Incidental Mutation 'R6183:Scart2'
ID 487625
Institutional Source Beutler Lab
Gene Symbol Scart2
Ensembl Gene ENSMUSG00000054672
Gene Name scavenger receptor family member expressed on T cells 2
Synonyms 5830411N06Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6183 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 139827197-139880649 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 139875947 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 404 (T404A)
Ref Sequence ENSEMBL: ENSMUSP00000091520 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093984] [ENSMUST00000164583]
AlphaFold B3F5L4
Predicted Effect noncoding transcript
Transcript: ENSMUST00000059882
SMART Domains Protein: ENSMUSP00000061346
Gene: ENSMUSG00000054672

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
SR 29 130 1.49e-18 SMART
SR 137 233 2.53e-4 SMART
SR 238 336 1.65e-34 SMART
SR 340 440 4.53e-32 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000093984
AA Change: T404A

PolyPhen 2 Score 0.817 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000091520
Gene: ENSMUSG00000054672
AA Change: T404A

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
SR 29 130 1.49e-18 SMART
SR 137 233 2.53e-4 SMART
SR 238 336 1.65e-34 SMART
SR 340 440 4.53e-32 SMART
SR 446 546 8.78e-30 SMART
SR 551 651 1.26e-53 SMART
SR 656 756 2.88e-16 SMART
SR 783 883 7.62e-48 SMART
transmembrane domain 903 925 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000164583
AA Change: T520A

PolyPhen 2 Score 0.151 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000131905
Gene: ENSMUSG00000054672
AA Change: T520A

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
SR 29 130 1.49e-18 SMART
SR 137 233 2.53e-4 SMART
Blast:SR 291 349 5e-12 BLAST
SR 354 452 1.65e-34 SMART
SR 456 556 4.53e-32 SMART
SR 562 662 8.78e-30 SMART
SR 667 767 1.26e-53 SMART
SR 772 872 2.88e-16 SMART
SR 899 999 7.62e-48 SMART
transmembrane domain 1019 1041 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210212
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211749
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 94.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 T A 5: 8,968,718 (GRCm39) D352E probably benign Het
Adgrb3 T A 1: 25,133,451 (GRCm39) I972L probably damaging Het
Alg3 T C 16: 20,429,391 (GRCm39) Y33C probably benign Het
Atp1a3 C T 7: 24,681,177 (GRCm39) G816D probably damaging Het
Ccdc121 T C 5: 31,645,320 (GRCm39) Y358H probably damaging Het
Ces1g C T 8: 94,057,867 (GRCm39) V145M possibly damaging Het
Clip1 A G 5: 123,780,667 (GRCm39) S339P probably damaging Het
Col2a1 G T 15: 97,886,671 (GRCm39) T378N unknown Het
Dennd4b ACAGCAGCAGCAGCAGCAGCAGCAGCAGCAG ACAGCAGCAGCAGCAGCAGCAGCAGCAG 3: 90,182,875 (GRCm39) probably benign Het
Dnah12 T A 14: 26,583,726 (GRCm39) L3207Q probably damaging Het
Efcab5 T C 11: 77,028,084 (GRCm39) T416A probably benign Het
Ephb1 A T 9: 102,072,524 (GRCm39) I85N probably damaging Het
Etnppl T C 3: 130,413,966 (GRCm39) C22R probably damaging Het
F830016B08Rik A G 18: 60,432,949 (GRCm39) T11A probably benign Het
Gm5458 C A 14: 19,649,712 (GRCm39) V171L probably damaging Het
Helb G T 10: 119,948,903 (GRCm39) probably null Het
Hnrnpll A G 17: 80,357,305 (GRCm39) V237A possibly damaging Het
Hps3 T C 3: 20,063,032 (GRCm39) T712A probably benign Het
Ibsp A G 5: 104,453,896 (GRCm39) E78G possibly damaging Het
Ighv1-62-2 G A 12: 115,410,056 (GRCm39) A111V probably damaging Het
Igkv4-63 G T 6: 69,355,108 (GRCm39) Q58K probably damaging Het
Iqcg T C 16: 32,851,293 (GRCm39) Y226C probably damaging Het
Khdc1a A T 1: 21,420,332 (GRCm39) D30V possibly damaging Het
Krtap5-5 C A 7: 141,783,524 (GRCm39) C42F unknown Het
Lmod3 T C 6: 97,229,514 (GRCm39) N7D probably damaging Het
Lvrn A G 18: 46,983,752 (GRCm39) N165S probably benign Het
Ms4a4c A G 19: 11,403,593 (GRCm39) T192A possibly damaging Het
Ncald A T 15: 37,397,476 (GRCm39) V68D probably damaging Het
Or4e5 T A 14: 52,728,188 (GRCm39) T78S probably benign Het
Pcdhgb7 A T 18: 37,885,315 (GRCm39) I162F probably damaging Het
Prokr1 T C 6: 87,565,834 (GRCm39) T4A possibly damaging Het
Qrich2 T A 11: 116,348,955 (GRCm39) probably benign Het
Rgl1 C T 1: 152,462,321 (GRCm39) E60K possibly damaging Het
Rtn1 A T 12: 72,455,265 (GRCm39) W21R probably benign Het
Spast A G 17: 74,680,353 (GRCm39) I438M probably damaging Het
Sptbn5 C T 2: 119,889,898 (GRCm39) probably benign Het
Sry C G Y: 2,662,975 (GRCm39) Q228H unknown Het
Tas1r1 A G 4: 152,116,998 (GRCm39) I212T probably damaging Het
Tbc1d1 A G 5: 64,432,768 (GRCm39) N439D probably damaging Het
Tjp2 C T 19: 24,078,155 (GRCm39) A913T probably damaging Het
Tnfrsf26 A G 7: 143,165,494 (GRCm39) L47P probably damaging Het
Unc13a A T 8: 72,097,310 (GRCm39) S1195T probably damaging Het
Usp54 T C 14: 20,602,313 (GRCm39) R1346G probably damaging Het
Vmn1r54 T A 6: 90,246,272 (GRCm39) M62K possibly damaging Het
Vmn2r125 A T 4: 156,702,364 (GRCm39) D50V probably damaging Het
Vmn2r66 T C 7: 84,644,766 (GRCm39) D548G possibly damaging Het
Vmn2r95 T A 17: 18,664,192 (GRCm39) N470K probably damaging Het
Zc3h7a A T 16: 10,965,234 (GRCm39) I633N possibly damaging Het
Other mutations in Scart2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00465:Scart2 APN 7 139,874,755 (GRCm39) missense probably damaging 0.99
IGL01101:Scart2 APN 7 139,876,017 (GRCm39) missense probably benign 0.35
IGL01120:Scart2 APN 7 139,876,472 (GRCm39) missense probably benign 0.02
IGL01958:Scart2 APN 7 139,854,040 (GRCm39) missense probably damaging 1.00
IGL02150:Scart2 APN 7 139,877,772 (GRCm39) missense possibly damaging 0.84
IGL02193:Scart2 APN 7 139,828,913 (GRCm39) missense probably benign 0.17
IGL02239:Scart2 APN 7 139,875,756 (GRCm39) missense probably damaging 1.00
IGL02335:Scart2 APN 7 139,876,453 (GRCm39) missense probably damaging 1.00
IGL02569:Scart2 APN 7 139,878,275 (GRCm39) missense probably benign 0.01
IGL02993:Scart2 APN 7 139,876,486 (GRCm39) missense probably benign 0.07
IGL03261:Scart2 APN 7 139,874,746 (GRCm39) missense probably benign 0.00
IGL03365:Scart2 APN 7 139,876,682 (GRCm39) missense probably damaging 1.00
IGL03399:Scart2 APN 7 139,827,869 (GRCm39) missense probably benign 0.00
IGL03052:Scart2 UTSW 7 139,828,827 (GRCm39) missense probably damaging 1.00
PIT4791001:Scart2 UTSW 7 139,853,975 (GRCm39) missense possibly damaging 0.53
R0021:Scart2 UTSW 7 139,876,310 (GRCm39) missense probably benign 0.15
R0021:Scart2 UTSW 7 139,876,310 (GRCm39) missense probably benign 0.15
R0347:Scart2 UTSW 7 139,877,767 (GRCm39) missense probably damaging 1.00
R0374:Scart2 UTSW 7 139,828,874 (GRCm39) missense probably damaging 1.00
R0639:Scart2 UTSW 7 139,827,872 (GRCm39) missense probably benign 0.01
R0667:Scart2 UTSW 7 139,841,450 (GRCm39) missense possibly damaging 0.73
R0789:Scart2 UTSW 7 139,828,133 (GRCm39) missense probably damaging 1.00
R0959:Scart2 UTSW 7 139,874,704 (GRCm39) missense probably damaging 1.00
R1316:Scart2 UTSW 7 139,879,583 (GRCm39) missense probably benign 0.09
R1764:Scart2 UTSW 7 139,877,178 (GRCm39) missense probably benign 0.00
R2247:Scart2 UTSW 7 139,829,042 (GRCm39) missense probably null 0.96
R2379:Scart2 UTSW 7 139,879,682 (GRCm39) missense probably benign 0.15
R4112:Scart2 UTSW 7 139,878,281 (GRCm39) nonsense probably null
R4114:Scart2 UTSW 7 139,877,823 (GRCm39) missense probably damaging 1.00
R4346:Scart2 UTSW 7 139,827,878 (GRCm39) missense probably damaging 0.97
R4836:Scart2 UTSW 7 139,879,021 (GRCm39) missense probably benign
R4956:Scart2 UTSW 7 139,878,275 (GRCm39) missense probably benign 0.00
R5208:Scart2 UTSW 7 139,877,949 (GRCm39) missense probably benign 0.00
R5571:Scart2 UTSW 7 139,829,036 (GRCm39) missense probably damaging 1.00
R5583:Scart2 UTSW 7 139,876,739 (GRCm39) missense probably damaging 1.00
R5645:Scart2 UTSW 7 139,828,853 (GRCm39) missense possibly damaging 0.95
R6995:Scart2 UTSW 7 139,841,514 (GRCm39) missense probably benign
R7436:Scart2 UTSW 7 139,841,520 (GRCm39) missense probably benign
R7621:Scart2 UTSW 7 139,876,742 (GRCm39) missense probably damaging 1.00
R7662:Scart2 UTSW 7 139,874,725 (GRCm39) missense possibly damaging 0.58
R7669:Scart2 UTSW 7 139,876,234 (GRCm39) missense possibly damaging 0.47
R7686:Scart2 UTSW 7 139,828,965 (GRCm39) missense probably benign 0.00
R7985:Scart2 UTSW 7 139,876,806 (GRCm39) missense probably damaging 1.00
R8330:Scart2 UTSW 7 139,876,231 (GRCm39) nonsense probably null
R8843:Scart2 UTSW 7 139,828,913 (GRCm39) missense possibly damaging 0.93
R8888:Scart2 UTSW 7 139,841,532 (GRCm39) missense possibly damaging 0.93
R8895:Scart2 UTSW 7 139,841,532 (GRCm39) missense possibly damaging 0.93
R9044:Scart2 UTSW 7 139,828,010 (GRCm39) missense probably damaging 1.00
R9142:Scart2 UTSW 7 139,877,806 (GRCm39) missense probably damaging 1.00
R9152:Scart2 UTSW 7 139,877,256 (GRCm39) missense possibly damaging 0.55
R9470:Scart2 UTSW 7 139,827,345 (GRCm39) missense probably benign 0.07
R9509:Scart2 UTSW 7 139,879,644 (GRCm39) nonsense probably null
R9522:Scart2 UTSW 7 139,853,987 (GRCm39) missense possibly damaging 0.73
R9755:Scart2 UTSW 7 139,841,544 (GRCm39) critical splice donor site probably null
R9794:Scart2 UTSW 7 139,874,716 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCCGACTGGTCAATGGCAG -3'
(R):5'- GACCTGACAGGGAGAAACTC -3'

Sequencing Primer
(F):5'- ACTTAGCAGATGCCACTG -3'
(R):5'- GAGGACCATCGCTCCGAAC -3'
Posted On 2017-10-10