Incidental Mutation 'R6182:Vmn2r77'
| ID |
487031 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r77
|
| Ensembl Gene |
ENSMUSG00000090949 |
| Gene Name |
vomeronasal 2, receptor 77 |
| Synonyms |
EG546983 |
| MMRRC Submission |
044324-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.079)
|
| Stock # |
R6182 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
86444349-86461240 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 86460957 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 761
(V761A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129540
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164996]
|
| AlphaFold |
L7N2B7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000164996
AA Change: V761A
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000129540
Gene: ENSMUSG00000090949
AA Change: V761A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
78 |
467 |
1.4e-30 |
PFAM |
|
Pfam:NCD3G
|
510 |
562 |
1e-20 |
PFAM |
|
Pfam:7tm_3
|
594 |
830 |
2.6e-52 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.3%
- 20x: 95.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 65 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts7 |
T |
C |
9: 90,074,489 (GRCm39) |
S884P |
probably benign |
Het |
| Akap13 |
C |
A |
7: 75,236,028 (GRCm39) |
A201E |
probably benign |
Het |
| Ces1f |
T |
G |
8: 93,983,124 (GRCm39) |
E540A |
probably benign |
Het |
| Chid1 |
T |
A |
7: 141,108,415 (GRCm39) |
M137L |
probably benign |
Het |
| Chsy3 |
A |
G |
18: 59,312,414 (GRCm39) |
T296A |
probably benign |
Het |
| Clec4f |
A |
G |
6: 83,622,284 (GRCm39) |
V519A |
probably benign |
Het |
| Clk4 |
T |
A |
11: 51,159,009 (GRCm39) |
F41I |
possibly damaging |
Het |
| Cntnap5c |
A |
G |
17: 58,183,390 (GRCm39) |
D32G |
probably benign |
Het |
| Ctsl |
T |
C |
13: 64,515,786 (GRCm39) |
Y95C |
probably damaging |
Het |
| Cyp2c54 |
T |
C |
19: 40,036,005 (GRCm39) |
M302V |
probably benign |
Het |
| Cyp2c65 |
C |
G |
19: 39,049,606 (GRCm39) |
L45V |
probably benign |
Het |
| Cyp2j6 |
G |
C |
4: 96,424,323 (GRCm39) |
L145V |
probably damaging |
Het |
| Daam1 |
C |
T |
12: 72,006,661 (GRCm39) |
Q693* |
probably null |
Het |
| Dgcr8 |
A |
T |
16: 18,098,172 (GRCm39) |
D406E |
probably benign |
Het |
| Dock2 |
G |
T |
11: 34,179,476 (GRCm39) |
P1760Q |
probably damaging |
Het |
| Epb41l2 |
G |
A |
10: 25,383,715 (GRCm39) |
R940H |
probably damaging |
Het |
| Erc2 |
A |
C |
14: 28,039,210 (GRCm39) |
D951A |
probably damaging |
Het |
| Fbxw7 |
T |
C |
3: 84,723,078 (GRCm39) |
|
probably null |
Het |
| Frem2 |
T |
A |
3: 53,555,390 (GRCm39) |
I1716F |
probably damaging |
Het |
| Fus |
A |
G |
7: 127,576,465 (GRCm39) |
D295G |
probably damaging |
Het |
| Gm5093 |
A |
G |
17: 46,750,568 (GRCm39) |
I153T |
probably benign |
Het |
| Gnptab |
T |
C |
10: 88,265,342 (GRCm39) |
V318A |
possibly damaging |
Het |
| Gpc2 |
T |
C |
5: 138,276,676 (GRCm39) |
D150G |
probably benign |
Het |
| Gsc2 |
A |
G |
16: 17,731,483 (GRCm39) |
*215R |
probably null |
Het |
| Hectd3 |
T |
C |
4: 116,857,476 (GRCm39) |
S552P |
probably damaging |
Het |
| Katnal1 |
C |
A |
5: 148,841,407 (GRCm39) |
K152N |
possibly damaging |
Het |
| Kcnh1 |
A |
T |
1: 191,873,361 (GRCm39) |
T16S |
probably damaging |
Het |
| Lrrc71 |
T |
C |
3: 87,653,101 (GRCm39) |
D105G |
probably benign |
Het |
| Mon2 |
T |
C |
10: 122,874,564 (GRCm39) |
|
probably null |
Het |
| Mroh9 |
G |
A |
1: 162,893,612 (GRCm39) |
Q188* |
probably null |
Het |
| Mtmr14 |
A |
G |
6: 113,246,469 (GRCm39) |
S81G |
possibly damaging |
Het |
| Nrap |
T |
A |
19: 56,350,130 (GRCm39) |
M628L |
probably benign |
Het |
| Odad3 |
A |
G |
9: 21,901,698 (GRCm39) |
F553S |
probably damaging |
Het |
| Or1o1 |
T |
A |
17: 37,716,883 (GRCm39) |
I148K |
possibly damaging |
Het |
| Or5k1 |
A |
G |
16: 58,617,655 (GRCm39) |
Y185H |
probably damaging |
Het |
| Pals2 |
A |
G |
6: 50,175,206 (GRCm39) |
I506V |
probably benign |
Het |
| Pate4 |
A |
T |
9: 35,519,586 (GRCm39) |
S35T |
possibly damaging |
Het |
| Pkd1l1 |
T |
C |
11: 8,815,555 (GRCm39) |
E1452G |
probably benign |
Het |
| Pld5 |
T |
C |
1: 175,872,420 (GRCm39) |
D239G |
probably benign |
Het |
| Ppef2 |
C |
T |
5: 92,374,925 (GRCm39) |
V728M |
probably damaging |
Het |
| Rasip1 |
TGCCGCCGCCGCCGCCGCCGCCGC |
TGCCGCCGCCGCCGCCGCCGC |
7: 45,277,879 (GRCm39) |
|
probably benign |
Het |
| Rsf1 |
G |
A |
7: 97,229,117 (GRCm39) |
|
probably benign |
Het |
| Serpina3c |
C |
A |
12: 104,115,690 (GRCm39) |
V285L |
probably benign |
Het |
| Serpinb9f |
T |
C |
13: 33,518,405 (GRCm39) |
S302P |
probably damaging |
Het |
| Sis |
C |
T |
3: 72,811,626 (GRCm39) |
V1642I |
probably benign |
Het |
| Slc12a4 |
G |
A |
8: 106,674,531 (GRCm39) |
L601F |
probably damaging |
Het |
| Slc39a6 |
G |
T |
18: 24,734,013 (GRCm39) |
N225K |
probably benign |
Het |
| Snrnp70 |
G |
A |
7: 45,026,497 (GRCm39) |
R291* |
probably null |
Het |
| Spin1 |
C |
T |
13: 51,298,374 (GRCm39) |
T131I |
probably benign |
Het |
| St18 |
T |
G |
1: 6,914,342 (GRCm39) |
|
probably null |
Het |
| Stox1 |
A |
G |
10: 62,500,721 (GRCm39) |
L613P |
probably damaging |
Het |
| Tgm3 |
T |
G |
2: 129,867,221 (GRCm39) |
Y155* |
probably null |
Het |
| Tmem67 |
T |
C |
4: 12,051,402 (GRCm39) |
I809V |
probably benign |
Het |
| Tnc |
T |
A |
4: 63,927,033 (GRCm39) |
D831V |
probably damaging |
Het |
| Ttll13 |
A |
T |
7: 79,909,981 (GRCm39) |
E762D |
probably benign |
Het |
| Unc5b |
A |
T |
10: 60,601,015 (GRCm39) |
V937E |
probably damaging |
Het |
| Vmn1r34 |
A |
G |
6: 66,614,312 (GRCm39) |
I142T |
probably damaging |
Het |
| Vmn2r104 |
A |
G |
17: 20,250,507 (GRCm39) |
M588T |
probably benign |
Het |
| Wdr48 |
G |
T |
9: 119,753,832 (GRCm39) |
G665W |
probably damaging |
Het |
| Xpot |
T |
A |
10: 121,442,163 (GRCm39) |
R550S |
probably damaging |
Het |
| Ydjc |
A |
G |
16: 16,964,943 (GRCm39) |
T33A |
probably benign |
Het |
| Zfc3h1 |
A |
G |
10: 115,226,764 (GRCm39) |
T274A |
probably benign |
Het |
| Zfp202 |
G |
A |
9: 40,118,638 (GRCm39) |
G17E |
probably damaging |
Het |
| Zfp788 |
T |
A |
7: 41,299,940 (GRCm39) |
C859S |
probably damaging |
Het |
| Zscan4c |
T |
C |
7: 10,740,709 (GRCm39) |
M76T |
probably benign |
Het |
|
| Other mutations in Vmn2r77 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00954:Vmn2r77
|
APN |
7 |
86,449,975 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01105:Vmn2r77
|
APN |
7 |
86,460,872 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01367:Vmn2r77
|
APN |
7 |
86,461,124 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01634:Vmn2r77
|
APN |
7 |
86,460,857 (GRCm39) |
missense |
probably benign |
|
|
IGL01805:Vmn2r77
|
APN |
7 |
86,460,395 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01868:Vmn2r77
|
APN |
7 |
86,452,224 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01980:Vmn2r77
|
APN |
7 |
86,450,678 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL02055:Vmn2r77
|
APN |
7 |
86,450,763 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02066:Vmn2r77
|
APN |
7 |
86,452,836 (GRCm39) |
nonsense |
probably null |
|
|
IGL02185:Vmn2r77
|
APN |
7 |
86,444,360 (GRCm39) |
missense |
unknown |
|
|
IGL02200:Vmn2r77
|
APN |
7 |
86,451,187 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02336:Vmn2r77
|
APN |
7 |
86,451,224 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02445:Vmn2r77
|
APN |
7 |
86,452,848 (GRCm39) |
nonsense |
probably null |
|
|
IGL02557:Vmn2r77
|
APN |
7 |
86,444,342 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02659:Vmn2r77
|
APN |
7 |
86,449,979 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL02978:Vmn2r77
|
APN |
7 |
86,460,555 (GRCm39) |
missense |
probably benign |
|
|
IGL03180:Vmn2r77
|
APN |
7 |
86,450,843 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL03255:Vmn2r77
|
APN |
7 |
86,461,131 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL03273:Vmn2r77
|
APN |
7 |
86,460,494 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0046:Vmn2r77
|
UTSW |
7 |
86,451,146 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0047:Vmn2r77
|
UTSW |
7 |
86,460,858 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0066:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0066:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0389:Vmn2r77
|
UTSW |
7 |
86,450,702 (GRCm39) |
missense |
probably benign |
0.29 |
|
R0635:Vmn2r77
|
UTSW |
7 |
86,460,383 (GRCm39) |
missense |
probably benign |
|
|
R0689:Vmn2r77
|
UTSW |
7 |
86,460,872 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0827:Vmn2r77
|
UTSW |
7 |
86,451,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1167:Vmn2r77
|
UTSW |
7 |
86,450,954 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1228:Vmn2r77
|
UTSW |
7 |
86,450,242 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1353:Vmn2r77
|
UTSW |
7 |
86,451,394 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1392:Vmn2r77
|
UTSW |
7 |
86,450,830 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1392:Vmn2r77
|
UTSW |
7 |
86,450,830 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1613:Vmn2r77
|
UTSW |
7 |
86,460,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1654:Vmn2r77
|
UTSW |
7 |
86,461,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1742:Vmn2r77
|
UTSW |
7 |
86,444,543 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1827:Vmn2r77
|
UTSW |
7 |
86,450,821 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1911:Vmn2r77
|
UTSW |
7 |
86,461,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1974:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
|
R2008:Vmn2r77
|
UTSW |
7 |
86,450,921 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2093:Vmn2r77
|
UTSW |
7 |
86,450,702 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2143:Vmn2r77
|
UTSW |
7 |
86,461,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2269:Vmn2r77
|
UTSW |
7 |
86,460,897 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2972:Vmn2r77
|
UTSW |
7 |
86,452,893 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2974:Vmn2r77
|
UTSW |
7 |
86,452,893 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3037:Vmn2r77
|
UTSW |
7 |
86,450,191 (GRCm39) |
missense |
probably benign |
|
|
R3694:Vmn2r77
|
UTSW |
7 |
86,450,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3695:Vmn2r77
|
UTSW |
7 |
86,450,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3805:Vmn2r77
|
UTSW |
7 |
86,444,368 (GRCm39) |
nonsense |
probably null |
|
|
R3870:Vmn2r77
|
UTSW |
7 |
86,461,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4732:Vmn2r77
|
UTSW |
7 |
86,450,195 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4733:Vmn2r77
|
UTSW |
7 |
86,450,195 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5009:Vmn2r77
|
UTSW |
7 |
86,451,015 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5201:Vmn2r77
|
UTSW |
7 |
86,460,846 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5218:Vmn2r77
|
UTSW |
7 |
86,451,341 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5469:Vmn2r77
|
UTSW |
7 |
86,451,271 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5673:Vmn2r77
|
UTSW |
7 |
86,461,214 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5771:Vmn2r77
|
UTSW |
7 |
86,461,235 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5832:Vmn2r77
|
UTSW |
7 |
86,460,670 (GRCm39) |
nonsense |
probably null |
|
|
R5899:Vmn2r77
|
UTSW |
7 |
86,460,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6151:Vmn2r77
|
UTSW |
7 |
86,450,878 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6326:Vmn2r77
|
UTSW |
7 |
86,451,031 (GRCm39) |
missense |
probably benign |
|
|
R6419:Vmn2r77
|
UTSW |
7 |
86,460,767 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6549:Vmn2r77
|
UTSW |
7 |
86,450,065 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6874:Vmn2r77
|
UTSW |
7 |
86,451,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6972:Vmn2r77
|
UTSW |
7 |
86,452,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7056:Vmn2r77
|
UTSW |
7 |
86,451,023 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7185:Vmn2r77
|
UTSW |
7 |
86,451,035 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7261:Vmn2r77
|
UTSW |
7 |
86,460,518 (GRCm39) |
nonsense |
probably null |
|
|
R7298:Vmn2r77
|
UTSW |
7 |
86,449,979 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7662:Vmn2r77
|
UTSW |
7 |
86,460,492 (GRCm39) |
nonsense |
probably null |
|
|
R8182:Vmn2r77
|
UTSW |
7 |
86,460,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8327:Vmn2r77
|
UTSW |
7 |
86,450,680 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8387:Vmn2r77
|
UTSW |
7 |
86,450,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8825:Vmn2r77
|
UTSW |
7 |
86,452,855 (GRCm39) |
missense |
probably benign |
|
|
R8898:Vmn2r77
|
UTSW |
7 |
86,444,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8973:Vmn2r77
|
UTSW |
7 |
86,452,150 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9258:Vmn2r77
|
UTSW |
7 |
86,452,302 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9338:Vmn2r77
|
UTSW |
7 |
86,460,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9358:Vmn2r77
|
UTSW |
7 |
86,452,236 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9377:Vmn2r77
|
UTSW |
7 |
86,444,442 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9404:Vmn2r77
|
UTSW |
7 |
86,451,247 (GRCm39) |
missense |
probably benign |
|
|
R9673:Vmn2r77
|
UTSW |
7 |
86,450,171 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R9679:Vmn2r77
|
UTSW |
7 |
86,460,741 (GRCm39) |
missense |
probably benign |
0.07 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCACCATGATCCAAATGATTC -3'
(R):5'- TGGTCTCAACAGAATAATGTAGCAC -3'
Sequencing Primer
(F):5'- CCAAATGATTCTCTGTGGAATCTGGC -3'
(R):5'- CAACAGAATAATGTAGCACTTTGGG -3'
|
| Posted On |
2017-10-10 |
Incidental Mutation