Incidental Mutation 'R6134:Oas3'
ID 487269
Institutional Source Beutler Lab
Gene Symbol Oas3
Ensembl Gene ENSMUSG00000032661
Gene Name 2'-5' oligoadenylate synthetase 3
Synonyms Oasl10, 2'-5' oligoadenylate synthetase-like 10
MMRRC Submission 044281-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R6134 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 120891163-120915726 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 120907113 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 508 (V508A)
Ref Sequence ENSEMBL: ENSMUSP00000035588 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044833]
AlphaFold Q8VI93
Predicted Effect unknown
Transcript: ENSMUST00000044833
AA Change: V508A
SMART Domains Protein: ENSMUSP00000035588
Gene: ENSMUSG00000032661
AA Change: V508A

DomainStartEndE-ValueType
Pfam:OAS1_C 159 341 6.3e-83 PFAM
Pfam:OAS1_C 610 795 3.1e-78 PFAM
Pfam:NTP_transf_2 831 920 4.5e-11 PFAM
Pfam:OAS1_C 954 1136 9e-85 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000166703
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.6%
Validation Efficiency 94% (51/54)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810021J22Rik G A 11: 58,767,619 (GRCm39) E39K probably damaging Het
Afg3l2 G T 18: 67,554,329 (GRCm39) L458M probably damaging Het
Aktip T A 8: 91,856,388 (GRCm39) S30C probably damaging Het
Anxa10 G T 8: 62,530,977 (GRCm39) H78N probably damaging Het
Aoah C T 13: 21,095,293 (GRCm39) R196W probably damaging Het
Arl4c A T 1: 88,629,152 (GRCm39) W79R probably damaging Het
Brd2 A T 17: 34,332,669 (GRCm39) D178E probably benign Het
Cacna1e G A 1: 154,577,037 (GRCm39) P120L probably damaging Het
Cdh16 A T 8: 105,342,697 (GRCm39) M17K probably benign Het
Cdhr17 A T 5: 17,029,683 (GRCm39) D473V probably damaging Het
Chit1 A G 1: 134,071,798 (GRCm39) T103A possibly damaging Het
Clcn3 T C 8: 61,387,607 (GRCm39) Y214C probably damaging Het
Coch T A 12: 51,649,536 (GRCm39) D282E probably damaging Het
Col1a2 C A 6: 4,538,035 (GRCm39) S1181R unknown Het
Col6a2 T C 10: 76,442,978 (GRCm39) D506G probably damaging Het
Crx A T 7: 15,602,032 (GRCm39) Y215* probably null Het
Fasn A T 11: 120,713,012 (GRCm39) S58T probably benign Het
Fhip1a T C 3: 85,580,651 (GRCm39) E518G possibly damaging Het
Garem1 A T 18: 21,262,881 (GRCm39) D644E probably benign Het
H2-Q2 A C 17: 35,562,217 (GRCm39) T155P probably damaging Het
Insr A T 8: 3,242,572 (GRCm39) I49N probably damaging Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Lnpep A G 17: 17,773,454 (GRCm39) M639T probably benign Het
Lypd11 G A 7: 24,425,481 (GRCm39) A3V probably damaging Het
Map3k20 C T 2: 72,240,503 (GRCm39) S333F probably damaging Het
Miga2 A G 2: 30,261,229 (GRCm39) S175G probably benign Het
Muc3a A T 5: 137,244,579 (GRCm39) I191N probably damaging Het
Ncoa2 A G 1: 13,244,595 (GRCm39) V701A probably damaging Het
Nid2 T C 14: 19,828,851 (GRCm39) V565A probably damaging Het
Nova2 G A 7: 18,691,794 (GRCm39) A244T unknown Het
Numbl G C 7: 26,980,739 (GRCm39) A574P probably damaging Het
Or8b36 ATTGCTGTTT ATTGCTGTTTGCTGTTT 9: 37,937,836 (GRCm39) probably null Het
Otx1 A T 11: 21,949,406 (GRCm39) L24H probably damaging Het
Pcdhb21 T A 18: 37,647,461 (GRCm39) S197T probably benign Het
Pck2 T A 14: 55,781,419 (GRCm39) M180K probably damaging Het
Pgr T C 9: 8,900,740 (GRCm39) V91A possibly damaging Het
Phtf1 A T 3: 103,911,721 (GRCm39) M643L probably damaging Het
Prokr1 T C 6: 87,565,837 (GRCm39) T3A possibly damaging Het
Ptgs1 T C 2: 36,141,190 (GRCm39) Y546H probably damaging Het
Rasa1 A G 13: 85,374,745 (GRCm39) L742P probably benign Het
Rbbp6 T C 7: 122,596,534 (GRCm39) probably null Het
Rgs22 A G 15: 36,107,194 (GRCm39) L64P probably damaging Het
Rnf213 A T 11: 119,302,296 (GRCm39) I407F probably damaging Het
Rp1l1 C T 14: 64,267,545 (GRCm39) P1044S probably damaging Het
Scin G A 12: 40,110,578 (GRCm39) P690L probably damaging Het
Septin9 T C 11: 117,242,987 (GRCm39) L58P probably damaging Het
Slc1a7 A G 4: 107,869,633 (GRCm39) E566G probably damaging Het
Speer4f1 G A 5: 17,681,140 (GRCm39) R6Q probably benign Het
Tnxb A T 17: 34,890,986 (GRCm39) Y443F probably damaging Het
Trpv1 A G 11: 73,135,143 (GRCm39) I79V probably benign Het
Ttll6 C T 11: 96,030,568 (GRCm39) T245I possibly damaging Het
Vmn2r26 T C 6: 124,038,444 (GRCm39) I673T probably damaging Het
Zfp60 T C 7: 27,449,323 (GRCm39) F664L probably benign Het
Other mutations in Oas3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00547:Oas3 APN 5 120,915,507 (GRCm39) splice site probably benign
IGL01095:Oas3 APN 5 120,910,954 (GRCm39) missense probably damaging 1.00
IGL01835:Oas3 APN 5 120,904,193 (GRCm39) nonsense probably null
IGL02006:Oas3 APN 5 120,907,300 (GRCm39) missense probably benign 0.00
IGL02811:Oas3 APN 5 120,902,387 (GRCm39) missense unknown
IGL03194:Oas3 APN 5 120,897,018 (GRCm39) missense probably damaging 1.00
R0066:Oas3 UTSW 5 120,896,940 (GRCm39) missense probably damaging 1.00
R0195:Oas3 UTSW 5 120,894,210 (GRCm39) missense probably damaging 1.00
R0196:Oas3 UTSW 5 120,894,210 (GRCm39) missense probably damaging 1.00
R0197:Oas3 UTSW 5 120,894,210 (GRCm39) missense probably damaging 1.00
R0445:Oas3 UTSW 5 120,894,210 (GRCm39) missense probably damaging 1.00
R0523:Oas3 UTSW 5 120,904,209 (GRCm39) missense unknown
R0592:Oas3 UTSW 5 120,909,214 (GRCm39) missense probably damaging 1.00
R0946:Oas3 UTSW 5 120,907,128 (GRCm39) missense unknown
R1354:Oas3 UTSW 5 120,908,065 (GRCm39) missense possibly damaging 0.94
R1642:Oas3 UTSW 5 120,915,639 (GRCm39) missense possibly damaging 0.90
R1681:Oas3 UTSW 5 120,907,973 (GRCm39) missense probably benign 0.22
R1844:Oas3 UTSW 5 120,898,045 (GRCm39) missense probably damaging 0.99
R1981:Oas3 UTSW 5 120,899,900 (GRCm39) splice site probably benign
R2443:Oas3 UTSW 5 120,915,553 (GRCm39) missense probably benign 0.35
R2902:Oas3 UTSW 5 120,896,982 (GRCm39) missense probably damaging 1.00
R3034:Oas3 UTSW 5 120,909,121 (GRCm39) missense probably damaging 1.00
R4565:Oas3 UTSW 5 120,909,104 (GRCm39) missense probably damaging 1.00
R4692:Oas3 UTSW 5 120,907,420 (GRCm39) missense probably benign 0.03
R4723:Oas3 UTSW 5 120,904,321 (GRCm39) missense unknown
R4812:Oas3 UTSW 5 120,899,212 (GRCm39) unclassified probably benign
R5288:Oas3 UTSW 5 120,895,055 (GRCm39) missense probably damaging 1.00
R5343:Oas3 UTSW 5 120,894,303 (GRCm39) missense possibly damaging 0.70
R5494:Oas3 UTSW 5 120,899,709 (GRCm39) missense unknown
R5688:Oas3 UTSW 5 120,896,867 (GRCm39) missense probably benign 0.31
R5894:Oas3 UTSW 5 120,895,019 (GRCm39) missense probably damaging 1.00
R5921:Oas3 UTSW 5 120,908,046 (GRCm39) missense probably damaging 1.00
R6037:Oas3 UTSW 5 120,907,384 (GRCm39) missense probably benign 0.41
R6037:Oas3 UTSW 5 120,907,384 (GRCm39) missense probably benign 0.41
R6066:Oas3 UTSW 5 120,910,989 (GRCm39) missense probably damaging 0.97
R6104:Oas3 UTSW 5 120,899,758 (GRCm39) missense unknown
R6255:Oas3 UTSW 5 120,909,295 (GRCm39) missense probably benign 0.04
R6257:Oas3 UTSW 5 120,899,200 (GRCm39) unclassified probably benign
R6776:Oas3 UTSW 5 120,896,939 (GRCm39) missense probably damaging 1.00
R8022:Oas3 UTSW 5 120,895,031 (GRCm39) missense possibly damaging 0.91
R8137:Oas3 UTSW 5 120,915,565 (GRCm39) missense probably benign 0.07
R8967:Oas3 UTSW 5 120,896,907 (GRCm39) missense probably damaging 0.99
R9124:Oas3 UTSW 5 120,912,170 (GRCm39) missense probably damaging 1.00
R9287:Oas3 UTSW 5 120,892,754 (GRCm39) missense probably damaging 1.00
R9661:Oas3 UTSW 5 120,904,230 (GRCm39) missense unknown
R9745:Oas3 UTSW 5 120,899,284 (GRCm39) missense unknown
RF006:Oas3 UTSW 5 120,912,165 (GRCm39) missense probably damaging 1.00
X0024:Oas3 UTSW 5 120,899,793 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CTCCATTGTAACCCAAGGAGTGTC -3'
(R):5'- ATGTTCGGATCACCCAGAGC -3'

Sequencing Primer
(F):5'- AACCCAAGGAGTGTCTGTTTGTC -3'
(R):5'- TAGCATCTCCACCGCTGG -3'
Posted On 2017-10-10