Incidental Mutation 'R6133:Vmn2r43'
ID487232
Institutional Source Beutler Lab
Gene Symbol Vmn2r43
Ensembl Gene ENSMUSG00000053720
Gene Namevomeronasal 2, receptor 43
SynonymsEC2-V2R
MMRRC Submission 044280-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.115) question?
Stock #R6133 (G1)
Quality Score89.0077
Status Not validated
Chromosome7
Chromosomal Location8244348-8260599 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 8244971 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Serine at position 731 (F731S)
Ref Sequence ENSEMBL: ENSMUSP00000069647 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066317]
Predicted Effect probably damaging
Transcript: ENSMUST00000066317
AA Change: F731S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000069647
Gene: ENSMUSG00000053720
AA Change: F731S

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 453 5.1e-35 PFAM
Pfam:NCD3G 496 549 7.7e-21 PFAM
Pfam:7tm_3 582 817 3e-56 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.2%
Validation Efficiency 100% (47/47)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy7 A G 8: 88,325,439 T912A possibly damaging Het
Akap12 G T 10: 4,355,178 G663C probably benign Het
Akap2 C T 4: 57,855,516 Q525* probably null Het
Ankhd1 T C 18: 36,625,126 S958P possibly damaging Het
Cmtm2a T C 8: 104,292,730 I76V probably benign Het
Cpxm2 G A 7: 132,128,453 P146S probably damaging Het
Cubn A G 2: 13,308,618 V3047A probably benign Het
Dgkd T A 1: 87,938,240 V198E possibly damaging Het
Dnah3 A T 7: 120,086,246 M181K probably benign Het
Dnah7a T C 1: 53,419,655 T3775A probably benign Het
Dsg2 A G 18: 20,590,089 I391V probably benign Het
Ebi3 T A 17: 55,954,311 V69E probably benign Het
Fn1 T C 1: 71,597,727 T1998A probably damaging Het
Frmpd1 T A 4: 45,284,915 H1245Q probably benign Het
Gm7145 T A 1: 117,985,888 C167S probably damaging Het
Hydin C T 8: 110,601,276 T4805I probably benign Het
Itgb4 C T 11: 115,984,157 R447W probably benign Het
Kcnma1 C T 14: 24,003,868 M21I probably damaging Het
Lrfn5 A G 12: 61,843,788 D621G probably benign Het
Lrrc15 C T 16: 30,274,236 G95D probably benign Het
Mex3d A G 10: 80,386,786 L212P probably damaging Het
Mmel1 C T 4: 154,895,018 H728Y probably damaging Het
Naip1 A G 13: 100,444,643 V32A probably benign Het
Nsl1 T C 1: 191,071,206 L158P probably damaging Het
Olfr638 A T 7: 104,003,325 T17S possibly damaging Het
Olfr771 G A 10: 129,160,883 L34F possibly damaging Het
Olfr883 ATTGCTGTTT ATTGCTGTTTGCTGTTT 9: 38,026,540 probably null Het
Pcdh15 A T 10: 74,645,973 probably null Het
Pramef20 T C 4: 144,377,777 R53G possibly damaging Het
Ptpn1 T C 2: 167,967,796 V108A possibly damaging Het
Rad9b T C 5: 122,339,768 N182D possibly damaging Het
Rp1l1 C T 14: 64,030,096 P1044S probably damaging Het
Scn2a G A 2: 65,743,104 V1433I probably benign Het
Ssrp1 T G 2: 85,045,339 probably benign Het
Suco T A 1: 161,835,183 K560* probably null Het
Tbx3 T C 5: 119,680,953 V531A probably benign Het
Tmem30c T C 16: 57,277,737 Y107C probably damaging Het
Topbp1 T A 9: 103,311,764 probably null Het
Trpm5 A T 7: 143,088,951 D86E probably damaging Het
Urb2 C T 8: 124,028,561 Q336* probably null Het
Xkr9 A G 1: 13,684,135 T118A probably benign Het
Zcchc2 A C 1: 106,019,879 K117N probably damaging Het
Zfp52 T C 17: 21,560,471 Y194H probably damaging Het
Zfp763 C T 17: 33,018,701 C490Y possibly damaging Het
Zmynd19 G T 2: 24,958,119 R148L possibly damaging Het
Other mutations in Vmn2r43
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01756:Vmn2r43 APN 7 8255584 missense probably benign 0.00
IGL01777:Vmn2r43 APN 7 8255273 missense probably damaging 1.00
IGL02096:Vmn2r43 APN 7 8257513 splice site probably benign
IGL02429:Vmn2r43 APN 7 8255552 missense probably benign 0.00
IGL03026:Vmn2r43 APN 7 8255097 missense probably benign 0.05
IGL03155:Vmn2r43 APN 7 8255069 missense possibly damaging 0.91
R1722:Vmn2r43 UTSW 7 8255068 missense probably damaging 0.99
R1813:Vmn2r43 UTSW 7 8255056 missense possibly damaging 0.81
R1896:Vmn2r43 UTSW 7 8255056 missense possibly damaging 0.81
R1975:Vmn2r43 UTSW 7 8255551 missense possibly damaging 0.91
R3951:Vmn2r43 UTSW 7 8255320 missense probably benign 0.00
R4658:Vmn2r43 UTSW 7 8255071 missense probably benign 0.01
R4879:Vmn2r43 UTSW 7 8255103 missense probably benign 0.01
R4896:Vmn2r43 UTSW 7 8244849 missense probably damaging 1.00
R5004:Vmn2r43 UTSW 7 8244849 missense probably damaging 1.00
R5041:Vmn2r43 UTSW 7 8244807 missense probably damaging 1.00
R5577:Vmn2r43 UTSW 7 8244812 missense probably damaging 1.00
R6073:Vmn2r43 UTSW 7 8255185 missense probably benign 0.13
R6867:Vmn2r43 UTSW 7 8255126 missense probably benign 0.00
R7214:Vmn2r43 UTSW 7 8253380 critical splice donor site probably null
R7339:Vmn2r43 UTSW 7 8255307 nonsense probably null
R7424:Vmn2r43 UTSW 7 8255329 missense probably damaging 0.99
R7534:Vmn2r43 UTSW 7 8255231 nonsense probably null
R7542:Vmn2r43 UTSW 7 8255489 missense probably benign 0.00
R7757:Vmn2r43 UTSW 7 8255254 missense possibly damaging 0.77
Predicted Primers PCR Primer
(F):5'- CCTTGGTGCTATGGTAGACAGG -3'
(R):5'- TGGCGAAAACAGTCACTGTG -3'

Sequencing Primer
(F):5'- GGAGGAAGGTGACCCAGACAC -3'
(R):5'- CGAAAACAGTCACTGTGGTTCTCG -3'
Posted On2017-10-10