Incidental Mutation 'R6131:Taar7b'
ID 487138
Institutional Source Beutler Lab
Gene Symbol Taar7b
Ensembl Gene ENSMUSG00000095171
Gene Name trace amine-associated receptor 7B
Synonyms LOC209517
MMRRC Submission 044278-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.128) question?
Stock # R6131 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 23875837-23876913 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 23876615 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 260 (Y260F)
Ref Sequence ENSEMBL: ENSMUSP00000090328 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092658]
AlphaFold Q5QD11
Predicted Effect probably benign
Transcript: ENSMUST00000092658
AA Change: Y260F

PolyPhen 2 Score 0.205 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000090328
Gene: ENSMUSG00000095171
AA Change: Y260F

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 56 261 1.9e-7 PFAM
Pfam:7tm_1 64 326 7.3e-59 PFAM
Meta Mutation Damage Score 0.0750 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.8%
Validation Efficiency 96% (50/52)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5031439G07Rik A T 15: 84,844,793 (GRCm39) W75R probably damaging Het
Aadacl2fm3 A G 3: 59,776,324 (GRCm39) K165R possibly damaging Het
Abca15 T C 7: 119,939,428 (GRCm39) V274A probably benign Het
Afg3l2 G T 18: 67,554,329 (GRCm39) L458M probably damaging Het
Ap1m2 T C 9: 21,207,797 (GRCm39) Y396C probably damaging Het
Apob T C 12: 8,065,874 (GRCm39) S405P probably benign Het
Arhgap26 G T 18: 39,419,638 (GRCm39) G533* probably null Het
Atxn2l T C 7: 126,102,337 (GRCm39) probably benign Het
Ccdc88c A T 12: 100,907,387 (GRCm39) L995H probably damaging Het
Ccn3 A G 15: 54,612,756 (GRCm39) D255G probably benign Het
Cep192 A G 18: 67,971,068 (GRCm39) H1023R possibly damaging Het
Cog5 T A 12: 31,936,220 (GRCm39) M589K possibly damaging Het
Col25a1 C A 3: 130,329,114 (GRCm39) P337Q probably damaging Het
Cyfip1 T G 7: 55,523,228 (GRCm39) V51G possibly damaging Het
Dnah7b A T 1: 46,292,626 (GRCm39) I3004F probably damaging Het
Dsg3 A T 18: 20,671,569 (GRCm39) D758V probably damaging Het
Dsg3 A G 18: 20,653,534 (GRCm39) probably null Het
Eml5 A T 12: 98,827,510 (GRCm39) H573Q probably damaging Het
Erp27 T C 6: 136,885,201 (GRCm39) D199G probably damaging Het
Flnb A G 14: 7,894,635 (GRCm38) Y811C possibly damaging Het
G6pd2 A T 5: 61,966,593 (GRCm39) S123C probably benign Het
Gm1818 T A 12: 48,602,319 (GRCm39) noncoding transcript Het
Gm29340 C T 2: 116,798,519 (GRCm39) noncoding transcript Het
H2bc7 C A 13: 23,758,310 (GRCm39) probably benign Het
Hcn2 G T 10: 79,569,742 (GRCm39) G581W probably damaging Het
Kidins220 T C 12: 25,042,313 (GRCm39) probably null Het
Lonp1 T C 17: 56,921,457 (GRCm39) E926G probably benign Het
Lrp1 T C 10: 127,396,026 (GRCm39) I2415V probably benign Het
Mmel1 C T 4: 154,979,475 (GRCm39) H728Y probably damaging Het
Mmp10 A G 9: 7,503,633 (GRCm39) probably null Het
Myo16 T A 8: 10,619,877 (GRCm39) I1476N probably benign Het
Nectin3 G T 16: 46,215,515 (GRCm39) H76N probably damaging Het
Nphs2 G A 1: 156,153,521 (GRCm39) R204Q probably damaging Het
Or5ac15 T C 16: 58,940,256 (GRCm39) Y59C probably damaging Het
Or8b36 ATTGCTGTTT ATTGCTGTTTGCTGTTT 9: 37,937,836 (GRCm39) probably null Het
Or8b53 T A 9: 38,667,362 (GRCm39) I126N probably damaging Het
Otx1 A T 11: 21,949,406 (GRCm39) L24H probably damaging Het
Pate10 T A 9: 35,652,840 (GRCm39) C27* probably null Het
Psme2b T C 11: 48,836,752 (GRCm39) D65G probably damaging Het
Rlf T C 4: 121,012,172 (GRCm39) K214E probably damaging Het
Rnasel A T 1: 153,630,206 (GRCm39) T241S probably damaging Het
Samd9l C G 6: 3,377,252 (GRCm39) G3A probably benign Het
Smg7 A G 1: 152,720,962 (GRCm39) probably null Het
Spag16 A G 1: 70,764,242 (GRCm39) probably null Het
Spata31d1c T A 13: 65,183,485 (GRCm39) D342E probably benign Het
Stab2 A G 10: 86,719,642 (GRCm39) probably null Het
Vcpip1 T C 1: 9,817,517 (GRCm39) I289V probably damaging Het
Vmn2r130 C T 17: 23,282,629 (GRCm39) A103V probably benign Het
Vmn2r39 A G 7: 9,017,963 (GRCm39) V791A probably damaging Het
Vmn2r66 T A 7: 84,644,224 (GRCm39) I729F probably damaging Het
Zfp536 T A 7: 37,269,137 (GRCm39) D93V probably damaging Het
Other mutations in Taar7b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00330:Taar7b APN 10 23,876,740 (GRCm39) missense probably benign 0.01
IGL00771:Taar7b APN 10 23,876,096 (GRCm39) missense probably benign 0.01
IGL01662:Taar7b APN 10 23,875,874 (GRCm39) missense probably benign 0.02
IGL02186:Taar7b APN 10 23,875,879 (GRCm39) missense probably benign 0.00
IGL02399:Taar7b APN 10 23,876,050 (GRCm39) missense probably damaging 0.99
IGL02514:Taar7b APN 10 23,876,882 (GRCm39) missense probably benign 0.00
IGL02601:Taar7b APN 10 23,876,204 (GRCm39) missense probably damaging 1.00
IGL02717:Taar7b APN 10 23,876,258 (GRCm39) missense probably damaging 1.00
IGL02724:Taar7b APN 10 23,876,581 (GRCm39) missense probably benign
IGL02725:Taar7b APN 10 23,875,961 (GRCm39) missense probably benign 0.03
R0103:Taar7b UTSW 10 23,876,192 (GRCm39) missense probably benign 0.00
R2060:Taar7b UTSW 10 23,876,573 (GRCm39) missense possibly damaging 0.95
R4973:Taar7b UTSW 10 23,876,243 (GRCm39) missense probably benign 0.08
R5055:Taar7b UTSW 10 23,876,845 (GRCm39) missense possibly damaging 0.75
R5068:Taar7b UTSW 10 23,876,359 (GRCm39) missense probably benign 0.00
R5069:Taar7b UTSW 10 23,876,359 (GRCm39) missense probably benign 0.00
R5070:Taar7b UTSW 10 23,876,359 (GRCm39) missense probably benign 0.00
R5205:Taar7b UTSW 10 23,875,916 (GRCm39) missense probably benign 0.05
R5994:Taar7b UTSW 10 23,876,246 (GRCm39) missense probably damaging 1.00
R6302:Taar7b UTSW 10 23,876,158 (GRCm39) missense possibly damaging 0.57
R6332:Taar7b UTSW 10 23,875,849 (GRCm39) missense probably benign 0.05
R6809:Taar7b UTSW 10 23,876,756 (GRCm39) missense probably benign 0.03
R7126:Taar7b UTSW 10 23,875,960 (GRCm39) missense possibly damaging 0.93
R7520:Taar7b UTSW 10 23,876,381 (GRCm39) missense probably damaging 0.99
R8962:Taar7b UTSW 10 23,876,359 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGGATCTAGTGAGTGCCCTC -3'
(R):5'- ATAAATCAAAGGGTTCATGGCTGAG -3'

Sequencing Primer
(F):5'- TGAGTGCCCTCACCTGTGTG -3'
(R):5'- CATGGCTGAGTTATAGTAAGCGATCC -3'
Posted On 2017-10-10