C 10: 39,724,045 (GRCm39) V785A probably benign Het
Rnf11 T C 4: 109,314,119 (GRCm39) D90G probably benign Het
Sh3tc1 GCCTCCTCCTCCTCCTCC GCCTCCTCCTCCTCC 5: 35,881,410 (GRCm39) probably benign Het
Smad2 T A 18: 76,395,623 (GRCm39) S21T probably benign Het
Smc4 A G 3: 68,933,221 (GRCm39) D639G probably damaging Het
Smtn A T 11: 3,474,664 (GRCm39) S716T possibly damaging Het
Smug1 G T 15: 103,064,136 (GRCm39) Q262K probably benign Het
Sspo G T 6: 48,428,794 (GRCm39) G403V probably benign Het
Tas2r131 A G 6: 132,934,414 (GRCm39) F132L possibly damaging Het
Tgm3 T C 2: 129,886,582 (GRCm39) probably null Het
Tigd2 C T 6: 59,187,358 (GRCm39) T75M probably benign Het
Tnfrsf13b T C 11: 61,038,413 (GRCm39) V232A probably benign Het
Tnfrsf21 C T 17: 43,349,104 (GRCm39) H239Y probably benign Het
Trim47 A G 11: 115,998,716 (GRCm39) L301S probably damaging Het
Trim75 G A 8: 65,436,442 (GRCm39) H3Y probably benign Het
Trp53bp1 C A 2: 121,082,349 (GRCm39) A317S probably null Het
Tsbp1 G T 17: 34,664,473 (GRCm39) probably null Het
Ttc29 G C 8: 79,003,466 (GRCm39) L227F probably benign Het
Ttc39d G A 17: 80,523,886 (GRCm39) D182N possibly damaging Het
Ttll10 T A 4: 156,129,818 (GRCm39) R164* probably null Het
Ufsp2 T A 8: 46,449,780 (GRCm39) D447E probably benign Het
Ugt2b37 T A 5: 87,399,691 (GRCm39) L272F possibly damaging Het
Vps13b T C 15: 35,472,196 (GRCm39) V833A probably benign Het
Zbbx T C 3: 74,989,165 (GRCm39) T308A probably benign Het
Zfp933 G A 4: 147,910,919 (GRCm39) Q226* probably null Het
Other mutations in Oas3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00547:Oas3 APN 5 120,915,507 (GRCm39) splice site probably benign
IGL01095:Oas3 APN 5 120,910,954 (GRCm39) missense probably damaging 1.00
IGL01835:Oas3 APN 5 120,904,193 (GRCm39) nonsense probably null
IGL02006:Oas3 APN 5 120,907,300 (GRCm39) missense probably benign 0.00
IGL02811:Oas3 APN 5 120,902,387 (GRCm39) missense unknown
IGL03194:Oas3 APN 5 120,897,018 (GRCm39) missense probably damaging 1.00
R0066:Oas3 UTSW 5 120,896,940 (GRCm39) missense probably damaging 1.00
R0195:Oas3 UTSW 5 120,894,210 (GRCm39) missense probably damaging 1.00
R0196:Oas3 UTSW 5 120,894,210 (GRCm39) missense probably damaging 1.00
R0197:Oas3 UTSW 5 120,894,210 (GRCm39) missense probably damaging 1.00
R0445:Oas3 UTSW 5 120,894,210 (GRCm39) missense probably damaging 1.00
R0592:Oas3 UTSW 5 120,909,214 (GRCm39) missense probably damaging 1.00
R0946:Oas3 UTSW 5 120,907,128 (GRCm39) missense unknown
R1354:Oas3 UTSW 5 120,908,065 (GRCm39) missense possibly damaging 0.94
R1642:Oas3 UTSW 5 120,915,639 (GRCm39) missense possibly damaging 0.90
R1681:Oas3 UTSW 5 120,907,973 (GRCm39) missense probably benign 0.22
R1844:Oas3 UTSW 5 120,898,045 (GRCm39) missense probably damaging 0.99
R1981:Oas3 UTSW 5 120,899,900 (GRCm39) splice site probably benign
R2443:Oas3 UTSW 5 120,915,553 (GRCm39) missense probably benign 0.35
R2902:Oas3 UTSW 5 120,896,982 (GRCm39) missense probably damaging 1.00
R3034:Oas3 UTSW 5 120,909,121 (GRCm39) missense probably damaging 1.00
R4565:Oas3 UTSW 5 120,909,104 (GRCm39) missense probably damaging 1.00
R4692:Oas3 UTSW 5 120,907,420 (GRCm39) missense probably benign 0.03
R4723:Oas3 UTSW 5 120,904,321 (GRCm39) missense unknown
R4812:Oas3 UTSW 5 120,899,212 (GRCm39) unclassified probably benign
R5288:Oas3 UTSW 5 120,895,055 (GRCm39) missense probably damaging 1.00
R5343:Oas3 UTSW 5 120,894,303 (GRCm39) missense possibly damaging 0.70
R5494:Oas3 UTSW 5 120,899,709 (GRCm39) missense unknown
R5688:Oas3 UTSW 5 120,896,867 (GRCm39) missense probably benign 0.31
R5894:Oas3 UTSW 5 120,895,019 (GRCm39) missense probably damaging 1.00
R5921:Oas3 UTSW 5 120,908,046 (GRCm39) missense probably damaging 1.00
R6037:Oas3 UTSW 5 120,907,384 (GRCm39) missense probably benign 0.41
R6037:Oas3 UTSW 5 120,907,384 (GRCm39) missense probably benign 0.41
R6066:Oas3 UTSW 5 120,910,989 (GRCm39) missense probably damaging 0.97
R6104:Oas3 UTSW 5 120,899,758 (GRCm39) missense unknown
R6134:Oas3 UTSW 5 120,907,113 (GRCm39) missense unknown
R6255:Oas3 UTSW 5 120,909,295 (GRCm39) missense probably benign 0.04
R6257:Oas3 UTSW 5 120,899,200 (GRCm39) unclassified probably benign
R6776:Oas3 UTSW 5 120,896,939 (GRCm39) missense probably damaging 1.00
R8022:Oas3 UTSW 5 120,895,031 (GRCm39) missense possibly damaging 0.91
R8137:Oas3 UTSW 5 120,915,565 (GRCm39) missense probably benign 0.07
R8967:Oas3 UTSW 5 120,896,907 (GRCm39) missense probably damaging 0.99
R9124:Oas3 UTSW 5 120,912,170 (GRCm39) missense probably damaging 1.00
R9287:Oas3 UTSW 5 120,892,754 (GRCm39) missense probably damaging 1.00
R9661:Oas3 UTSW 5 120,904,230 (GRCm39) missense unknown
R9745:Oas3 UTSW 5 120,899,284 (GRCm39) missense unknown
RF006:Oas3 UTSW 5 120,912,165 (GRCm39) missense probably damaging 1.00
X0024:Oas3 UTSW 5 120,899,793 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CTTTAAGATCTCCCAGGGGCGATTTTC -3'
(R):5'- GAGTCTAAAGTCTGAGCTGCACTTCC -3'

Sequencing Primer
(F):5'- GGAATATGACAGGTGCCCC -3'
(R):5'- ACTTCCCTCCACAGGGC -3'
Posted On 2013-06-12