Incidental Mutation 'R6128:Vmn1r177'
ID 487510
Institutional Source Beutler Lab
Gene Symbol Vmn1r177
Ensembl Gene ENSMUSG00000057513
Gene Name vomeronasal 1 receptor 177
Synonyms V1rd12
MMRRC Submission 044275-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R6128 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 23564945-23565874 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 23565268 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Cysteine at position 203 (S203C)
Ref Sequence ENSEMBL: ENSMUSP00000073621 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073967]
AlphaFold E9PXM3
Predicted Effect probably damaging
Transcript: ENSMUST00000073967
AA Change: S203C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073621
Gene: ENSMUSG00000057513
AA Change: S203C

DomainStartEndE-ValueType
Pfam:TAS2R 8 299 4.1e-13 PFAM
Pfam:V1R 41 297 5.3e-14 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930553M12Rik T C 4: 88,786,596 (GRCm39) I7M unknown Het
A430033K04Rik A G 5: 138,646,038 (GRCm39) H641R probably damaging Het
Acyp2 C T 11: 30,456,354 (GRCm39) E98K possibly damaging Het
Asah1 C T 8: 41,807,092 (GRCm39) V111M probably damaging Het
Ascc3 T C 10: 50,526,734 (GRCm39) L611P probably damaging Het
Atl2 C A 17: 80,172,470 (GRCm39) probably null Het
Bhlhe22 A T 3: 18,109,987 (GRCm39) S346C probably damaging Het
Bicc1 T C 10: 70,776,313 (GRCm39) probably null Het
Bptf G T 11: 106,965,516 (GRCm39) A1163D possibly damaging Het
Bub1b T A 2: 118,448,293 (GRCm39) C382S probably benign Het
Carmil1 A T 13: 24,197,177 (GRCm39) Y158* probably null Het
Ccdc175 A T 12: 72,175,933 (GRCm39) I473K probably benign Het
Ccdc18 A G 5: 108,311,625 (GRCm39) I444V possibly damaging Het
Cep131 T A 11: 119,956,801 (GRCm39) I880F probably damaging Het
Ces2e T A 8: 105,655,428 (GRCm39) I117N probably benign Het
Clk2 C T 3: 89,081,531 (GRCm39) T289M probably damaging Het
Crocc2 A T 1: 93,122,123 (GRCm39) D672V probably benign Het
Cul7 T A 17: 46,962,588 (GRCm39) I73N probably damaging Het
Cyp2d12 C A 15: 82,443,166 (GRCm39) D358E probably benign Het
Cyp7a1 A G 4: 6,272,788 (GRCm39) S142P possibly damaging Het
Daw1 T A 1: 83,183,647 (GRCm39) C232* probably null Het
Dhx9 T C 1: 153,353,835 (GRCm39) K195R probably damaging Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Dpp3 A G 19: 4,972,420 (GRCm39) V168A probably benign Het
Eml2 G A 7: 18,935,088 (GRCm39) V432I probably damaging Het
Ercc6l2 T C 13: 64,001,563 (GRCm39) V459A probably damaging Het
Erp44 A T 4: 48,243,493 (GRCm39) N38K probably damaging Het
Fam135a A G 1: 24,069,821 (GRCm39) probably null Het
Fblim1 G A 4: 141,312,033 (GRCm39) R231C probably damaging Het
Fdps T C 3: 89,006,740 (GRCm39) E117G possibly damaging Het
Gbp4 A C 5: 105,283,030 (GRCm39) V80G possibly damaging Het
Glt1d1 A T 5: 127,754,335 (GRCm39) D179V probably damaging Het
Gtf2a1l T A 17: 89,002,086 (GRCm39) V314E probably null Het
Gzmf G T 14: 56,443,443 (GRCm39) Y178* probably null Het
Hira C T 16: 18,751,727 (GRCm39) P509S probably benign Het
Ifi44 T C 3: 151,454,823 (GRCm39) N134S probably benign Het
Igfbp2 T A 1: 72,863,958 (GRCm39) C74S probably damaging Het
Il24 A G 1: 130,813,435 (GRCm39) L54P probably damaging Het
Ints10 T C 8: 69,274,904 (GRCm39) probably null Het
Ipo9 A G 1: 135,318,311 (GRCm39) C700R possibly damaging Het
Kalrn T A 16: 34,033,255 (GRCm39) Q469L probably damaging Het
Lrp1b T G 2: 40,750,667 (GRCm39) I2966L probably benign Het
Lta C A 17: 35,422,817 (GRCm39) V169L possibly damaging Het
Lyst T C 13: 13,933,964 (GRCm39) V3554A possibly damaging Het
Mobp A G 9: 119,997,392 (GRCm39) probably benign Het
Myorg T A 4: 41,498,445 (GRCm39) N395I probably damaging Het
Or10d1 C G 9: 39,484,549 (GRCm39) R2T probably benign Het
Or4b1d A T 2: 89,968,954 (GRCm39) C176* probably null Het
Or8c14-ps1 T C 9: 38,101,299 (GRCm39) S93P probably benign Het
Pacs1 A T 19: 5,202,400 (GRCm39) probably null Het
Phf21a G T 2: 92,181,953 (GRCm39) probably null Het
Pick1 T A 15: 79,123,896 (GRCm39) M89K probably damaging Het
Pik3cb T C 9: 98,946,152 (GRCm39) D558G possibly damaging Het
Pnma8a A G 7: 16,694,661 (GRCm39) D172G probably benign Het
Polr2a A C 11: 69,627,803 (GRCm39) V1368G probably damaging Het
Pomt2 A G 12: 87,158,109 (GRCm39) probably null Het
Pou2f1 T C 1: 165,703,056 (GRCm39) probably benign Het
Rnf145 T C 11: 44,446,018 (GRCm39) V284A probably damaging Het
Robo1 A T 16: 72,809,956 (GRCm39) M1235L probably benign Het
Rsf1 ATGGCG ATGGCGACGGTGGCG 7: 97,229,111 (GRCm39) probably benign Het
Ryr3 C T 2: 112,784,639 (GRCm39) probably null Het
Scamp1 A C 13: 94,344,735 (GRCm39) L202R possibly damaging Het
Snx25 C T 8: 46,558,240 (GRCm39) V110I probably benign Het
Spata31e2 G A 1: 26,724,506 (GRCm39) P225S probably benign Het
Susd6 T A 12: 80,915,388 (GRCm39) H124Q possibly damaging Het
Tarm1 T C 7: 3,537,720 (GRCm39) T248A probably benign Het
Tc2n A G 12: 101,675,748 (GRCm39) M1T probably null Het
Tcerg1 C A 18: 42,644,563 (GRCm39) probably null Het
Ticrr C A 7: 79,343,716 (GRCm39) P1194T probably damaging Het
Trim31 T G 17: 37,220,491 (GRCm39) V469G probably benign Het
Vcp T C 4: 42,980,941 (GRCm39) E723G probably benign Het
Vmn1r210 A T 13: 23,012,277 (GRCm39) L3* probably null Het
Wdr27 T A 17: 15,152,796 (GRCm39) R104* probably null Het
Wnk1 A C 6: 119,940,747 (GRCm39) probably null Het
Zfp157 A G 5: 138,453,281 (GRCm39) E88G possibly damaging Het
Zfp708 A T 13: 67,222,965 (GRCm39) L22Q probably damaging Het
Zfp788 T C 7: 41,299,785 (GRCm39) F787S probably damaging Het
Other mutations in Vmn1r177
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01456:Vmn1r177 APN 7 23,565,753 (GRCm39) missense possibly damaging 0.58
IGL01504:Vmn1r177 APN 7 23,565,835 (GRCm39) missense probably damaging 0.98
IGL01535:Vmn1r177 APN 7 23,565,765 (GRCm39) missense probably damaging 1.00
IGL01551:Vmn1r177 APN 7 23,565,688 (GRCm39) missense probably benign 0.04
IGL01647:Vmn1r177 APN 7 23,565,600 (GRCm39) missense probably damaging 1.00
ANU74:Vmn1r177 UTSW 7 23,565,645 (GRCm39) missense possibly damaging 0.86
R0396:Vmn1r177 UTSW 7 23,565,022 (GRCm39) missense probably damaging 1.00
R0894:Vmn1r177 UTSW 7 23,565,475 (GRCm39) missense probably benign 0.09
R1446:Vmn1r177 UTSW 7 23,565,765 (GRCm39) missense probably damaging 1.00
R1835:Vmn1r177 UTSW 7 23,565,111 (GRCm39) missense probably damaging 1.00
R1893:Vmn1r177 UTSW 7 23,565,573 (GRCm39) missense probably benign 0.02
R1995:Vmn1r177 UTSW 7 23,565,112 (GRCm39) missense probably damaging 1.00
R2206:Vmn1r177 UTSW 7 23,565,556 (GRCm39) missense probably damaging 1.00
R3889:Vmn1r177 UTSW 7 23,565,289 (GRCm39) missense possibly damaging 0.86
R4458:Vmn1r177 UTSW 7 23,565,645 (GRCm39) missense possibly damaging 0.86
R4579:Vmn1r177 UTSW 7 23,565,772 (GRCm39) missense possibly damaging 0.46
R5290:Vmn1r177 UTSW 7 23,565,498 (GRCm39) missense probably damaging 0.99
R6128:Vmn1r177 UTSW 7 23,565,267 (GRCm39) missense probably damaging 0.99
R6730:Vmn1r177 UTSW 7 23,565,237 (GRCm39) missense probably damaging 1.00
R6785:Vmn1r177 UTSW 7 23,565,562 (GRCm39) missense probably damaging 1.00
R7100:Vmn1r177 UTSW 7 23,565,535 (GRCm39) missense probably benign 0.15
R7738:Vmn1r177 UTSW 7 23,565,559 (GRCm39) missense probably damaging 1.00
R8191:Vmn1r177 UTSW 7 23,565,736 (GRCm39) nonsense probably null
R8980:Vmn1r177 UTSW 7 23,565,144 (GRCm39) missense probably damaging 1.00
R9723:Vmn1r177 UTSW 7 23,565,774 (GRCm39) missense probably damaging 0.97
R9771:Vmn1r177 UTSW 7 23,565,657 (GRCm39) missense probably damaging 0.98
X0020:Vmn1r177 UTSW 7 23,565,718 (GRCm39) missense probably damaging 1.00
Z1177:Vmn1r177 UTSW 7 23,565,360 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CCACAGATGGGAGTCTACAAA -3'
(R):5'- CCCAAGGTCATAAGCTATTCCTGT -3'

Sequencing Primer
(F):5'- TGGGAGTCTACAAAAACAATGTG -3'
(R):5'- AGGTCATAAGCTATTCCTGTTGTAG -3'
Posted On 2017-10-10